Article
Biochemistry & Molecular Biology
Marwa Ben-Khemis, Dan Liu, Coralie Pintard, Zhuoyao Song, Margarita Hurtado-Nedelec, Jean-Claude Marie, Jamel El-Benna, Pham My-Chan Dang
Summary: TNF alpha disrupts IL-10 signaling by inducing STAT3 dephosphorylation through a NOX2-ROS-Lyn-SHP1 axis in human monocytes, leading to prolonged inflammation. These findings explain the poor efficacy of IL-10 therapy in patients with inflammatory diseases and suggest that anti-TNF alpha agents and SHP1/2 inhibitors could improve the therapeutic use of IL-10.
Article
Clinical Neurology
Anan Shtaya, Leslie R. Bridges, Rebecca Williams, Sarah Trippier, Liqun Zhang, Anthony C. Pereira, James A. R. Nicoll, Delphine Boche, Atticus H. Hainsworth
Summary: The study identified an anti-inflammatory process occurring alongside neuroinflammation post-sICH in clinical patients, involving native microglia and blood monocytes. This novel pathway offers therapeutic targets and a treatment opportunity window for delivering therapeutics through invading monocytes during 3-5 days post-sICH.
Article
Biochemistry & Molecular Biology
Marta Donini, Francesca Pettinella, Giorgia Zanella, Salvatore Calogero Gaglio, Carlo Laudanna, Monica Jimenez-Carretero, Concepcion Jimenez-Lopez, Massimiliano Perduca, Stefano Dusi
Summary: The use of magnetic nanoparticles and biomimetic magnetic nanoparticles does not trigger inflammatory response in human monocytes. Biomimetic magnetic nanoparticles can promote the maturation of dendritic cells, potentially used for vaccine design. Nanoparticles can serve as vehicles to deliver molecules into immune cells and regulate immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Gilson P. Dorneles, Paula C. Teixeira, Alessandra Peres, Luiz Carlos Rodrigues Junior, Simone Goncalves da Fonseca, Marta Chagas Monteiro, Sarah Eller, Tiago F. Oliveira, Eliana M. Wendland, Pedro R. T. Romao
Summary: Higher levels of endotoxin and systemic inflammatory markers were found in severe COVID-19 patients compared to healthy controls and mild COVID-19 patients. Severe COVID-19 patients also exhibited higher levels of inflammatory cytokines and altered monocyte populations. The response to endotoxin stimulation differed between severe COVID-19 patients and controls, with lower cytokine production but higher levels of PGE-2.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Cell Biology
Samia Rahman, Alexander R. A. Szojka, Yan Liang, Melanie Kunze, Victoria Goncalves, Aillette Mulet-Sierra, Nadr M. Jomha, Adetola B. Adesida
Summary: Human IFP-MSC did not undergo chondrogenesis under 2% low oxygen tension, but chondrogenic medium with TGFβ3 induced in vitro chondrogenesis, which did not lead to endochondral ossification after implantation in athymic mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marialucia Gallorini, Monica Rapino, Helmut Schweikl, Amelia Cataldi, Rosa Amoroso, Cristina Maccallini
Summary: The study demonstrates that new iNOS inhibitors selectively reduce cytotoxicity, IL-6 secretion, and LPS-stimulated monocyte migration, indicating promising therapeutic potential.
Article
Immunology
Sloan A. Lewis, Suhas Sureshchandra, Brianna Doratt, Vanessa A. Jimenez, Cara Stull, Kathleen A. Grant, Ilhem Messaoudi
Summary: Chronic heavy drinking can alter classical monocyte subset composition, leading to a hyper-inflammatory response to LPS but a compromised response to pathogens. This dysregulated inflammatory response may increase susceptibility to infections and impair wound healing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Buesra Geckin, Gizem Kilic, Priya A. Debisarun, Konstantin Fohse, Azahara Rodriguez-Luna, Pablo Fernandez-Gonzalez, Ana Lopez Sanchez, Jorge Dominguez-Andres
Summary: The proper functioning of the immune system relies on the balance between pro-inflammation and anti-inflammation. Disruption of this balance can lead to autoimmune or inflammatory diseases. A fungal compound called AM3 has been found to modulate immune responses by decreasing excessive cytokine production and maintaining the capacity of immune cells to respond to stimuli. AM3 may help reduce immune activation and keep immune responses within a normal range.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Suelen Queiroz Diniz, Andrea Teixeira-Carvalho, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Bruno Coelho Rocha, Olindo Assis Martins-Filho, A. Ricardo Goncalves, Dhelio Batista Pereira, Mauro Shugiro Tada, Fabiano Oliveira, Ricardo Tostes Gazzinelli, Lis Ribeiro do Valle Antonelli
Summary: Monocytes play a crucial role in host defense against Plasmodium vivax by producing inflammatory cytokines and mitochondrial reactive oxygen species (mROS). During human P. vivax malaria, monocyte metabolism is altered, with mitochondria playing a key role in this change. This metabolic reprogramming leads to an increase in mROS production, contributing to protective responses against P. vivax and potentially triggering immunomodulatory mechanisms.
