Review
Physiology
Lucia Hoppanova, Lubica Lacinova
Summary: This article reviews current knowledge about the expression and distribution of calcium channels in the nociceptive pathway, their regulation and gating during pain pathology, and their suitability as targets for pharmacological therapy.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Volker Herzig, Yong-Cyuan Chen, Yanni K-Y Chin, Zoltan Dekan, Yu-Wang Chang, Hui-Ming Yu, Paul F. Alewood, Chien-Chang Chen, Glenn F. King
Summary: This study identified a tarantula venom from Avicularia spec. that can inhibit specific subtypes of T-type calcium channels, with the active toxin being omega-Avsp1a. The research suggests that omega-Avsp1a can inhibit specific subtypes of T-type calcium channels, and the domain-1 of Ca(V)3.3 is crucial for this inhibitory effect.
Article
Nanoscience & Nanotechnology
Yan Li, Jipeng Xu, Huibin Liu, Xuewen Hu, Qicheng Zhang, Wenchao Peng, Yang Li, Fengbao Zhang, You Han, Xiaobin Fan
Summary: In this study, a layered sodium-ion pseudocapacitive material was prepared, and improved durability and a larger voltage window were achieved in a high-concentration NaClO4 electrolyte. The dissolution of vanadium in the high-concentration electrolyte was effectively suppressed. An asymmetric sodium-ion capacitor was successfully assembled and exhibited a high energy density at a high power density.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Yan Li, Jipeng Xu, Huibin Liu, Xuewen Hu, Qicheng Zhang, Wenchao Peng, Yang Li, Fengbao Zhang, You Han, Xiaobin Fan
Summary: Low-cost sodium-ion-based electrochemical energy storage devices have been gaining attention, and in this study, a new sodium ion pseudocapacitive material was developed with improved cycling stability and a wide voltage window.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yan-Song Ye, Rui Liu, Na-Na Jiang, Song-Yu Li, Yin Nian, Gang Xu
Summary: Five caged polycyclic polyprenylated acylphloroglucinols, including a novel octahydro-2,5-methanoindene skeleton, were discovered from Hypericum curvisepalum. Compounds 1 and 2 exhibit potent inhibitory effects on the Ca(v)3.2 T-type Ca2+ channel, with compound 2 also showing strong analgesic effects in mice.
CHEMICAL COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Travis J. Morgenstern, Neha Nirwan, Erick O. Hernandez-Ochoa, Hugo Bibollet, Papiya Choudhury, Yianni D. Laloudakis, Manu Ben Johny, Roger A. Bannister, Martin F. Schneider, Daniel L. Minor, Henry M. Colecraft
Summary: This study identifies a nanobody, nb.E8, that selectively binds to the SH3 domain of Ca-V beta(1) and inhibits associated HVACCs. Functionalizing nb.E8 with Nedd4L HECT domain yielded Chisel-1, which eliminates current through Ca-V beta(1)-reconstituted channels and suppresses Ca2+ influx and excitation-transcription coupling in neurons. This research introduces a new method for probing distinctive functions of ion channel auxiliary subunit isoforms, and describes a genetically-encoded HVACC inhibitor with unique properties.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Robin N. Stringer, Leos Cmarko, Gerald W. Zamponi, Michel De Waard, Norbert Weiss
Summary: T-type calcium channelopathies are a group of human disorders caused or exacerbated by mutations in genes encoding T-type calcium channels. A new mutation in the CACNA1H gene encoding the Ca(v)3.2 T-type calcium channel was found in a patient with epilepsy and hearing loss, the first CACNA1H mutation associated with a sensorineural hearing condition. This mutation results in minor gating alterations and enhanced sensitivity to external pH change in the channel.
