Article
Biology
Tobit Dehnen, Josh J. Arbon, Damien R. Farine, Neeltje J. Boogert
Summary: In animal societies, individuals differ in their ability to win agonistic interactions, resulting in dominance hierarchies. Factors such as intrinsic attributes, resource value asymmetry, winner-loser effects, interaction-outcome history, and third-party support can influence interaction outcomes and individuals' positions in dominance hierarchies. These factors are unlikely to act independently, but instead, form feedback loops and feed-forward mechanisms that determine dominance outcomes within and between generations. Understanding these factors and their interactions is crucial for studying dominance dynamics in animal groups.
BIOLOGICAL REVIEWS
(2022)
Review
Neurosciences
Jeann L. Sabino-Carvalho, Barbara Falquetto, Ana C. Takakura, Lauro C. Vianna
Summary: The incidence of Parkinson's disease is increasing worldwide, with nonmotor dysfunctions gaining recognition. Research suggests that baroreflex dysfunction may be an underlying mechanism of cardiovascular dysregulation in PD patients. This review summarizes potential altered central and peripheral mechanisms affecting the feedback-controlled loops in PD patients.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Florence Netzer, Caroline Sevoz-Couche
Summary: The rostral cuneiform nucleus participates in the defense inhibition of baroreflex bradycardia by activating LPGi and projecting to raphe magnus to activate NTS 5-HT3 receptors, providing new insights into the primary and secondary mechanisms involved in vital baroreflex prevention during stress.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Jesmine SH. Tan, Wenli Chen
Summary: Online peer feedback plays a critical role in collaborative learning, improving learning outcomes and the metacognitive knowledge of both givers and receivers. This study examined the effects of different types of peer feedback, specificity, and affective nature on collaborative knowledge improvement in a computer-supported learning environment. The results showed that feedback raising concerns and providing suggestions facilitated further improvement in TEL design. Elaborated feedback had a greater impact than short verification responses. The implications of online peer feedback on collaborative knowledge improvement are discussed.
COMPUTERS & EDUCATION
(2022)
Article
Engineering, Electrical & Electronic
Ramin Babaee, Shahab Oveis Gharan, Martin Bouchard
Summary: We propose a feed-forward frequency domain adaptive linear equalizer to track fast state-of-polarization (SOP) transients in the fiber. The proposed method estimates the channel response using pilot symbols inserted into the DSP frame and compensates for it. Unlike the decision-directed least mean squares (DD-LMS) algorithm, our circuit is designed in a feed-forward fashion, avoiding the latencies involved in DD-LMS feedback loop for optimal SOP tracking capabilities. The proposed algorithm shows robustness against high order differential group delay (DGD) and polarization dependent loss (PDL) and achieves significant tracking improvement compared to DD-LMS.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Automation & Control Systems
Ridvan Keskin, Ibrahim Aliskan, Ersin Das
Summary: This paper proposes a method to improve the output voltage stability of DC-DC converters by considering sensor noise, input voltage, and load current disturbances. A robust fixed-order control framework is developed and optimized using an iterative convex-concave optimization-based algorithm. Real-time implementation on a boost converter demonstrates the effectiveness of the proposed control approach.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2023)
Article
Biochemical Research Methods
Anupam Dey, Debashis Barik
Summary: Bistability in living systems is closely related to decision making processes, with the operating principles of a bistable switch from a positive feedback loop well understood. Investigating feed-forward signaling of a positive feedback loop reveals the generation of various emergent bistable switches in hybrid motifs. The emergent behaviors of these switches depend on logic gate configuration and regulatory thresholds, rather than the nature of the positive feedback loop.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Education & Educational Research
Nourollah Zarrinabadi, Mohsen Rezazadeh
Summary: This study investigated the impact of feedback, feed up, and feed forward on writing motivation, self-efficacy, and anxiety. The results showed that groups receiving feedback experienced significant improvements in self-efficacy. Additionally, groups receiving feed up and feed forward showed significant improvements in writing motivation. Furthermore, the combination of feedback, feed up, and feed forward was found to reduce learners' writing anxiety.
