Article
Endocrinology & Metabolism
Nicole Stantonyonge, Frederic Sampedro, Jorge Mendez, Saul Martinez-Horta, Ana Chico, Beatriz Gomez-Anson
Summary: This study investigated structural brain differences between T1D patients with IAH and NAH, revealing reduced gray matter volumes and cortical surface areas in IAH patients, especially in frontal and parietal regions. These MRI differences correlated with both SH frequency and IAH severity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Sherman S. Leung, Nataliya Lenchik, Clayton Mathews, Alberto Pugliese, Domenica A. McCarthy, Selena Le Bagge, Adam Ewing, Mark Harris, Kristen J. Radford, Danielle J. Borg, Ivan Gerling, Josephine M. Forbes
Summary: This study compared the expression of RAGE in islets of donors without diabetes, those at risk of, and those with type 1 diabetes. The results showed differential expression of the RAGE gene and its correlated genes in the islets of type 1 diabetes donors. The study also found an association between RAGE expression and glucagon levels in the islets.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Justin B. Echouffo-Tcheugui, Arnaud D. Kaze, Gregg C. Fonarow, Sam Dagogo-Jack
Summary: In individuals with type 2 diabetes, severe hypoglycemia is independently associated with a higher risk of incident heart failure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pediatrics
Winnie M. Sigal, Ohoud Alzahrani, Gabriela M. Guadalupe, Herodes Guzman, Jerilynn Radcliffe, Nina H. Thomas, Abbas F. Jawad, Diva D. De Leon
Summary: Perinatal stress induced hyperinsulinism (PSIHI) in infants is associated with high risk of neurodevelopmental deficits, with a significant proportion scoring below average on developmental assessments compared to the general population. Risk factors include male sex, being small for gestational age (SGA), and treatment with continuous feeds.
FRONTIERS IN PEDIATRICS
(2022)
Review
Medicine, General & Internal
Tatsuhiko Urakami
Summary: Hypoglycemia is a common acute complication in the management of children and adolescents with type 1 diabetes, which can affect glycemic outcomes and quality of life. Severe hypoglycemia is associated with cognitive impairment and brain abnormalities, especially in young children. Therefore, reducing the frequency of hypoglycemia and severe hypoglycemia is crucial. Advanced diabetes technologies, such as continuous glucose monitoring and sensor-augmented insulin pumps, can effectively reduce the occurrence of hypoglycemia without worsening glycemic control. The hybrid closed-loop system, an automated insulin delivery system, shows promise in achieving appropriate glycemic control and preventing severe hypoglycemia for children and adolescents with type 1 diabetes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Arnaud D. Kaze, Matthew F. Yuyun, Sebhat Erqou, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: In a large population with type 2 diabetes, severe hypoglycemia is associated with an increased risk of QTc prolongation independently of other risk factors, and the association is strongest among younger participants.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Laura Costanza De Angelis, Giorgia Brigati, Giulia Polleri, Mariya Malova, Alessandro Parodi, Diego Minghetti, Andrea Rossi, Paolo Massirio, Cristina Traggiai, Mohamad Maghnie, Luca Antonio Ramenghi
Summary: Neonatal hypoglycemia is common and usually resolves within the first 48 to 72 hours of life. Severe and prolonged hypoglycemia is associated with cerebral damage, potentially leading to neuronal injury.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Health Care Sciences & Services
Nai-Ching Chen, Chien-Liang Chen, Feng-Chih Shen
