Article
Biochemistry & Molecular Biology
Daniela Vejrazkova, Marketa Vankova, Petra Lukasova, Martin Hill, Josef Vcelak, Andrea Tura, Denisa Chocholova, Bela Bendlova
Summary: The shape of glycemic curve during OGTT predicts impaired glucose homeostasis and metabolic syndrome. Men are more likely to have biphasic curves, while women are more likely to have triphasic curves. Monophasic curves are associated with higher risk of impaired glucose regulation and metabolic syndrome.
Article
Endocrinology & Metabolism
Claudia Piona, Sonia Volpi, Chiara Zusi, Enza Mozzillo, Antonella Tosco, Adriana Franzese, Valeria Raia, Maria Linda Boselli, Maddalena Trombetta, Marco Cipolli, Riccardo C. Bonadonna, Claudio Maffeis
Summary: In patients with cystic fibrosis, each of the 5 glucose tolerance stages demonstrates a distinct pattern of defects in the direct determinants of glucose regulation. Early elevation of AGT140 patients significantly differ from NGT and are similar to IGT.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medical Laboratory Technology
Dominika Szoke, Cristina Robbiano, Roberta Dolcini, Laura Montefusco, Gioconda Barbara Aiello, Simone Caruso, Anna Ottolenghi, Sarah Birindelli, Mauro Panteghini
Summary: The objective of this study was to investigate the incidence of flat shaped glucose curves (FC) in pregnant women and compare the insulin and C-peptide secretion in women with FC to a well-matched control group. The results showed that women with FC had significantly lower levels of C-peptide and insulin, suggesting hypersensitivity to insulin with normal beta-cell function. Additionally, a delayed glucose absorption could be hypothesized due to the shape of the insulin curve in the FC group.
CLINICAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Anne Bonhoure, Kathryn J. Potter, Johann Colomba, Valerie Boudreau, Cindy Bergeron, Katherine Desjardins, Maite Carricart, Francois Tremblay, Annick Lavoie, Remi Rabasa-Lhoret
Summary: In cystic fibrosis patients, maximum OGTT glucose (Gmax) is strongly associated with the risk of developing CFRD; Gmax < 8 mmol/l may identify those at very low risk of future CFRD; additionally, individuals with higher Gmax are more likely to have pancreatic insufficiency, poor insulin secretory capacity, and impaired pulmonary function.
Article
Endocrinology & Metabolism
Bibi Uhre Nielsen, Inger Hee Mabuza Mathiesen, Rikke Moller, Rikke Krogh-Madsen, Terese Lea Katzenstein, Tacjana Pressler, James A. M. Shaw, Christian Ritz, Michael R. Rickels, Darko Stefanovski, Thomas Peter Almdal, Daniel Faurholt-Jepsen
Summary: The study aims to further understand the pathophysiology of CF-related diabetes and explore potential factors causing hypoglycaemia. The results indicate that there is an association between beta cell stress and abnormal alpha cell function in adults with CF. Hypoglycaemia in CF patients may be due to a temporal mismatch between glucose and insulin levels rather than an impaired glucagon response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Emily A. Rosenberg, Ellen W. Seely, Kaitlyn James, Marti D. Soffer, Stacey Nelson, Jacinda M. Nicklas, Camille E. Powe
Summary: The study found no association between carbohydrate intake and post-OGTT glucose levels among postpartum individuals. Therefore, dietary preparation prior to the OGTT may not be necessary in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Shaofeng Huo, Liang Sun, Geng Zong, Xia Shen, He Zheng, Qianlu Jin, Huaixing Li, Huiyong Yin, Xu Lin
Summary: This study aimed to characterize plasma metabolomic profiles during an oral glucose tolerance test (OGTT) in Chinese individuals with different glycemic statuses. The results showed distinct metabolite responses in individuals with type 2 diabetes (T2D), with certain metabolites significantly higher at 2 hours post-OGTT. Differences in metabolite levels were also observed between T2D, prediabetes, and normal glucose subjects, suggesting potential implications for glucose homeostasis.
