A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins

Emergence of Local Ca Oscillators in Cardiac Pacemaker Cells: 2d Ca Dynamics Measurements, An Analytical Theory, and Complex Systems Numerical Modeling

(2010) Anna V. Maltsev et al.   BIOPHYSICAL JOURNAL

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model

(2009) Victor A. Maltsev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca2+ cycling and IKACh

(2009) Alexey E. Lyashkov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells

(2009) Marcel M. G. J. Borren et al.   BASIC RESEARCH IN CARDIOLOGY

Intracellular Calcium Dynamics and Acceleration of Sinus Rhythm by β-Adrenergic Stimulation

(2009) Boyoung Joung et al.   CIRCULATION

What keeps us ticking: a funny current, a calcium clock, or both?

(2009) Edward G. Lakatta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Control of heart rate by cAMP sensitivity of HCN channels

(2009) J. Alig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel

(2009) P. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calmodulin kinase II is required for fight or flight sinoatrial node physiology

(2009) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Missing Link in the Mystery of Normal Automaticity of Cardiac Pacemaker Cells

(2008) Edward G. Lakatta et al.   Annals of the New York Academy of Sciences

Ionic Mechanisms Underlying the Positive Chronotropy Induced by β1-Adrenergic Stimulation in Guinea Pig Sinoatrial Node Cells: a Simulation Study

(2008) Yukiko Himeno et al.   Journal of Physiological Sciences