Article
Biochemistry & Molecular Biology
Olayiwola O. Oduwole, Ariel Poliandri, Anthony Okolo, Phil Rawson, Milena Doroszko, Marcin Chrusciel, Nafis A. Rahman, Gilberto Serrano de Almeida, Charlotte L. Bevan, Wolfgang Koechling, Ilpo T. Huhtaniemi
Summary: The study suggests that FSH, rather than LH, may directly stimulate the growth of androgen-independent prostate cancer. Continuous suppression of FSH during GnRH antagonist treatment may offer a therapeutic advantage over agonist in inhibiting tumor growth.
Article
Biology
Vitaly Ryu, Anisa Gumerova, Funda Korkmaz, Seong Su Kang, Pavel Katsel, Sari Miyashita, Hasni Kannangara, Liam Cullen, Pokman Chan, TanChun Kuo, Ashley Padilla, Farhath Sultana, Soleil A. Wizman, Natan Kramskiy, Samir Zaidi, Se-Min Kim, Maria New, Clifford J. Rosen, Ki A. Goosens, Tal Frolinger, Vahram Haroutunian, Keqiang Ye, Daria Lizneva, Terry F. Davies, Tony Yuen, Mone Zaidi
Summary: There is increasing evidence that anterior pituitary hormones have multiple functions in regulating somatic tissues and brain receptors. A comprehensive neuroanatomical atlas on the expression of TSHR, LHCGR, and FSHR has been created using single-transcript detection technology. This atlas provides a vital resource for studying the impact of glycoprotein hormone receptors on somatic function and may uncover new pathways for human disease.
Article
Reproductive Biology
Hirofumi Ohga, Michiya Matsuyama
Summary: The chub mackerel LPXRFamide gene produces three mature peptides and does not have the ability to suppress gonadotropin secretion but may promote gonadotropin secretion.
BIOLOGY OF REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
Hao-Qi Wang, Wen-Hua Wang, Cheng-Zhen Chen, Hai-Xiang Guo, Hao Jiang, Bao Yuan, Jia-Bao Zhang
Summary: Gonadotropin-releasing hormone (GnRH) and follicle-stimulating hormone (FSH) play crucial roles in regulating mammalian reproductive activities. The study discovered the potential mechanism of miR-488 in GnRH-mediated regulation of FSH synthesis, providing additional evidence for the significance of miRNAs in animal reproduction regulation.
Review
Biochemistry & Molecular Biology
Monica Lispi, Peter Humaidan, George R. Bousfield, Thomas D'Hooghe, Alfredo Ulloa-Aguirre
Summary: Follicle-stimulating hormone (FSH), along with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), is crucial for human reproduction. The discovery of FSH and other gonadotropins has significantly contributed to our knowledge of reproduction and the development of infertility treatments. However, the structural heterogeneity of FSH glycoforms influences the biological activity of human FSH products, and potency does not accurately predict the effects in terms of pharmacokinetics, pharmacodynamics, and clinical response in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Wenxiu Tian, Huimin Qi, Zhimei Wang, Sen Qiao, Ping Wang, Junhong Dong, Hongmei Wang
Summary: This article summarizes the functions of female-associated hormones in tumors and investigates the mechanisms underlying female hormone-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Agriculture, Dairy & Animal Science
Hao-Qi Wang, Wei-Di Zhang, Bao Yuan, Jia-Bao Zhang
Summary: Mammalian reproduction is mainly regulated by the hypothalamic-pituitary-gonadal axis, with follicle-stimulating hormone (FSH) playing a key role in fertility. Research is ongoing to explore the molecular mechanisms underlying FSH synthesis and secretion, presenting new ideas for the use of FSH in livestock breeding and therapeutic development.
Article
Cell Biology
Hamideh P. Fallah, Maira S. Rodrigues, Maya Zanardini, Rafael H. Nobrega, Hamid R. Habibi
Summary: The study found that zGnih has a direct effect on spermatogenesis induced by both basal and gonadotropin (Lh and Fsh) in zebrafish testis. Specific concentrations of zGnih can significantly decrease the number of G0/G1 cells after 7 days in culture, with no significant impact on the proportion area of spermatogonia cell types. The research also revealed that zGnih reduces the proliferative activity of type A spermatogonia and increases the mitotic activity of type B spermatogonia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Jia Duan, Peiyu Xu, Xi Cheng, Chunyou Mao, Tristan Croll, Xinheng He, Jingjing Shi, Xiaodong Luan, Wanchao Yin, Erli You, Qiufeng Liu, Shuyang Zhang, Hualiang Jiang, Yan Zhang, Yi Jiang, H. Eric Xu
Summary: Luteinizing hormone and chorionic gonadotropin are essential for human reproduction and play a role in activating the same G-protein-coupled receptor. Recent cryo-electron microscopy structures have revealed the mechanism by which these hormones activate their receptor, providing a common model for understanding glycoprotein hormone receptors' signaling and a basis for drug discovery for endocrine diseases.