LANGUAGE TEACHING RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Ans Pauwels, Jan Tack, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study found that slow, deep breathing can reduce visceral pain intensity, which is not specific to the frequency of slow breathing and is not mediated by autonomic or emotional responses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Neurosciences
Shoou-Jeng Yeh, Chi-Wen Lung, Yih-Kuen Jan, Ben-Yi Liau
Summary: Diabetes is a chronic disease that causes damage to various organs in the body. This study proposes a new method to detect autonomic neuropathy in diabetes patients by analyzing the changes in blood pressure and heart rate. The results show that this method can differentiate between different types of diabetes and uncover hidden changes in blood pressure control.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Physics, Fluids & Plasmas
Ayan Biswas
Summary: In this study, a biochemical assay was used to convert fan-in networks into feed-forward loops (FFLs). The researchers discovered that redundant information about the output gene product can be broken down into finer components mediated by the constituent pathways. They found that variance-based information within the linear noise regime played a role in quantifying these submodular redundancies. Contrary to conventional wisdom, they found that information redundancy depended nontrivially on inter-regulator correlation.
Article
Biochemistry & Molecular Biology
Zhi-Wei Zhang, Haitao Tu, Mei Jiang, Sarivin Vanan, Sook Yoong Chia, Se-Eun Jang, Wuan-Ting Saw, Zhi-Wei Ong, Dong-Rui Ma, Zhi-Dong Zhou, Jie Xu, Kai-Hua Guo, Wei-Ping Yu, Shuo-Chien Ling, Richard A. Margolin, Daniel G. Chain, Li Zeng, Eng-King Tan
Summary: This study reveals a feed-forward mechanism through which AICD promotes LRRK2-mediated neurotoxicity in Parkinson's disease. APP deficiency reduces LRRK2 expression and associated neurotoxicity, while overexpression of AICD increases LRRK2 expression and neurotoxicity. Inhibiting AICD may have therapeutic benefits in idiopathic Parkinson's disease.
Article
Computer Science, Information Systems
Khalid Ijaz, Muhammad Adnan, Waqas Tariq Toor, Muhammad Asim Butt, Muhammad Idrees, Usman Ali, Izaz Hassan, Yazeed Yasin Ghadi, Fuad A. Awwad, Mohamed R. Abonazel, Syed Rehan Ashraf
Summary: Sigma-delta modulators utilize noise-shaping techniques to reduce noise power in the specific frequency band during digital-to-analog conversion. Compared to other sigma-delta modulators, error feedback modulators employ a more efficient noise transfer function for time varying inputs. However, conventional noise transfer functions degrade in efficiency and face quantizer saturation issues when the input signal reaches full scale. This study proposes a new noise transfer function that combines transfer functions of two-stage Feed-forward delays with a novel Hybrid multi-stage noise shaping-error feedback sigma-delta modulator. The proposed approach mitigates quantizer saturation and provides sustainable solutions to limit cycles and idle tones, leading to improved performance parameters such as signal-to-quantization noise ratio, spurious-free dynamic range, effective number of bits, and signal-to-noise plus distortion ratio.
Article
Biotechnology & Applied Microbiology
Lucrecia C. Teran, Pablo Mortera, Gisela Tubio, Sergio H. Alarcon, Victor S. Blancato, Martin Espariz, Luis Esteban, Christian Magni
Summary: This study aimed to identify and evaluate lactic acid bacteria and yeast involved in the production of fermented feed, isolating Lactobacillus paracasei and Kazachstania unispora. Genome sequence analyses were performed to predict potential pathways and safety evaluations were conducted. The study concluded that these strains are good candidates for starter cultures in feed fermentation, providing valuable data for further biotechnological exploration.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Engineering, Mechanical
Maliheh Sadeghi Kati, Jonas Fredriksson, Bengt Jacobson, Leo Laine
Summary: A control strategy based on H-infinity-type static output feedback combined with dynamic feed-forward is proposed to improve the high-speed lateral performance of an A-double combination vehicle. The controller is simple and easy to implement, requiring only the measurement of the driver steering angle and one articulation angle for feed-forward and feedback control.
