Article
Critical Care Medicine
Samuel Tuffet, Tommaso Maraffi, Matthieu Lacheny, Francois Perier, Anne-Fleur Haudebourg, Mohamed Ahmed Boujelben, Glasiele Alcala, Armand Mekontso-Dessap, Guillaume Carteaux
Summary: Electrical impedance tomography (EIT) can be used to assess V/Q mismatch in the lungs, but neglecting the absolute values of alveolar ventilation and cardiac output may result in significant bias. The direction of the bias depends on the V-A/Q(C) ratio in ARDS patients.
Article
Multidisciplinary Sciences
Cristian Crisosto, Andreas Voskrebenzev, Marcel Gutberlet, Filip Klimes, Till F. Kaireit, Gesa Poehler, Tawfik Moher, Lea Behrendt, Robin Mueller, Maximilian Zubke, Frank Wacker, Jens Vogel-Claussen
Summary: This study aimed to improve automated lung segmentation on 2D lung MR images using balanced augmentation and artificially-generated consolidations for training of a convolutional neural network (CNN). The results showed that by increasing balanced augmentation and artificially-generated consolidations, the CNN performance was improved, especially in datasets with parenchymal consolidations. This is an important step towards a robust automated postprocessing of lung MRI datasets in clinical routine.
Article
Multidisciplinary Sciences
Axel Neulen, Michael Molitor, Michael Kosterhon, Tobias Pantel, Elisa Holzbach, Wolf-Stephan Rudi, Susanne H. Karbach, Philip Wenzel, Florian Ringel, Serge C. Thal
Summary: The study found that cerebral perfusion improved over time in a murine SAH model and was significantly correlated with left ventricular end-diastolic volume. Transient cardiac dysfunction manifestations (such as right bundle branch block, reduced left ventricular contractility) can indicate the occurrence of NSC.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Shigehiko Ogoh, Jun Sugawara, Shigeki Shibata
Summary: Heart failure (HF) in patients may increase the risk of cognitive dysfunction and stroke due to physiological factors associated with cardiac dysfunctions affecting cerebral circulation. Reduced cerebral blood flow and abnormal autoregulation in chronic HF can lead to decreased perfusion, metabolic insufficiency, and structural deteriorations in the brain. The mechanism underlying HF-induced brain disease is still unclear, and future studies should focus on physiological factors to prevent brain disease and cardiovascular dysfunction in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yen-Fen Ko, Kuo-Sheng Cheng
Summary: Electrical impedance tomography (EIT) is commonly used for monitoring lung ventilation, but poor spatial resolution affects image reconstruction; the semi-Siamese U-Net shows performance improvement in separating heart and lung impedance images.
Article
Physiology
Abhilash S. Kizhakke Puliyakote, Ann R. Elliott, Rui C. Sa, Kevin M. Anderson, Laura E. Crotty Alexander, Susan R. Hopkins
Summary: This study demonstrates that vaping-induced disruptions in ventilation-perfusion matching are present in young, healthy, asymptomatic adults with normal spirometry who habitually vape. The changes in ventilation and perfusion distributions, both at baseline and acutely after vaping, as well as the potential implications on hypoxic vasoconstriction, are crucial in understanding the pathogenesis of vaping-induced dysfunction. Using imaging-based approach provides evidence of potential subclinical alterations in lung function below thresholds of detection using spirometry.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilyes Benlala, Rabea Klaar, Thomas Gaass, Julie Macey, Stephanie Bui, Baudouin Denis De Senneville, Patrick Berger, Francois Laurent, Gael Dournes, Julien Dinkel
Summary: This study evaluated whether Fourier decomposition (FD) functional lung MRI can detect response to treatment of allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients. The results showed that non-contrast-enhanced FD lung MRI can reproducibly assess the response to ABPA treatment in CF patients and correlates with pulmonary function test obstructive parameters.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Respiratory System
Piotr Harbut, G. Kim Prisk, Robert Lindwall, Sarah Hamzei, Jenny Palmgren, Catherine E. Farrow, Goran Hedenstierna, Terence C. Amis, Atul Malhotra, Peter D. Wagner, Kristina Kairaitis
Summary: This study investigated the measurement and changes of shunt and alveolar dead space in moderate COVID-19 patients during acute illness and recovery. The results showed that most patients' abnormalities resolved within weeks, but about 30% of recovered patients still had pulmonary vascular pathology.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Critical Care Medicine
Yu-xian Wang, Ming Zhong, Min-hui Dong, Jie-qiong Song, Yi-jun Zheng, Wei Wu, Jia-le Tao, Ling Zhu, Xin Zheng
Summary: This study investigated the effect of prone positioning on ventilation-perfusion matching in ARDS patients using contrast-enhanced electrical impedance tomography (EIT). The findings showed that prolonged prone ventilation improved dorsal ventilation and perfusion, resulting in improved ventilation-perfusion matching and oxygenation.
