Article
Medicine, General & Internal
Esra'a Abudouleh, Fatimah Alhamlan, Arwa A. Al-Qahtani, Marie Fe Bohol, Amal Al Hazzani, Khadija Khorfan, Morad Alkaff, Tarek Owaidah, Ahmed A. Al-Qahtani
Summary: This study investigated coagulation and fibrinolysis parameters in COVID-19 patients and their association with disease severity. The results showed significantly elevated levels of thrombin activatable fibrinolysis inhibitor, fibrinogen, and tissue plasminogen activator in severe patients. Additionally, patients in the ICU had significantly higher levels of plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombin activatable fibrinolysis inhibitor. These coagulation markers can serve as suitable prognostic indicators for hypofibrinolysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Manuel Yepes
Summary: Dementia is a global clinical syndrome, with Alzheimer's disease being the most common type. While it was previously believed that cognitive decline in dementia was caused by extracellular accumulation of A beta, recent studies have shown that it is actually associated with soluble A beta-induced synaptic dysfunction, which can be targeted for therapeutic interventions to prevent irreversible brain damage.
NEURAL REGENERATION RESEARCH
(2021)
Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Nina C. Teske, Joo-Yeon Engelen-Lee, Susanne Dyckhoff-Shen, Hans-Walter Pfister, Matthias Klein, Diederik van de Beek, Carsten K. Kirschning, Uwe Koedel, Matthijs C. Brouwer
Summary: This study found that PAI-2 levels are elevated in both patients and mice with pneumococcal meningitis. PAI-2 deficiency leads to an imbalance in inflammation, exacerbating brain pathology and increasing mortality.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Yukiko Asano, Takayuki Iwaki, Kazuo Umemura, Naohiro Kanayama, Hiroaki Itoh
Summary: The study showed that fibrin had no effect on mouse blastocysts, but significantly suppressed trophoblast growth in human blastocysts. However, trophoblasts in human blastocysts then switched to growth promotion through increased fibrinolysis with urokinase-type plasminogen activator (uPA) activity.
HUMAN REPRODUCTION
(2021)
Review
Endocrinology & Metabolism
Yongzhuo Yu, Wenxuan Li, Lili Xu, Yangang Wang
Summary: Cardiovascular complications are a common cause of death in type 2 diabetes patients, and Plasminogen-activator Inhibitor 1 (PAI-1) plays a crucial role in their development and progression. Insulin resistance increases PAI-1 production, leading to an environment conducive to thrombosis and severe vascular disease. PAI-1 also exhibits circadian rhythm characteristics, which may explain the higher incidence of cardiovascular events in the morning. PAI-1 is a potential drug target, but currently, no PAI-1 inhibitors have been approved for clinical use. Chronotherapy, based on rhythm, may offer improved treatment for cardiovascular complications in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kiyotaka Okada, Naoyuki Kawao, Daisho Nakai, Rei Wakabayashi, Yoshitaka Horiuchi, Katsumi Okumoto, Shinji Kurashimo, Yoshimasa Takafuji, Osamu Matsuo, Hiroshi Kaji
Summary: This study demonstrated that glucocorticoids decrease the number of macrophages at the injured site during early bone repair after femoral bone injury partly through PAI-1 and M-CSF in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Matilde Kanstrup Andersen, Isabella Hangaard Rudiger, Anna Louise Vestergaard, Yaseelan Palarasah, Pinar Bor, Agnete Larsen, Mustafa Vakur Bor
Summary: Vitamin D deficiency is associated with an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio in pregnant women, which may increase thrombotic risk and lead to pregnancy complications. Further research is needed to determine the optimal vitamin D supplementation in pregnancy.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Medicine, Research & Experimental
Florence Boissiere-Michot, Caroline Mollevi, Volker Baecker, Evelyne Crapez, William Jacot
Summary: Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) have been identified as prognostic and predictive biomarkers in breast cancer, but their clinical use is limited due to the need for fresh-frozen or fresh tumor samples for quantification. This study compared the expression levels of PLAU and SERPINE1 mRNA (corresponding to uPA and PAI-1 proteins) using in situ hybridization with immunometric assay in breast tumor samples. The results showed that in situ hybridization cannot replace the immunometric assay for quantification of uPA and PAI-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Krol, Salvador Pane, Tessa Luehmann
Summary: The study developed three polyethylene glycol (PEG)ylated tPA bioconjugates based on the recombinant human tPA drug Alteplase using site-specific conjugation strategies. These bioconjugates showed improved proteolytic activity, slower inhibition kinetics by PAI-1, and increased hydrodynamic size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Oncology
Bofang Wang, Baohong Gu, Tao Zhang, Xuemei Li, Na Wang, Chenhui Ma, Lin Xiang, Yunpeng Wang, Lei Gao, Yang Yu, Kewei Song, Puyi He, Yueyan Wang, Jingyu Zhu, Hao Chen
Summary: The fibrinolytic system is involved in various physiological functions and plays a significant role in the pathogenesis of many diseases. Plasminogen activator inhibitor 1 (PAI-1) is a crucial element of this system and acts as an anti-fibrinolytic agent in the normal blood clotting process. PAI-1 is involved in blood diseases, inflammation, obesity, metabolic syndrome, and tumor pathology, exhibiting a paradoxical role in different digestive system tumors.
