Article
Biology
Argyrios Petras, Matthias A. F. Gsell, Christoph M. Augustin, Jairo Rodriguez-Padilla, Alexander Jung, Marina Strocchi, Frits W. Prinzen, Steven A. Niederer, Gernot Plank, Edward J. Vigmond
Summary: Mechanoelectric feedback (MEF) in the heart operates through various mechanisms to regulate cardiac function, including the stretch activated channels (SACs) and tension dependence. SACs do not significantly affect mechanical response, while tension and shortening velocity have a bigger impact on stroke volume. MEF reduces heterogeneity in stretch and could potentially mitigate activation problems.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Laura Rolland, Angelo Giovanni Torrente, Emmanuel Bourinet, Dounia Maskini, Aurelien Drouard, Philippe Chevalier, Chris Jopling, Adele Faucherre
Summary: The cardiovascular system generates dynamic mechanical forces due to its rhythmic nature. The heart, as the center of this system, detects and adjusts its performance according to these changes. Mechanoelectric feedback rapidly detects subtle changes in the mechanical environment and converts these signals into electrical responses, affecting various cardiac parameters. However, pathological conditions can disrupt this complex mechansensory system and lead to potentially life-threatening cardiac arrhythmias. Mechanosensitive ion channels, particularly PIEZO1, play a crucial role in mechanoelectric feedback, and their dysfunction may be associated with heritable cardiac arrhythmias in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Mechanical
J. I. Colorado-Cervantes, P. Nardinocchi, P. Piras, V. Sansalone, L. Teresi, C. Torromeo, P. E. Puddu
Summary: A computational framework for studying cardiac motion is presented, which analyzes the deformation of cardiac tissue and investigates the relationship between myocardial fiber arrangement and cardiac strain patterns.
ACTA MECHANICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Smiljana Tomasevic, Miljan Milosevic, Bogdan Milicevic, Vladimir Simic, Momcilo Prodanovic, Srboljub M. Mijailovich, Nenad Filipovic
Summary: Cardiomyopathy, including hypertrophic and dilated forms, is a condition characterized by structural and functional abnormalities of the ventricular myocardium. Computational modeling and drug design methods are being used in the SILICOFCM project to accelerate drug discovery and improve treatment for cardiomyopathy. By simulating fluid-structure interactions and molecular drug interactions, this project aims to provide valuable insights into the effects of specific drugs and facilitate risk prediction and personalized treatment for cardiac disease patients.
Article
Biotechnology & Applied Microbiology
Marilena Pannone
Summary: A theoretical fluid mechanical model was proposed for investigating myocardial perfusion in healthy and stenotic conditions. The model reformulates equations based on Terzaghi's consolidation theory to simulate the swelling-drainage alternation characterizing diastolic-systolic phases. Results showed that the model consistently reproduces the basic mechanisms of both healthy and ischemic perfusion.
