Article
Endocrinology & Metabolism
Bella Martazanova, Nona Mishieva, Irina Vedikhina, Anastasia Kirillova, Irina Korneeva, Tatyana Ivanets, Aydar Abubakirov, Gennady T. Sukhikh
Summary: The use of GnRHa triggering in fresh embryo transfer cycles has limitations due to luteal phase insufficiency. Low-dose hCG supplementation can effectively address this issue and achieve comparable pregnancy rates to full-dose hCG.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Peripheral Vascular Disease
Natalie A. Cameron, Ciantel A. Blyler, Natalie A. Bello
Summary: Oral contraceptive pills (OCPs) are widely used as effective contraception, but they have a certain association with hypertension. Understanding the relationship between OCPs and hypertension is crucial for assessing the risks and benefits of use, and making individualized contraceptive decisions in light of the increasing prevalence of hypertension.
Article
Endocrinology & Metabolism
Silvia Vannuccini, Sara Clemenza, Margherita Rossi, Felice Petraglia
Summary: Endometriosis is a chronic uterine disorder that affects women's health, and hormonal drugs are the main medical treatment used to manage the disease based on endocrine and inflammatory changes. The key events causing pain and infertility are estrogen-dependency and progesterone-resistance. Current treatments aim to inhibit menstruation, block the hypothalamus-pituitary-ovary axis, and control the progression of endometriotic implants.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Hematology
Doris Barcellona, Francesco Marongiu, Elvira Grandone
Summary: The development of oral contraceptives (OCs) started in 1921 and faced challenges in understanding and managing the risk of venous thrombosis. Second-generation and later third-generation OCs were found to have increased thrombotic risk. In the 2000s, fourth-generation OCs with natural estrogens and a progestin were introduced. Research also provided insights into risk factors associated with OCs use.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Obstetrics & Gynecology
Tasuku Harada, Yutaka Osuga, Yusuke Suzuki, Masaki Fujisawa, Motoko Fukui, Jo Kitawaki
Summary: This study evaluated the efficacy and safety of 40-mg relugolix compared with leuprorelin in treating endometriosis-associated pain. The results demonstrated that relugolix was noninferior to leuprorelin in relieving pelvic pain, and both medications had comparable safety profiles.
FERTILITY AND STERILITY
(2022)
Review
Endocrinology & Metabolism
Li Gu, Xurui Li, Wentao Liu
Summary: In prostate cancer patients, GnRH antagonists have shown a reduced risk of cardiovascular events, cardiovascular death, and myocardial infarctions compared to GnRH agonists. However, there was no significant difference in the incidence of stroke and heart failure. The beneficial effects of GnRH antagonists were more pronounced in patients with preexisting cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Yutaka Osuga, Yoshifumi Seki, Masataka Tanimoto, Takeru Kusumoto, Kentarou Kudou, Naoki Terakawa
Summary: This study evaluated the efficacy and safety of relugolix in treating endometriosis-associated pain, showing that oral administration of relugolix alleviated pain in a dose-response manner and was generally well tolerated. Relugolix demonstrated efficacy and safety comparable to leuprorelin, another treatment option.
FERTILITY AND STERILITY
(2021)
Article
Agriculture, Dairy & Animal Science
Julia Schutz, Jurn Rudolph, Adrian Steiner, Esther Rothenanger, Jurg Husler, Gaby Hirsbrunner
Summary: The study successfully postponed puberty in beef heifers using the Improvac(R) vaccine, preventing unwanted pregnancies and inbreeding. None of the vaccinated calves exceeded a progesterone value >1 ng/mL until the scheduled age of slaughter, compared to 56.5% in the control group.
Article
Obstetrics & Gynecology
Hoon Kim, Soo Jin Han, Yun Soo Hong, Sung Woo Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim
Summary: The optimal number of oocytes for maximizing the rate of clinical pregnancy varies depending on the method of pituitary suppression. Too many oocytes may not lead to better clinical outcomes.
REPRODUCTIVE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marie-Madeleine Dolmans, Jacques Donnez
Summary: Endometriosis is a chronic inflammatory disease that requires lifelong management. This review evaluates the pathways involved in endometriosis and explores new therapies. Inflammation and inflammatory molecules play a crucial role in the disease, and targeting inflammation, nuclear factor kappa B and cytokines, as well as pathways related to apoptosis and autophagy, may offer new perspectives for non-hormonal treatment.
Review
Endocrinology & Metabolism
Shelli Graham, David F. Archer, James A. Simon, Kathleen M. Ohleth, Brian Bernick
Summary: This document reviewed and summarized the reported outcomes of menopausal hormone therapy (MHT) containing different estrogens and progesterone. The results suggested that MHT with estradiol (E2) and progesterone (P4) may have a potentially better safety profile compared to other estrogens and progestins, but further research is needed due to limitations of some studies.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Review
Cell Biology
Carsten Gruendker, Guenter Emons
Summary: The HPG axis regulates the female menstrual cycle through GnRH, which can impact ovarian cancer either indirectly through the HPG axis or directly through receptors on the surface of tumor cells.
Review
Cell Biology
Fabrizio Fontana, Patrizia Limonta
Summary: Understanding the molecular mechanisms of prostate cancer progression to the castration-resistant stage is crucial for improving therapeutic options. The activation of the androgen/androgen receptor axis and the GnRH/GnRH-R axis in CRPC cells play significant roles in antitumor activity, suggesting potential therapeutic implications.
Article
Medicine, General & Internal
Anna Biasioli, Anjeza Xholli, Francesca Previtera, Alessandro Balzano, Valentina Capodicasa, Alice Tassi, Ambrogio P. Londero, Angelo Cagnacci
Summary: This study aimed to evaluate the systemic oxidative stress balance in women with different types of endometriosis during hormone therapy and found that women with endometriosis had a higher oxidative stress balance compared to the control group. Additionally, hormone therapy significantly improved the oxidative stress balance in women with endometriosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Jamie Merkison, Carrie Malcom, Alan Decherney
Summary: Stem cell transplantation has shown significant improvement and potentially a cure in patients with various hematologic disorders and genetic immune deficiencies. However, it often leads to primary ovarian insufficiency, highlighting the importance of optimizing fertility preservation protocols.
FRONTIERS IN ENDOCRINOLOGY
(2022)