Article
Plant Sciences
Mengyuan Xiong, Xiantao Chen, Hongmei Wang, Xiang Tang, Qiaojiao Wang, Xuegang Li, Hang Ma, Xiaoli Ye
Summary: This study found that Zuojin capsule (ZJC) can improve spasmolytic polypeptide-expressing metaplasia (SPEM) and alleviate its symptoms such as gastric mucosal damage, hyperplasia of gastric pits, and increased gastric mucus secretion. The study also revealed that ZJC exerts its therapeutic effects by inhibiting the abnormal activation of cell cycle-related proteins (CDK1, CCNB1, CCNA2) and the PI3K-AKT signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Megan D. Radyk, Lillian B. Spatz, Bianca L. Pena, Jeffrey W. Brown, Joseph Burclaff, Charles J. Cho, Yan Kefalov, Chien-Cheng Shih, James A. J. Fitzpatrick, Jason C. Mills
Summary: ATF3 and RAB7B are upregulated in the early Stage 1 of paligenosis to help cells induce autophagic and lysosomal mechanisms. Atf3(-/-) mice fail to induce autophagic and lysosomal vesicles, leading to increased cell death. The evolutionarily conserved ATF3 gene orchestrates early paligenotic autodegradative events.
Article
Pathology
Yasuhiro Wada, Shigemi Nakajima, Ryoji Kushima, Shizuki Takemura, Naoko Mori, Hiroshi Hasegawa, Takahisa Nakayama, Ken-ichi Mukaisho, Akiko Yoshida, Shinji Umano, Kazuo Yamamoto, Hiroyuki Sugihara, Kazunari Murakami
Summary: There are two types of pyloric gland-like metaplasia in the corpus of stomach: pyloric and pseudopyloric metaplasias. While they share similarities in morphology, there are differences in immunohistochemical expression of TFF2. The majority of metaplasia in autoimmune gastritis is pyloric metaplasia, with differences in TFF2 expression between pyloric and pseudopyloric metaplasia.
Review
Medicine, General & Internal
Mian-Li Li, Xin-Xin Hong, Wei-Jian Zhang, Yi-Zhong Liang, Tian-Tian Cai, Yi-Fei Xu, Hua-Feng Pan, Jian-Yuan Kang, Shao-Ju Guo, Hai-Wen Li
Summary: Heliobacter pylori infection is associated with chronic gastritis, gastric mucosal atrophy, and gastric cancer. Spasmolytic polypeptide-expressing metaplasia (SPEM) is a type of mucous cell metaplasia that may have a stronger association with gastric adenocarcinoma than intestinal metaplasia. SPEM is caused by acute injury or inflammation and is characterized by abnormal expression of certain proteins in the stomach glands. The specific mechanism of SPEM progression driven by H. pylori infection needs further investigation.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Cell Biology
Zhi-Feng Miao, Charles J. Cho, Zhen-Ning Wang, Jason C. Mills
Summary: Differentiated cells have evolved a conserved program called paligenosis to return to a stem or progenitor state and reenter the cell cycle for tissue repair. Key regulators of paligenosis, such as Ddit4 and Ifrd1, control different stages of the process, providing potential new insights for tissue regeneration and cancer therapy.
Editorial Material
Oncology
James R. Goldenring
Summary: Intestinal-type gastric cancer can arise from precancerous metaplastic lineages, specifically from spasmolytic polypeptide-expressing metaplasia (SPEM) cells. A recent study identified an activating Kras(G12D) mutation in SPEM cells, which propagated into adenomatous and cancerous lesions, suggesting that SPEM lineages can serve as a direct precursor for dysplasia and intestinal-type gastric cancer.
JOURNAL OF PATHOLOGY
(2023)
Article
Immunology
Lin Liu, Yang Wang, Yukun Zhao, Wei Zhang, Jiong Liu, Fengyun Wang, Ping Wang, Xudong Tang
Summary: Spasmolytic polypeptide expression metaplasia (SPEM) is a lesion in the corpus of the stomach closely associated with inflammations caused by H. pylori infection. It has been suggested as a dubious precancerous lesion of gastric cancer (GC), and further research on SPEM cell transdifferentiation and its underlying mechanisms could contribute to the development of new molecular targets for GC therapeutics. This study analyzed publications related to SPEM-GC using bibliometrics, identified research hotspots, and provided references for scientific researchers in related fields.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Oncology
Wan-Qun Chen, Feng-Liang Tian, Jin-Wei Zhang, Xiao-Jun Yang, Yan-Ping Li
Summary: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa. YWXY is able to inhibit cell proliferation and restore miR-7 expression by mediating TFF2 in the SPEM mouse model.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peijun Tian, Huiyue Zhu, Renying Zou, Qinming Kong, Mengshu Xu, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang
Summary: This study developed an in vitro screening method based on RIN14B to screen probiotics with antidepressant-like potential, identifying certain strains that can produce neurobehavioral effects by enhancing Tph1 expression.
