Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sandra Diaz del Moral, Maha Benaouicha, Ramon Munoz-Chapuli, Rita Carmona
Summary: The translation introduces the importance of insulin and insulin-like growth factors during embryonic development and their role in cardiac development and cardiomyocyte proliferation. The study also discusses the clinical potential of utilizing the IGF signaling pathway for adult cardiac repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Engineering, Biomedical
Mingsheng Xie, Yiqian Zhang, Zixuan Xiong, Sophie Hines, Jiangyinzi Shang, Karen L. Clark, Susheng Tan, Peter G. Alexander, Hang Lin
Summary: In this study, hyaline cartilage-like tissues were generated from human mesenchymal stromal cells (hMSCs) and displayed robust capacity in repairing osteochondral defects in rats. The use of hMSC-generated extracellular matrix eliminated the need for exogenous scaffolds. Through optimization, it was determined that hypoxic culture and supplementation of insulin-like growth factor-1 (IGF1) in the chondrogenic medium resulted in robust cartilage formation with minimal hypertrophy. It was also demonstrated that hypoxic culture suppressed chondrogenesis and hypertrophy by modulating the Wnt/β-catenin and IGF1 pathways, respectively. This study provides a new method for generating hyaline cartilage-like tissue from hMSCs, which has potential clinical applications in cartilage tissue engineering.
ACTA BIOMATERIALIA
(2022)
Article
Endocrinology & Metabolism
Kentaro Suda, Jaime Pignatelli, Laura Genis, Ana M. Fernandez, Estrella Fernandez de Sevilla, Ines Fernandez de la Cruz, Andrea Pozo-Rodrigalvarez, Maria L. de Ceballos, Sonia Diaz-Pacheco, Raquel Herrero-Labrador, Ignacio Torres Aleman
Summary: This study investigated the role of IGF-IR in astrocytes in response to ischemic injury. The results showed that astrocytic IGF-IR plays a protective role in the response to ischemic insult, and its deletion leads to larger lesions, increased blood-brain-barrier disruption, and worsened sensorimotor coordination. In addition, the deletion of IGF-IR also resulted in increased inflammatory, cell adhesion, and angiogenic pathways.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Oncology
Lian E. M. Stadhouders, Jonathon A. B. Smith, Brendan M. Gabriel, Sander A. J. Verbrugge, Tim D. Hammersen, Detmar Kolijn, Ilse S. P. Vogel, Abdalla D. Mohamed, Gerard M. J. de Wit, Carla Offringa, Willem M. H. Hoogaars, Sebastian Gehlert, Henning Wackerhage, Richard T. Jaspers
Summary: The Warburg effect, commonly associated with cancer, was investigated in relation to muscle hypertrophy, showing that glycolysis and non-essential amino acid synthesis play important roles in the process. Inhibiting glycolysis or key enzymes in the serine biosynthesis pathway decreased myotube size, while promoting glycolytic flux increased myotube size, suggesting a reprogramming of metabolism to facilitate anabolism in hypertrophying muscle cells.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Cell & Tissue Engineering
H. J. Kok, C. N. Crowder, L. Koo Min Chee, H. Y. Choi, N. Lin, E. R. Barton
Summary: IGF-I plays a crucial role in muscle and bone development, acting as a primary mediator of growth hormone actions. Studies using mice with muscle-specific IGF-I overexpression have shown that increased muscle IGF-I can indirectly affect craniofacial growth through IGF-I-dependent increases in muscle hypertrophy, which has implications for therapeutic strategies for craniofacial disorders.
EUROPEAN CELLS & MATERIALS
(2021)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Multidisciplinary Sciences
Samia S. Barrera, Juan S. Naranjo-Gomez, Iang S. Rondon-Barragan
Summary: Heat stress has negative effects on the welfare and productivity of cattle, leading to economic losses. Supplementation of the culture medium with insulin-like growth factor-1 (IGF-1) can protect the oocyte maturation process and improve thermotolerance of oocytes exposed to high temperatures.
