Review
Biochemistry & Molecular Biology
Ulrike Meyer-Lindemann, Aldo Moggio, Alexander Dutsch, Thorsten Kessler, Hendrik B. Sager
Summary: Physical exercise is an effective strategy to prevent and treat various diseases by modifying metabolic and inflammatory pathways. The intensity and duration of exercise strongly influence the response. This comprehensive review provides insights into the beneficial effects of exercise on innate and adaptive immunity, and its impact on the progression of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Sibo Liu, Yuhe Liu, Zhihan Liu, Yansong Hu, Meixiu Jiang
Summary: Atherosclerosis, a chronic inflammatory vascular disease, is a major pathological basis of coronary heart disease. The incidence of atherosclerosis has been increasing due to changes in people's lifestyles and diets. Physical activity and exercise training have been found to be effective strategies for reducing cardiovascular disease risk. However, the optimal exercise mode for improving risk factors related to atherosclerosis is still unclear.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Gurneet S. Sangha, Craig J. Goergen, Steven J. Prior, Sushant M. Ranadive, Alisa M. Clyne
Summary: Atherosclerosis is a dynamic process that begins with endothelial dysfunction and inflammation, leading to arterial plaques. Exercise can improve endothelial function by altering hemodynamics, but excessive exercise may also contribute to arterial plaques. Studying the mechanisms of atherosclerosis in sedentary versus exercise states may lead to novel ways to improve exercise compliance and physical activity.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Hematology
Qingyuan Yang, Shiliang Chen, Xingyi Wang, Xinyu Yang, Liangqi Chen, Tuo Huang, Yang Zheng, Xianghui Zheng, Xiaojun Wu, Yong Sun, Jian Wu
Summary: This study reveals that exercise can improve atherosclerosis by regulating the expression of long non-coding RNA NEAT1. The study found that exercise can downregulate NEAT1 expression by decreasing m6A modification and METTL14 expression, thereby attenuating endothelial pyroptosis and improving atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Reza Alipanah-Moghadam, Leila Molazadeh, Zeinab Jafari-Suha, Abbas Naghizadeh-Baghi, Mahsa Mohajeri, Ali Nemati
Summary: This study investigated the effects of glutamine supplementation on atherosclerosis markers in young healthy males after exhaustive exercise. The results showed that serum levels of certain markers were significantly lower in the intervention group compared to the control group after glutamine supplementation. Additionally, levels of serum markers and the ratio of oxidized low-density lipoprotein to high-density lipoprotein decreased significantly in the intervention group after exhaustive exercise.
Article
Physiology
Samuel Montalvo, Manuel Gomez, Alondra Lozano, Sabrina Arias, Lisa Rodriguez, Francisco Morales-Acuna, Alvaro N. Gurovich
Summary: Endothelial dysfunction is the initial step in the development of atherosclerosis and a major cause of stroke. This study aimed to investigate the effects of different exercise modalities and intensities on blood flow patterns in the carotid artery. The results showed that treadmill exercise at high intensity resulted in the highest endothelial shear stress (ESS), while bench press and biceps curls had the lowest ESS.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mitsuharu Okutsu, Mami Yamada, Ken Tokizawa, Shuri Marui, Katsuhiko Suzuki, Vitor A. Lira, Kei Nagashima
Summary: Regular exercise helps protect arterial endothelial cells and reduce atherosclerotic plaque formation in mice, potentially through increasing autophagy levels in endothelial cells.
Article
Clinical Neurology
Mauro F. F. Mediano, Yejin Mok, Josef Coresh, Anna Kucharska-Newton, Priya Palta, Kamakshi Lakshminarayan, Wayne D. Rosamond, Kunihiro Matsushita, Silvia Koton
Summary: Higher levels of total prestroke physical activity, as well as work and leisure activities, are associated with a lower risk of mortality after incident stroke. It is suggested that promoting physical activity throughout life could be beneficial in reducing long-term mortality post-stroke.
Article
Geriatrics & Gerontology
Yixiao Wang, Yunnan Liu, Siyan Zhang, Na Li, Changyang Xing, Chen Wang, Jia Wang, Mengying Wei, Guodong Yang, Lijun Yuan
Summary: This study demonstrates that exercise-induced extracellular vesicles (EVs) derived from skeletal muscle can improve metabolism and reduce the risk of obesity and atherosclerosis. These EVs can be taken up by major metabolic organs, such as the liver and adipose tissue, and remodel metabolism towards beneficial cardiovascular outcomes. Therapeutic delivery of these EVs or their analogues may hold promise for preventing certain cardiovascular and metabolic diseases.
Article
Biochemistry & Molecular Biology
Milena Schonke, Zhixiong Ying, Artemiy Kovynev, Wietse In Het Panhuis, Anne Binnendijk, Sabine van Der Poel, Amanda C. M. Pronk, Trea C. M. Streefland, Menno Hoekstra, Sander Kooijman, Patrick C. N. Rensen
Summary: The timing of exercise training plays a critical role in reducing fat mass and early-stage atherosclerotic lesions, as well as affecting the composition of gut microbiota.
Article
Cardiac & Cardiovascular Systems
Yanan Wang, Liangqi Chen, Meiju Zhang, Xin Li, Xueyan Yang, Tuo Huang, Yunting Ban, Yunqi Li, Qifeng Li, Yang Zheng, Yong Sun, Jian Wu, Bo Yu
Summary: This study found that exercise can change lactylation modification, inhibiting the progression of atherosclerotic cardiovascular disease (ASCVD). Exercise training promotes lactylation of the Mecp2 protein, reducing the expression of vascular cell adhesion molecules, cytokines, and increasing the level of endothelial nitric oxide synthase. Mechanistically, lactylation represses the expression of epiregulin, affecting the MAPK signaling pathway and promoting the regression of atherosclerosis. This study provides new insights into the anti-atherosclerotic effects of exercise-induced post-translational modification (PTM).
Article
Surgery
Aluisio Andrade-Lima, Natan Silva Junior, Marcel Chehuen, Roberto Miyasato, Rodrigo W. A. Souza, Anthony S. Leicht, Patricia C. Brum, Edilamar M. de Oliveira, Nelson Wolosker, Claudia L. M. Forjaz
Summary: The study found that submaximal walking training can improve nitric oxide bioavailability, reduce systemic and local oxidative stress and inflammation in patients with intermittent claudication. The proposed training protocol may contribute to cardiovascular health improvement in these patients.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Geriatrics & Gerontology
Yunfeng Sun, Yawei Wu, Yingping Jiang, Hao Liu
Summary: Aerobic exercise can suppress the release of inflammatory factors by increasing the expression level of SESN1, thereby reducing the occurrence and development of atherosclerosis. Additionally, aerobic exercise can impede the activation of NF-kappa B signaling, playing a positive role in plaque stability.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Michael F. F. Mendoza, Carl J. J. Lavie
Summary: The review examines the relationship between exercise training, lipoprotein readings, and cardiovascular disease (CVD) and all-cause morbidity and mortality. It finds that aerobic exercise training and resistance exercise training can independently reduce mortality and improve lipid profiles, regardless of weight loss. Participation in both modes of exercise is shown to have more pronounced improvements in DLD and CVD-related mortality compared to either mode alone. However, exercise training has no direct effect on Lipoprotein-a (Lp(a)) levels. Increasing the use of wearable devices may help monitor physical activity and combat increasing morbidity related to unhealthy lifestyles and inactivity.
CURRENT OPINION IN LIPIDOLOGY
(2022)
Article
Physiology
Lauren N. Pedersen, Anson M. Blanks, Natalie J. Bohmke, Virginia L. Mihalick, R. Lee Franco
Summary: The study aimed to determine if an individual's physical activity level impacts the phenotype of monocytes and monocyte-derived macrophages when stimulated with LDL and fatty acid ex vivo. The findings suggest that acute exercise modulates monocyte phenotype after LDL and palmitate stimulation in a protective manner, however, chronic physical activity does not alter monocyte/macrophage responses to any experimental condition in this population.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Martin Bahls, Marwa H. Gaber, Harald T. Jorstad, Najat Mouine, Martijn Scherrenberg, Elena Marques-Sule
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Clinical Neurology
Silke M. Wortha, Stefan Frenzel, Martin Bahls, Mohamad Habes, Katharina Wittfeld, Sandra Van der Auwera, Robin Buelow, Stephanie Zylla, Nele Friedrich, Matthias Nauck, Henry Voelzke, Hans J. Grabe, Claudia Schwarz, Agnes Floeel
Summary: This study found that elevated spermidine levels are associated with Alzheimer's disease and vascular brain pathology, suggesting that spermidine may serve as an early biomarker. Higher levels of spermidine were correlated with smaller hippocampal volume, higher AD score, and lower global cortical thickness.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Kuemmel, Stefan Gross, Rico Feldtmann, Bishwas Chamling, Anne Strohbach, Kristin Lehnert, Martin Bahls, Lisa Loerzer, Katharina Moormann, Jeannine Witte, Alexander Riad, Marcus Doerr, Jens Fielitz, Stephan B. Felix
Summary: This study found that the levels of HMGB1 were associated with increased mortality in patients with dilated cardiomyopathy. Multivariable Cox regression analysis confirmed HMGB1 as a risk factor for mortality in DCM patients, independent of NT-proBNP, age, and gender.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Obstetrics & Gynecology
Juliane Bauer, Madlen Steinbrueckner, Marcus Doerr, Martin Bahls, Thorsten Schmidt, Sabina Ulbricht
Summary: This study investigated sedentary behavior and physical activity levels in pregnant women. The results showed that pregnant women spent most of their day in sedentary activities, and only half of them met the recommendations for physical activity in the second and third trimester. The study suggests that sedentary behavior and physical activity should be given more attention in clinical practice and research to motivate pregnant women to adopt an active lifestyle.
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2023)
Letter
Cardiac & Cardiovascular Systems
Camila Campos Santana, Anke Hannemann, Till Ittermann, Stefan Gross, Guillermo Pierdant, Jan Schielke, Martin Bahls, Henry Voelzke, Nele Friedrich, Stephan Burkhard Felix, Elisabeth Steinhagen-Thiessen, Marcus Doerr, Marcello Ricardo Paulista Markus
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Martin Junge, Markus Krueger, Dietlind L. Wahner-Roedler, Brent A. Bauer, Marcus Doerr, Martin Bahls, Jean-Francois Chenot, Reiner Biffar, Carsten O. Schmidt
Summary: The studies aimed to evaluate the reliability and measurement agreement of a preventive medical device, the Preventiometer, for cardiovascular outcomes. The results showed high retest-reliability of the clinical examinations in the Preventiometer, but there were some differences in measurement agreement compared to other methods.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mengya Shi, Siyu Han, Kristin Klier, Gisela Fobo, Corinna Montrone, Shixiang Yu, Makoto Harada, Ann-Kristin Henning, Nele Friedrich, Martin Bahls, Marcus Doerr, Matthias Nauck, Henry Voelzke, Georg Homuth, Hans J. Grabe, Cornelia Prehn, Jerzy Adamski, Karsten Suhre, Wolfgang Rathmann, Andreas Ruepp, Johannes Hertel, Annette Peters, Rui Wang-Sattler
Summary: This research aimed to identify candidate metabolite biomarkers of Metabolic Syndrome (MetS) and its associated risk factors. The study identified 56 specific metabolites related to MetS, with 13 of them being positively associated and 43 being negatively associated. The majority of these metabolites were associated with low HDL-C and hypertension. Additionally, one lipid metabolite, lysoPC a C18:2, was negatively associated with MetS and its five components. The study also revealed impaired metabolism of branched-chain and aromatic amino acids, as well as accelerated Glycine catabolism through metabolic networks.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Schielke, Till Ittermann, Stefan Gross, Eileen Moritz, Matthias Nauck, Nele Friedrich, Edzard Schwedhelm, Bernhard H. Rauch, Henry Voelzke, Robin Buelow, Bishwas Chamling, Stephan Burkhard Felix, Martin Bahls, Marcus Doerr, Marcello Ricardo Paulista Markus