Article
Obstetrics & Gynecology
Esra Demirel, Reem Sabouni, Neelima Chandra, Ov D. Slayden, David F. Archer
Summary: The study investigates the distribution and concentrations of several receptors and activators within the primate endometrium during artificial menstrual cycles, showing similarities in their expression patterns suggesting overlapping pathways. These findings indicate potential interactions between the plasminogen activator system and steroid receptors in the endometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
David Karasek, Jaromira Spurna, Dominika Macakova, Ondrej Krystynik, Veronika Kucerova
Summary: This study compared vascular damage indicators in different age groups of patients with type 2 diabetes (T2D) and determined their relationship to glycometabolic control. The results showed that older patients had higher arterial stiffness parameters, while markers of endothelial damage were unrelated to glycometabolic control. Age and systolic blood pressure were major determinants of arterial stiffness in T2D patients.
Article
Oncology
J. Dinesh Kumar, Sandhir Kandola, Laszlo Tiszlavicz, Zita Reisz, Graham J. Dockray, Andrea Varro
BRITISH JOURNAL OF CANCER
(2016)
Article
Pharmacology & Pharmacy
Peter Major, Istvan Baczko, Laszlo Hiripi, Katja E. Odening, Viktor Juhasz, Zsofia Kohajda, Andras Horvath, Gyorgy Seprenyi, Maria Kovacs, Laszlo Virag, Norbert Jost, Janos Prorok, Balazs Ordog, Zoltan Doleschall, Stanley Nattel, Andras Varro, Zsuzsanna Bosze
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
Torsten Christ, Peter P. Kovacs, Karoly Acsai, Michael Knaut, Thomas Eschenhagen, Norbert Jost, Andras Varro, Erich Wettwer, Ursula Ravens
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Review
Pharmacology & Pharmacy
Karoly Acsai, Balazs Oerdoeg, Andras Varro, Peter P. Nanasi
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Balks Horvath, Krisztina Vaczi, Bence Hegyi, Monika Gonczi, Beatrix Dienes, Kornel Kistamas, Tamas Banyasz, Janos Magyar, Istvan Baczko, Andras Varro, Gyorgy Seprenyi, Laszlo Csernoch, Peter P. Nanasi, Norbert Szentandrassy
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2016)
Correction
Neurosciences
Colleen E. Clancy, Ye Chen-Izu, DonaldM. Bers, Luiz Belardinelli, Penelope A. Boyden, Laszlo Csernoch, Sanda Despa, Bernard Fermini, Livia C. Hool, Leighton Izu, Robert S. Kass, W. Jonathan Lederer, William E. Louch, Christoph Maack, Alicia Mattiazzi, Zhilin Qu, Sridharan Rajamani, Crystal M. Rippinger, Ole M. Sejersted, Brian O'Rourke, James N. Weiss, Andras Varro, Antonio Zaza
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Article
Biochemistry & Molecular Biology
Reidar Fossmark, Shalini Rao, Patricia Mjones, Bjorn Munkvold, Arnar Flatberg, Andrea Varro, Liv Thommesen, Kristin G. Norsett
Article
Multidisciplinary Sciences
E. Pueyo, C. E. Dangerfield, O. J. Britton, L. Virag, K. Kistamas, N. Szentandrassy, N. Jost, A. Varro, P. P. Nanasi, K. Burrage, B. Rodriguez
Review
Biochemistry & Molecular Biology
Istvan Baczko, Norbert Jost, Laszlo Virag, Zsuzsanna Bosze, Andras Varro
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Z. Bosze, P. Major, I. Baczko, K. E. Odening, L. Bodrogi, L. Hiripi, A. Varro
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2016)
Article
Pharmacology & Pharmacy
Hedvig Takacs, Peter Kui, Attila S. Farkas, Annamaria Sarusi, Tamas Forster, Julius Gy. Papp, Andras Varro, Michael J. Curtis, Michael J. Shattock, Andras Farkas
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2016)
Article
Pharmacology & Pharmacy
Peter Kui, Szabolcs Orosz, Hedvig Takacs, Annamaria Sarusi, Norbert Csik, Ferenc Rarosi, Csongor Cseko, Andras Varro, Julius Gy. Papp, Tamas Forster, Attila S. Farkas, Andras Farkas
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
P. Kui, H. Takacs, A. Polyak, N. Morvay, I. Lepran, L. Tiszlavicz, N. Nagy, B. Ordog, A. Farkas, T. Forster, A. Varro, A. S. Farkas
CARDIOVASCULAR RESEARCH
(2016)
Meeting Abstract
Biochemical Research Methods
Peter Major, Istvan Baczko, Laszlo Hiripi, Katja E. Odening, Balazs Oerdoeg, Andras Varro, Zsuzsanna Bosze
TRANSGENIC RESEARCH
(2016)
Meeting Abstract
Biochemical Research Methods
Oriol Calvete, Pierfrancesco Vargiu, Andrea Varro, Marta Oteo, Miguel Angel Morcillo, Alicia Barroso, Mark Pritchard, Jose Reyes, Miriam Garcia, Jaime Munoz, Javier Benitez, Sagrario Ortega
TRANSGENIC RESEARCH
(2016)