Review
Immunology
Kenji Rowel Q. Lim, Douglas L. Mann, Tsuneaki Kenzaka, Tomohiro Hayashi
Summary: Takotsubo syndrome (TTS) is characterized by the temporary dysfunction of the heart with abnormal regional wall motion, primarily caused by a sudden increase in catecholamines. Inflammation plays a crucial role in determining patient outcomes and the early pathogenesis of the disorder.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Zhiyu Zhang, Xia Guo, Jingyue Wang, Shipeng Wang, Yushi Wang
Summary: A 52-year-old Chinese woman presented with nausea, vomiting, and dyspnea, which worsened after admission. Initial treatment for acute myocardial infarction (AMI) was administered based on ECG findings and elevated cTnI levels. However, the patient developed additional symptoms the following day, including fever, sweating, rapid heart rate, and high blood pressure. Further examinations and tests led to the diagnosis of pheochromocytoma-induced takotsubo cardiomyopathy (Pheo-TCM), which was successfully treated with medication and surgical excision.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ying Liu, Carine Fillebeen, Anik Forest, Amy Botta, Thibault V. Varin, Andre Marette, Yan Burelle, Christine Des Rosiers, Kostas Pantopoulos, Gary Sweeney
Summary: This study using the Th3/+ mouse model found that altered lipid metabolism and gut microbiota may be related to the development of cardiomyopathy in thalassemia. These findings are important for understanding the early biomarkers and therapeutic targets for the development of cardiomyopathy in thalassemia.
Article
Cardiac & Cardiovascular Systems
Sheng-Ling Jan, Yun-Ching Fu, Ching-Shiang Chi, Hsiu-Fen Lee, Fang-Liang Huang, Chung-Chi Wang, Hao-Ji Wei, Ming-Chih Lin, Po-Yen Chen, Betau Hwang
Summary: EV 71-related AHF is associated with high mortality rate, but close monitoring of cardiac function and early intervention with ECLS can improve survival and neurological outcomes. The condition may share similarities with Takotsubo syndrome, suggesting a direct causal link to catecholamine-induced secondary TTS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sara Brethel, Seth Locker, Renee Girens, Paulo Rivera, Kathryn Meurs, Darcy Adin
Summary: The role of taurine in the treatment of congestive heart failure in dogs was explored in this study. Oral taurine supplementation was found to suppress the renin-angiotensin aldosterone system in dogs with CHF. The study showed that taurine increased blood taurine concentrations and decreased the aldosterone to angiotensin II ratio, indicating potential benefits in CHF treatment.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Yi Wang, Xuerong Yu, Yuguang Huang
Summary: This study identified maximum resting heart rate, maximum resting systolic blood pressure, blood glucose level, number of symptoms and signs, and onset age as possible predictive factors for Catecholamine-Induced Cardiomyopathy in Pheochromocytoma and Paraganglioma (CICMPP) patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Angkawipa Trongtorsak, Natapat Chaisidhivej, Jakrin Kewcharoen, Poranee Ganokroj, Artit Torpongpun
Summary: The case report describes a 50-year-old male patient presenting with chest pain, ultimately diagnosed with cardiomyopathy caused by Pheochromocytoma. Further investigations confirmed the reversible nature of the cardiomyopathy related to Pheochromocytoma.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Sirinart Kumfu, Jirapas Sripetchwandee, Chanisa Thonusin, Natticha Sumneang, Chayodom Maneechote, Busarin Arunsak, Titikorn Chunchai, Thura Tun Oo, Aphisek Kongkaew, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Iron overload cardiomyopathy (IOC) is the leading cause of death in patients with iron overload. This study indicates that ferroptosis may play a dominant role in IOC, and inhibiting ferroptosis could be a potential novel treatment for improving cardiac function in iron-overloaded rats.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
John E. Madias
Summary: The management of TTS is currently empirical and supportive, with therapies being extrapolated from principles used for other cardiovascular diseases. While the pathophysiology of TTS remains elusive, treatment strategies may be targeted at addressing common consequences shared with coronary artery disease and other cardiovascular disorders. New therapeutic hypotheses are being considered based on animal studies and limited patient applications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Takahide Arai, Hideaki Kanazawa, Kensuke Kimura, Masahito Munakata, Hiroyuki Yamakawa, Ken Shinmura, Shinsuke Yuasa, Motoaki Sano, Keiichi Fukuda
Summary: Long-term emotional or physical stress may lead to stress cardiomyopathy and transient left ventricular ballooning, but the precise mechanisms are still unclear. In this study, researchers established an animal model of epilepsy-induced stress cardiomyopathy and found that neuropeptide Y (NPY) was upregulated in the cardiac sympathetic nerves and could interrupt beta-adrenergic signaling in cardiomyocytes, resulting in cardiac dysfunction.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Kyle Gobeil, Kevin White, Anusha Bhat, Heidi Szalai, Tara C. Lagu, Quinn R. Pack
Summary: The study found that utilization of cardiac rehabilitation in Takotsubo cardiomyopathy patients is inconsistent, despite the potential benefits of exercise for improving exercise capacity.
