Article
Biochemistry & Molecular Biology
Ana-Maria Gan, Zuzanna Tracz-Gaszewska, Aleksandra Ellert-Miklaszewska, Viktor O. Navrulin, James M. Ntambi, Pawel Dobrzyn
Summary: New blood vessel formation is a crucial component of cardiac repair after myocardial infarction (MI). This study identifies stearoyl-CoA desaturase (SCD) as a significant regulator of angiogenesis in the hypoxic myocardium, independent of HIF1 alpha expression. Inhibition of SCD activity disrupts the expression and secretion of proangiogenic factors and impairs the proangiogenic potential of ischemic cardiomyocytes. Additionally, SCD is involved in shaping the energy metabolism of the ischemic heart. These findings highlight the role of SCD in cardiac repair processes after MI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jacopo Di Gregorio, Sabrina Petricca, Roberto Iorio, Elena Toniato, Vincenzo Flati
Summary: Metabolic alterations, including enhanced aerobic glycolysis, oxidative phosphorylation, gluconeogenesis, and fatty acid beta-oxidation, play crucial roles in the development and survival of cancers.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Physiology
Maria Eugenia Vazquez-Mosquera, Mercedes Fernandez-Moreno, Estefania Cortes-Pereira, Sara Relano, Andrea Dalmao-Fernandez, Paula Ramos-Louro, Alejandro Duran Sotuela, Ignacio Rego-Perez, Francisco J. Blanco
Summary: The study reveals that palmitate can cause mitochondrial dysfunction, contributing to the understanding of the relationship between obesity and osteoarthritis, while oleate leads to increased accumulation of lipid droplets.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zhen Li, Huijing Xia, Thomas E. Sharp, Kyle B. LaPenna, John W. Elrod, Kevin M. Casin, Ken Liu, John W. Calvert, Vinh Q. Chau, Fadi N. Salloum, Shi Xu, Ming Xian, Noriyuki Nagahara, Traci T. Goodchild, David J. Lefer
Summary: This study reveals that the reduction of 3-MST in the myocardium is associated with heart failure. Knockout of 3-MST worsens cardiac and vascular dysfunction in a mouse model of pressure overload-induced heart failure. Restoring branched-chain amino acid metabolism and administrating an H2S donor can alleviate the detrimental effects of 3-MST deficiency in heart failure.
CIRCULATION RESEARCH
(2022)
Article
Physiology
Juan Diego Hernandez-Camacho, Daniel J. M. Fernandez-Ayala, Cristina Vicente-Garcia, Ignacio Navas-Enamorado, Guillermo Lopez-Lluch, Clara Oliva, Rafael Artuch, Judith Garcia-Villoria, Antonia Ribes, Rafael de Cabo, Jaime J. Carvajal, Placido Navas
Summary: ADCK2 haploinsufficiency leads to mitochondrial coenzyme Q deficiency in skeletal muscle, causing mitochondrial myopathy and defects in beta-oxidation of fatty acids. Calorie restriction improves glucose and fatty acid metabolism, enhances mitochondrial function and differentiation, and increases physical performance in mutant mice.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Kerri L. M. Smith, Agnieszka Swiderska, Mitchell C. Lock, Lucia Graham, Wulan Iswari, Tashi Choudhary, Donna Thomas, Hager M. Kowash, Michelle Desforges, Elizabeth C. Cottrell, Andrew W. Trafford, Dino A. Giussani, Gina L. J. Galli
Summary: Insufficient oxygen supply during fetal development affects fetal cardiac mitochondrial respiration in a sex-dependent manner. Maternal antioxidant treatments do not provide similar protection to cardiac mitochondria in male and female fetuses.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Cell Biology
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian
Summary: It was found that deficiency of Ppm1k leads to reduced metabolism of branched-chain amino acids (BCAAs) and protects against obesity-induced glucose intolerance. Accumulation of branched-chain keto acids (BCKAs) inhibits glucose production in liver cells. It was observed that BCKAs suppress the activity of liver mitochondrial pyruvate carrier (MPC) and pyruvate-supported respiration. Selective suppression of pyruvate-supported gluconeogenesis was seen in Ppm1k-deficient mice and could be restored through pharmacological activation of BCKA catabolism by BT2. Furthermore, liver MPC was found to be most sensitive to circulating BCKA levels, making it a sensor of BCAA metabolism.