VEHICLE SYSTEM DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Ivy C. Mason, Daniela Grimaldi, Kathryn J. Reid, Chloe D. Warlick, Roneil G. Malkani, Sabra M. Abbott, Phyllis C. Zee
Summary: This study found that exposure to light during nighttime sleep can negatively affect glucose homeostasis the following morning, potentially through reduced sleep quality, melatonin suppression, or activation of the sympathetic nervous system (SNS) during sleep.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Alessandro Silvani, Luca Baldelli, Giulia Giannini, Pietro Guaraldi, Luisa Sambati, Annagrazia Cecere, Francesco Mignani, Pietro Cortelli, Giovanna Calandra-Buonaura, Federica Provini
Summary: Patients with multiple system atrophy exhibit pervasive muscle activity during sleep, involving axial and limb muscles, and occurring not only during REM sleep but also during non-REM sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Editorial Material
Clinical Neurology
Jose-Alberto Palma, Pietro Cortelli
Summary: Efferent baroreflex failure is a major symptom in synucleinopathies, causing unstable blood pressure and leading to orthostatic hypotension and supine hypertension. Managing both conditions is challenging due to their opposite effects and the cognitive domains are also affected in these diseases.
Review
Clinical Neurology
Maria P. Mogavero, Alessandro Silvani, Giuseppe Lanza, Lourdes M. DelRosso, Luigi Ferini-Strambi, Raffaele Ferri
Summary: After describing orexins and their roles in sleep and medical disorders, the article discusses the clinical evidence on the effects of DORAs and SORAs on insomnia to provide recommendations for further assessment in personalized and precision medicine. Trials with orexin receptor antagonists have shown potential as a valid therapeutic option for insomnia in various medical conditions, but more studies are needed to determine the most suitable options for different patient populations.
NATURE AND SCIENCE OF SLEEP
(2023)
Review
Clinical Neurology
Chiara Berteotti, Carmen Calvello, Claudio Liguori
Summary: Epilepsy is a common neurological disorder that affects patients of all ages and is associated with reduced quality of life and comorbidities. Sleep impairment is frequently observed in epilepsy patients, and the relationship between sleep and epilepsy is bidirectional. The orexin system, which plays a role in controlling the sleep-wake cycle, may be affected in epilepsy patients. Clinical studies have shown inconsistent results due to different methodologies in quantifying orexin levels. Dual orexin receptor antagonists (DORAs) have been suggested as a potential treatment for sleep impairment and insomnia in epilepsy patients.
Article
Clinical Neurology
Alessandra Fanciulli, Fabian Leys, Magdalena Krbot Skoric, Diogo Reis Carneiro, Giovanna Calandra-Buonaura, Jennifer Camaradou, Giacomo Chiaro, Pietro Cortelli, Cristian Falup-Pecurariu, Roberta Granata, Pietro Guaraldi, Raimund J. Helbok, Max Hilz, Valeria Iodice, Jens Jordan, Evert C. A. Kaal, Anita Kamondi, Anne Pavy Le Traon, Isabel Rocha, Johann Sellner, Jean Michel Senard, Astrid K. Terkelsen, Gregor Wenning, Elena Moro, Thomas D. Berger, Roland Thijs, Walter Struhal, Mario Habek
Summary: This study investigated the impact of the COVID-19 pandemic on European clinical autonomic practice. The results showed a significant decrease in the number of autonomic tests and visits during the first year of the pandemic. COVID-19 infection was associated with the development or worsening of cardiovascular autonomic disorders, while the association with COVID-19 vaccines was deemed unlikely.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manuela Loi, Stefano Bastianini, Giulia Candini, Nicola Rizzardi, Giorgio Medici, Valentina Papa, Laura Gennaccaro, Nicola Mottolese, Marianna Tassinari, Beatrice Uguagliati, Chiara Berteotti, Viviana Lo Martire, Giovanna Zoccoli, Giovanna Cenacchi, Stefania Trazzi, Christian Bergamini, Elisabetta Ciani
Summary: CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disease caused by mutations in the CDKL5 gene. Mouse models of CDD have helped understand the role of CDKL5 in brain development and function. This study reveals cardiac alterations in Cdkl5 +/- mice, including prolonged QT interval, increased heart rate, fibrosis, altered gap junction organization, mitochondrial dysfunction, and increased ROS production. These findings provide new insights into the function of CDKL5 in heart structure/function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Martina Gatti, Katarina Stoklund Dittlau, Francesca Beretti, Laura Yedigaryan, Manuela Zavatti, Pietro Cortelli, Carla Palumbo, Emma Bertucci, Ludo van den Bosch, Maurilio Sampaolesi, Tullia Maraldi
Summary: Neuromuscular junctions are important for communication between spinal motor neurons and skeletal muscle, and their vulnerability in degenerative diseases like muscle atrophy is poorly understood. Recent studies have shown the regenerative potential of stem cells and extracellular vesicles in muscle fiber regeneration, but their role in counteracting NMJ perturbations is not clear. In this study, a co-culture system was used to investigate the effects of AFSC-derived EVs on NMJ alterations induced by muscle atrophy. The presence of EVs reduced morphological and functional defects and prevented oxidative stress in atrophic myotubes. This study provides a valuable tool for studying MN and myotube interactions and demonstrates the efficacy of AFSC-EVs in counteracting NMJ perturbations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Vittoria Schirinzi, Carolina Poli, Chiara Berteotti, Alessandro Leone
Summary: The increasing prevalence of overweight and obesity indicates that current strategies are insufficient to tackle this epidemic. Brown adipose tissue (BAT) is receiving attention as a potential weapon against obesity. Research is focused on developing strategies to increase BAT activity and energy expenditure. This review summarizes knowledge on molecules that promote white-to-brown adipose tissue conversion and assesses the potential role of thermogenic nutraceuticals in combating obesity.