Summary: This study found that the drug regimen affects hypoglycemic episodes in older patients with dementia and T2DM. However, HbA1c levels are not correlated with hypoglycemic events. Patients with more comorbidities have an increased risk of hypoglycemia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Seung Eun Lee, Kyoung-Ah Kim, Kang Ju Son, Sun Ok Song, Kyeong Hye Park, Se Hee Park, Joo Young Nam
Summary: In Korea, the prevalence of type 2 diabetes has been continuously increasing, while the trends of severe hypoglycemia are associated with changes in drug classes rather than the number of antidiabetic drugs. Predictors of severe hypoglycemia include female gender, older age, comorbidities, polypharmacy, and the use of sulfonylurea or insulin. Efforts to reduce the prescription of drugs with a high risk of hypoglycemia should be implemented, especially for older women with multiple comorbidities.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Nadine Taleb, Veronique Gingras, Ran Cheng, Valerie Parent, Virginie Messier, Danijela Bovan, Azadeh Shohoudi, Anne-Sophie Brazeau, Remi Rabasa-Lhoret
Summary: Non-severe hypoglycemia (NS-H) is a challenge for individuals with type 1 diabetes (PWT1D) and is often caused by excessive insulin. Current guidelines recommend a one-size-fits-all approach for treating NS-H regardless of the specific conditions. This study aimed to test different amounts of carbohydrates (CHO) to treat insulin-induced NS-H at various glucose ranges.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Weronika E. Pasciak, David N. Berg, Emily Cherlin, Terri Fried, Kasia J. Lipska
Summary: The study found that some hypoglycemic events may be unavoidable, but healthcare systems need to shift their focus from general avoidance of hyperglycemia to prevention of hypoglycemia for older adults at risk. Furthermore, clinicians and patients need to collaborate in designing treatment plans that are manageable for patients and flexible enough to accommodate life's demands.
Article
Medicine, General & Internal
J. Ware, J. M. Allen, C. K. Boughton, M. E. Wilinska, S. Hartnell, A. Thankamony, C. de Beaufort, U. Schierloh, E. Froehlich-Reiterer, J. K. Mader, T. M. Kapellen, B. Rami-Merhar, M. Tauschmann, K. Nagl, S. E. Hofer, F. M. Campbell, J. Yong, K. K. Hood, J. Lawton, S. Roze, J. Sibayan, L. E. Bocchino, C. Kollman, R. Hovorka
Summary: Hybrid closed-loop therapy significantly improves glycemic control in very young children with type 1 diabetes without increasing the time spent in hypoglycemia.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Domingo Orozco-Beltran, Alberto Guillen-Molla, Ana Maria Cebrian-Cuenca, Jorge Navarro-Perez, Vicente F. Gil-Guillen, Jose A. Quesada, Francisco J. Pomares-Gomez, Adriana Lopez-Pineda, Concepcion Carratala-Munuera
Summary: The study analyzed hospital admissions trends, inpatient mortality, and mean length of hospital stay due to hypoglycemia in diabetes patients in Spain from 2005 to 2015. The results showed a decrease in hospital admissions and mortality, with a more pronounced trend in women. Mean length of hospital stay decreased specifically for women.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Endocrinology & Metabolism
Marcia Roeper, Henrike Hoermann, Sebastian Kummer, Thomas Meissner
Summary: Neonatal hypoglycemia lacks a uniform definition and guidelines vary in screening, intervention, and management. Further research is needed to address this issue and develop better management strategies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Multidisciplinary Sciences
Elizabeth Sanchez-Rangel, Jelani Deajon-Jackson, Janice Jin Hwang
Summary: In the century since the discovery of insulin, diabetes has evolved from a fatal condition to a manageable chronic disease. However, hypoglycemia continues to be a major obstacle to achieving optimal glycemic control. Understanding of the mechanisms of hypoglycemia has expanded to include various factors such as changes in brain glucose, fuel sensing, and neural networks that affect behavior, mood, and cognition. Different strategies have been developed to prevent and treat hypoglycemia.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Behavioral Sciences