Article
Cell Biology
Shanshan Liu, Song Fu, Guodong Wang, Yu Cao, Lanlan Li, Xuemei Li, Jun Yang, Ning Li, Yabing Shan, Yang Cao, Yan Ma, Mengqiu Dong, Qinghua Liu, Hui Jiang
Summary: Through experimental validation, Gro3P synthesis has been identified as an endogenous pathway for NAD(+) regeneration, effectively restoring the effects of inhibited electron transport chain on cells and maintaining a certain consistency in different organisms. This discovery has the potential to become a therapeutic target for mitochondrial complex I diseases.
Article
Cell Biology
Mikael Flockhart, Lina C. Nilsson, Senna Tais, Bjorn Ekblom, William Apro, Filip J. Larsen
Summary: Exercise training positively affects metabolic health, but excess exercise may lead to reduced mitochondrial function and impaired glucose tolerance. Studies have shown that world-class endurance athletes have issues with glucose control compared to matched control groups.
Article
Medicine, Research & Experimental
Luis F. Grilo, Joao D. Martins, Mariana S. Diniz, Carolina Tocantins, Chiara H. Cavallaro, Ines Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, Peter W. Nathanielsz, Paulo J. Oliveira, Susana P. Pereira
Summary: Maternal obesity may significantly affect liver function and pathophysiology, increasing the risk of pregnancy-associated liver diseases and hepatic diseases. Oxidative stress and mitochondrial dysfunction may play crucial roles in this process.
Article
Biochemistry & Molecular Biology
Giovanna Trinchese, Fabiano Cimmino, Gina Cavaliere, Luigi Rosati, Angela Catapano, Daniela Sorriento, Elisabetta Murru, Luca Bernardo, Luciana Pagani, Paolo Bergamo, Rosaria Scudiero, Guido Iaccarino, Luigi Greco, Sebastiano Banni, Marianna Crispino, Maria Pina Mollica
Summary: This study investigated the impact of different types of dairy consumption on heart mitochondrial functions, inflammation, and oxidative stress, finding that dietary supplementation with various types of milk can significantly affect metabolic and inflammatory status through modulation of mitochondrial functions.
Article
Medical Laboratory Technology
Ahmed Ismaeel, Emma Fletcher, Dimitrios Miserlis, Marissa Wechsler, Evlampia Papoutsi, Gleb Haynatzki, Robert S. Smith, William T. Bohannon, Panagiotis Koutakis
Summary: Previous studies have shown that circulating microRNA (miR)-210 levels are elevated in patients with peripheral artery disease (PAD). This study aimed to investigate the relationship between miR-210 expression and mitochondrial function in PAD patients. The results revealed that miR-210 expression was significantly increased in skeletal muscle of PAD patients, and there were significant reductions in the respiratory function of certain mitochondrial complexes. These findings may contribute to a better understanding of the metabolic pathophysiology of PAD.
TRANSLATIONAL RESEARCH
(2022)
Article
Environmental Sciences
Yiming Gao, Zhe Xie, Jin Qian, Zhihan Tu, Chuangye Yang, Yuewen Deng, Yucai Xue, Yueyong Shang, Menghong Hu, Youji Wang
Summary: In this study, the effects of diel-cycling hypoxia under different salinities on fatty acid composition and lipid metabolism in the oyster Crassostrea hongkongensis were evaluated. The results showed that both hypoxia and elevated salinity caused a decrease in the saturated fatty acid (SFA)/polyunsaturated fatty acid (PUFA) ratio of C. hongkongensis. Changes in specific fatty acids were mainly induced by salinity, while hypoxia accelerated the synthesis of certain fatty acids. Additionally, the activity of hepatic lipase (HL) and lipoprotein lipase (LPL) was affected by both salinity and dissolved oxygen. The findings indicate that exposure to combined stressors of salinity and hypoxia can disrupt the protective mechanisms of oysters and affect their lipid metabolism.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Inigo San-Millan, Genevieve C. Sparagna, Hailey L. Chapman, Valerie L. Warkins, Kathryn C. Chatfield, Sydney R. Shuff, Janel L. Martinez, George A. Brooks
Summary: Chronic lactate exposure decreases cardiac mitochondrial activity, which may have implications for metabolic health and flexibility.