Article
Multidisciplinary Sciences
Alessandra F. Thompson, Lillian Moraes, Nazareth N. Rocha, Marcos V. S. Fernandes, Mariana A. Antunes, Soraia C. Abreu, Cintia L. Santos, Vera L. Capelozzi, Cynthia S. Samary, Marcelo G. de Abreu, Felipe Saddy, Paolo Pelosi, Pedro L. Silva, Patricia R. M. Rocco
Summary: The study found that adjusting the frequency of controlled breaths and the level of pressure support can mitigate lung and diaphragm damage in an animal model of acute respiratory distress syndrome. Increasing pressure support can improve lung mechanics and reduce lung injury, while partitioning inspiratory effort and pressure in spontaneous breathing can minimize lung and diaphragm damage.
Review
Immunology
Sanaz Hatami, Joshua Hefler, Darren H. Freed
Summary: Extracorporeal circulation systems and machine perfusion of donor organs play important roles in cardiothoracic surgeries and organ transplantation. However, the use of these systems can activate inflammatory and oxidative stress responses, which may negatively affect patient outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Keir A. Forgie, Nicholas Fialka, Mubashir Khan, Max Buchko, Sanaz Hatami, Sayed Himmat, Xiao Qi, Xiuhua Wang, Katie-Marie Buswell, Ryan Edgar, Daina Domahidi, Darren H. Freed, Jayan Nagendran
Summary: Lung transplantation is an effective treatment for end-stage lung disease but is limited by donor organ shortage. Ex situ lung perfusion (ESLP) has improved donor lung utilization rates and can be validated using porcine models. The porcine lung transplantation model is easily reproducible and can be used to validate ESLP strategies and evaluate interventions.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Edward Castillo, Girish Nair, Danielle Turner-Lawrence, Nicholas Myziuk, Scott Emerson, Sayf Al-Katib, Sarah Westergaard, Richard Castillo, Yevgeniy Vinogradskiy, Thomas Quinn, Thomas Guerrero, Craig Stevens
Summary: The CT-Perfusion (CT-P) method introduced in this study aims to quantify pulmonary perfusion by analyzing mass changes apparent on dynamic noncontrast CT images. Initial results show promising correlations with single photon emission CT perfusion (SPECT-P), but further investigation is needed to optimize CT acquisition protocols and numerical methods for CT-P imaging.
Article
Physiology
Philip J. Peyton
Summary: The study proposes a new model based on ideal alveolar gas, taking into account the distribution of ventilation-perfusion ratios, and suggests that each gas has its individual ideal ventilation-perfusion ratio.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Joshua R. Astley, Alberto M. Biancardi, Helen Marshall, Laurie J. Smith, Paul J. C. Hughes, Guilhem J. Collier, Laura C. Saunders, Graham Norquay, Malina-Maria Tofan, Matthew Q. Hatton, Rod Hughes, Jim M. Wild, Bilal A. Tahir
Summary: In this study, a 3D multi-channel convolutional neural network called PhysVENeT was proposed to synthesize 3D ventilation surrogates using physiologically-informed ventilation mapping and multi-inflation structural H-1-MRI. The performance of the synthetic ventilation surrogates was evaluated and compared with conventional H-1-MRI ventilation mapping and other DL approaches. The PhysVENeT framework significantly outperformed other methods, indicating its potential in accurately reflecting ventilation defects.
SCIENTIFIC REPORTS
(2023)
Article
Sport Sciences
Ming-Lu Lin, Chih-Chin Hsu, Tieh-Cheng Fu, Yu-Ting Lin, Yu-Chieh Huang, Jong-Shyan Wang
Summary: This study investigates the effects of interval and continuous exercise on NK cell phenotypes and mitochondrial bioenergetics. The results show that both high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) can increase the expressions of cytotoxic granule proteins and decrease mitochondrial matrix oxidant burden (MOB) in NK cells. Additionally, HIIT is superior to MICT in improving aerobic capacity.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Sport Sciences
Shu-Chun Huang, Chih-Chin Hsu, Tieh-Cheng Fu, Carl P. C. Chen, Ming-Feng Liao, Chien-Ya Hsu, Jong-Shyan Wang
Summary: The study found that stepper-based exercise training can improve cardiopulmonary fitness in nonambulatory hemiplegic patients with ischemic stroke and reduce heteroaggregation of monocytes with platelets. This research provides new possibilities for the rehabilitation of nonambulatory hemiplegic patients.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Physiology
Chih-Chin Hsu, Yu-Ting Lin, Tieh-Cheng Fu, Shu-Chun Huang, Cheng-Hsien Lin, Jong-Shyan Wang
Summary: Supervised cycling training (SCT) improves aerobic capacity and quality of life by enhancing erythrocyte deformability in patients with peripheral arterial disease (PAD).
