Review
Biochemistry & Molecular Biology
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann
Summary: IL-4 and IL-13 are pleiotropic Th2 cytokines involved in immune responses and have been found to play a role in oncogenesis and tumor progression. Their effects on tumor cells are mediated through specific receptors, with IL-4R alpha/IL-13R alpha 1 being the main target in tumors. Understanding the implications of these cytokines and their receptors in pancreatic cancer helps in developing potential new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann
Summary: IL-4 and IL-13 are structurally and functionally related cytokines that regulate immune responses and are involved in the pathogenesis of various human neoplasms. They can mediate tumor cell proliferation, survival, and metastasis in solid tumors through different receptors. This review summarizes their role in gastric and colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Amirala Bakhshian Nik, Santiago Alvarez-Argote, Caitlin C. O'Meara
Summary: IL4 and IL13 play a significant role in cardiac regeneration and repair following injury, leading to beneficial outcomes. However, there is still a lack of comprehensive understanding about their molecular and cellular actions in the heart.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyunghee Kim, Hyeju Kim, Gun Yong Sung
Summary: The study indicates that short-term use of I3LA for approximately one week can effectively suppress the progression of atopic dermatitis and impact the expression of major constituent proteins of the skin barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Fangyuan Chen, Yiman Wang, Xinyi Chen, Nan Yang, Li Li
Summary: This review aims to discuss the role of IL-4/13 in the pathogenesis of BP and the potential of using IL-4/13 antagonists for treatment. The study found that IgE, eosinophils, IL-4, and IL-13 may interact with each other in the pathogenesis of BP, providing clues for finding targets for molecular treatment.
ANNALS OF MEDICINE
(2023)
Review
Immunology
Zachary J. J. Bernstein, Anjali Shenoy, Amy Chen, Nicola M. M. Heller, Jamie B. B. Spangler
Summary: IL-4 and IL-13 cytokines play important roles in immune activity, especially in T helper 2 cell-mediated inflammation, immune regulation, antibody production, and fibrosis. Manipulating the IL-4/IL-13 axis through cytokine engineering, fusion protein formulation, antagonist development, cell engineering, and biosensor design can lead to the discovery of new immunotherapies targeting allergy, autoimmune diseases, and cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Medicine, Research & Experimental
Jesus Amo-Aparicio, Joana Garcia-Garcia, Isaac Francos-Quijorna, Andrea Urpi, Anna Esteve-Codina, Marta Gut, Albert Quintana, Ruben Lopez-Vales
Summary: The study found that while IL-13 induced anti-inflammatory markers in microglia and macrophages after SCI, it did not promote functional recovery as effectively as IL-4. IL-13 and IL-4 induced different gene signatures in these cells after SCI, with IL-4 shifting metabolism towards oxidative phosphorylation. This metabolic shift is important for minimizing cytotoxic responses of microglia and macrophages.
Article
Allergy
Laura Maintz, Thomas Welchowski, Nadine Herrmann, Juliette Brauer, Claudia Traidl-Hoffmann, Regina Havenith, Svenja Mueller, Claudio Rhyner, Anita Dreher, Matthias Schmid, Thomas Bieber
Summary: This study found that many patients with mild-to-moderate atopic dermatitis have elevated levels of biomarkers, suggesting a systemic impact of skin inflammation. Identifying different patient subtypes can better predict their response to specific treatments.
Review
Medicine, General & Internal
Georgia Pappa, Dimitrios Sgouros, Konstantinos Theodoropoulos, Antonios Kanelleas, Evangelia Bozi, Stamatios Gregoriou, Konstantinos Krasagakis, Alexander C. Katoulis
Summary: Atopic dermatitis is a complex inflammatory skin disease with multiple underlying factors. Recent studies have highlighted the important roles of interleukins-4 and -13 in the pathogenesis of atopic dermatitis. Novel therapeutic approaches targeting Th2 cytokines and their pathways offer potential for optimizing the treatment of atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kyunghee Kim, Hyeju Kim, Gun Yong Sung
Summary: This study successfully fabricated human skin equivalents with disease features and simulated the lesions of atopic dermatitis. Unlike existing studies relying solely on mouse models, this study overcame limitations and provided useful results for the development of therapeutic agents for atopic dermatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sonika Patial, Brandon W. Lewis, Thao Vo, Ishita Choudhary, Kshitiz Paudel, Yun Mao, Dhruthi Singamsetty, Frank Brombacher, Yogesh Saini
Summary: Research has shown that IL-33, ILCs, and IL4R alpha play important roles in the recruitment of eosinophils during normal postnatal lung development in mice. Myeloid-specific IL4R alpha deficiency results in reduced eosinophil numbers in the airspaces and decreased levels of related cytokines.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Celina Dubin, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis is a common inflammatory skin disease with a complex pathophysiology involving immune dysregulation and barrier defects. The IL-4, IL-13, and IL-31 pathways play key roles in the disease's pathogenesis, and novel therapeutics targeting these pathways are being developed for potential treatments.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Hematology
Johanna Melo-Cardenas, Lavanya Bezavada, Jeremy Chase Crawford, Sandeep Gurbuxani, Anitria Cotton, Guolian Kang, Jeffrey Gossett, Christian Marinaccio, Rona Weinberg, Ronald Hoffman, Anna Rita Migliaccio, Yan Zheng, Marta Derecka, Ciro R. Rinaldi, John D. Crispino
Summary: This study analyzed MF mouse models and samples from MF patients, and found that high levels of IL-13 are associated with MF progression and fibrosis. Inhibition of the IL-13/IL-4 signaling pathway may serve as a novel therapeutic target for treating MF.
Article
Dermatology
Jussi Tuusa, Nina Kokkonen, Anja Mattila, Laura Huilaja, Outi Varpuluoma, Sirpa Rannikko, Virpi Glumoff, Jouko Miettunen, Kaisa Tasanen
Summary: Dipeptidyl peptidase 4 inhibitors (DPP4is), commonly used drugs for type 2 diabetes, increase the risk of bullous pemphigoid (BP). The mechanism leading to the loss of immunological tolerance and the differences between DPP4i-associated BP (DPP4i-BP) and regular BP are largely unknown. This study analyzed cytokine expression in lesional and nonlesional skin samples of patients with regular BP or DPP4i-BP, and found distinct molecular fingerprints between the two.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Paul S. Foster, Hock L. Tay, Simon P. Hogan
Summary: Allergic asthma is characterized by dysregulated type 2 immune responses, including degranulating airway eosinophils that induce tissue damage and airway hyperresponsiveness. A study identified a mechanism involving UDP-glucose and P2Y(14)R in amplifying eosinophil accumulation in the lung, suggesting potential as an alternative therapy for asthma. By targeting P2Y(14)R, eosinophil infiltration and AHR can be attenuated, providing a promising approach for asthma treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2021)