Review
Biochemistry & Molecular Biology
Jonathan A. Zegarra-Valdivia, Jaime Pignatelli, Angel Nunez, Ignacio Torres Aleman
Summary: Understanding the mechanisms of resilience and vulnerability to Alzheimer's disease (AD) may lead to the identification of new treatment targets. Insulin-like growth factor I (IGF-I) activity in the brain plays a role in both resilience and vulnerability to AD. Preserved brain IGF-I activity is associated with resilience to AD pathology, while disturbed IGF-I activity is found in many AD risk factors. Considering IGF-I activity may help prevent the progression of AD pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Tina B. McKay, Shrestha Priyadarsini, Dimitrios Karamichos
Summary: This review focuses on the effects of systemic hormones, including androgens, estrogens, human growth hormone, and insulin growth factor-1, on ocular surface homeostasis, wound healing, and corneal thickness. The findings suggest that age-related changes in hormone levels should be considered as an important factor in the study of corneal health and disease.
Review
Neurosciences
Rashita Makkar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazmi, Aldulkarim M. Meraya
Summary: The degradation of neurons is the pathological reason for onset of most neurological diseases. IGF-I can promote neuronal regeneration and has neuroprotective properties. Studying the signaling pathways of IGF-I is significant for the treatment and management of neurological disorders.
NEUROTOXICITY RESEARCH
(2022)
Review
Environmental Sciences
Chiara Talia, Lisa Connolly, Paul A. Fowler
Summary: This review discusses the effects of endocrine disruptors on the IGF system, focusing on different categories of EDs and their potential molecular mechanisms. While there is a lack of studies linking ED exposure to changes in IGF levels for some ED classes, this remains an area of concern that requires further research to improve reproducibility and determine the degree of risk EDs pose to the IGF system.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Cell Biology
Hiroki Nishi, Kaito Uchida, Maki Saito, Daisuke Yamanaka, Haruka Nagata, Hinako Tomoshige, Ichiro Miyata, Koichi Ito, Yuka Toyoshima, Shin-Ichiro Takahashi, Fumihiko Hakuno, Asako Takenaka
Summary: This study evaluates the contribution of protein nutrition and the GH/IGF-I system to body growth regulation. The results show that a reduction in serum EAA concentration hinders Igf1 transcription and decreases serum IGF-I levels. Restoring serum IGF-I levels through recombinant IGF-I infusion rescues body growth, indicating the importance of EAAs for animal growth.
Article
Gastroenterology & Hepatology
Hui Li, Georgia S. Clarke, Stewart Christie, Sharon R. Ladyman, Stephen J. Kentish, Richard L. Young, Kathryn L. Gatford, Amanda J. Page
Summary: This study shows that gastric vagal afferent signaling is attenuated during pregnancy and is inversely associated with meal size. Growth hormone reduces the mechanosensitivity of gastric vagal afferents, suggesting that increased maternal growth hormone levels may play a role in mediating adaptations in gastric vagal afferent signaling during pregnancy. These findings have significant implications for the peripheral control of food intake during pregnancy.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Editorial Material
Neurosciences
Kathryn L. Gatford
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cell Biology
Sonia Tamanna, Saije K. Morosin, Sarah J. Delforce, Dirk F. van Helden, Eugenie R. Lumbers, Kirsty G. Pringle
Summary: This study found that the mRNA levels of ACE, ACE2 and NEP are altered during syncytialisation in primary trophoblasts, but not in BeWo cells. The protein levels and activity of ACE, ACE2 and NEP remained unchanged. Further studies are needed to investigate the placental levels of these enzymes in pregnancies complicated by placental insufficiency.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bevyn Jarrott, Richard Head, Kirsty G. Pringle, Eugenie R. Lumbers, Jennifer H. Martin
