Article
Cardiac & Cardiovascular Systems
Dandan Yang, Xiaoping Wan, Adrienne T. Dennis, Emre Bektik, Zhihua Wang, Mauricio G. S. Costa, Charline Fagnen, Catherine Venien-Bryan, Xianyao Xu, Daniel H. Gratz, Thomas J. Hund, Peter J. Mohler, Kenneth R. Laurita, Isabelle Deschenes, Ji-Dong Fu
Summary: This study reveals a novel biophysical action of endogenous miRs in modulating cardiac electrophysiology through noncanonical mechanisms. Endogenous miR1 physically binds with cardiac membrane protein Kir2.1, suppressing I-K1 and affecting action potential of cardiomyocytes. The findings suggest that miRs may be involved in the pathogenesis of cardiac arrhythmias by regulating ion channel physiology and pathology.
Article
Multidisciplinary Sciences
Dena Esfandyari, Bio Maria Gheo Idrissou, Konstantin Hennis, Petros Avramopoulos, Anne Dueck, Ibrahim El-Battrawy, Laurenz Grueter, Melanie Annemarie Meier, Anna Christina Naeger, Deepak Ramanujam, Tatjana Dorn, Thomas Meitinger, Christian Hagl, Hendrik Milting, Martin Borggrefe, Stefanie Fenske, Martin Biel, Andreas Dendorfer, Yassine Sassi, Alessandra Moretti, Stefan Engelhardt
Summary: MicroRNA-365 regulates human cardiac action potential by modulating key cardiac repolarizing channels.
NATURE COMMUNICATIONS
(2022)
Review
Physiology
Andras Varro, Jakub Tomek, Norbert Nagy, Laszlo Virag, Elisa Passini, Blanca Rodriguez, Istvan Baczko
Summary: Cardiac arrhythmias often stem from changes in the electro-physiological properties of cardiac cells and their ionic mechanisms. Understanding the pathophysiology of human cellular electrophysiology can aid in developing novel antiarrhythmic strategies.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Immunology
Lin Li, Junpei Du, Shipan Liu, Runan Yang, Xiumei Xu, Yuxin Yang, Xiaoqian Ma, Guilin Li, Shuangmei Liu, Guodong Li, Shangdong Liang
Summary: CpG-ODN 1826 activates TLR9 receptor, regulates the expression of P2Y12 receptor and NF-kappa B, and improves blood pressure, heart rate, heart rate variability, sympathetic nerve activity, and neuroinflammation in diabetic rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Khalil Saadeh, Ibrahim Talal Fazmin
Summary: The incidence of cardiac arrhythmias increases significantly with age, with changes in mitochondrial dysfunction playing a crucial role in promoting arrhythmic triggers and substrate. Understanding the mechanisms behind age-related mitochondrial dysfunction can lead to the development of novel anti-arrhythmic therapies that target upstream mitochondrial function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin, Robert Dumaine
Summary: Lamotrigine is commonly used for treating bipolar disorder and epilepsy. The US FDA has recently issued a warning regarding the drug's potential to cause conduction anomalies and Brugada syndrome in epileptic patients. In this study, researchers used patch clamp technique on rat cardiomyocytes to investigate the effect of Lamotrigine on cardiac sodium current (I-Na). The results showed that Lamotrigine inhibited I-Na peak amplitude, reduced cardiac excitability, and prolonged the action potential refractory period in epileptic rats.
Article
Physiology
Junqing Sun, Shiyue Pan, Emma Karey, Yi-Je Chen, Kent E. Pinkerton, Christopher G. Wilson, Chao-Yin Chen
Summary: Exposure to secondhand smoke reduces excitability of cardiac vagal neurons, alters action potential characteristics, and impacts small conductance calcium-activated potassium channel activity, potentially leading to changes in regulatory cardiac vagal signaling and cardiovascular consequences associated with exposure to secondhand smoke.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Physiology
Balazs Horvath, Norbert Szentandrassy, Csaba Dienes, Zsigmond M. Kovacs, Peter P. Nanasi, Ye Chen-Izu, Leighton T. Izu, Tamas Banyasz
Summary: The patch clamp technique has undergone continuous advancement in cardiac electrophysiology, allowing for the recording of multiple currents under various command pulses. Its potential applications in integrative physiology are highlighted in this review.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kirin D. Gada, Mengmeng Chang, Aishwarya Chandrashekar, Leigh D. Plant, Sami F. Noujaim, Diomedes E. Logothetis
Summary: G-protein-gated inwardly rectifying potassium (GIRK) channel activity is regulated by phosphatidylinositol-4,5-bisphosphate (PI 4,5P(2)), and PKC epsilon plays a role in the activation of GIRK channels in cardiac atrial cells and human stem cell-derived atrial cardiomyocytes. PKC epsilon enhances the interaction between GIRK4 and GIRK1/4 with PIP2, leading to increased channel activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Camille E. Blandin, Basile J. Gravez, Stephane N. Hatem, Elise Balse
Summary: Both inherited and acquired cardiac arrhythmias are often linked to abnormal functional expression of ion channels at the cellular level, with mutations in genes encoding ion channels being a major factor in inherited cases. Disruption of normal channel trafficking due to factors like fibrosis and altered myocyte contacts is common in acquired cardiac arrhythmias. Channel availability, particularly in hERG and K(V)1.5 channels, may be another significant arrhythmogenic mechanism. Knowledge of these molecular mechanisms could lead to novel antiarrhythmic strategies.
