Article
Multidisciplinary Sciences
Saman Lashkari, Tove N. Clausen, Leslie Foldager, Soren K. Jensen
Summary: The bioavailability of alpha-tocopherol in mink kits during the weaning period is affected by the source and dose of supplementation. RRR-alpha-tocopherol content in plasma and tissues increases linearly with supplementation and is highest in mink kits fed ALC at the highest doses. The interaction between source and dose may be due to limitations in the hydrolysis of ester bond in alpha-tocopheryl acetate.
SCIENTIFIC REPORTS
(2021)
Article
Reproductive Biology
Chun-Ling Zhu, Lei Wang, Xue-Qin Zhao, Rui Yang, Bo-Yang Zhang, Ya-Ya Zhao, Xiao-Jing Xia, Hui-Hui Zhang, Shi-Jun Chen, Jin-Qing Jiang, Jian-He Hu, Gai-Ping Zhang, Yue-yu Bai, Lian-Cheng Lei, Xue-Ming Zhang
Summary: Antimicrobial peptides (AMPs) have the potential to protect Sertoli cells, reduce inflammatory response, decrease oxidative stress, maintain the integrity of the blood-testis barrier, inhibit apoptosis, and restore spermatogenesis in orchitis, as demonstrated in a mouse model.
Article
Veterinary Sciences
Yufei Zhang, Baozeng Xu
Summary: In this study, we found that the dynamics of N-glycosylation of testicular proteins play an important role in seasonal spermatogenesis in the American mink, affecting their folding, distribution, stability, and activity.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Weiqi Sun, Fang Tian, Hongjie Pan, Xiuli Chang, Minjie Xia, Jingying Hu, Yuzhu Wang, Runsheng Li, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: This study systematically explored the male reproductive toxicity of FLC and found that it caused testicular dysfunction and damage in mice, leading to abnormal spermatogenesis and decreased sperm quality. The potential mechanisms include interference with spermatogonial proliferation and meiosis, as well as apoptosis and mitochondrial damage in testicular Sertoli cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Indrashis Bhattacharya, Partigya Sharma, Shriya Purohit, Sachin Kothiyal, Moitreyi Das, Arnab Banerjee
Summary: This opinion article briefly reviews our current understanding on the RA-driven spermatogonial differentiation in murine testes, including the role of RA in the transition of spermatogonia types and the regulation of meiotic prophase.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Yi Zheng, Qiang Gao, Tianjiao Li, Ruifang Liu, Zechao Cheng, Ming Guo, Jinhong Xiao, De Wu, Wenxian Zeng
Summary: The study systematically investigated the development patterns of Sertoli cells and spermatogonia in pigs from neonate to sexual maturity, shedding light on previously unknown details. The findings not only expand knowledge about spermatogenesis and testicular development in pigs, but also provide a theoretical basis for porcine breeding and rearing.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Angela K. Lucas-Herald, Rod T. Mitchell
Summary: Sertoli cells play an important role in gonadal development, germ cell survival, and spermatogenesis. The levels of AMH and inhibin B in individuals with DSD are regulated and can impact their gonadal function throughout life.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Wasim Shah, Ranjha Khan, Basit Shah, Asad Khan, Sobia Dil, Wei Liu, Jie Wen, Xiaohua Jiang
Summary: The process of spermatogenesis relies on hormones and growth factors acting through endocrine and paracrine pathways. Sertoli cells are major regulators, while sex hormones play a significant role in determining their proliferation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joao C. Ribeiro, Ana D. Martins, Ivana Jarak, Rui A. Carvalho, Marco G. Alves, Pedro F. Oliveira
Summary: The combination therapy of dapagliflozin and exenatide shows promising effects in improving the treatment of type 2 diabetes mellitus, protecting male fertility, inducing weight loss, and improving glucose homeostasis.
Article
Agriculture, Dairy & Animal Science
Sergio Villanueva-Saz, Jacobo Giner, Ana Maria Palomar, Maria Asuncion Gomez, Madis Podra, Maria del Carmen Aranda, Maria de los Angeles Jimenez, Patricia Lizarraga, Raquel Hernandez, Aranzazu Portillo, Jose Antonio Oteo, Ignacio Ruiz-Arrondo, Maria Dolores Perez, Ana Pilar Tobajas, Maite Verde, Delia Lacasta, Diana Marteles, Ramon Hurtado-Guerrero, Llipsy Santiago, Hector Ruiz, Antonio Fernandez
Summary: This study evaluates the presence of SARS-CoV-2 in European mink and American mink in Spain. The results show a low risk of wild mink exposure to SARS-CoV-2 in an area seriously affected by COVID-19, reducing the likelihood of virus transmission to humans through this route. However, continued surveillance and early detection of risks in wildlife remains important.
Article
Developmental Biology
Yi Jacky Peng, Xinyu Thomas Tang, Hui Sophie Shu, Wenjie Dong, Hongfang Shao, Bo O. Zhou
Summary: The study found that testicular stromal cells, including Sertoli, endothelial, Leydig, smooth muscle, and Tcf21-CreER+ stromal cells, express stem cell factor (SCF), an essential growth factor for spermatogenesis. Undifferentiated and differentiating spermatogonia were associated with SCF-expressing Sertoli cells. Conditional deletion of SCF from Sertoli cells blocked the differentiation of spermatogonia, leading to male infertility. Conditional overexpression of SCF in Sertoli cells significantly increased spermatogenesis.
Review
Endocrinology & Metabolism
Maia Corpuz-Hilsabeck, Martine Culty
Summary: Sertoli cells play crucial roles in male reproduction, and dysregulation of their functions can have lifelong adverse effects on testis development and spermatogenesis. Understanding the impact of endocrine disrupting chemicals and drugs on Sertoli cells is important for comprehending the adverse outcomes on the reproductive system that these compounds may induce.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Kehan Wang, Feifei Kong, Yuexin Qiu, Tao Chen, Jiayi Fu, Xin Jin, Youqiang Su, Yayun Gu, Zhibin Hu, Jing Li
Summary: Sertoli cells provide a nurturing environment for germ cell development and maturation, and the role of phosphatidylinositol 3-kinase (PtdIns3K) in Sertoli cells is unclear. Deleting the Pik3c3 gene specifically in Sertoli cells resulted in infertility, disrupted Sertoli cell polarity, and impaired spermiogenesis. Accumulation of SCIN caused the disorganization of the F-actin cytoskeleton, while accumulated HDAC6 deacetylated SCIN, leading to a disorganized F-actin cytoskeleton.
Article
Developmental Biology
Catherine C. Baker, Lorenzo Gallicchio, Neuza R. Matias, Douglas F. Porter, Lucineh Parsanian, Emily Taing, Cheuk Tam, Margaret T. Fuller
Summary: A group of germ cell-specific regulators control the expression of CycB protein and the cell cycle progression during the male meiotic prophase in Drosophila.
Article
Cell Biology
Nikol Dibus, Eliska Zobalova, Mario A. M. Monleon, Vladimir Korinek, Dominik Filipp, Jana Petrusova, Radislav Sedlacek, Petr Kasparek, Lukas Cermak
Summary: The ubiquitin ligase SCFFBXO38 regulates centromeric chromatin by promoting the degradation of the ZXDB protein. Loss of FBXO38 leads to growth retardation, pathological changes in the testes, decreased sperm production, and reduced fertility in mice. FBXO38 is specifically expressed in Sertoli cells in the testes, and its absence results in Sertoli cell maturation defect and impaired spermatogonial differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)