FRONTIERS IN NUTRITION
(2022)
Article
Thermodynamics
Caifen Xia, Boqiao Fu, Jian-Cheng Jin
Summary: This study investigated the effect of Nd(III) on mitochondrial metabolism and evaluated its toxicology effect, using microcalorimetry assays to determine thermokinetic parameters. The results showed that Nd(III) affected mitochondrial energy metabolism depending on its concentration, with low levels promoting activity and high levels inhibiting it. The study also assessed the impact of Nd(III) on the respiratory chain of mitochondria, which aligned with the microcalorimetry results. These findings deepen our understanding of the mechanism of Nd(III) in mitochondrial metabolic processes and provide insights for the biosafety of rare-earth elements.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Urology & Nephrology
Nirmal Verma, Miao Liu, Han Ly, Analia Loria, Kenneth S. Campbell, Heather Bush, Philip A. Kern, Pedro A. Jose, Heinrich Taegtmeyer, Donald M. Bers, Sanda Despa, Larry B. Goldstein, Andrew J. Murray, Florin Despa
KIDNEY INTERNATIONAL
(2020)
Review
Physiology
Marina Makrecka-Kuka, Edgars Liepinsh, Andrew J. Murray, Helene Lemieux, Maija Dambrova, Kersti Tepp, Marju Puurand, Tuuli Kaambre, Woo H. Han, Paul de Goede, Katie A. O'Brien, Belma Turan, Erkan Tuncay, Yusuf Olgar, Anabela P. Rolo, Carlos M. Palmeira, Neoma T. Boardman, Rob C. I. Wust, Terje S. Larsen
Article
Neurosciences
K. L. Davies, E. J. Camm, E. V. Atkinson, T. Lopez, A. J. Forhead, A. J. Murray, A. L. Fowden
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Medicine, General & Internal
Silverio Perrotta, Domenico Roberti, Debora Bencivenga, Paola Corsetto, Katie A. O'Brien, Martina Caiazza, Emanuela Stampone, Leanne Allison, Roland A. Fleck, Saverio Scianguetta, Immacolata Tartaglione, Peter A. Robbins, Maddalena Casale, James A. West, Clara Franzini-Armstrong, Julian L. Griffin, Angela M. Rizzo, Antonio A. Sinisi, Andrew J. Murray, Adriana Borriello, Federico Formenti, Fulvio Della Ragione
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Genetics & Heredity
Alice P. Sowton, Nisha Padmanabhan, Simon J. Tunster, Ben D. McNally, Antonio Murgia, Aisha Yusuf, Julian L. Griffin, Andrew J. Murray, Erica D. Watson
MOLECULAR GENETICS AND METABOLISM REPORTS
(2020)
Article
Multidisciplinary Sciences
K. J. Botting, K. L. Skeffington, Y. Niu, B. J. Allison, K. L. Brain, N. Itani, C. Beck, A. Logan, A. J. Murray, M. P. Murphy, D. A. Giussani
Article
Biochemistry & Molecular Biology
Katie L. Davies, Danielle J. Smith, Tatiana El-Bacha, Max E. Stewart, Akshay Easwaran, Peter F. P. Wooding, Alison J. Forhead, Andrew J. Murray, Abigail L. Fowden, Emily J. Camm
Summary: Thyroid hormones play a crucial role in the prepartum development of cerebral mitochondria, affecting mitochondrial function and neurodevelopment, as demonstrated by alterations in respiration, mitochondrial density, and gene expression in hypothyroid fetal sheep.