Article
Endocrinology & Metabolism
Gillian P. Johnson, Caitlan G. A. Onabanjo, Kate Hardy, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas
Summary: The glycosylation variants of follicle-stimulating hormone (FSH) have differential effects on ovarian follicle growth and survival, with partially glycosylated FSH promoting follicle function and fully glycosylated FSH causing follicle damage and apoptosis.
Article
Neurosciences
Cathryn A. Cutia, Leanna K. Leverton, Karen E. Weis, Lori T. Raetzman, Catherine A. Christian-Hinman
Summary: Gonadotropin hormone release is important in regulating reproductive endocrine function. People with epilepsy have altered levels of gonadotropin hormones, but pituitary function is not well-studied in preclinical epilepsy research.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
George A. Stamatiades, Chirine Toufaily, Han Kyeol Kim, Xiang Zhou, Iain R. Thompson, Rona S. Carroll, Min Chen, Lee S. Weinstein, Stefan Offermanns, Ulrich Boehm, Daniel J. Bernard, Ursula B. Kaiser
Summary: GnRH regulates gonadal function by stimulating gonadotropin production. The pulse frequency of GnRH differentially regulates FSH and LH synthesis and secretion. The GnRHR activates G alpha (q/11) signaling, but can also couple with G alpha (s).
Article
Psychology, Biological
Himeka Hayashi, Ryoko Kumagai, Yasuhiko Kondo
Summary: The study showed that sexually experienced male rats have a preference for the odor of castrated male rats due to elevated levels of GnRH and FSH produced by the lack of androgens.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Endocrinology & Metabolism
Kim Carol Jonas, Adolfo Rivero Muller, Olayiwola Oduwole, Hellevi Peltoketo, Ilpo Huhtaniemi
Summary: Mouse models with altered gonadotropin functions have provided insight into the essential role of functional LHR and FSHR in mediating ovarian functions. The repurposing of genetically modified mouse models offers potential for answering outstanding questions in reproductive physiology.
Article
Endocrinology & Metabolism
Teresa Zarinan, Julio Mayorga, Eduardo Jardon-Valadez, Ruben Gutierrez-Sagal, Jose Luis Maravillas-Montero, Nancy R. Mejia-Dominguez, Ivan Martinez-Luis, Omar G. Yacini-Torres, Ma del-Carmen Cravioto, Eric Reiter, Alfredo Ulloa-Aguirre
Summary: A novel missense mutation (I423T) in the FSHR second transmembrane domain was identified in a woman with primary ovarian failure, leading to impaired receptor expression and signaling. Meanwhile, the D408Y mutation severely affected membrane expression and signal transduction. Molecular dynamics simulations showed important disruptions in both mutant FSHRs, explaining the differences in expression levels, signaling, and phenotypic expression between I423T and D408Y mutant FSHRs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Developmental Biology
Franco G. Brunello, Rodolfo A. Rey
Summary: Anti-mullerian hormone (AMH) is crucial for male fetal genital development, with its deficiency potentially leading to abnormalities. Defects in the AMH pathway, resulting in Persistent Mullerian Duct Syndrome, cause a rare condition where patients have male external genitalia but also internal female reproductive organs.
SEXUAL DEVELOPMENT
(2022)
Editorial Material
Endocrinology & Metabolism
Rodolfo A. Rey
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lloyd J. W. Tack, Saskia van der Straaten, Stefan Riedl, Alexander Springer, Paul-Martin Holterhus, Nadine C. Hornig, Zofia Kolesinska, Marek Niedziela, Federico Baronio, Antonio Balsamo, Sabine E. Hannema, Anna Nordenstrom, Sukran Poyrazoglu, Fatma F. Darendeliler, Romina Grinspon, Rodolfo Rey, Fahad Aljuraibah, Jillian Bryce, Faisal Ahmed, Rieko Tadokoro-Cuccaro, Ieuan Hughes, Guilherme Guaragna-Filho, Andrea T. Maciel-Guerra, Gil Guerra-Junior, Martine Cools
Summary: The study found that almost one out of three SGA boys experience insufficient catch-up growth by the age of 2. Additionally, SGA boys had higher LH levels during minipuberty and lower testosterone levels in stimulation tests.
CLINICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Romina P. Grinspon, Sebastian Castro, Rodolfo A. Rey
Summary: In this review, we present a practical and updated approach to clinical and hormonal laboratory workup for newborns, children, and adolescents with suspected DSD. We emphasize the importance of tailoring the diagnostic approach based on age and presentation.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Richard L. Cate, Nathalie di Clemente, Chrystele Racine, Nigel P. Groome, R. Blake Pepinsky, Adrian Whitty
Summary: This study demonstrates that complexes of transforming growth factor-beta family growth/differentiation factors with their prodomains undergo prodomain displacement upon binding to their respective receptors. Bivalent binding of the complex to the receptor leads to rapid release of the prodomain, suggesting a general mechanism of receptor-mediated prodomain displacement.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Rodolfo A. Rey
Summary: Clinical manifestations and treatment needs of hypogonadism in males vary according to age. Early onset hypogonadism may result in disorders of sex development, while hypogonadism established later in fetal life presents with micropenis, cryptorchidism, and/or micro-orchidism. Diagnosis of hypogonadism becomes challenging after neonatal activation of the gonadal axis diminishes. Treatment usually focuses on micropenis and/or cryptorchidism in infancy and childhood, and on lack of pubertal development and relative short stature in teenagers.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2022)
Editorial Material
Endocrinology & Metabolism
Rodolfo A. Rey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pediatrics
Sebastian Castro, Franco G. Brunello, Gabriela Sanso, Paula Scaglia, Maria Esnaola Azcoiti, Agustin Izquierdo, Florencia Villegas, Ignacio Bergada, Maria Gabriela Ropelato, Marcelo A. Marti, Rodolfo A. Rey, Romina P. Grinspon
Summary: Pubertal delay in males can be caused by constitutional delay of growth and puberty or pathologic hypogonadism. Central (or hypogonadotropic) hypogonadism, resulting from a defective function of the GnRH/gonadotropin axis, is the main differential diagnosis after ruling out general illnesses and primary testicular failure. Ciliopathies arising from defects in non-motile cilia can cause developmental disorders affecting the sense organs and reproductive system.
FRONTIERS IN PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Nadia Y. Edelsztein, Clara Valeri, Maria M. Lovaisa, Helena F. Schteingart, Rodolfo A. Rey
Summary: Anti-Mullerian hormone (AMH) is a biomarker of immature Sertoli cells, which is regulated by specific transcription factors and plays a role in the regression of Mullerian ducts in males. AMH is highly expressed before puberty and then downregulated. FSH increases AMH output, while intratesticular levels of androgens and estrogens also regulate AMH secretion.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nathalie di Clemente, Chrystele Racine, Rodolfo A. Rey
Summary: This article reviews the main findings on anti-Mullerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. AMH has important roles in ovarian reserve, follicular development, and the differentiation of the genital tract. It is also used to assess Sertoli cell function in children and has potential implications for male fertility.
Editorial Material
Endocrinology & Metabolism
Lourdes Correa Brito, Rodolfo A. Rey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Jimena Lopez Dacal, Sebastian Castro, Sofia Suco, Lourdes Correa Brito, Romina P. Grinspon, Rodolfo A. Rey
Summary: This review addresses the approaches to evaluate the hypothalamic-pituitary-testicular axis in newborns, children, and adolescents, focusing on hormonal laboratory and genetic studies, clinical signs, and imaging studies.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Lourdes Correa Brito, Romina P. Grinspon, Jimena Lopez Dacal, Paula Scaglia, Maria Esnaola Azcoiti, Agustin Izquierdo, Maria Gabriela Ropelato, Rodolfo A. Rey
Summary: This study reported a case of a patient with 46,XY disorders of sex development (DSDs) in whom a novel variant in MYRF gene was identified, leading to the detection of a clinically inapparent congenital heart defect.
JOURNAL OF PERSONALIZED MEDICINE
(2023)