Article
Immunology
Julia C. Berentschot, Hemmo A. Drexhage, Daniel G. Aynekulu Mersha, Annemarie J. M. Wijkhuijs, Corine H. Geurtsvankessel, Marion P. G. Koopmans, Jolanda J. C. Voermans, Rudi W. Hendriks, Nicole M. A. Nagtzaam, Maaike de Bie, Majanka H. Heijenbrok-Kal, L. Martine Bek, Gerard M. Ribbers, Rita J. G. van den Berg-emons, Joachim G. J. V. Aerts, Willem A. Dik, Merel E. Hellemons
Summary: This study investigated the clinical and immune characteristics of fatigued and non-fatigued long COVID patients. The results showed that fatigued patients had more severe clinical profiles and cognitive dysfunction compared to non-fatigued patients. Immune abnormalities, including low-grade inflammation and signs of T-lymphocyte senescence, were found in the entire group of long COVID patients. The severity of fatigue was associated with increased monocyte activation, inflammatory gene expression, and higher CD8(+) T-lymphocyte counts.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Toxicology
Adelaide Sousa, Ana T. Rufino, Rui Fernandes, Ana Malheiro, Felix Carvalho, Eduarda Fernandes, Marisa Freitas
Summary: Silver nanoparticles exert harmful effects on both monocytes and macrophages, through the establishment of a strong pro-inflammatory response that leads to cell death. Smaller polyvinylpyrrolidone-coated silver nanoparticles exhibit more pronounced cytotoxic effects. Human monocytes are more sensitive to silver nanoparticle exposure compared to human macrophages.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi-Ching Lin, Yu-Chih Lin, Mei-Lan Tsai, Wei-Ting Liao, Chih-Hsing Hung
Summary: Researchers found that TSLP can regulate ROS production and mitophagy through AMPK activation and histone modification, thus affecting the expression of M1/M2 chemokines in human monocytes.
CELL AND BIOSCIENCE
(2022)
Article
Cell Biology
Zichao Luo, Erlinda The, Peijian Zhang, Yufeng Zhai, Qingzhou Yao, Lihua Ao, Qingchun Zeng, David A. Fullerton, Xianzhong Meng
Summary: This study found that monocytes enhance inflammatory responses in aortic valve interstitial cells (AVICs) to soluble extracellular matrix (ECM) protein. Monocyte beta(2)-integrin interacts with AVIC ICAM-1 to augment AVIC inflammatory responses by enhancing the activation of YAP and NF-kappa B signaling pathways.
