Targeting therapeutic effects: subcellular location matters. Focus on “Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology”

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Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology

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Clinical trials of resveratrol

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AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress

(2011) Peiling Tsou et al.   Cell Metabolism

Adenosine monophosphate-activated kinase α1 promotes endothelial barrier repair

(2011) Judy Creighton et al.   FASEB JOURNAL

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

(2011) Tz-Chuen Ju et al.   JOURNAL OF CELL BIOLOGY

AMP-activated protein kinase: nature's energy sensor

(2011) David Carling et al.   Nature Chemical Biology

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase

(2010) Nevzat Kazgan et al.   MOLECULAR BIOLOGY OF THE CELL

Resveratrol: a promising agent in promoting cardioprotection against coronary heart diseaseThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 2 of a 2-part Special Issue).

(2009) Suresh Varma Penumathsa et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Fluorescent protein-based biosensors: resolving spatiotemporal dynamics of signaling

(2009) Lisa M DiPilato et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules

(2007) Hemal H. Patel et al.   Annual Review of Pharmacology and Toxicology