Protein C and acute inflammation: a clinical and biological perspective

A REGISTRY OF PATIENTS TREATED WITH DROTRECOGIN ALFA (ACTIVATED) IN BELGIAN INTENSIVE CARE UNITS - AN OBSERVATIONAL STUDY

(2014) J.-L. Vincent et al.   ACTA CLINICA BELGICA

90-DAY FOLLOW-UP OF PATIENTS TREATED WITH DROTRECOGIN ALFA (ACTIVATED) FOR SEVERE SEPSIS: A BELGIAN OPEN LABEL STUDY

(2014) J. Decruyenaere et al.   ACTA CLINICA BELGICA

Recombinant Human Activated Protein C for Adults with Septic Shock. A Randomized Controlled Trial

(2013) Djillali Annane et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activated protein C attenuates pulmonary coagulopathy in patients with acute respiratory distress syndrome

(2013) A. D. Cornet et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Molecular circuits in thrombosis and inflammation

(2013) Charles Esmon   THROMBOSIS AND HAEMOSTASIS

Inflection points in sepsis biology: from local defense to systemic organ injury

(2012) Eric J. Seeley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activated protein C and septic shock

(2012) Emily Rimmer et al.   CRITICAL CARE MEDICINE

Protein C anticoagulant and cytoprotective pathways

(2012) John H. Griffin et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Extracellular histone release in response to traumatic injury

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Coagulation system changes associated with susceptibility to infection in trauma patients

(2012) Elaine Cole et al.   Journal of Trauma and Acute Care Surgery

Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression

(2012) Andre C Kalil et al.   LANCET INFECTIOUS DISEASES

Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis

(2012) Anders Perner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recombinant Tissue Factor Pathway Inhibitor in Severe Community-acquired Pneumonia

(2011) Richard G. Wunderink et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cytoprotective-Selective Activated Protein C AttenuatesPseudomonas aeruginosa–Induced Lung Injury in Mice

(2011) Nastasha Bir et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Critical Role of Activated Protein C in Early Coagulopathy and Later Organ Failure, Infection and Death in Trauma Patients

(2011) Mitchell Jay Cohen et al.   ANNALS OF SURGERY

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice

(2011) A. Goolaerts et al.   THORAX

Efficacy of Therapy with Recombinant Human Activated Protein C of Critically Ill Surgical Patients with Infection Complicated by Septic Shock and Multiple Organ Dysfunction Syndrome

(2011) Philip S. Barie et al.   Surgical Infections

Activated protein C and hospital mortality in septic shock: A propensity-matched analysis*

(2010) Peter K. Lindenauer et al.   CRITICAL CARE MEDICINE

Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways

(2010) A.R. Rezaie   CURRENT MEDICINAL CHEMISTRY

Nebulized Anticoagulants Limit Pulmonary Coagulopathy, But Not Inflammation, in a Model of Experimental Lung Injury

(2010) Jorrit J. Hofstra et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

A prospective, observational study of Xigris Use in the United States (XEUS)

(2010) Jay S. Steingrub et al.   JOURNAL OF CRITICAL CARE

Comparison of Dopamine and Norepinephrine in the Treatment of Shock

(2010) Daniel De Backer et al.   NEW ENGLAND JOURNAL OF MEDICINE

PROTEIN C CONCENTRATE AS ADJUVANT TREATMENT IN NEONATES WITH SEPSIS-INDUCED COAGULOPATHY

(2010) Lidia Decembrino et al.   SHOCK

Effectiveness of Treatments for Severe Sepsis

(2009) Ricard Ferrer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protective mechanisms of activated protein C in severe inflammatory disorders

(2009) Arne P Neyrinck et al.   BRITISH JOURNAL OF PHARMACOLOGY

A retrospective observational study of drotrecogin alfa (activated) in adults with severe sepsis: Comparison with a controlled clinical trial*

(2009) Arthur Wheeler et al.   CRITICAL CARE MEDICINE

Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)*

(2009) Fabián Jaimes et al.   CRITICAL CARE MEDICINE

Extended drotrecogin alfa (activated) treatment in patients with prolonged septic shock

(2009) Jean-Francois Dhainaut et al.   INTENSIVE CARE MEDICINE

Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery

(2009) Martina Crivellari et al.   INTENSIVE CARE MEDICINE

Influence of Nebulized Unfractionated Heparin and N-Acetylcysteine in Acute Lung Injury After Smoke Inhalation Injury

(2009) Andrew C. Miller et al.   Journal of Burn Care & Research

Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock

(2009) J. XU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

INCREASE IN ACTIVATED PROTEIN C MEDIATES ACUTE TRAUMATIC COAGULOPATHY IN MICE

(2009) Brian B. Chesebro et al.   SHOCK

Randomized Clinical Trial of Activated Protein C for the Treatment of Acute Lung Injury

(2008) Kathleen D. Liu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions*

(2008) Chris A. Gentry et al.   CRITICAL CARE MEDICINE

Protein C concentrate to restore physiological values in adult septic patients

(2008) Fabio Baratto et al.   INTENSIVE CARE MEDICINE

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

(2008) X. V. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drotrecogin alfa (activated)

(2007) S. Ridley et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY