Article
Oncology
J. Schiavi, D. M. Fodera, M. A. Brennan, L. M. McNamara
Summary: Estrogen depletion affects osteoblasts' response to mechanical stimulation, leading to changes in differentiation and matrix production. These alterations contribute to the deterioration of bone quality during estrogen depletion, potentially increasing bone fragility in postmenopausal osteoporosis.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Li Kang Lyu, Jian Shuang Li, Xiao Jie Wang, Yi Jia Yao, Ji Fang Li, Yun Li, Hai Shen Wen, Xin Qi
Summary: The study found that AVT promotes PG biosynthesis via ITR and induces delivery behavior in ovoviviparous guppies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Hematology
Robert Eckenstaler, Anne Ripperger, Michael Hauke, Markus Petermann, Sandra A. Hemkemeyer, Edzard Schwedhelm, Sueleyman Erguen, Maike Frye, Oliver Werz, Andreas Koeberle, Heike Braun, Ralf A. Benndorf
Summary: This study reveals the direct link between upregulation of TP expression and angiostatic TP signaling in endothelial cells, leading to endothelial dysfunction, microvascular rarefaction, and systemic hypertension.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Immunology
Wenfei Wang, Yuping Ning, Yejun Wang, Guofang Deng, Simona Pace, Stefanie A. Barth, Christian Menge, Kehong Zhang, Youchao Dai, Yi Cai, Xinchun Chen, Oliver Werz
Summary: This study found that infection of human macrophages by M.tb significantly increases the expression of COX-2 and mPGES-1, leading to the formation of a large amount of PGE(2). However, the anti-inflammatory drug SASP can reduce the expression of COX-2 and the release of PGE(2).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Piotr Wojcik, Michal Biernacki, Natalia Domian, Neven Zarkovic, Elzbieta Skrzydlewska
Summary: This study evaluated the impact of Celecoxib on apoptosis in keratinocytes, and the results suggested that COX-2 inhibition can attenuate UVB-induced apoptosis, with AEA playing a significant role as an anti-apoptotic agent in this process.
Review
Endocrinology & Metabolism
Kun Yu, Zheng-Yuan Huang, Xue-Ling Xu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This article discusses the role of estrogen in the female endometrium and its regulatory role through nuclear and membrane-associated receptors. The importance of ERs in maintaining endometrial function is emphasized, and references for treating endometrial diseases are provided.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Aylin Del Moral-Morales, Juan Carlos Gonzalez-Orozco, Ana Maria Hernandez-Vega, Karina Hernandez-Ortega, Karla Mariana Pena-Gutierrez, Ignacio Camacho-Arroyo
Summary: A study found that in human Glioblastomas (GBM), the pro-oncogenic actions of 17 beta-estradiol (E2) are mediated by EZH2, which promotes proliferation, migration, and invasion of GBM cells. Although E2 does not modify EZH2 expression, gene silencing and pharmacological inhibition of EZH2 can block these pro-oncogenic actions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Pingping Han, Cedryck Vaquette, Abdalla Abdal-hay, Saso Ivanovski
Summary: The study evaluated human primary osteoblast cells' sensing and response to random and aligned PCL fibrous scaffolds, revealing that aligned fibers can result in elongated cell and nucleus shape, as well as increased global DNA methylation levels, which have long-term effects on osteoblast osteogenic differentiation.
Article
Biochemistry & Molecular Biology
Haiyan Yao, Quanping Guo, Mengran Wang, Rui Wang, Zhaoqing Xu
Summary: A novel class of molecules with a basic structure of pyrazole N-aryl sulfonate was designed and synthesized using a new pyrazole sulfonate synthetic method. Several compounds within this class showed excellent anti-inflammatory and analgesic activities, as well as selective COX-2 inhibitory properties. The LD50 of two compounds in mice were found to be greater than 2000 mg/kg in acute oral toxicity assays conducted in vivo.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Rosangela Mayer Goncalves, Marina Delgobo, Jonathan Paulo Agnes, Raquel Nascimento das Neves, Marcelo Falchetti, Tuany Casagrande, Ana Paula Vargas Garcia, Thaynan Cunha Vieira, Nauana Somensi, Maciel Alencar Bruxel, Daniel Augusto Gasparin Bueno Mendes, Alex Rafacho, Andre Bafica, Daniel Pens Gelain, Jose Claudio Fonseca Moreira, Geovanni Dantas Cassali, Alexander James Roy Bishop, Alfeu Zanotto-Filho
Summary: Obesity is a major risk factor for breast cancer, especially in post-menopausal women. An obesogenic diet has been shown to promote mammary tissue inflammation and local estrogen production, accelerating mammary tumor formation in a COX-2-dependent manner. Treatment with a COX-2 inhibitor was found to decrease inflammation, estrogen levels, and mammary tumor formation, leading to prolonged animal survival.
Review
Endocrinology & Metabolism
Peng Chen, Bo Li, Ling Ou-Yang
Summary: Estrogen receptors play crucial roles in regulating various physiological processes in humans. Abnormal signaling of these receptors can lead to a wide range of disorders. This review provides an overview of ER alpha, ER beta, and GPER1, highlighting their functions in both health and disease. Additionally, it discusses the potential clinical applications and challenges associated with these receptors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Ka-Ying Wong, Tsz-Hung Kong, Christina Chui-Wa Poon, Wenxuan Yu, Liping Zhou, Man-Sau Wong
Summary: In this study, the role of ER-α66, ER-α36, and GPER in bone metabolism following icariin treatment was investigated. It was found that icariin regulated ER-α36 and GPER protein expression in osteoblasts by downregulating them and upregulating ER-α66. ER-α36 and GPER acted as negative regulators of ER-α66 in intact osteoblasts.