Article
Multidisciplinary Sciences
Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda D. V. MacCannell, Jason L. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, Samuel Virtue, John Wright, Jack Garnham, Graeme R. Davies, James Dodgson, Jurgen E. Schneider, Andrew J. Murray, Christopher Church, Antonio Vidal-Puig, Klaus K. Witte, Julian L. Griffin, Lee D. Roberts
Summary: The study identifies a group of metabolites synthesized in brown adipose tissue that can influence the metabolism of fat tissue and skeletal muscle, with anti-obesity effects in mouse models of obesity and diabetes. Brown and beige adipose tissue appear to have a significant impact on systemic metabolism through secreted signals.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin
Summary: This study demonstrates rapid, specific and coordinated changes in cellular respiratory machinery, intermediary metabolism, and redox response in critically ill patients, with different trajectories in survivors and non-survivors. Differences in survival rates and metabolic activities were observed between survivors and non-survivors at 48 hours and day 7. Increases in oxidative stress and reductive drive were evident in critically ill patients, with non-survivors showing greater oxidative pressure and vascular inflammation compared to survivors.
Article
Biology
Ross T. Lindsay, Sophie Dieckmann, Dominika Krzyzanska, Dominic Manetta-Jones, James A. West, Cecilia Castro, Julian L. Griffin, Andrew J. Murray
Summary: Under conditions of low-flow ischemia, the heart can generate ketones through pathways involving HMGCS2 and SCOT, impacting cardiac functional recovery.
Article
Biology
Katie A. O'Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray
Summary: Short-term exposure to hypoxia enhances hepatic respiratory capacity and alters lipid metabolism, but these changes are transient and resolved after 14 days. These findings may have implications in understanding and treating hepatic pathologies associated with hypoxia.
Article
Endocrinology & Metabolism
K. L. Davies, E. J. Camm, D. J. Smith, O. R. Vaughan, A. J. Forhead, A. J. Murray, A. L. Fowden
Summary: This study investigated the impact of manipulating cortisol concentrations in fetal sheep during late gestation on mitochondrial OXPHOS capacity of different skeletal muscles. The results showed that cortisol has a muscle-specific role in prepartum maturation of mitochondrial OXPHOS capacity, which has important implications for the health of neonates born pre-term or after intrauterine glucocorticoid overexposure.
JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Geriatrics & Gerontology
Madu N. Soares, Moritz Eggelbusch, Elie Naddaf, Karin H. L. Gerrits, Marike van der Schaaf, Bram van den Borst, W. Joost Wiersinga, Michele van Vugt, Peter J. M. Weijs, Andrew J. Murray, Rob C. I. Wust
Summary: Skeletal muscle-related symptoms, including weakness and exercise intolerance, are common in acute Covid-19 and PASC. Severe cases show muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue include systemic inflammation, disuse, hypoxemia, and malnutrition. The mechanisms underlying muscle issues in PASC are more complex and may be related to direct viral infiltration or aberrant immune response. Further research is needed to understand the similarities with chronic fatigue syndrome.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Medicine, General & Internal
Lorenz M. W. Holzner, Andrew J. Murray
Summary: NAFLD and NASH are major public health concerns with limited treatment options. Studies show that HIF plays important roles in modulating these diseases, potentially aiding in the development of new therapeutic strategies.
FRONTIERS IN MEDICINE
(2021)
Article
Clinical Neurology
Han Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Donna M. Wilcock, Larry B. Goldstein, Rita Guerreiro, Jose Bras, Angela J. Hanson, Suzanne Craft, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Summary: This study found cross-seeding of amylin-Aβ in the brains of AD patients. High levels of amylin in the CSF were associated with decreased Aβ(42) concentrations. The risk of AD and the amylin gene are not correlated.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2021)