Article
Gastroenterology & Hepatology
Hsuan Hsieh, Hsiao-Bai Yang, Bor-Shyang Sheu, Yao-Jong Yang
Summary: This study aimed to evaluate the histopathological pattern of H. pylori atrophic gastritis in children and the extent of precancerous lesions. The results showed that the prevalence rates of gastric glandular atrophy, intestinal metaplasia, and spasmolytic peptide-expressing metaplasia (SPEM) in children with H. pylori infection were 30.4%, 4.3%, and 8.7% respectively. SPEM and high-grade atrophy were more common in female patients.
Review
Cell Biology
Patrizia Cammareri, Kevin B. Myant
Summary: Cellular plasticity plays a crucial role in cancer initiation and therapy resistance, leading to phenotypic and functional heterogeneity within tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Brianna Caldwell, Anne R. Meyer, Jared A. Weis, Amy C. Engevik, Eunyoung Choi
Summary: Our study provides pivotal evidence for cell plasticity and lineage contributions from differentiated gastric chief cells during acute metaplasia development. Mature chief cells, rather than isthmal progenitor cells, serve as the predominant origin of SPEM cells during the metaplastic process after acute mucosal injury. Furthermore, long-term label-retaining chief cells can be identified, with only a very small subset displaying reprogramming ability in homoeostasis.
Article
Medicine, Research & Experimental
Maria Jose Pastre, Marcelo Biondaro Gois, Lucas Casagrande, Leticia Sarturi Pereira-Severi, Lainy Leiny de Lima, Aline Rosa Trevizan, Carlos Alberto Miqueloto, Joao Luis Garcia, Silvia Lima Costa, Gessilda de Alcantara Nogueira-Melo, Debora de Mello Goncales Sant'Ana
Summary: The interaction of Toxoplasma gondii with the gastrointestinal tract of its host is highly regulated, leading to ruptures in the basement membrane and activation of the immune system. The study found an increase in cells expressing 5-HT in the jejunal wall and an increase in the number of mast cells after T. gondii infection.
Article
Gastroenterology & Hepatology
Du-Min Go, Seung Hyun Lee, Su-Hyung Lee, Sang-Ho Woo, Kibyeong Kim, Kyeongdae Kim, Kyu Seong Park, Jong-Hwan Park, Sang-Jun Ha, Woo Ho Kim, Jae-Hoon Choi, Dae-Yong Kim
Summary: In Helicobacter-induced gastritis, PD-L1 may play a role in regulating immune responses. Gastric classical DCs express significantly higher levels of PD-L1 compared to other immune cells. Furthermore, PD-L1-expressing DCs co-localize with T cells and show a positive correlation with H pylori infection.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Laurent Knerr, Thazha P. Prakash, Richard Lee, William J. Drury, Mehran Nikan, Wuxia Fu, Elaine Pirie, Leonardo De Maria, Eric Valeur, Ahlke Hayen, Maria Olwegard-Halvarsson, Johan Broddefalk, Carina Ammala, Michael E. Ostergaard, Johan Meuller, Linda Sundstrom, Patrik Andersson, David Janzen, Rasmus Jansson-Lofmark, Punit P. Seth, Shalini Andersson
Summary: The study demonstrates the potential of GLP1R agonist conjugation to improve the delivery efficiency of ASOs in diabetes treatment, particularly for pancreatic beta cells. Optimization of linker chemistry and exploration of GLP1R agonist ligands can effectively enhance the in vivo efficacy of ASOs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Gastroenterology & Hepatology
Hiroto Kinoshita, Yoku Hayakawa, Zhengchuan Niu, Mitsuru Konishi, Masahiro Hata, Mayo Tsuboi, Yuki Hayata, Yohko Hikiba, Sozaburo Ihara, Hayato Nakagawa, Yoshihiro Hirata, Timothy C. Wang, Kazuhiko Koike
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Zinaida A. Dubeykovskaya, Phaneendra Kumar Duddempudi, Huan Deng, Giovanni Valenti, Krystle L. Cuti, Karan Nagar, Yagnesh Tailor, Chandan Guha, Jan Kitajewski, Timothy C. Wang
CANCER GENE THERAPY
(2019)
Article
Cell Biology
Carolina Pinzon-Guzman, Anne R. Meyer, Rachel Wise, Eunyoung Choi, Sureshkumar Muthupalani, Timothy C. Wang, James G. Fox, James R. Goldenring
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Stefan Harmsen, Stephan Rogalla, Ruimin Huang, Massimiliano Spaliviero, Volker Neuschmelting, Yoku Hayakawa, Yoomi Lee, Yagnesh Tailor, Ricardo Toledo-Crow, Jeon Woong Kang, Jason M. Samii, Hazem Karabeber, Ryan M. Davis, Julie R. White, Matt van de Rijn, Sanjiv S. Gambhir, Christopher H. Contag, Timothy C. Wang, Moritz F. Kircher
