Review
Cell Biology
Nawazish Naqvi, Siiri E. Iismaa, Robert M. Graham, Ahsan Husain
Summary: Heart failure is a major cause of morbidity and mortality globally. Regenerative therapy for the heart requires addressing issues such as loss of cardiomyocyte replicative capacity, neovascularization, inflammation, fibrosis, and adverse left ventricular remodeling, while also ensuring safety and ease of translation. Failure to overcome these challenges can delay the translation of regenerative approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Paige Dausinas Ni, Melissa Hartman, Jacob Slack, Christopher Basile, Sheng Liu, Jun Wan, Heather A. O'Leary
Summary: Low oxygen bone marrow niches provide critical signals for HSC/HSPCs. Our data analyze the differential Ca2+ regulation in live, sorted HSC/HSPCs in low oxygen conditions, revealing phenotypic, signaling, and functional consequences in HSC/HSPCs. Inhibition of the Ca2+ regulator NHE1 attenuates the low oxygen-induced high Ca2+ population and enhances the maintenance of phenotypic LSK and LSKCD150 during low oxygen replating.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Physiology
Xue-Ying Zhang, De-Hua Wang
Summary: This review summarizes the recent progress in understanding the role of gut microbiota in physiological and behavioral thermoregulation of small mammals in cold environments.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi Lei, Liandong Yang, Yu Zhou, Cheng Wang, Wenqi Lv, Lin Li, Shunping He
Summary: Research on the genetic basis of hypoxic adaptation in high-altitude environments is active in evolutionary biology. The study investigated Hb concentration in fish at different altitudes, finding species-specific Hb concentration with a non-positive correlation with altitude. The discovery of positively selected Hb genes in schizothoracinae fishes indicates potential functional divergence in Hb isoforms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Matteo Duque Rodriguez, Camila O. Cittadini, Gabriela M. Teplitz, Adrian De Stefano, Daniel M. Lombardo, Daniel F. Salamone
Summary: Assisted reproductive technologies in canine species are limited by the low efficiency of in vitro maturation (IVM). Different IVM media and additives were compared, with SOF + BSA and SOF + BSA + FBS showing significant differences in oocyte maturation. Supplementation with ITS improved maturation rates, reduced ROS levels, and enhanced membrane integrity in domestic dog oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pediatrics
Liang Zou, Di Yu, Ruonan Wang, Yueshuang Cun, Yaping Li, Qingfeng Wang, Yaqin Shu, Xuming Mo
Summary: This study found that the incidence of LCOS after cardiopulmonary bypass in infants with congenital heart disease was 28.11%. It was demonstrated that preoperative FT3 levels, ACC time, and body weight were independent predictors of LCOS.
FRONTIERS IN PEDIATRICS
(2022)
Article
Ecology
David M. Anderson, James F. Gillooly
Summary: Different species have varying strategies in allocating resources to offspring size and number, with tradeoffs between offspring survivorship and fecundity limiting reproductive success. Research shows that survivorship tends to increase proportionally with relative offspring mass, while fecundity decreases in proportion with offspring mass. The overall reproductive success is generally independent of offspring mass.
Review
Biochemistry & Molecular Biology
Fan Yu, Shuo Cong, En Ping Yap, Derek J. Hausenloy, Chrishan J. Ramachandra
Summary: Ischemic heart disease is a major cause of heart failure and has a significant impact on global health. The limited regenerative capacity of cardiomyocytes poses challenges for heart repair. Recent research has shown that cardiac metabolism plays a crucial role in heart regeneration and modulating this metabolism could promote regeneration. However, there is a lack of mechanistic understanding in this field, hindering the development of effective therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bahareh Nazari, Vincent Jaquet, Karl-Heinz Krause
Summary: This study analyzed the conservation of the NOX family during mammalian evolution using an in-silico approach. The absence of NOX isoforms was investigated in 164 mammalian species, and it was found that NOX5 was absent in some rodent, lagomorph, and bat species. Most NOX isoforms had highly conserved amino acid sequences, except for NOX2 which had a relatively small conserved region. The study shed new light on the essentiality of different NOX isoforms and identified isoform-defining sequences within specific NOX isoforms.
Article
Cell Biology
Samia Rahman, Alexander R. A. Szojka, Yan Liang, Melanie Kunze, Victoria Goncalves, Aillette Mulet-Sierra, Nadr M. Jomha, Adetola B. Adesida
Summary: Human IFP-MSC did not undergo chondrogenesis under 2% low oxygen tension, but chondrogenic medium with TGFβ3 induced in vitro chondrogenesis, which did not lead to endochondral ossification after implantation in athymic mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Optics
Mark Golberg, Ran Califa, Sagi Polani, Orit Goldstein, Zailer Aviram, Meir Niska, Zeev Zalevsky
Summary: This article presents an optical sensor for contactless measurement of diabetic foot based on laser speckle techniques. The sensor analyzes the speckle patterns to differentiate the perfusion of the foot. A simple and inexpensive PAD monitoring system design is proposed.