Summary: Infection with SARS-CoV-2 can lead to COVID-19, with a range of symptoms from asymptomatic to severe. Some patients, diagnosed with LONG COVID, experience various symptoms even after 12 weeks. Longitudinal clinical studies suggest that a battery of cytokine markers can identify infected patients with persistent inflammation and troubling symptoms. There is a hypothesis that drugs activating NRF2 or the hormone melatonin may help alleviate symptoms in LONG COVID patients.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Review
Pharmacology & Pharmacy
Richard J. Head, Eugenie R. Lumbers, Bevyn Jarrott, Felix Tretter, Gary Smith, Kirsty G. Pringle, Saiful Islam, Jennifer H. Martin
Summary: This article discusses the importance of viewing the COVID-19 pandemic from a systems analysis perspective and highlights the thermodynamic basis of SARS-CoV-2 infection. By combining pharmacology and human physiology, the study reveals the key mechanisms of SARS-CoV-2 infection and emphasizes the impact of viral surface structure variations on immune evasion and infectivity.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Review
Pharmacology & Pharmacy
Eugenie R. Lumbers, Richard Head, Gary R. Smith, Sarah J. Delforce, Bevyn Jarrott, Jennifer H. Martin, Kirsty G. Pringle
Summary: Interaction between SARS-CoV-2 and its receptor ACE2 leads to an uncontrolled inflammatory response, resulting in the pathogenesis of COVID-19. The renin-angiotensin system plays a crucial role in the host response to infection and injury, and disruption of ACE2 by SARS-CoV-2 leads to tissue damage.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Review
Public, Environmental & Occupational Health
Brian J. Morris, Athos Katelaris, Norman J. Blumenthal, Mohamed Hajoona, Adrian C. Sheen, Leslie Schrieber, Eugenie R. Lumbers, Alex D. Wodak, Phillip Katelaris
Summary: This article presents the benefits of male circumcision and the preventive effect of early circumcision on medical conditions in Australia. The research shows that early circumcision can prevent various diseases and has no adverse effect on sexual function and pleasure. Survey data and evidence support early circumcision as an important public health measure.
JOURNAL OF MENS HEALTH
(2022)
Editorial Material
Public, Environmental & Occupational Health
Burc Barin, Zisis Kozlakidis, Fabrizio Ricci, Longxiang Su, Constantinos Tsioutis, Susan C. Welburn, Catherine Ropert, Marco Iosa, Thomas Rawson, Jiufeng Sun, Eugenie R. Lumbers
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Physiology
T. Sebastian Overduin, Hannah R. Wardill, Richard L. Young, Amanda J. Page, Kathryn L. Gatford
Summary: The study optimized Ussing chamber methodology to measure region-specific active glucose transport in the small intestine of mice and found that jejunal active glucose transport changes during the ovarian cycle, with higher levels at proestrus than estrus. This study provides the first direct evidence of changes in SGLT1-mediated glucose transport in the jejunum across the ovarian cycle.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Cell Biology
Lachlan G. Schofield, Richard G. S. Kahl, Samantha L. Rodrigues, Joshua J. Fisher, Saije K. Endacott, Sarah J. Delforce, Eugenie R. Lumbers, Jacinta H. Martin, Kirsty G. Pringle
Summary: The (P)RR is a multifunctional receptor involved in activating tissue renin-angiotensin system and regulating intracellular pathways. Our study demonstrated that (P)RR plays a crucial role in placental development and function, affecting trophoblast cell proliferation, migration, and invasion. Furthermore, altered (P)RR expression leads to changes in placental morphology and maternal blood space.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Lachlan George Schofield, Sarah A. Marshall, Sarah J. Delforce, Saije K. Morosin, Eugenie R. Lumbers, Kirsty G. Pringle
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Sonia Tamanna, Sarah J. Delforce, Saije K. Morosin, Dirk F. Van Helden, Eugenie R. Lumbers, Kirsty G. Pringle
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Alyssa J. Lochrin, Sarah J. Delforce, Eugenie R. Lumbers, Kirsty G. Pringle
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Saije K. Morosin, India A. Brooker, Ava Tollard, Richard G. S. Kahl, Oyepeju M. Onifade, Eugenie R. Lumbers, Kym Rae, Kirsty G. Pringle
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Sarah J. Delforce, Fisher J. Joshua, Eugenie R. Lumbers, G. Pringle Pringle
REPRODUCTIVE SCIENCES
(2023)