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chi-Hsiao Yeh, Yi-Ju Chou, Tsung-Hsien Tsai, Paul Wei-Che Hsu, Chun-Hsien Li, Yun-Hsuan Chan, Shih-Feng Tsai, Soh-Ching Ng, Kuei-Mei Chou, Yu-Ching Lin, Yu-Hsiang Juan, Tieh-Cheng Fu, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Summary: A study in Taiwan found a high proportion of clopidogrel resistance among diabetic PAD patients, suggesting that platelet function test-guided therapy could reduce adverse events. AI-assisted genome-wide association study identified a SNP signature composed of 20 SNPs in 9 protein-coding genes, revealing a protein interaction network related to the endocytosis and recycling of the drug target of clopidogrel. The findings suggest potential for developing precision medicine for antiplatelet therapy in diabetic PAD patients.
Article
Multidisciplinary Sciences
Ke-Yun Chao, Wei-Lun Liu, Yasser Nassef, Pin-Zhen Lai, Jong-Shyan Wang
Summary: Noninvasive ventilation improves exercise performance in patients with chronic obstructive pulmonary disease. This study investigated the use of helmet ventilation during a 6 min walk test and analyzed its short-term cardiopulmonary outcomes in stable COPD patients. The results showed that the use of helmet ventilation did not significantly improve the distance walked in the 6 min walk test, but it led to a significantly higher peak heart rate.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Li-Hua Wu, Chao-Hung Wang, Min-Hui Liu, Chih-Chin Hsu, Pei-Hsun Yuan, Tieh-Cheng Fu
Summary: This study aimed to investigate the factors associated with participation and completion rates of cardiac rehabilitation (CR) in patients with heart failure (HF) and predict the improvement after CR. Factors associated with CR participation included sex and days between hospital discharge and cardiopulmonary exercise test. CR improved peak oxygen uptake (Vo(2peak)) and quality of life (QOL), and the improvement was related to male sex, younger age, no diabetes mellitus, and higher entry Vo(2peak).
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Editorial Material
Medicine, General & Internal
Tieh-Cheng Fu, Yen-Ying Kung, Jr-Rung Lin, Ching-Mao Chang
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shu-Chun Huang, Chi-Hsiao Yeh, Chih-Chin Hsu, Yu-Ching Lin, Chen-Hung Lee, Ching-Chung Hsiao, Chien-Hung Chiu, Tieh-Cheng Fu
Summary: This study compared the effects of exercise training on cardiopulmonary fitness and quality of life in patients with peripheral arterial disease (PAD), heart failure (HF), and stroke. The results showed that although there was an improvement in cardiorespiratory fitness and quality of life in all three groups, the increase was smaller in PAD patients and they had a higher non-response rate, especially in terms of cardiorespiratory fitness and quality of life. Therefore, a higher dose of exercise may be needed to promote adaptation in PAD patients.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Medicine, Research & Experimental
Chih-Chin Hsu, Jong-Shyan Wang, Yu-Chiau Shyu, Tieh-Cheng Fu, Yu-Hsiang Juan, Shin-Sheng Yuan, Chao-Hung Wang, Chi-Hsiao Yeh, Po-Cheng Liao, Hsin-Yi Wu, Pang-Hung Hsu
Summary: This translational research examined the implications of DNA methylation associated with high-intensity interval training (HIIT) on cardiac fibrosis in patients with heart failure (HF). The study found that HIIT can reduce cardiac fibrosis and improve cardiorespiratory fitness. This was confirmed through a variety of tests on HF patients, including cardiovascular magnetic resonance imaging and cardiopulmonary exercise tests, as well as cell experiments and proteomics analysis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Letter
Surgery
Chien-Ming Yen, Tieh-Cheng Fu, Ching-Mao Chang
Article
Physiology
Yu-Chieh Huang, Chih-Chin Hsu, Tieh-Cheng Fu, Jong-Shyan Wang
Summary: This study investigated the effects of combined aerobic and resistance exercise training on aerobic/muscular fitness and lymphocyte apoptosis/autophagy in sedentary males. Results showed that interval training (IT) may be more beneficial than continuous training (CT) in improving aerobic/muscular fitness and simultaneously ameliorating apoptosis of blood lymphocytes evoked by intense exercise or adrenergic stimulation in sedentary males.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-Ching Lin, Tieh-Cheng Fu, Gigin Lin, Shu-Hang Ng, Chi-Hsiao Yeh, Soh-Chin Ng, Tsun-Ching Chang, Yu-Hsiang Juan
Summary: This study aimed to investigate interstitial muscle fibrosis using T1 mapping indices and its relationships with muscle function and conservative treatment outcomes. The results showed that T1 mapping indices were significantly correlated with the 6-min walking test and the 3-min stepping test. The extracellular volume fraction (ECV) was found to be an independent predictor of treatment intolerance.
EUROPEAN RADIOLOGY
(2023)