Molecular pathogenesis of CLL and its evolution

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial

(2014) S. Stilgenbauer et al.   BLOOD

Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia

(2014) R. Claus et al.   BLOOD

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

(2014) A. Martinez-Trillos et al.   BLOOD

Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness

(2014) M. Messina et al.   BLOOD

Somatic mutation as a mechanism of Wnt/ -catenin pathway activation in CLL

(2014) L. Wang et al.   BLOOD

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110 , for relapsed/refractory chronic lymphocytic leukemia

(2014) J. R. Brown et al.   BLOOD

Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia

(2014) D. Rossi et al.   BLOOD

Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia

(2014) Dan A. Landau et al.   CANCER CELL

Prognostic and Predictive Factors in Patients With Chronic Lymphocytic Leukemia: Relevant in the Era of Novel Treatment Approaches?

(2014) Daniel Mertens et al.   JOURNAL OF CLINICAL ONCOLOGY

NOTCH1, SF3B1, BIRC3andTP53mutations in patients with chronic lymphocytic leukemia undergoing first-line treatment: correlation with biological parameters and response to treatment

(2014) Sabina Chiaretti et al.   LEUKEMIA & LYMPHOMA

Evolving Understanding of the CLL Genome

(2014) Michaela Gruber et al.   SEMINARS IN HEMATOLOGY

MYD88 L265P mutation in Waldenstrom macroglobulinemia

(2013) S. Poulain et al.   BLOOD

The genomic landscape of chronic lymphocytic leukemia: clinical implications

(2013) Víctor Quesada et al.   BMC Medicine

Genetic and epigenetic basis of chronic lymphocytic leukemia

(2013) José I. Martín-Subero et al.   CURRENT OPINION IN HEMATOLOGY

Uncovering the DNA methylome in chronic lymphocytic leukemia

(2013) Nicola Cahill et al.   Epigenetics

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

(2013) P. G. Ferreira et al.   GENOME RESEARCH

Functional analysis of sucrase–isomaltase mutations from chronic lymphocytic leukemia patients

(2013) David Rodríguez et al.   HUMAN MOLECULAR GENETICS

Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients

(2013) S Weissmann et al.   LEUKEMIA

SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients

(2013) S Jeromin et al.   LEUKEMIA

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

The evolutionary biography of chronic lymphocytic leukemia

(2013) Xose S Puente et al.   NATURE GENETICS

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

(2013) Andrew J Ramsay et al.   NATURE GENETICS

Evolution of DNA Methylation Is Linked to Genetic Aberrations in Chronic Lymphocytic Leukemia

(2013) C. C. Oakes et al.   Cancer Discovery

Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics

(2013) Dan A Landau et al.   Genome Medicine

Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB

(2013) Angela Garding et al.   PLoS Genetics

Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns

(2012) A. Schuh et al.   BLOOD

Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia

(2012) D. Rossi et al.   BLOOD

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

(2012) R. Lapalombella et al.   BLOOD

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

(2012) H. Makishima et al.   BLOOD

The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial

(2012) D. G. Oscier et al.   BLOOD

The B-cell receptor signaling pathway as a therapeutic target in CLL

(2012) J. A. Woyach et al.   BLOOD

Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

(2012) Evgeny A Moskalev et al.   BMC CANCER

Extensive Promoter DNA Hypermethylation and Hypomethylation Is Associated with Aberrant MicroRNA Expression in Chronic Lymphocytic Leukemia

(2012) C. Baer et al.   CANCER RESEARCH

Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome

(2012) Andrew J. Ramsay et al.   Clinical & Translational Oncology

Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia

(2012) Lirong Pei et al.   Epigenetics

Molecular pathogenesis of chronic lymphocytic leukemia

(2012) Gianluca Gaidano et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative DNA Methylation Analysis Identifies a Single CpG Dinucleotide Important for ZAP-70 Expression and Predictive of Prognosis in Chronic Lymphocytic Leukemia

(2012) Rainer Claus et al.   JOURNAL OF CLINICAL ONCOLOGY

Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders

(2012) V Visconte et al.   LEUKEMIA

Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia

(2012) A J Ramsay et al.   LEUKEMIA

NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia

(2012) L Mansouri et al.   LEUKEMIA

450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments

(2012) N Cahill et al.   LEUKEMIA

NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome

(2012) N Villamor et al.   LEUKEMIA

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia

(2012) Marta Kulis et al.   NATURE GENETICS

Chronic Lymphocytic Leukemia withSF3B1Mutation

(2012) Victor Quesada et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines

(2011) M. Lia et al.   BLOOD

Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia

(2011) D. Sampath et al.   BLOOD

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

(2011) D. Rossi et al.   BLOOD

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

(2011) D. Rossi et al.   BLOOD

ATM and chronic lymphocytic leukemia: mutations, and not only deletions, matter

(2011) D. Rossi et al.   HAEMATOLOGICA

ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression

(2011) A. Guarini et al.   HAEMATOLOGICA

Association of a MicroRNA/TP53 Feedback Circuitry With Pathogenesis and Outcome of B-Cell Chronic Lymphocytic Leukemia

(2011) Muller Fabbri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

(2011) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL

(2010) Paolo Sportoletti et al.   BRITISH JOURNAL OF HAEMATOLOGY

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

TP53Mutation and Survival in Chronic Lymphocytic Leukemia

(2010) Thorsten Zenz et al.   JOURNAL OF CLINICAL ONCOLOGY

Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial

(2010) M Hallek et al.   LANCET

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications

(2010) R Alan Harris et al.   NATURE BIOTECHNOLOGY

Advances in understanding cancer genomes through second-generation sequencing

(2010) Matthew Meyerson et al.   NATURE REVIEWS GENETICS

Molecular basis of CLL

(2010) Yuri Pekarsky et al.   SEMINARS IN CANCER BIOLOGY

Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage

(2009) J. Malcikova et al.   BLOOD

Characteristics Associated With Important Clinical End Points in Patients With Chronic Lymphocytic Leukemia at Initial Treatment

(2009) William G. Wierda et al.   JOURNAL OF CLINICAL ONCOLOGY

ZAP-70 intron1 DNA methylation status: Determination by pyrosequencing in B chronic lymphocytic leukemia

(2009) Sylvain P. Chantepie et al.   LEUKEMIA RESEARCH

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA)

(2008) V. Grubor et al.   BLOOD

Epigenetic dysregulation of the Wnt signalling pathway in chronic lymphocytic leukaemia

(2008) C S Chim et al.   JOURNAL OF CLINICAL PATHOLOGY

The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype

(2008) F Dicker et al.   LEUKEMIA

Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia

(2007) V. Gattei et al.   BLOOD