Article
Energy & Fuels
Jun Ren, Qing Wang, Qian Xiang, Chunming Yang, Yun Liang, Jinlong Liu, Junhua Li, Dong Qian
Summary: In this study, the voltage window of all-solid-state symmetrical supercapacitors (ASSCs) is extended by using a novel self-supporting hybrid electrode. The assembled ASSC device shows an extra-wide workable voltage window and high energy exporting densities.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Materials Science, Multidisciplinary
Huawei Song, Chengxin Wang
Summary: This article investigates the anodic stability issues of calcium metal electrodeposition/dissolution and proposes the construction of an artificial hybrid solid electrolyte layer to address this problem. The study reveals that after cycling, the artificial hybrid solid electrolyte layer transforms into a Na/K/Ca hybrid solid electrolyte interphase, which greatly enhances the performance of the calcium metal electrode.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Quinton Banks, Hugo Bibollet, Minerva Contreras, Daniel F. Bennett, Roger A. Bannister, Martin F. Schneider, Erick O. Hernandez-Ochoa
Summary: The study investigates the role of voltage-sensing domains (VSDs) in excitation-contraction coupling (ECC) by encoding cysteine substitutions on each S4 voltage-sensing segment of Ca(V)1.1 and using in cellulo AP fluorometry to track the movement of each VSD in skeletal muscle fibers. The results suggest that VSDs play a crucial role in charge movement and Ca2+ release during skeletal muscle fiber activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simo, James S. Trimmer, Rose E. Dixon, Eamonn J. Dickson
Summary: The loss of NPC1 function alters the nanoscale distribution and function of ion channels, leading to abnormal calcium entry, mitochondrial dysfunction, and neurotoxicity. These findings provide insights into the molecular mechanisms connecting NPC1 loss to NPC-associated neuropathology.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Albert Vallejo-Gracia, Daniel Sastre, Magali Colomer-Molera, Laura Sole, Maria Navarro-Perez, Jesusa Capera, Sara R. Roig, Oriol Pedros-Gamez, Irene Estadella, Orsolya Szilagyi, Gyorgy Panyi, Peter Hajdu, Antonio Felipe
Summary: KCNE4 serves as a crucial regulator in modulating immune system physiology by controlling Kv1.3-associated leukocyte functions.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Electrical & Electronic
Long Zhang, Chengwu Pan, Jie Ma, Nailong He, Jiaxing Wei, Sheng Li, Siyang Liu, Sen Zhang, Weifeng Sun
Summary: Potential control technique is utilized to achieve a 1200V isolation structure using potential delivering field plates (PDFPs). By distributing PDFPs in a high voltage junction termination (HVJT) region, the surface potentials from HVJT can be delivered to the lateral diffused MOSFET (LDMOS) regions, thereby modulating the surface potential profile and suppressing leakage.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Chemistry, Medicinal
Nace Zidar, Tihomir Tomasic, Danijel Kikelj, Martina Durcik, Jan Tytgat, Steve Peigneur, Marc Rogers, Alexander Haworth, Robert W. Kirby
Summary: Voltage-gated sodium channels (Navs) play a crucial role in neurotransmission and their dysfunction is associated with various neurological disorders. In this study, a new series of aryl and acylsulfonamides were discovered as state-dependent inhibitors of Nav1.3 channels. These compounds displayed strong selective activity against the inactivated state of the Nav1.3 channel, with weaker activity against Nav1.5 and Nav1.7 channels. These findings provide a valuable tool for further evaluation of Nav1.3 channel as a potential drug target.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bank G. Fenyves, Andreas Arnold, Vaibhav G. Gharat, Carmen Haab, Kiril Tishinov, Fabian Peter, Dominique de Quervain, Andreas Papassotiropoulos, Attila Stetak
Summary: This study reveals that the MiRP family member mps-2 controls long-term associative memory in AVA neurons and plays a key role in age-related memory decline. The research demonstrates that mps-2 modulates LTAM through the regulation of K(v)2.1/KVS-3 and K(v)2.2/KVS-4 heteromeric potassium channels, contributing to a programmed control of physiological age-dependent memory decline.