INFLAMMATION RESEARCH
(2022)
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
Summary: Obesity is an emerging non-communicable disease associated with chronic low-grade inflammation and oxidative stress. The ketogenic diet (KD), characterized by high fat intake, moderate to low protein consumption, and very low carbohydrate intake, has proven to be effective in weight loss and improving the inflammatory state and oxidative stress in individuals with obesity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Balaji Krishnamachary, Aatish Mahajan, Ashok Kumar, Stuti Agarwal, Aradhana Mohan, Ling Chen, Priscilla Y. Hsue, Prabhakar Chalise, Alison Morris, Navneet K. Dhillon
Summary: This study revealed higher levels of TGF-beta 1 in circulating extracellular vesicles (EVs) among HIV-positive individuals with PH compared to those without, suggesting a potential clinical implication as a biomarker for HIV-associated PH. EVs released by HIV-infected human monocyte-derived macrophages were found to induce TGF-beta 1-dependent pulmonary endothelial injury and smooth muscle hyperplasia, contributing to the development of PH. Treatment with a TGF-beta receptor 1 inhibitor prevented EV-mediated changes in a rat model, highlighting the role of macrophage-derived EVs in pulmonary vascular modeling and PH through modulation of TGF-beta signaling.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Rheumatology
Joy Feld, Sarit Nissan, Lihi Eder, Michal Amit Rahat, Muna Elias, Doron Rimar, Arie Laor, Haim Bitterman, Devy Zisman
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2018)
Article
Multidisciplinary Sciences
Tamar L. Ben-Shaanan, Maya Schiller, Hilla Azulay-Debby, Ben Korin, Nadia Boshnak, Tamar Koren, Maria Krot, Jivan Shakya, Michal A. Rahat, Fahed Hakim, Asya Rolls
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Elinoar Hoffman, Michal A. Rahat, Joy Feld, Muna Elias, Itzhak Rosner, Lisa Kaly, Idit Lavie, Tal Gazitt, Devy Zisman
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Immunology
Michal A. Rahat
FRONTIERS IN IMMUNOLOGY
(2019)
Editorial Material
Immunology
Michal A. Rahat, Julia Kzhyshkowska, Vijaya Iragavarapu-Charyulu
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Nizar Hijaze, Max Ledersnaider, Elina Simanovich, Sameer Kassem, Michal A. Rahat
Summary: Inducing immunogenic cell death (ICD) in tumor cells using 161-pAb and complement factors can enhance the release of dsRNA and promote the anticancer activity of macrophages.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Boris Schminke, Orr Shomroni, Gabriela Salinas, Felix Bremmer, Philipp Kauffmann, Henning Schliephake, Felix Oyelami, Michal A. Rahat, Phillipp Brockmeyer
Summary: This study aimed to identify and validate changes in protein expression during the progression of oral squamous cell carcinoma (OSCC) and their impact on patient prognosis. The researchers treated human OSCC cells with TGF-beta 1 and analyzed the differentially expressed genes (DEGs). They then validated the protein expression levels of the most important genes on tissue samples from OSCC patients and correlated them with disease-free survival. The study found that stearoyl-CoA desaturase-1 and sclerostin acted as independent prognostic factors in OSCC.
Review
Immunology
Michal A. Rahat
Summary: Solid tumors metastasize early in their development through a process called the metastatic cascade, which involves detachment, migration, intravasation, extravasation, adhesion, and outgrowth of tumor cells. The interactions between tumor cells and immune cells, particularly macrophages, play a critical role in driving the metastatic cascade. CD147/EMMPRIN is a molecule that is involved in all steps of the process and targeting it can block metastasis and prevent tumor recurrence.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gabriele Feigelman, Elina Simanovich, Phillipp Brockmeyer, Michal A. Rahat
Summary: Metastasis is responsible for most colorectal cancer deaths. Cancer cells undergo epithelial-to-mesenchymal transition (EMT) to promote migration. CD147/EMMPRIN controls entry and exit from dormancy in CT26 colon carcinoma cells. Knocking down EMMPRIN expression pushes cells towards dormancy, while co-culture with macrophages can promote an exit from dormancy. The study suggests that EMMPRIN acts as a gatekeeper for dormancy and macrophages play a role in promoting tumor growth.
Editorial Material
Immunology
Michal A. Rahat, Maria Rosaria Galdiero
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Michal A. Rahat, Mirna Safieh, Elina Simanovich, Eliran Pasand, Tal Gazitt, Amir Haddad, Muna Elias, Devy Zisman
ARTHRITIS RESEARCH & THERAPY
(2020)
Meeting Abstract
Medicine, General & Internal
M. A. Rahat, E. Simanovich, V. Brod
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2018)
Meeting Abstract
Rheumatology
E. Hoffman, M. A. Rahat, J. Feld, M. Elias, I. Rosner, L. Kaly, I. Lavi, D. Zisman
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Meeting Abstract
Rheumatology
Devy Zisman, Mirna Saphieh, Joy Feld, Amir Haddad, Muna Elias, Alina Kaganovitch, Idit Lavi, Michal Amit Rahat
ARTHRITIS & RHEUMATOLOGY
(2018)
Meeting Abstract
Rheumatology
Muna Elias, Michal Amit Rahat, Joy Feld, Itzhak Rosner, Lisa Kaly, Idit Lavi, Tal Gazitt, Devy Zisman
ARTHRITIS & RHEUMATOLOGY
(2018)