Article
Gastroenterology & Hepatology
Yoku Hayakawa, Mayo Tsuboi, Samuel Asfaha, Hiroto Kinoshita, Ryota Niikura, Mitsuru Konishi, Masahiro Hata, Yukiko Oya, Woosook Kim, Moritz Middelhoff, Yohko Hikiba, Naoko Higashijima, Sozaburo Ihara, Tetsuo Ushiku, Masashi Fukayama, Yagnesh Tailor, Yoshihiro Hirata, Chandan Guha, Kelley S. Yan, Kazuhiko Koike, Timothy C. Wang
Editorial Material
Gastroenterology & Hepatology
Timothy C. Wang, Martin G. Martin, Calvin J. Kuo, Ophir D. Klein, Joyce Niland
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Mara Roxana Rubinstein, Jung Eun Baik, Stephen M. Lagana, Richard P. Han, William J. Raab, Debashis Sahoo, Piero Dalerba, Timothy C. Wang, Yiping W. Han
Article
Oncology
Jorge L. Sepulveda, Elena Komissarova, Sarawut Kongkarnka, Richard A. Friedman, Jon M. Davison, Brynn Levy, Diana Bryk, Vaidehi Jobanputra, Armando Del Portillo, Gary W. Falk, Joshua R. Sonett, Charles J. Lightdale, Julian A. Abrams, Timothy C. Wang, Antonia R. Sepulveda
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Haisheng Zhang, Antje Schaefer, Yichen Wang, Richard G. Hodge, Devon R. Blake, J. Nathaniel Diehl, Alex G. Papageorge, Matthew D. Stachler, Jennifer Liao, Jin Zhou, Zhong Wu, Fahire G. Akarca, Leonie K. de Klerk, Sarah Derks, Mariaelena Pierobon, Katherine A. Hoadley, Timothy C. Wang, George Church, Kwok-Kin Wong, Emanuel F. Petricoin, Adrienne D. Cox, Douglas R. Lowy, Channing J. Der, Adam J. Bass
Article
Gastroenterology & Hepatology
Henrik Nienhuser, Woosook Kim, Ermanno Malagola, Tuo Ruan, Giovanni Valenti, Moritz Middelhoff, Adam Bass, Channing J. Der, Yoku Hayakawa, Timothy C. Wang
Summary: The study revealed that gastric Mist1+ isthmus cells are activated in response to injury and inflammation, playing a crucial role in the regeneration of gastric glands through the Wnt5a pathway.
Article
Gastroenterology & Hepatology
Magdalena Kasendra, Misty Troutt, Taylor Broda, W. Clark Bacon, Timothy C. Wang, Joyce C. Niland, Michael A. Helmrath
Summary: Recent advances in intestinal organoid research have shown promising therapeutic potential for treating severely injured or diseased bowels using induced pluripotent stem cell (iPSC)-derived organoids. However, careful planning, significant resources, and collaboration between experts from various disciplines are required to address the safety and efficacy challenges in transitioning from laboratory discovery to first-in-human clinical trials.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Woosook Kim, Timothy C. Wang
Editorial Material
Biochemistry & Molecular Biology
Ermanno Malagola, Yoku Hayakawa, Timothy C. Wang
Summary: Recent research has identified distinct roles for Lgr4 and Lgr5 in directing gland reconstitution following H. pylori infection, shedding new light on the complexities of Rspo signaling during gastric regeneration and raising questions about antral stem cell hierarchy.
Article
Cell Biology
Toni T. Lemmetyinen, Emma W. Viitala, Linnea Wartiovaara, Tuomas Kaprio, Jaana Hagstrom, Caj Haglund, Pekka Katajisto, Timothy C. Wang, Eva Domenech-Moreno, Saara Ollila
Summary: Growth factors secreted by stromal fibroblasts, such as NRG1 and EREG, play a crucial role in regulating the intestinal epithelium. NRG1 promotes epithelial regeneration and protects against radiation-induced damage, while also suppressing the stem cell pool and remodeling the actin cytoskeleton. Interestingly, NRG1 does not support the growth of pre-tumorigenic intestinal organoids lacking the tumor suppressor Apc, suggesting a tumor-suppressive function.
DISEASE MODELS & MECHANISMS
(2023)
Article
Oncology
Jung Eun Baik, Li Li, Manish A. Shah, Daniel E. Freedberg, Zhezhen Jin, Timothy C. Wang, Yiping W. Han
Summary: Fusobacterium nucleatum (Fn) is a common gram-negative anaerobic bacterium that promotes colorectal cancer development through the secretion of FadAc. This study found that circulating levels of anti-FadAc IgA were significantly increased in patients with colorectal cancer, particularly in those with proximal tumors. Therefore, anti-FadAc IgA may serve as a serological biomarker for early detection of colorectal cancer.
CANCER RESEARCH COMMUNICATIONS
(2022)