Article
Biochemistry & Molecular Biology
Ana B. Munoz-Manchado, Javier Villadiego, Sonia Romo-Madero, Nela Suarez-Luna, Alfonso Bermejo-Navas, Jose A. Rodriguez-Gomez, Pablo Garrido-Gil, Jose L. Labandeira-Garcia, Miriam Echevarria, Jose Lopez-Barneo, Juan J. Toledo-Aral
JOURNAL OF NEUROCHEMISTRY
(2016)
Article
Neurosciences
Patricia Ortega-Saenz, David Macias, Konstantin L. Levitsky, Jose A. Rodriguez-Gomez, Patricia Gonzalez-Rodriguez, Victoria Bonilla-Henao, Ignacio Arias-Mayenco, Jose Lopez-Barneo
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Article
Cell & Tissue Engineering
Damia Romero-Moya, Carlos Santos-Ocana, Julio Castano, Gloria Garrabou, Jose A. Rodriguez-Gomez, Vanesa Ruiz-Bonilla, Clara Bueno, Patricia Gonzalez-Rodriguez, Alessandra Giorgetti, Eusebio Perdiguero, Cristina Prieto, Constanza Moren-Nunez, Daniel J. Fernandez-Ayala, Maria Victoria Cascajo, Ivan Velasco, Josep Maria Canals, Raquel Montero, Delia Yubero, Cristina Jou, Jose Lopez-Barneo, Francesc Cardellach, Pura Munoz-Canoves, Rafael Artuch, Placido Navas, Pablo Menendez
Article
Biochemistry & Molecular Biology
Maria T. Marcos-Almaraz, Jose A. Rodriguez-Gomez, Jose Lopez-Barneo, Alberto Pascual
BIOCHEMICAL JOURNAL
(2012)
Review
Medicine, General & Internal
Juan Garcia-Revilla, Isabel M. Alonso-Bellido, Miguel A. Burguillos, Antonio J. Herrera, Ana M. Espinosa-Oliva, Rocio Ruiz, Luis Cruz-Hernandez, Irene Garcia-Dominguez, Maria A. Roca-Ceballos, Marti Santiago, Jose A. Rodriguez-Gomez, Manuel Sarmiento Soto, Rocio M. de Pablos, Jose L. Venero
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Marta Gallardo-Fernandez, Ruth Hornedo-Ortega, Isabel M. Alonso-Bellido, Jose A. Rodriguez-Gomez, Ana M. Troncoso, M. Carmen Garcia-Parrilla, Jose L. Venero, Ana M. Espinosa-Oliva, Rocio M. de Pablos
Review
Cell Biology
Jose A. Rodriguez-Gomez, Edel Kavanagh, Pinelopi Engskog-Vlachos, Mikael K. R. Engskog, Antonio J. Herrera, Ana M. Espinosa-Oliva, Bertrand Joseph, Nabil Hajji, Jose L. Venero, Miguel A. Burguillos
Article
Clinical Neurology
Irene Garcia-Dominguez, Irene Suarez-Pereira, Marti Santiago, Eva M. Perez-Villegas, Lidia Bravo, Carolina Lopez-Martin, Maria Angustias Roca-Ceballos, Juan Garcia-Revilla, Ana M. Espinosa-Oliva, Jose A. Rodriguez-Gomez, Bertrand Joseph, Esther Berrocoso, Jose Angel Armengol, Jose L. Venero, Rocio Ruiz, Rocio M. de Pablos
Summary: Apoptotic caspases are crucial for synapse elimination and cell removal during development, with potential implications for neurological disorders. Depletion of caspase-3 affects the development of catecholaminergic neurons, leading to dopaminergic hypofunction. This study highlights the role of dopamine in autism spectrum disorder (ASD) and provides a valuable model for understanding ASD pathogenesis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
JH Kim, JM Auerbach, JA Rodríguez-Gómez, I Velasco, D Gavin, N Lumelsky, SH Lee, J Nguyen, R Sánchez-Pernaute, K Bankiewicz, R McKay
Article
Cell & Tissue Engineering
Jose A. Rodriguez-Gomez, Jian-Qiang Lu, Ivan Velasco, Seth Rivera, Sami S. Zoghbi, Jeih-San Liow, John L. Musachio, Frederick T. Chin, Hiroshi Toyama, Jurgen Seidel, Michael V. Green, Panayotis K. Thanos, Masanori Ichise, Victor W. Pike, Robert B. Innis, Ron D. G. McKay
Meeting Abstract
Neurosciences
JQ Lu, JA Rodriguez-Gomez, I Velasco, SS Zoghbi, JS Liow, JL Musachio, J Shah, FT Chin, H Toyama, J Seidel, MV Green, M Ichise, VW Pike, R McKay, RB Innis
Article
Neurosciences
D Charytoniuk, B Porcel, JR Gomez, H Faure, M Ruat, E Traiffort
JOURNAL OF PHYSIOLOGY-PARIS
(2002)
Article
Neurosciences
M Romero-Ramos, JL Venero, M Santiago, JA Rodriguez-Gomez, ML Vizuete, J Cano, A Machado