4.3 Article

The cardiovascular and endocrine responses to voluntary and forced diving in trained and untrained rats

Publisher

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00592.2009

Keywords

implanted biotelemetric transmitters; underwater maze; habituation; swimming; cardiorespiratory control system

Categories

Funding

  1. National Institutes of Health [HL080007]
  2. Midwestern University Office of Research
  3. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R15HL080007] Funding Source: NIH RePORTER

Ask authors/readers for more resources

McCulloch PF, DiNovo KM, Connolly TM. The cardiovascular and endocrine responses to voluntary and forced diving in trained and untrained rats. Am J Physiol Regul Integr Comp Physiol 298: R224-R234, 2010. First published November 18, 2009; doi:10.1152/ajpregu.00592.2009.-The mammalian diving response, consisting of apnea, bradycardia, and increased total peripheral resistance, can be modified by conscious awareness, fear, and anticipation. We wondered whether swim and dive training in rats would 1) affect the magnitude of the cardiovascular responses during voluntary and forced diving, and 2) whether this training would reduce or eliminate any stress due to diving. Results indicate Sprague-Dawley rats have a substantial diving response. Immediately upon submersion, heart rate (HR) decreased by 78%, from 453 +/- 12 to 101 +/- 8 beats per minute (bpm), and mean arterial pressure (MAP) decreased 25%, from 143 +/- 1 to 107 +/- 5 mmHg. Approximately 4.5 s after submergence, MAP had increased to a maximum 174 +/- 3 mmHg. Blood corticosterone levels indicate trained rats find diving no more stressful than being held by a human, while untrained rats find swimming and diving very stressful. Forced diving is stressful to both trained and untrained rats. The magnitude of bradycardia was similar during both voluntary and forced diving, while the increase in MAP was greater during forced diving. The diving response of laboratory rats, therefore, appears to be dissimilar from that of other animals, as most birds and mammals show intensification of diving bradycardia during forced diving compared with voluntary diving. Rats may exhibit an accentuated antagonism between the parasympathetic and sympathetic branches of the autonomic nervous system, such that in the autonomic control of HR, parasympathetic activity overpowers sympathetic activity. Additionally, laboratory rats may lack the ability to modify the degree of parasympathetic outflow to the heart during an intense cardiorespiratory response (i.e., the diving response).

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Physiology

Animal models for investigating the central control of the mammalian diving response

Paul Frederick McCulloch

FRONTIERS IN PHYSIOLOGY (2012)

Article Multidisciplinary Sciences

Training Rats to Voluntarily Dive Underwater: Investigations of the Mammalian Diving Response

Paul F. McCulloch

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2014)

Article Anatomy & Morphology

Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response

Paul F. McCulloch, Kenneth A. Lahrman, Benjamin DelPrete, Karyn M. DiNovo

FRONTIERS IN NEUROANATOMY (2018)

Article Physiology

Bilateral sectioning of the anterior ethmoidal nerves does not eliminate the diving response in voluntarily diving rats

Jill S. Chotiyanonta, Karyn M. DiNovo, Paul F. McCulloch

PHYSIOLOGICAL REPORTS (2013)

Article Neurosciences

Activation of brainstem catecholaminergic neurons during voluntary diving in rats

PF McCulloch, WM Panneton

BRAIN RESEARCH (2003)

Article Neurosciences

Facial immersion bradycardia in teenagers and adults accustomed to swimming

NH West, PF McCulloch, PM Browne

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2001)

Article Neurosciences

Trigemino-autonomic connections in the muskrat: the neural substrate for the diving response

WM Panneton, PF McCulloch, W Sun

BRAIN RESEARCH (2000)

No Data Available