Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia

Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors

(2012) John Cuppoletti et al.   BMC Pharmacology & Toxicology

Genetic Variation and Clinical Heterogeneity in Cystic Fibrosis

(2011) Mitchell L. Drumm et al.   Annual Review of Pathology-Mechanisms of Disease

Severe Defects in Absorptive Ion Transport in Distal Colons of Mice That Lack ClC-2 Channels

(2011) Marcelo A. Catalán et al.   GASTROENTEROLOGY

Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: a randomized, placebo-controlled and dose-finding study

(2011) S. Fukudo et al.   NEUROGASTROENTEROLOGY AND MOTILITY

β-Adrenergic activation of electrogenic K+ and Cl− secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways

(2010) Susan T. Halm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lubiprostone targets prostanoid EP4 receptors in ovine airways

(2010) AW Cuthbert   BRITISH JOURNAL OF PHARMACOLOGY

Lubiprostone Activates Cl− Secretion via cAMP Signaling and Increases Membrane CFTR in the Human Colon Carcinoma Cell Line, T84

(2010) Mei Ao et al.   DIGESTIVE DISEASES AND SCIENCES

Emerging Treatments in Cystic Fibrosis

(2009) Andrew M. Jones et al.   DRUGS

Activation of Intestinal Cl− Secretion by Lubiprostone Requires the Cystic Fibrosis Transmembrane Conductance Regulator

(2009) Marcel J.C. Bijvelds et al.   GASTROENTEROLOGY

Isolation and Characterization of a High Affinity Peptide Inhibitor of ClC-2 Chloride Channels

(2009) Christopher H. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epac1 mediates protein kinase A–independent mechanism of forskolin-activated intestinal chloride secretion

(2009) Kazi Mirajul Hoque et al.   JOURNAL OF GENERAL PHYSIOLOGY

Chloride channels as drug targets

(2009) Alan S. Verkman et al.   NATURE REVIEWS DRUG DISCOVERY

A synthetic prostone activates apical chloride channels in A6 epithelial cells

(2008) Hui Fang Bao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice

(2008) Kelvin D. MacDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Novel agents in cystic fibrosis

(2008) Shane Storey et al.   NATURE REVIEWS DRUG DISCOVERY

Denufosol: A review of studies with inhaled P2Y2 agonists that led to Phase 3

(2008) Donald Kellerman et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS