Article
Biochemistry & Molecular Biology
Rob C. I. Wust, Bram F. Coolen, Ntsiki M. Held, Mariah R. R. Daal, Vida Alizadeh Tazehkandi, Lucienne Baks-te Bulte, Marit Wiersma, Diederik W. D. Kuster, Bianca J. J. M. Brundel, Michel van Weeghel, Gustav J. Strijkers, Riekelt H. Houtkooper
Summary: Doxycycline impairs mitochondrial function by inhibiting mitochondrial translation, causing cardiac dysfunction with systolic and diastolic impairments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Zhiwang Zhang, Tingli Pan, Yu Sun, Siqi Liu, Ziyi Song, Haojie Zhang, Yixing Li, Lei Zhou
Summary: The study showed that calcium addition promotes intramuscular fat accumulation by inhibiting fatty acid oxidation, providing a new approach for increasing intramuscular fat content and improving meat quality.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Ana Torres-Costoso, Vicente Martinez-Vizcaino, Ruben Fernandez-Rodriguez, Irene Sequi-Dominguez, Sara Reina-Gutierrez, Sergio Nunez de Arenas-Arroyo, Miriam Garrido-Miguel
Summary: This study found that young adults with higher dietary calcium intake have better muscle strength and lower fat mass percentage. Muscle strength mediates the relationship between dietary calcium intake and fat mass percentage, explaining 33.33% of this relationship. Both high dietary calcium intake and exercise activities aimed at improving muscle strength levels may help to prevent the cardiometabolic risk associated with an excess of fat mass in young people.
Article
Cell Biology
Jacob R. Enriquez, Heather A. McCauley, Kevin X. Zhang, J. Guillermo Sanchez, Gregory T. Kalin, Richard A. Lang, James M. Wells
Summary: This study investigates the immediate response of the intestinal epithelium to a high-fat diet using physiological metrics and single-cell transcriptomics. The findings indicate that mice exhibit altered whole-body physiology and increased intestinal epithelial proliferation within one day of high-fat diet exposure. Furthermore, the study reveals a shift towards fatty acid metabolism and an emergence of progenitor cells in response to the high-fat diet.
Article
Biochemistry & Molecular Biology
Salome Rognant, Samuel N. Baldwin, Harry A. T. Pritchard, Adam Greenstein, Kirstine Calloe, Christian Aalkjaer, Thomas A. Jepps
Summary: Prorenin enhances arterial contractility by inhibiting BKCa and increasing intracellular Ca2+ release, which is likely mediated through a local shift in pH upon activation of (P)RR and stimulation of V-ATPase.
Article
Cardiac & Cardiovascular Systems
Satya Murthy Tadinada, Eric T. Weatherford, Greg Collins, Gourav Bhardwaj, Jesse Cochran, William Kutschke, Kathy Zimmerman, Alyssa Bosko, Brian T. O'Neill, Robert M. Weiss, E. Dale Abel
Summary: The study found that despite inducing cardiac hypertrophy and increasing cardiac fatty acid metabolism, long-term fat feeding in mice may not be enough to activate pathological hypertrophic mechanisms that impair cardiac function or induce cardiac fibrosis. Additionally, unknown factors may contribute to the cardiac abnormalities reported by many research groups.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jiahui Fan, Huaping Li, Rong Xie, Xudong Zhang, Xiang Nie, Xiaolu Shi, Jiabing Zhan, Zhongwei Yin, Yanru Zhao, Beibei Dai, Shuai Yuan, Zheng Wen, Chen Chen, Dao Wen Wang
Summary: This study aimed to elucidate the role of lncRNA in dilated cardiomyopathy (DCM) and heart failure, with a focus on the ZNF593-AS molecule. Through a series of experiments and observations, the research demonstrated the critical function of ZNF593-AS in improving cardiac function in DCM, potentially offering a new avenue for therapeutic interventions in the future.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Heather L. Petrick, Stuart Brownell, Bayley Vachon, Henver S. Brunetta, Rachel M. Handy, Luc J. C. van Loon, Coral L. Murrant, Graham P. Holloway
Summary: This study shows that nitrate supplementation can increase force production during muscle fatigue, enhance submaximal SERCA activity, and boost mitochondrial respiration supported by SERCA-derived ADP. These effects are primarily observed in type I muscle fibers.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Endocrinology & Metabolism
Alexis M. Ceasrine, Staci D. Bilbo
Summary: Poor nutrition, lack of exercise, and genetic predisposition all contribute to the epidemic of obesity, leading to chronic inflammation and negative physiological and neurological outcomes. The neuroimmune system plays a key role in regulating metabolism, with microglia being crucial in this process, especially in perinatal programming.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Editorial Material
Multidisciplinary Sciences
Patricia M. Nunes, Dimitrios Anastasiou
Summary: Feeding mice high-fructose corn syrup has been found to increase gut surface area, enhancing absorption of dietary nutrients and resulting in weight gain.
Article
Cardiac & Cardiovascular Systems
Shuang Zheng, Weijiang Tan, Xiang Li, Binglin Li, Baoyong Gong, W. Glen Pyle, Jian Wu, Lei Li, Ting Luo, Yunzeng Zou, Feng Hua Yang, Peter H. Backx
Summary: This study demonstrated that aged male cynomolgus monkeys fed a high-fat/high-sugar diet exhibited metabolic disorders and cardiac contractile dysfunction, including altered serum metabolic profiles, tissue damage, cardiac remodeling, contractile dysfunction, and increased expression of proinflammatory cytokines.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Physiology
Hiroaki Eshima, Yoshifumi Tamura, Saori Kakehi, Ryo Kakigi, Ryuzo Kawamori, Hirotaka Watada
Summary: The study demonstrates that consumption of a high-fat diet can increase fatigue resistance in slow-twitch dominant muscle fibers, potentially through elevated oxidative enzyme activity and mitochondrial content.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Humberto Yevenes-Briones, Francisco Felix Caballero, Ellen A. Struijk, Alberto Lana, Fernando Rodriguez-Artalejo, Esther Lopez-Garcia
Summary: The study suggests that dietary intake of polyunsaturated fatty acids is associated with a decreased risk of disabling hearing impairment in women, but not in men.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Veterinary Sciences
Fan Zhang, Yiguang Zhao, Yue Wang, Hui Wang, Xuemei Nan, Yuming Guo, Benhai Xiong
Summary: This study showed that dietary supplementation with calcium propionate can improve immune function, liver function, and fecal microbial composition in early lactation dairy cows. Increasing levels of calcium propionate did not affect serum protein, immunoglobulin, and calcium concentrations, but had quadratic effects on albumin and IgA concentrations. Additionally, calcium propionate supplementation altered the abundance and composition of the rectal microbiota.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Jibran A. Wali, Duan Ni, Harrison J. W. Facey, Tim Dodgson, Tamara J. Pulpitel, Alistair M. Senior, David Raubenheimer, Laurence Macia, Stephen J. Simpson
Summary: This study investigates the metabolic effects of sugars and fat, specifically the interaction between dietary fat and the main monosaccharides, fructose and glucose, on body composition and metabolic health. The results show that a 50:50 mixture of fructose and glucose, similar to high-fructose corn syrup, consumed in low and medium dietary fat content, is more obesogenic and metabolically adverse than when either monosaccharide is consumed alone. The effects of dietary sugar composition become less pronounced with increasing dietary fat content, and higher fat intake is more harmful for glucose tolerance and insulin sensitivity regardless of the sugar mix consumed.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Ren Mao, Genevieve Doyon, Ilyssa O. Gordon, Jiannan Li, Sinan Lin, Jie Wang, Thi Hong Nga Le, Michael Elias, Satya Kurada, Brian Southern, Mitchell Olman, Minhu Chen, Shuai Zhao, Dina Dejanovic, Jyotsna Chandra, Pranab K. Mukherjee, Gail West, David R. Van Wagoner, Claudio Fiocchi, Florian Rieder
Summary: Creeping fat in Crohn's disease is formed by the migration of preadipocytes out of mesenteric fat and their differentiation into adipocytes due to increased production of fibronectin by activated muscularis propria cells. These findings may lead to novel approaches for preventing creeping fat-associated stricture formation.
Meeting Abstract
Gastroenterology & Hepatology
Ren Mao, Genevieve Doyon, Ilyssa Gordon, Jiannan Li, Sinan Lin, Jie Wang, Thi Hong Nga Le, Michael Elias, Satya Kurada, Brian Southern, Mitchell Olman, Shuai Zhao, Dina Dejanovic, Jyotsna Chandra, Mukherjee Pranab, Gail West, David van Wagoner, Claudio Fiocchi, Florian Rieder
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Physiology
Julie H. Rennison, Ling Li, Cheryl R. Lin, Beth S. Lovano, Laurie Castel, Sojin Youn Wass, Catherine C. Cantlay, Meghan McHale, A. Marc Gillinov, Reena Mehra, Belinda B. Willard, Jonathan D. Smith, Mina K. Chung, John Barnard, David R. Van Wagoner
Summary: Atrial fibrillation (AF) is strongly associated with the risk of stroke and heart failure, leading to left atrial thrombogenesis and increased energy demand. Proteomic analysis revealed mitochondrial dysfunction, oxidative phosphorylation, and sirtuin signaling as affected pathways in AF patients, suggesting reduced ATP availability, tissue contractile and electrophysiologic heterogeneity as potential consequences of uncoordinated response to AF.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Shadi Ahmadmehrabi, Binglan Li, Joseph Park, Batsal Devkota, Marijana Vujkovic, Yi-An Ko, David Van Wagoner, W. H. Wilson Tang, Ian Krantz, Marylyn Ritchie, Jason Brant, Michael J. Ruckenstein, Douglas J. Epstein, Daniel J. Rader
Summary: The study found that EYA4 gene burden is significantly associated with audiometric proven HL, Mobitz Type II AV block, and syndromic presentation of HL and primary cardiomyopathy. These associations were more subtle cardio-auditory phenotypes in an adult medical biobank population, which have not been previously reported. The findings suggest a role for genetic testing in adults presenting with hearing loss.
Review
Immunology
Jie Wang, Sinan Lin, Jonathan Mark Brown, David van Wagoner, Claudio Fiocchi, Florian Rieder
Summary: The incidence of inflammatory bowel diseases poses a global public health challenge, with intestinal fibrosis being a common complication in Crohn's disease. Recent progress has implicated mesenchymal cells, cytokines, microbial products, and mesenteric adipocytes in the pathogenesis of intestinal fibrosis. This information suggests that innovative therapies validated by reliable clinical trial endpoints may prevent or reverse intestinal strictures.
IMMUNOLOGICAL REVIEWS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
David R. Van Wagoner
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Michael A. Labarbera, Thomas Atta-Fosu, Albert K. Feeny, Marjan Firouznia, Meghan Mchale, Catherine Cantlay, Tyler Roach, Alexis Axtell, Paul Schoenhagen, John Barnard, Jonathan D. Smith, David R. Van Wagoner, Anant Madabhushi, Mina K. Chung
Summary: This study aimed to identify radiomic and clinical features associated with post-ablation recurrence of atrial fibrillation (AF). Cardiac CT scans were analyzed to find pulmonary vein morphology that is associated with increased likelihood of AF recurrence within 1 year of catheter ablation. Predictive models based on radiomic and clinical features may help identify candidates with the greatest likelihood of successful outcome in AF ablation.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kymberleigh A. Romano, Ina Nemet, Prasenjit Prasad Saha, Arash Haghikia, Xinmin S. Li, Maradumane L. Mohan, Beth Lovano, Laurie Castel, Marco Witkowski, Jennifer A. Buffa, Yu Sun, Lin Li, Christopher M. Menge, Ilja Demuth, Maximilian Koenig, Elisabeth Steinhagen-Thiessen, Joseph A. DiDonato, Arjun Deb, Fredrik Baeckhed, W. H. Wilson Tang, Sathyamangla Venkata Naga Prasad, Ulf Landmesser, David R. Van Wagoner, Stanley L. Hazen
Summary: A study found that the gut microbiota-dependent metabolite PAGln is associated with the presence and severity of heart failure both clinically and mechanistically. The circulating levels of PAGln are dose-dependently correlated with heart failure presence and indices of severity. It was also found that PAGln directly promotes heart failure-related phenotypes. Modulating the gut microbiome and PAGln production may be a potential therapeutic target for heart failure.
CIRCULATION-HEART FAILURE
(2023)
Article
Multidisciplinary Sciences
Jelena Kornej, Maha A. Qadan, Mona Alotaibi, David R. Van Wagoner, Jeramie D. Watrous, Ludovic Trinquart, Sarah R. Preis, Darae Ko, Mohit Jain, Emelia J. Benjamin, Susan Cheng, Honghuang Lin
Summary: This study found an association between chronic inflammation and atrial fibrillation (AF). Using liquid chromatography-mass spectrometry, researchers measured 161 eicosanoids and found that six of them were associated with incident AF. A joint score weighted by the effect sizes of these eicosanoids was also found to be associated with incident AF.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Julie H. Rennison, David R. Van Wagoner
EUROPEAN HEART JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuning Gu, Yongsheng Pan, Zhenghan Fang, Lei Ma, Yuran Zhu, Charlie Androjna, Kai Zhong, Xin Yu, Dinggang Shen
Summary: This study developed a deep learning-assisted fast MRF framework for sub-millimeter T-1 and T-2 mapping of the entire macaque brain. The proposed framework showed good adaptability to experimental MRF images and outperformed existing methods in handling aliasing artifacts and capturing detailed cerebral structures. The study demonstrated the potential of using deep learning in preclinical applications to achieve efficient organ-level high-resolution quantitative MRI.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Cell Biology
Jessica C. Lal, Chengsheng Mao, Yadi Zhou, Shamone R. Gore-Panter, Julie H. Rennison, Beth S. Lovano, Laurie Castel, Jiyoung Shin, A. Marc Gillinov, Jonathan D. Smith, John Barnard, David R. Van Wagoner, Yuan Luo, Feixiong Cheng, Mina K. Chung
Summary: This study utilizes network proximity analysis and functional testing to identify metformin as a candidate repurposed drug for atrial fibrillation, showing significant association with reduced risk of the condition.
CELL REPORTS MEDICINE
(2022)
Meeting Abstract
Clinical Neurology
Catherine Heinzinger, Nicolas Thompson, Alex Milinovich, Nancy Foldvary-Schaefer, David Van Wagoner, Mina Chung, Reena Mehra
Meeting Abstract
Clinical Neurology
Catherine Heinzinger, Nicolas Thompson, Alex Milinovich, Nancy Foldvary-Schaefer, David Van Wagoner, Mina Chung, Reena Mehra
Meeting Abstract
Cardiac & Cardiovascular Systems
Julie H. Rennison, Beth Lovano, Laurie Castel, Cheryl R. Lin, Feixong Cheng, Rohit Moudgil, Jonathan D. Smith, John Barnard, Mina K. Chung, David R. Van Wagoner