Summary: This study investigated the associations of S1P with cardiac structure and systolic function. The results showed that lower levels of S1P were associated with increased left ventricular and left atrial parameters, as well as increased left ventricular stroke volume and work in men, but not in women.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Till Ittermann, Ralf Ewert, Dirk Habedank, Sabine Kaczmarek, Stephan B. Felix, Marcus Doerr, Beate Stubbe, Martin Bahls
Summary: This study found that the cost to initiate exercise (PIW) is related to cardiovascular disease risk and all-cause mortality. PIW can be used as a new parameter in cardiopulmonary exercise testing to assess the prevention and prognosis of cardiovascular disease.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Saima Bibi, Muhammad Naeem, Martin Bahls, Marcus Doerr, Nele Friedrich, Matthias Nauck, Robin Buellow, Henry Voelzke, Marcello Ricardo Paulista Markus, Till Ittermann
Summary: This study examined the associations of body composition markers derived from different modalities with inflammatory markers. The results showed positive associations between classic anthropometry markers, total body fat, subcutaneous and visceral fat, and liver fat with all inflammatory markers. Waist circumference showed the strongest association with high-sensitivity C-reactive protein and white blood cell counts, while visceral fat was strongly associated with ferritin. Relative body fat was strongly associated with several inflammatory markers, while body height, fat-free mass, and body cell mass showed inverse associations. These findings highlight the importance of waist circumference as an easily measured marker for early inflammation and the relevance of MRI-assessed markers of central obesity for ferritin levels.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Multidisciplinary Sciences
Ali Aghdassi, Edzard Schwedhelm, Dorothee Atzler, Matthias Nauck, Jens-Peter Kuehn, Marie-Luise Kromrey, Henry Voelzke, Stephan B. Felix, Marcus Doerr, Till Ittermann, Martin Bahls
Summary: Homoarginine (hArg), a non-essential amino acid, inhibits hepatic alkaline phosphatases and affects bile secretion. In this study, we investigated the relationship between hArg and liver biomarkers and evaluated the impact of hArg supplementation. Our results showed that hArg was positively associated with ALT, AST, GGT, AP, albumin, total bilirubin, cholinesterase, Quick's value, liver fat, and MELD score. However, hArg supplementation did not affect liver biomarkers. These findings suggest that hArg may serve as a marker of liver dysfunction and warrant further exploration.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Martin Bahls
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Katharina Noppes, Stefan Gross, Anke Hannemann, Marcello R. P. Markus, Martin Bahls, Henry Voelzke, Marcus Doerr, Matthias Nauck, Nele Friedrich, Stephanie Zylla
Summary: This study explores the association between plasma chemerin concentrations and all-cause mortality in the general population. It suggests that high chemerin concentrations are associated with increased overall mortality and may play a crucial role in cancer-related deaths, but not cardiovascular mortality.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Daniel L. Pontzen, Martin Bahls, Diana Albrecht, Stephan B. Felix, Marcus Doerr, Till Ittermann, Matthias Nauck, Nele Friedrich
Summary: This study aimed to assess the relations between inflammatory biomarkers and lipoprotein subclass parameters. The study found that multiple inflammatory biomarkers were related to lipoprotein subclass components, forming two distinct clusters. Additionally, a cluster of cytokines linked to the Th1-immune response were associated with an atherogenic lipoprotein profile. These findings contribute to a better understanding of the interaction between inflammation and lipoproteins.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Martin Sebastian Winkler, Martin Bahls, Rainer H. Boger, Till Ittermann, Marcus Dorr, Nele Friedrich, Edzard Schwedhelm
Summary: Arg, ADMA, and SDMA are related to cardiovascular disease and systemic inflammation. This study found that Arg and SDMA were positively associated with hsCRP and fibrinogen. In addition, Arg was inversely related to APRIL, while SDMA was positively associated with osteocalcin, tumor necrosis factor receptor 1 and 2, and soluble cluster of differentiation 30.