Article
Endocrinology & Metabolism
Lewin Small, Amy Ehrlich, Jo Iversen, Stephen P. Ashcroft, Kajetan Trost, Thomas Moritz, Bolette Hartmann, Jens J. Holst, Jonas T. Treebak, Juleen R. Zierath, Romain Barres
Summary: The study compares the effect of different routes of glucose administration (oral and intraperitoneal) on glucose and insulin kinetics during a glucose tolerance test in mice. The results show that intraperitoneal glucose administration resulted in significantly elevated blood glucose levels, but had a lesser effect on insulin and incretin hormone levels compared to oral administration.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Vasudha Ahuja, Pasi Aronen, T. A. Pramodkumar, Helen Looker, Angela Chetrit, Aini H. Bloigu, Auni Juutilainen, Cristina Bianchi, Lucia La Sala, Ranjit Mohan Anjana, Rajendra Pradeepa, Ulagamadesan Venkatesan, Sarvanan Jebarani, Viswanathan Baskar, Teresa Vanessa Fiorentino, Patrick Timpel, Ralph A. DeFronzo, Antonio Ceriello, Stefano Del Prato, Muhammad Abdul-Ghani, Sirkka Keinanen-Kiukaanniemi, Rachel Dankner, Peter H. Bennett, William C. Knowler, Peter Schwarz, Giorgio Sesti, Rie Oka, Viswanathan Mohan, Leif Groop, Jaakko Tuomilehto, Samuli Ripatti, Michael Bergman, Tiinamaija Tuomi
Summary: The 1-h PG of >= 11.6 mmol/L during OGTT has good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator is suggested to reduce the proportion of false-positive cases, with further studies needed for other ethnic groups and complication risk assessment.
Article
Agriculture, Dairy & Animal Science
Elin Manell, Patricia Hedenqvist, Marianne Jensen-Waern
Summary: Animal models are crucial in biomedical research for developing new treatments. Refinement of animal models is necessary to ensure ethical and reliable research data. This publication describes improvements in training techniques for pigs in an oral glucose tolerance test model, aiding researchers in successful training and adhering to the 3Rs principles.
Article
Pediatrics
Monal Patel, Courtney McCracken, Tanicia Daley, Arlene Stecenko, Rachel Linnemann
Summary: This study aimed to identify patterns of glucose homeostasis progression in pediatric CF patients without CFRD and to explore the relationship to lung function. Three unique trajectories of 2hrGlu values were identified, with most patients exhibiting a trajectory of worsening glucose homeostasis over time. Lower baseline forced expiratory volume in 1 s percent predicted (ppFEV(1)) was associated with a trajectory of high to higher 2hrGlu values, suggesting early presence of lower lung function in the development of CFRD.
PEDIATRIC PULMONOLOGY
(2021)
Article
Endocrinology & Metabolism
Jesse J. Seegmiller, David L. Schmit, Valerie W. Arends, Michael E. Steffes, Steven Kahn, Naji Younes, GRADE Res Grp
Summary: This study measured the concentrations of insulin, glargine, and its metabolites in plasma and found that the metabolites did not fully cross-react in the insulin immunoassay, resulting in measurement bias. However, the study concluded that dynamic insulin responses can still be used to assess beta-cell responsiveness.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Elsa Vazquez Arreola, Robert L. Hanson, Clifton Bogardus, William C. Knowler
Summary: This study examined the relationship between insulin secretion, insulin sensitivity, and the development of type 2 diabetes in American Indians. It found that the combination of insulin secretion and sensitivity is a better predictor of diabetes than the disposition index alone.
Article
Cardiac & Cardiovascular Systems
Viola Zywicki, Paola Capozza, Paolo Caravelli, Stefano Del Prato, Raffaele De Caterina
Summary: Impaired glucose tolerance (IGT) has been associated with adverse cardiovascular outcomes. This study found that among non-diabetic ACS patients, only those with elevated 1-hour and 2-hour plasma glucose levels had more severe myocardial injury and longer hospitalization. 1-hour plasma glucose is important in assessing post-ACS cardiac risk.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria J. Redondo, Megan Warnock, Ingrid M. Libman, Laura E. Bocchino, David Cuthbertson, Susan Geyer, Alberto Pugliese, Andrea K. Steck, Carmella Evans-Molina, Dorothy Becker, Jay M. Sosenko, Fida Bacha
Summary: In non-diabetic individuals with autoantibodies, TCF7L2 SNPs were not associated with insulin sensitivity or secretion indices after adjusting for BMI z score, age, sex, and ethnicity.