Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice

Dantrolene Improves Survival After Ventricular Fibrillation by Mitigating Impaired Calcium Handling in Animal Models

(2014) Nima Zamiri et al.   CIRCULATION

Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias

(2014) Dobromir Dobrev et al.   CIRCULATION RESEARCH

Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias

(2014) Steven R. Houser   CIRCULATION RESEARCH

Phospholamban Knockout Breaks Arrhythmogenic Ca 2+ Waves and Suppresses Catecholaminergic Polymorphic Ventricular Tachycardia in Mice

(2013) Yunlong Bai et al.   CIRCULATION RESEARCH

Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+handling in ageing rabbit hearts

(2013) Leroy L. Cooper et al.   JOURNAL OF PHYSIOLOGY-LONDON

Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia

(2013) L. Brunello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Facilitation of cytosolic calcium wave propagation by local calcium uptake into the sarcoplasmic reticulum in cardiac myocytes

(2012) Joshua T. Maxwell et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dantrolene prevents arrhythmogenic Ca2+ release in heart failure

(2011) Joshua T. Maxwell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac Sarcoplasmic Reticulum Calcium Leak: Basis and Roles in Cardiac Dysfunction

(2011) Donald M. Bers   Annual Review of Physiology

Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content

(2011) Mathis K. Stokke et al.   CARDIOVASCULAR RESEARCH

Mutation-Linked Defective Interdomain Interactions Within Ryanodine Receptor Cause Aberrant Ca 2+ Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Takeshi Suetomi et al.   CIRCULATION

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor

(2011) Ruiwu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+content in rat ventricular myocytes

(2011) E. F. Bode et al.   JOURNAL OF PHYSIOLOGY-LONDON

Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors

(2011) Hsiang-Ting Ho et al.   JOURNAL OF PHYSIOLOGY-LONDON

Predicting Local SR Ca2+ Dynamics during Ca2+ Wave Propagation in Ventricular Myocytes

(2010) Hena R. Ramay et al.   BIOPHYSICAL JOURNAL

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure

(2010) Makoto Ono et al.   CARDIOVASCULAR RESEARCH

Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

(2010) Hitoshi Uchinoumi et al.   CIRCULATION RESEARCH

NADPH oxidase-derived superoxide impairs calcium transients and contraction in aged murine ventricular myocytes

(2010) Uwe Rueckschloss et al.   EXPERIMENTAL GERONTOLOGY

Modulation of sarcoplasmic reticulum Ca2+ cycling in systolic and diastolic heart failure associated with aging

(2010) Andrzej M. Janczewski et al.   HEART FAILURE REVIEWS

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death

(2009) Andriy E. Belevych et al.   CARDIOVASCULAR RESEARCH

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

(2009) Shigeki Kobayashi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

(2009) Hiroshi Watanabe et al.   NATURE MEDICINE

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca 2+ Leak in Chronic Heart Failure

(2008) Dmitry Terentyev et al.   CIRCULATION RESEARCH