Exercise training augments the dynamic heart rate response to vagal but not sympathetic stimulation in rats

We examined the transfer function of autonomic heart rate (HR) control in anesthetized sedentary and exercise-trained (16 wk, treadmill for 1 h, 5 times/wk at 15 m/min and 15-degree grade) rats for comparison to HR variability assessed in the conscious resting state. The transfer function from sympathetic stimulation to HR response was similar between groups (gain, 4.2 +/- 1.5 vs. 4.5 +/- 1.5 beats.min(-1).Hz(-1); natural frequency, 0.07 +/- 0.01 vs. 0.08 +/- 0.01 Hz; damping coefficient, 1.96 +/- 0.55 vs. 1.69 +/- 0.15; and lag time, 0.7 +/- 0.1 vs. 0.6 +/- 0.1 s; sedentary vs. exercise trained, respectively, means +/- SD). The transfer gain from vagal stimulation to HR response was 6.1 +/- 3.0 in the sedentary and 9.7 +/- 5.1 beats.min(-1).Hz(-1) in the exercise-trained group (P = 0.06). The corner frequency (0.11 +/- 0.05 vs. 0.17 +/- 0.09 Hz) and lag time (0.1 +/- 0.1 vs. 0.2 +/- 0.1 s) did not differ between groups. When the sympathetic transfer gain was averaged for very-low-frequency and low-frequency bands, no significant group effect was observed. In contrast, when the vagal transfer gain was averaged for very-low-frequency, low-frequency, and high-frequency bands, exercise training produced a significant group effect (P < 0.05 by two-way, repeated-measures ANOVA). These findings suggest that, in the frequency domain, exercise training augments the dynamic HR response to vagal stimulation but not sympathetic stimulation, regardless of the frequency bands.