Article
Cardiac & Cardiovascular Systems
Matthew H. Tranter, Bjorn Redfors, Peter T. Wright, Liam S. Couch, Alexander R. Lyon, Elmir Omerovic, Sian E. Harding
Summary: In a rat model of isoproterenol-induced Takotsubo syndrome, hyperthermia was found to be associated with the development of apical hypocontractility, suggesting a possible role of elevated body temperature in the pathogenesis of Takotsubo syndrome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Mengying Huang, Zhen Yang, Yingrui Li, Huan Lan, Lukas Cyganek, Goekhan Yuecel, Siegfried Lang, Karen Bieback, Ibrahim El-Battrawy, Xiaobo Zhou, Martin Borggrefe, Ibrahim Akin
Summary: This study investigated the involvement and underlying mechanisms of dopamine D1/D5 receptor signaling in arrhythmogenesis of Takotsubo cardiomyopathy (TTC). The results demonstrated that dopamine D1/D5 receptor signaling plays important roles in the arrhythmogenesis of TTC through the generation of reactive oxygen species (ROS). Activation of dopamine D1/D5 receptors led to dysfunctions of ion channels, including Na+, L-type Ca2+, and I-Kr channels, resulting in abnormal action potentials in cardiomyocytes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Adam Ioannou
Summary: Takotsubo cardiomyopathy (TCM) is an acute and reversible cardiac syndrome characterized by apical ballooning of the left ventricle without coronary artery obstruction or myocarditis. Catecholamine toxicity is the most widely accepted underlying pathophysiology. Atypical variants of TCM have been recently described.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Vivian Haffner, Zahra Nourian, Erika M. Boerman, Michelle D. Lambert, Laurin M. Hanft, Maike Krenz, Christopher P. Baines, Dongsheng Duan, Kerry S. McDonald, Timothy L. Domeier
Summary: In this study, the effects of Duchenne muscular dystrophy (DMD) on cardiomyocyte Ca2+ handling were investigated using a mouse model. The results indicate that DMD leads to Ca2+ overload in cardiomyocytes following preload challenge, as well as impaired cardiac function. These findings support the hypothesis that cardiomyocyte Ca2+ overload underlies cardiac dysfunction in muscular dystrophy.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tunde Berecz, Angela Yiu, Orsolya Vittay, Barbara Orsolits, Maxime Mioulane, Cristobal G. dos Remedios, Robin Ketteler, Bela Merkely, Agota Apati, Sian E. Harding, Nicola Hellen, Gabor Foldes
Summary: This study investigated the role of Hippo signalling pathway in doxorubicin-induced cardiomyopathy, showing that YAP may have a cardioprotective effect in response to cardiotoxic agents. The findings suggest potential mechanisms of cardiotoxicity and cardioprotection in anthracycline-induced heart failure.
Article
Biochemical Research Methods
Damiano Fassina, Caroline M. Costa, Stefano Longobardi, Elias Karabelas, Gernot Plank, Sian E. Harding, Steven A. Niederer
Summary: This study developed a modeling framework to examine the electrical interaction between engineered heart tissue patches (EHT) and the host myocardium. The results showed that modifying the conductivity of the EHT can restore physiological activation but may increase the risk of arrhythmia. Additionally, adjusting the action potential and I-K1 of hiPSC-CMs may restore pre-infarction activation without promoting arrhythmia.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew H. Tranter, Bjorn Redfors, Peter T. Wright, Liam S. Couch, Alexander R. Lyon, Elmir Omerovic, Sian E. Harding
Summary: In a rat model of isoproterenol-induced Takotsubo syndrome, hyperthermia was found to be associated with the development of apical hypocontractility, suggesting a possible role of elevated body temperature in the pathogenesis of Takotsubo syndrome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Veneta B. Todorova, Nicoleta Baxan, Matthew Delahaye, Sian E. Harding, Sara M. Rankin
Summary: There is a need for treatments that prevent cardiac dysfunction after myocardial infarction. The transplantation of mesenchymal stem/stromal cells (MSCs) is hindered by culture expansion. Pharmacological mobilisation of endogenous MSCs could be a potential alternative.
