Immortalized neurons for the study of hypothalamic function

Nutrient sensing and insulin signaling in neuropeptide-expressing immortalized, hypothalamic neurons: A cellular model of insulin resistance

(2010) Laura J. Fick et al.   CELL CYCLE

Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

(2010) Sabine D. Jordan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons

(2010) Ginah L. Kim et al.   ENDOCRINOLOGY

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

(2010) Michael N. Lehman et al.   ENDOCRINOLOGY

Age-associated changes of appetite-regulating peptides

(2010) Saeko Akimoto et al.   Geriatrics & Gerontology International

Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism

(2010) L.-Y. Fu et al.   JOURNAL OF NEUROSCIENCE

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

(2010) Stephanie L Padilla et al.   NATURE MEDICINE

Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models

(2010) S. Gingerich et al.   NEUROSCIENCE

Weighing Risks and Benefits of Liraglutide — The FDA's Review of a New Antidiabetic Therapy

(2010) Mary Parks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucose-induced inhibition: how many ionic mechanisms?

(2009) D. Burdakov et al.   Acta Physiologica

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Distribution and Postnatal Development ofGpr54Gene Expression in Mouse Brain and Gonadotropin-Releasing Hormone Neurons

(2009) Allan E. Herbison et al.   ENDOCRINOLOGY

Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons

(2009) Denise D. Belsham et al.   FASEB JOURNAL

Hypothalamic cell lines to investigate neuroendocrine control mechanisms

(2009) Christopher M. Mayer et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Neurobiological Mechanisms Underlying Oestradiol Negative and Positive Feedback Regulation of Gonadotrophin-Releasing Hormone Neurones

(2009) S. M. Moenter et al.   JOURNAL OF NEUROENDOCRINOLOGY

Hormone and glucose signalling in POMC and AgRP neurons

(2009) Bengt F. Belgardt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines

(2009) Horacio J. Novaira et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons

(2009) Christopher M. Mayer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons

(2009) S. Gingerich et al.   NEUROSCIENCE

Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond

(2009) A. Christine Könner et al.   PHYSIOLOGY & BEHAVIOR

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

(2009) Juliana C. Moraes et al.   PLoS One

Neuropeptide Y induces gonadotropin-releasing hormone gene expression directly and through conditioned medium from mHypoE-38 NPY neurons

(2009) Sandeep S. Dhillon et al.   REGULATORY PEPTIDES

Hypothalamic pathways linking energy balance and reproduction

(2008) Jennifer W. Hill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice

(2008) Eun Ran Kim et al.   BEHAVIOURAL BRAIN RESEARCH

Estradiol decreases the orexigenic effect of neuropeptide Y, but not agouti-related protein, in ovariectomized rats

(2008) Jessica Santollo et al.   BEHAVIOURAL BRAIN RESEARCH

Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1

(2008) Golnaz Madadi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Metabolism-Independent Sugar Sensing in Central Orexin Neurons

(2008) J. A. Gonzalez et al.   DIABETES

Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

(2008) Paty Karoll Picardi et al.   ENDOCRINOLOGY

Variation in Kisspeptin and RFamide-Related Peptide (RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep

(2008) Jeremy T. Smith et al.   ENDOCRINOLOGY

Central and Peripheral Effects of RFamide-Related Peptide-3 on Luteinizing Hormone and Prolactin Secretion in Rats

(2008) Greg M. Anderson et al.   ENDOCRINOLOGY

Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus

(2008) Minemori Watanabe et al.   FEBS LETTERS

Central Control of Body Weight and Appetite

(2008) Stephen C. Woods et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glial-Gonadotrophin Hormone (GnRH) Neurone Interactions in the Median Eminence and the Control of GnRH Secretion

(2008) S. R. Ojeda et al.   JOURNAL OF NEUROENDOCRINOLOGY

Estrogen Facilitates both Phosphatidylinositol 3-Kinase/Akt and ERK1/2 Mitogen-Activated Protein Kinase Membrane Signaling Required for Long-Term Neuropeptide Y Transcriptional Regulation in Clonal, Immortalized Neurons

(2008) D. Titolo et al.   JOURNAL OF NEUROSCIENCE

Dissociation between sensing and metabolism of glucose in sugar sensing neurones

(2008) J. Antonio Gonzàlez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Converse Regulatory Functions of Estrogen Receptor-α and -β Subtypes Expressed in Hypothalamic Gonadotropin-Releasing Hormone Neurons

(2008) Lian Hu et al.   MOLECULAR ENDOCRINOLOGY

Hypothalamic Preproghrelin Gene Expression Is Repressed by Insulin via Both PI3-K/Akt and ERK1/2 MAPK Pathways in Immortalized, Hypothalamic Neurons

(2008) L.J. Fick et al.   NEUROENDOCRINOLOGY

Neuroendocrine control of food intake

(2008) Elena Valassi et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Glia Are Essential for Sensory Organ Function in C. elegans

(2008) T. Bacaj et al.   SCIENCE

Inhibition of Agouti-Related Peptide Expression by Glucose in a Clonal Hypothalamic Neuronal Cell Line Is Mediated by Glycolysis, Not Oxidative Phosphorylation

(2007) Hui Cheng et al.   ENDOCRINOLOGY

Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol

(2007) Justyna Pielecka-Fortuna et al.   ENDOCRINOLOGY

RFamide-Related Peptide Gene Is a Melatonin-Driven Photoperiodic Gene

(2007) Florent G. Revel et al.   ENDOCRINOLOGY