Review
Neurosciences
Elizabeth A. Schroder, Makoto Ono, Sidney R. Johnson, Ezekiel R. Rozmus, Don E. Burgess, Karyn A. Esser, Brian P. Delisle
Summary: This article focuses on the impact of circadian rhythms, environmental and behavioral changes on 24-hour rhythms in heart rate and ventricular repolarization. The circadian clock in cardiomyocytes regulates the expression of cardiac ion channels, influences the sinoatrial node excitability and the duration of the ventricular action potential waveform. However, autonomic signaling primarily drives the 24-hour rhythms. Changing rhythmic behaviors can significantly affect heart rate and ventricular repolarization. Targeting endogenous circadian mechanisms and modifying rhythmic behaviors may emerge as therapeutic strategies for regulating cardiac electrophysiology.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Asfree Gwanyanya, Inga Andriule, Bogdan M. Istrate, Farjana Easmin, Kanigula Mubagwa, Regina Macianskiene
Summary: TRPM6 and TRPM7 proteins in the heart may be the molecular candidates for native cardiac Mg2+-sensitive channels, potentially influencing the duration of action potentials and having implications in arrhythmogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Murat Oz, Dietrich E. Lorke, Frank C. Howarth
Summary: Capsaicin, derived from chili pepper, has various pharmacological actions, including analgesic, anticancer, anti-inflammatory, antiobesity, and antioxidant effects. It acts on not only TRPV1 receptor, but also other ion channels and enzymes. This study categorizes the non-TRPV1 targets of capsaicin and discusses the cellular and molecular mechanisms of its TRPV1-independent effects.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Susumu Z. Sudo, Tadeu L. Montagnoli, Bruna de S. Rocha, Aimee D. Santos, Mauro P. L. de Sa, Gisele Zapata-Sudo
Summary: Cardiovascular autonomic neuropathy (CAN) is a severe complication of advanced diabetes, which can have various clinical manifestations. Current treatment options for CAN are limited, but potential targets for therapy include inflammatory and endothelial dysfunction as well as oxidative stress.
Article
Pharmacology & Pharmacy
Gan Tang, Lingzhi Pi, Hongmin Guo, Zihui Hu, Congfa Zhou, Qixing Hu, Hao Peng, Zehao Xiao, Zhihua Zhang, Miaomiao Wang, Taotao Peng, Jiaqi Huang, Shangdong Liang, Guilin Li
Summary: Diabetic cardiac autonomic neuropathy (DCAN) is a common complication of diabetes, and there is currently no effective treatment. This study found that naringin may alleviate DCAN by regulating the P2Y(14) receptor and modulating the NRF2/GPX4 pathway involved in ferroptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dongze Zhang, Huiyin Tu, Michael C. Wadman, Yu-Long Li
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Dongze Zhang, Huiyin Tu, Liang Cao, Hong Zheng, Robert L. Muelleman, Michael C. Wadman, Yu-Long Li
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Physiology
Ryan M. Corrick, Huiyin Tu, Dongze Zhang, Aaron N. Barksdale, Robert L. Muelleman, Michael C. Wadman, Yu-Long Li
FRONTIERS IN PHYSIOLOGY
(2018)
Review
Neurosciences
Huiyin Tu, Dongze Zhang, Yu-Long Li
NEUROSCIENCE BULLETIN
(2019)
Article
Cardiac & Cardiovascular Systems
Dongze Zhang, Huiyin Tu, Chaojun Wang, Liang Cao, Wenfeng Hu, Bryan T. Hackfort, Robert L. Muelleman, Michael C. Wadman, Yu-Long Li
Summary: Cardiac sympathetic overactivation is associated with ventricular arrhythmias in CHF patients; investigating the role of Cav2.2 channels in CHF revealed that transfection with Cav2.2-alpha shRNA reduced expression of Cav2.2-alpha mRNA and protein, decreasing neuronal currents and excitability, improving sympathetic nerve activity, and reducing ventricular arrhythmias.
CARDIOVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Huiyin Tu, Dongze Zhang, Michael C. Wadman, Yu-Long Li
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Dongze Zhang, Wenfeng Hu, Huiyin Tu, Bryan T. Hackfort, Bin Duan, Wanfen Xiong, Michael C. Wadman, Yu-Long Li
Summary: Macrophage depletion in the stellate ganglion can reduce cardiac sympathetic overactivation and ventricular arrhythmias in patients with chronic heart failure. The study found that reducing macrophage expansion and neuroinflammation can effectively inhibit cardiac sympathetic overexcitation and ventricular arrhythmias.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Critical Care Medicine
Huiyin Tu, Dongze Zhang, Junliang Qian, Aaron N. Barksdale, Iraklis I. Pipinos, Kaushik P. Patel, Michael C. Wadman, Yu-Long Li
Summary: The study compared tourniquet- and femoral artery ligation-induced ischemia-reperfusion (IR) injuries in mice hindlimbs. Tourniquet-induced injuries were more severe than those induced by femoral artery ligation, causing more muscle damage, impaired muscle contraction, and higher levels of proinflammatory cytokines. The findings suggest choosing the optimal hindlimb IR model depending on the research purpose.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Neurosciences
Wenfeng Hu, Dongze Zhang, Huiyin Tu, Yu-Long Li
Summary: The reduced excitability of cardiac parasympathetic postganglionic (CPP) neurons in T2DM rats is associated with decreased cardiac vagal function, leading to high mortality and malignant ventricular arrhythmias induced by myocardial infarction (MI).
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Junliang Qian, Huiyin Tu, Dongze Zhang, Aaron N. Barksdale, Kaushik P. Patel, Michael C. Wadman, Yu-Long Li
Summary: The use of masitinib can improve nerve damage and abnormal mechanoreception caused by tourniquet-induced ischemia-reperfusion injury, reduce inflammation, and significantly ameliorate sensory deficits and allodynia in mouse hind paw tourniquet-induced ischemia-reperfusion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Devin M. Frisby, Huiyin Tu, Junliang Qian, Dongze Zhang, Aaron N. Barksdale, Michael C. Wadman, Jeffrey S. Cooper, Yu-Long Li
Summary: Tourniquet application restricts blood flow and can cause acute ischemia-reperfusion (IR) injuries. Hyperbaric oxygen therapy increases oxygen supply but does not improve muscle morphology and contractile function in tourniquet/IR-injured muscles.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Huiyin Tu, Dongze Zhang, Michael C. Wadman, Yu-Long Li
Article
Cardiac & Cardiovascular Systems
Dongze Zhang, Huiyin Tu, Wenfeng Hu, Bin Duan, Matthew C. Zimmerman, Yu-Long Li
Summary: The withdrawal of cardiac vagal activity is associated with high mortality in patients with type 2 diabetes mellitus (T2DM) and ventricular arrhythmias. This study found that elevation of hydrogen peroxide (H2O2) inhibits the excitability of cardiac vagal postganglionic neurons, contributing to cardiac vagal dysfunction and ventricular arrhythmogenesis in T2DM. The study suggests that targeting the H2O2-N-type Ca2+ channel signaling axis could be an effective therapeutic approach for ventricular arrhythmias in T2DM patients with myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Huiyin Tu, Junliang Qian, Dongze Zhang, Aaron N. Barksdale, Michael C. Wadman, Iraklis I. Pipinos, Yu-Long Li
Summary: The study found that BALB/c mice showed more severe skeletal muscle changes, including muscle fiber atrophy, accumulation of adipose-like tissue, and fibrosis, compared to C57BL/6 mice after femoral artery ligation. Furthermore, BALB/c mice exhibited greater damage in neuromuscular junctions and muscle contraction responses to ischemia, suggesting potential differences in the strain-specific responses to PAD.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Huiyin Tu, Dongze Zhang, Aaron N. Barksdale, Michael C. Wadman, Robert L. Muelleman, Yu-Long Li
WILDERNESS & ENVIRONMENTAL MEDICINE
(2020)