DISEASE MODELS & MECHANISMS
(2023)
Correction
Cardiac & Cardiovascular Systems
Matthew H. Tranter, Bjorn Redfors, Peter T. Wright, Liam S. Couch, Alexander R. Lyon, Elmir Omerovic, Sian E. Harding
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Neda Mohammadi, Jose Sanchez-Alonso, Sian Harding, Julia Gorelik
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hao Xu, Steven E. Williams, Michelle C. Williams, David E. Newby, Jonathan Taylor, Radhouene Neji, Karl P. Kunze, Steven A. Niederer, Alistair A. Young
Summary: This study aims to develop a deep learning neural network for the estimation of 3D left atrial shape, volume, and surface area from two-chamber and four-chamber views. The network achieved excellent 3D shape reconstruction and showed higher accuracy and robustness compared to the bi-plane area-length method for both volume and surface area estimation.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Biology
Damiano Fassina, Caroline M. Costa, Martin Bishop, Gernot Plank, John Whitaker, Sian E. Harding, Steven A. Niederer
Summary: The presence of fibrotic tissue and disrupted electrical properties in post-MI ventricles increases the risk of life-threatening arrhythmias. Epicardial patches derived from hiPSC-CMs are a potential therapy for post-MI heart failure, but their effects on arrhythmias have not been studied. This study used in silico models to investigate the impact of EHT patch engraftment on arrhythmic risk.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biology
Argyrios Petras, Matthias A. F. Gsell, Christoph M. Augustin, Jairo Rodriguez-Padilla, Alexander Jung, Marina Strocchi, Frits W. Prinzen, Steven A. Niederer, Gernot Plank, Edward J. Vigmond
Summary: Mechanoelectric feedback (MEF) in the heart operates through various mechanisms to regulate cardiac function, including the stretch activated channels (SACs) and tension dependence. SACs do not significantly affect mechanical response, while tension and shortening velocity have a bigger impact on stroke volume. MEF reduces heterogeneity in stretch and could potentially mitigate activation problems.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Luuk H. G. A. Hopman, Irene M. Frenaij, Jose A. Solis-Lemus, Sulayman el Mathari, Steven A. Niederer, Cornelis P. Allaart, Marco J. W. Goette
Article
Multidisciplinary Sciences
L. Dvinskikh, H. Sparks, L. Brito, K. T. MacLeod, S. E. Harding, C. Dunsby
Summary: Improving cardiac function through stem-cell regenerative therapy requires integration of transplanted cells with host tissue, which can be visualized using high-resolution 3D imaging. A custom light-sheet fluorescence microscope was used to study calcium dynamics in co-cultures of rat and human cardiomyocytes. The two cell types showed synchronized calcium transients and contraction, and electromechanical coupling improved with co-culture duration.
SCIENTIFIC REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Nadeev Wijesuriya, Felicity De Vere, Vishal Mehta, Steven Niederer, Christopher A. Rinaldi, Jonathan M. Behar
Summary: Leadless pacing is a rapidly growing field that aims to provide long-term transvenous lead-free pacing for patients who require pacing. It shows potential benefits in special populations and may become a first-line therapy in the future.
ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Vishal S. Mehta, Nadeev Wijesuriya, Felicity DeVere, Sandra Howell, Mark K. Elliott, Nilanka Mannakarra, Tatiana Hamakarim, Steven Niederer, Reza Razavi, Christopher A. Rinaldi
Summary: This study aimed to evaluate the influence of sex on long-term survival in patients undergoing transvenous lead extraction (TLE). The results showed that female patients had more favorable long-term outcomes and similar factors influenced mortality in both groups.
Article
Cardiac & Cardiovascular Systems
Matthew O'Connor, Umberto Barbero, Daniel B. Kramer, Angela Lee, Alina Hua, Tevfik Ismail, Karen P. Mccarthy, Steven Niederer, Christopher A. Rinaldi, Vias Markides, John-Ross D. Clarke, Sonya Babu-Narayan, Siew Yen Ho, Tom Wong
Summary: This study evaluated the anatomy of the right atrium and the adjacent structures to identify the optimal and safest location for implanting an atrial leadless pacemaker. Three potential locations were identified: the base of the right atrial appendage, the anteromedial recess of the right atrial appendage apex, and the right atrial lateral wall. Based on anatomical review and 3D modeling, the base of the right atrial appendage appears to be the best compromise for implantation.
Article
Biochemical Research Methods
Nicola Dark, Marie-Victoire Cosson, Lorenza I. Tsansizi, Thomas J. Owen, Elisa Ferraro, Alice J. Francis, Selina Tsai, Camille Bouissou, Anne Weston, Lucy Collinson, Najah Abi-Gerges, Paul E. Miller, Kenneth T. MacLeod, Elisabeth Ehler, Richard Mitter, Sian E. Harding, James C. Smith, Andreia S. Bernardo
Summary: By leveraging knowledge of cardiac development, we have successfully guided the differentiation of human pluripotent stem cells into near-homogenous left ventricle-specific cardiomyocytes. These functionally matured hPSC-LV-CMs exhibit increased metabolism, reduced proliferation, and improved cytoarchitecture and functional maturity compared to age-matched cardiomyocytes generated using the standard WNT-ON/WNT-OFF protocol.
CELL REPORTS METHODS
(2023)