Review
Neurosciences
Alfredo Conti, Nicola Maria Gambadauro, Paolo Mantovani, Canio Pietro Picciano, Vittoria Rosetti, Marcello Magnani, Sebastiano Lucerna, Constantin Tuleasca, Pietro Cortelli, Giulia Giannini
Summary: Modern brain atlases derived from neuroimaging and functional information are crucial for accurate neurosurgical procedures. They help avoid targeting errors caused by imaging artifacts or insufficient anatomical details.
Article
Neurosciences
Luca Baldelli, Chiara Pirazzini, Luisa Sambati, Francesco Ravaioli, Davide Gentilini, Giovanna Calandra-Buonaura, Pietro Guaraldi, Claudio Franceschi, Pietro Cortelli, Paolo Garagnani, Maria Giulia Bacalini, Federica Provini
Summary: Isolated REM Sleep Behavior Disorder (iRBD) serves as a strong early indicator for alpha-synucleinopathies. However, little research has been done on the relationship between aging and prodromal phases of neurodegenerative diseases. This study used epigenetic clocks based on DNA methylation to measure biological aging in iRBD patients, as well as videopolysomnography-negative and population-based controls. The findings suggest that accelerated aging is a characteristic of prodromal neurodegeneration in iRBD patients.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Alessandro Silvani, Isabelle Lambert, Anna Heidbreder, Yves Dauvilliers, Lucie Barateau
Summary: This article provides a comprehensive overview of autonomic dysfunctions in central disorders of hypersomnolence, including narcolepsy type 1 and type 2, idiopathic hypersomnia, and Kleine-Levin syndrome. Recent studies have assessed autonomic symptoms in large cohorts of patients and found that autonomic impairment is frequent in these disorders. The pathophysiological mechanisms underlying this dysfunction are not fully understood and further research is needed to understand the effects of wake-promoting agents on the autonomic nervous system.
CURRENT SLEEP MEDICINE REPORTS
(2023)
Article
Clinical Neurology
Ilaria Cani, Pietro Guaraldi, Giulia Giannini, Luisa Sambati, Giorgio Barletta, Pietro Cortelli, Giovanna Calandra-Buonaura
Summary: This study evaluated the cardiovascular effects of levodopa (LD) in patients with parkinsonism. The results showed that LD administration caused a decrease in blood pressure and an increase in heart rate in both supine and orthostatic conditions. Patients with cardiovascular autonomic failure were more likely to develop LD-induced orthostatic hypotension, suggesting that LD-induced orthostatic hypotension could be a red flag for cardiovascular autonomic failure in clinical practice.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulia Sita, Agnese Graziosi, Camilla Corrieri, Luca Ghelli, Sabrina Angelini, Pietro Cortelli, Patrizia Hrelia, Fabiana Morroni
Summary: Alzheimer's disease, the most common type of dementia, is closely associated with aging. The endoplasmic reticulum (ER) is compromised in Alzheimer's disease due to the accumulation of beta-amyloid and phosphorylated Tau protein, leading to the activation of the Unfolded Protein Response (UPR). This study investigates the role of UPR in a mouse model of Alzheimer's disease and identifies dysregulation of protein kinase RNA-like ER kinase (PERK), inositol-requiring protein 1 alpha (IRE1 alpha), and activating transcription factor 6 (ATF-6) pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