Susan E. Maloney, Catherine E. Creeley, Richard E. Hartman, Carla M. Yuede, Charles F. Zorumski, Vesna Jevtovic-Todorovic, Krikor Dikranian, Kevin K. Noguchi, Nuri B. Farber, David F. Wozniak
NEUROBIOLOGY OF LEARNING AND MEMORY
(2019)
Article
Cell Biology
Cheng Cheng, Pan-Yue Deng, Yoshiho Ikeuchi, Carla Yuede, Daofeng Li, Nicholas Rensing, Ju Huang, Dustin Baldridge, Susan E. Maloney, Joseph D. Dougherty, John Constantino, Arezu Jahani-Asl, Michael Wong, David F. Wozniak, Ting Wang, Vitaly A. Klyachko, Azad Bonni
Article
Multidisciplinary Sciences
Susan E. Maloney, Carla M. Yuede, Catherine E. Creeley, Sasha L. Williams, Jacob N. Huffman, George T. Taylor, Kevin N. Noguchi, David F. Wozniak
SCIENTIFIC REPORTS
(2019)
Article
Behavioral Sciences
Kayla R. Nygaard, Susan E. Maloney, Joseph D. Dougherty
Article
Behavioral Sciences
Susan E. Maloney, Michael A. Rieger, Ream Al-Hasani, Michael R. Bruchas, David F. Wozniak, Joseph D. Dougherty
GENES BRAIN AND BEHAVIOR
(2019)
Article
Biochemistry & Molecular Biology
Nathan Kopp, Katherine McCullough, Susan E. Maloney, Joseph D. Dougherty
HUMAN MOLECULAR GENETICS
(2019)
Editorial Material
Psychiatry
Susan E. Maloney, Cynthia E. Rogers, John N. Constantino
AMERICAN JOURNAL OF PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Nathan D. Kopp, Kayla R. Nygaard, Yating Liu, Katherine B. McCullough, Susan E. Maloney, Harrison W. Gabel, Joseph D. Dougherty
HUMAN MOLECULAR GENETICS
(2020)
Article
Multidisciplinary Sciences
Alexander J. Cammack, Arnav Moudgil, Jiayang Chen, Michael J. Vasek, Mark Shabsovich, Katherine McCullough, Allen Yen, Tomas Lagunas, Susan E. Maloney, June He, Xuhua Chen, Misha Hooda, Michael N. Wilkinson, Timothy M. Miller, Robi D. Mitra, Joseph D. Dougherty
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Behavioral Sciences
Shyam K. Akula, Katherine B. McCullough, Claire Weichselbaum, Joseph D. Dougherty, Susan E. Maloney
BRAIN AND BEHAVIOR
(2020)
Article
Medicine, Research & Experimental
Arvind Palanisamy, Tusar Giri, Jia Jiang, Annie Bice, James D. Quirk, Sara B. Conyers, Susan E. Maloney, Nandini Raghuraman, Adam Q. Bauer, Joel R. Garbow, David F. Wozniak
Article
Multidisciplinary Sciences
Kristina Sakers, Yating Liu, Lorida Llaci, Scott M. Lee, Michael J. Vasek, Michael A. Rieger, Sean Brophy, Eric Tycksen, Renate Lewis, Susan E. Maloney, Joseph D. Dougherty
Summary: The study defines the targets of QKI in the mouse brain and shows that loss of QKI disrupts the expression of cell maturation-associated genes in astrocytes in vivo.
NATURE COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Elena Minakova, Simona Sarafinovska, Marwa O. Mikati, Kia M. Barclay, Katherine B. McCullough, Joseph D. Dougherty, Ream Al-Hasani, Susan E. Maloney
Summary: Nationwide, opioid misuse among pregnant women has increased four-fold from 1999 to 2014, leading to a rise in neonates hospitalized for neonatal abstinence syndrome (NAS). Research has found that in utero and prolonged post-natal exposure to oxycodone (Oxy) can impact offspring's behavior, development, and neurological outcomes, highlighting the need for therapeutic interventions. This novel model developed allows for further studies on the withdrawal physiology and opioid-mediated mechanisms that contribute to these neurodevelopmental deficits.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Rachel M. Rahn, Susan E. Maloney, Lindsey M. Brier, Joseph D. Dougherty, Joseph P. Culver
Article
Behavioral Sciences
Susan E. Maloney, Krystal C. Chandler, Corina Anastasaki, Michael A. Rieger, David H. Gutmann, Joseph D. Dougherty