BIOENGINEERING-BASEL
(2021)
Article
Physiology
Longling Fan, Jing Yao, Liang Wang, Di Xu, Dalin Tang
Summary: This study proposed a novel image-based ventricle animal modeling approach to optimize ventricular pacemaker site for better cardiac outcome. A healthy adult female pig was used to create pacing animal models with different ventricle pacing locations. Results showed that the model with pacemaker located in the right ventricular outflow tract had the best performance among the four models compared.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Hong Shen Wong, Hadi Wiputra, Andreas Tulzer, Gerald Tulzer, Choon Hwai Yap
Summary: In cases of fetal aortic stenosis and evolving Hypoplastic Left Heart Syndrome (feHLHS), specific abnormalities and altered fluid dynamics are observed in the left ventricles (LV). The feHLHS LV shows narrowed and fast diastole mitral inflow, elevated energy losses, intraventricular pressure gradients, and vortex formation numbers, and poor blood turnover, indicating energy inefficiency of flow and additional burden on the LV.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Martin Genet, Jerome Diaz, Dominique Chapelle, Philippe Moireau
Summary: Biomechanical modeling and simulation have great potential in medicine, but the computational cost of full-order finite element models for complex organs like the heart can be prohibitive. Therefore, reduced models are more practical, allowing for pre-calibration, fast predictions, and real-time applications. In this study, we develop a reduced ventricular model based on cylindrical geometry and kinematics, incorporating myofiber orientation and contraction patterns. Our model has a fully dynamical formulation, integrated into a lumped circulation model, and accounts for various physical parameters.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Michael J. J. Moulton, Timothy W. W. Secomb
Summary: In this study, a computationally efficient, biophysically based mathematical model is proposed to study the progression of diseases such as hypertension, systolic heart failure, and heart failure with preserved ejection fraction. The model includes four chambers of the heart, with the left ventricle represented by a low-order, wall volume-preserving model. The cardiac model is coupled with a wave propagation model for the aorta and a closed lumped-parameter circulation model. Changes in aortic properties due to aging are shown to affect pulse wave reflections, LV pressure-volume loops, and LV fiber stress and sarcomere shortening.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Engineering, Biomedical
Denisa Martonova, Muhannad Alkassar, Julia Seufert, David Holz, Minh Tuan Du'o'ng, Barbara Reischl, Oliver Friedrich, Sigrid Leyendecker
Summary: During the study, passive mechanical properties in healthy and infarcted rat myocardium were characterized using mechanical testing and parameter fitting. The infarcted myocardium exhibited significantly stiffer behavior compared to healthy tissue, with stiffness correlating with the amount of fibrosis. The proposed material model successfully captured the behavior of both types of tissues and represented the experimental data well after calibration with fitted parameters.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Michele Orini, Peter Taggart, Anish Bhuva, Neil Roberts, Carmelo Di Salvo, Martin Yates, Sveeta Badiani, Stefan Van Duijvenboden, Guy Lloyd, Andrew Smith, Pier D. Lambiase
Summary: This study found that increased ventricular loading leads to decreased longitudinal shortening and shortened ARI in certain cardiac segments. Regional longitudinal shortening was positively correlated with ARI shortening and increased local ARI dispersion. At the whole organ level, increased mechanical dispersion resulted in increased dispersion of repolarization.
Article
Computer Science, Interdisciplinary Applications
Nenad Filipovic, Tijana Sustersic, Miljan Milosevic, Bogdan Milicevic, Vladimir Simic, Momcilo Prodanovic, Srboljub Mijailovic, Milos Kojic
Summary: In silico clinical trials and virtual testing are the future of medicine, with the potential to reduce development costs and time. The SILICOFCM project developed a computational platform for simulating cardiovascular disease treatment and drug interactions. By simulating different parameters, the platform can study the effects of drugs on heart function.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Engineering, Biomedical
Emilio A. Mendiola, Sunder Neelakantan, Qian Xiang, Samer Merchant, Ke Li, Edward W. Hsu, Richard A. F. Dixon, Peter Vanderslice, Reza Avazmohammadi
Summary: Myocardial infarction results in changes in the structure and properties of the left ventricular free wall. Understanding the remodeling patterns is crucial for predicting cardiac function and intervening in heart diseases.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Medicine, General & Internal
Minqi Liao, Yifan Lian, Yongzhao Yao, Lihua Chen, Fei Gao, Long Xu, Xin Huang, Xinxing Feng, Suxia Guo
Summary: Left ventricular ejection fraction (LVEF) is crucial for assessing cardiac function in heart disease diagnosis. To address human bias and high labor costs in manual echocardiographic analysis, computer algorithms based on deep learning have been developed. This study proposes two models using pure Transformers for left ventricular (LV) segmentation in echocardiography, which demonstrate effectiveness and reveal the potential of Transformer structure in echocardiographic segmentation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alaettin Arslan, Elif Aktas, Burak Sengul, Burcu Tekin
Summary: This study evaluated the dosimetric results of using the left ventricle and left anterior descending artery as organs at risk in adjuvant radiotherapy after breast-conserving surgery. The findings showed that contouring these organs as organs at risk could lead to better protection and reduced doses to the heart.