PHYTOTHERAPY RESEARCH
(2023)
Article
Food Science & Technology
Baocai Xie, Dengke Pan, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu
Summary: Diosmetin treatment can reduce body weight and fat mass, improve glucose tolerance and insulin resistance by increasing energy expenditure through enhancing thermogenesis and browning of adipose tissue. Mechanistically, diosmetin acts as an agonist for estrogen receptors (ERs) to elevate their expression in adipose tissue, and the presence of ERs is essential for the metabolic benefits of diosmetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Chemistry, Medicinal
Yan Lyu, Xiaojia Wei, Xue Yang, Jiayuan Li, Guohui Wan, Yuqing Wang, Zhuangzhuang Hao, Yifan Lu, Jianyou Guo, Jinli Shi
Summary: This study investigated the anxiolytic potential of 11-ethoxyviburtinal extracted from Valeriana jatamansi Jones and found its efficacy in chronic restraint stress mice to be gender-specific. Network pharmacology and molecular docking predicted potential targets and pathways for 11-ethoxyviburtinal in treating anxiety disorder. The study also confirmed the influence of 11-ethoxyviburtinal on the PI3K/Akt signaling pathway, estrogen receptor beta expression, and anxiety-like behavior in mice through various experimental methods.
PHYTOTHERAPY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Vivian Bradaschia-Correa, Anne M. Josephson, Devan Mehta, Matthew Mizrahi, Shane S. Neibart, Chao Liu, Oran D. Kennedy, Alesha B. Castillo, Kenneth A. Egol, Philipp Leucht
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Multidisciplinary Sciences
B. Salmon, B. Liu, E. Shen, T. Chen, J. Li, M. Gillette, R. C. Ransom, M. Ezran, C. A. Johnson, A. B. Castillo, W. J. Shen, F. B. Kraemer, A. A. Smith, J. A. Helms
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
Chao Liu, Robert Carrera, Vittoria Flamini, Lena Kenny, Pamela Cabahug-Zuckerman, Benson M. George, Daniel Hunter, Bo Liu, Gurpreet Singh, Philipp Leucht, Kenneth A. Mann, Jill A. Helms, Alesha B. Castillo
Editorial Material
Orthopedics
Chao Liu, Alesha B. Castillo
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2018)
Correction
Multidisciplinary Sciences
B. Salmon, B. Liu, E. Shen, T. Chen, J. Li, M. Gillette, R. C. Ransom, M. Ezran, C. A. Johnson, A. B. Castillo, W. J. Shen, F. B. Kraemer, A. A. Smith, J. A. Helms
SCIENTIFIC REPORTS
(2018)
Article
Endocrinology & Metabolism
Chao Liu, Pamela Cabahug-Zuckerman, Christopher Stubbs, Martin Pendola, Cinyee Cai, Kenneth A. Mann, Alesha B. Castillo
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Review
Endocrinology & Metabolism
Tareq Anani, Alesha B. Castillo
Summary: Fracture healing is a complex and multistep process highly sensitive to mechanical signals, but challenges in accurately characterizing the mechanical environment and the ever-changing properties of the regenerate have hindered the clear definition of mechanical regulation principles. However, recent advances in using mechanobiological rodent models, imaging approaches, and single-cell analyses are improving our understanding of bone microenvironment response to loading.
Article
Medicine, Research & Experimental
Alexandra M. Burr, Pamela Cabahug Zuckerman, Alesha B. Castillo, Nicola C. Partridge, Biju Parekkadan
Summary: This study investigates the feasibility of delivering full-length PTH using AAV vectors. The results show the ability to secrete full-length PTH from various cell types in vitro and demonstrate the bioactivity of PTH in inducing proliferation in osteosarcoma cell lines. In vivo experiments also show increased liver and plasma concentrations of PTH, as well as dose-dependent changes in tumor growth and blood biomarkers. This proof-of-concept study suggests the potential of AAV gene therapy for hypoparathyroidism.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Endocrinology & Metabolism
Pamela Cabahug-Zuckerman, Tareq Anani, Pablo Atria, Anastasia Tikhonova, Alireza Khodadadi-Jamayran, Nitzan Segal, Ioannis Aifantis, Alesha Castillo
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
Pamela Cabahug-Zuckerman, Chao Liu, Cinyee Cai, Ian Mahaffey, Stephanie C. Norman, Whitney Cole, Alesha B. Castillo
Meeting Abstract
Endocrinology & Metabolism
Chao Liu, Pamela Cabahug, Shahar Qureshi, Olivia Patton, Cinyee Cai, Alesha Castillo
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Endocrinology & Metabolism
Pamela Cabahug-Zuckerman, Chao Liu, Emily Fang, Alesha Castillo
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Endocrinology & Metabolism
Ryan T. Scott, Joshua Alwood, Mohit Nalavadi, Sulekha Anand, Yasaman Shirazi-Fard, Alesha Castillo
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Meeting Abstract
Endocrinology & Metabolism
Pamela Cabahug-Zuckerman, Chao Liu, Cinyee Cai, Ian Mahaffey, Stephanie Norman, Whitney Cole, Alesha Castillo
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Nanoscience & Nanotechnology
Weiyi Qian, Lanqi Gong, Xin Cui, Zijin Zhang, Apratim Bajpai, Chao Liu, Alesha B. Castillo, Jeremy C. M. Teo, Weiqiang Chen
ACS APPLIED MATERIALS & INTERFACES
(2017)