Article
Materials Science, Multidisciplinary
Ensieh Yousefi, Youqing Sun, Anil Kunwar, Muxing Guo, Nele Moelans, David Seveno
Summary: In this study, the surface tension of pure Al and Al-O systems was thoroughly investigated using Molecular Dynamics simulations. The results showed that surface tension is sensitive to oxygen content and temperature, and a good agreement was found between measured and predicted values. Additionally, simulations at different temperatures with varying oxygen contents elucidated the effects of controlled atmospheric conditions on surface tension.
Article
Chemistry, Physical
Vlastimil Novak, Lenka Rehackova, Petra Vanova, Michal Sniegon, Dalibor Matysek, Katerina Konecna, Bedrich Smetana, Silvie Rosypalova, Marketa Tkadleckova, L'ubomira Drozdova, Petr Klus
Summary: This study assessed the effect of minimal oxygen content on the surface tension of low-alloy steels and found that increasing oxygen content leads to a reduction in surface tension. Additionally, the research investigated the difficulties in determining surface tension caused by increased chromium content and further analyzed the wetting mechanism using SEM and XRD analysis.
Article
Biochemistry & Molecular Biology
Maria Cruz Sueiro, Cynthia A. Awruch, Gustavo M. Somoza, Walter S. Svagelj, Maria G. Palacios
Summary: According to life-history theory, there might be different immunological strategies between reproductive and non-reproductive periods due to limited resources. Our study on two sympatric marine fish species, rockfish and sandperch, found that reproductive individuals showed lower immune function, but higher levels of natural antibodies in rockfish females, compared to their non-reproductive counterparts. On the other hand, reproductively active sandperch males showed lower levels of natural antibodies and higher neutrophil to lymphocyte ratio and spleen index compared to non-reproductive males. The study highlights the species-specific patterns of immunity and the potential influence of resource limitation and abiotic factors on immune trade-offs in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Nikolay Ozernyuk, Dimitry Schepetov
Summary: Hox genes play a critical role in morphogenesis, where fish and mammal demonstrate differences in alternative splicing and distribution along the anterior-posterior body axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Marine & Freshwater Biology
Mikko Nikinmaa, Ron Tjeerdema, Malin Celander, Alex Ford, Deirdre Dunne
AQUATIC TOXICOLOGY
(2015)
Article
Marine & Freshwater Biology
Jenni M. Prokkola, Mikko Nikinmaa, Pedro Lubiana, Mirella Kanerva, R. J. Scott McCairns, Miriam Goetting
AQUATIC TOXICOLOGY
(2015)
Article
Biology
Katja Anttila, Mario Lewis, Jenni M. Prokkola, Mirella Kanerva, Eila Seppanen, Irma Kolari, Mikko Nikinmaa
JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)
Article
Ecology
K. A. Vuori, K. K. Lehtonen, M. Kanerva, H. Peltonen, M. Nikinmaa, N. A. Berezina, E. Boikova
MARINE ECOLOGY PROGRESS SERIES
(2015)
Article
Ecology
K. A. Vuori, K. K. Lehtonen, M. Kanerva, H. Peltonen, M. Nikinmaa, N. A. Berezina, E. Boikova
MARINE ECOLOGY PROGRESS SERIES
(2015)
Editorial Material
Physiology
M. Nikinmaa
Article
Physiology
K. Anttila, T. Streng, J. Pispa, M. Vainio, M. Nikinmaa
Editorial Material
Marine & Freshwater Biology
Mikko Nikinmaa, Ron Tjeerdema, Alex T. Ford, Malin C. Celander
AQUATIC TOXICOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Pedro Lubiana, Jenni M. Prokkola, Mikko Nikinmaa, Thorsten Burmester, Mirella Kanerva, Miriam Goetting
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2016)
Article
Environmental Sciences
Jenni M. Prokkola, Ioanna Katsiadaki, Marion Sebire, Jessica Elphinstone-Davis, Sanna Pausio, Mikko Nikinmaa, Erica H. Leder
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2016)
Article
Genetics & Heredity
Victoria L. Pritchard, Heidi M. Viitaniemi, R. J. Scott McCairns, Juha Merila, Mikko Nikinmaa, Craig R. Primmer, Erica H. Leder
G3-GENES GENOMES GENETICS
(2017)
Article
Biology
Jenni M. Prokkola, Mikko Nikinmaa
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Review
Physiology
Mikko Nikinmaa, Michael Berenbrink, Colin J. Brauner
Editorial Material
Physiology
Mikko Nikinmaa
Article
Environmental Sciences
Mirella Kanerva, Mikko Kiljunen, Jyrki Torniainen, Mikko Nikinmaa, Joerg Dutz, Kristiina A. Vuori
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)