Review
Biochemistry & Molecular Biology
Stefania Iametti, Francesco Bonomi, Mattia Di Nunzio
Summary: Recent evidence suggests that chronic consumption of large amounts of fructose is associated with several non-communicable diseases. Plant polyphenols have the potential to inhibit fructose uptake and transport, making them an important target for studying the effects on fructose metabolism. However, the lack of standardized conditions in current studies prevents definitive conclusions. Future research should focus on standardized conditions to obtain comparable results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ruirui Zhang, Xin Li, Zhaoxin Su, Fangyuan Ning, Yuxue Gao
Summary: In this study, the effect of dietary antioxidants on the excretion of PFOA was investigated in mice. It was found that BHT increased urinary excretion of PFOA while TP decreased it. Mechanistic investigation revealed that BHT enhanced renal reabsorption of PFOA through increased expression of Oatp1a1, and αT increased fecal excretion of PFOA by reducing intestinal permeability.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Manzoor Ahmad, Naveen J. Roy, Anurag Singh, Debashis Mondal, Abhishek Mondal, Thangavel Vijayakanth, Mayurika Lahiri, Pinaki Talukdar
Summary: Artificial biomimetic chloride anionophores have potential applications in anticancer scaffolds. Stimuli-responsive chloride transporters that can be selectively activated inside cancer cells are rare. Light-responsive systems, with their spatiotemporal controllability, low toxicity, and high tunability, show promise for photodynamic therapy. In this work, o-nitrobenzyl-linked, benzimidazole-based protransporters and active transporters were studied, and one compound showed efficient ion transport activity. Detailed mechanistic studies revealed the main ion transport process and the necessity of double protection with photocages for complete activation by external light. The activated procarriers induced phototoxic cell death in MCF-7 cancer cells.
Article
Chemistry, Multidisciplinary
Manzoor Ahmad, Naveen J. Roy, Anurag Singh, Debashis Mondal, Abhishek Mondal, Thangavel Vijayakanth, Mayurika Lahiri, Pinaki Talukdar
Summary: Artificial biomimetic chloride anionophores have potential applications as anticancer scaffolds. Stimuli-responsive chloride transporters that can be selectively activated inside cancer cells are rare, and light-responsive systems show promise for photodynamic therapy. In this study, O-nitrobenzyl-linked, benzimidazole-based protransporters and benzimidazole-2-amine-based active transporters were synthesized. Trifluoromethyl-based anionophore showed efficient ion transport activity, and mechanistic studies revealed Cl-/NO3- antiport as the main ion transport process. Activation of the protransporters inside MCF-7 cancer cells induced phototoxic cell death.
Article
Chemistry, Organic
Krystyna Maslowska-Jarzyna, Alessio Cataldo, Anna Marszalik, Ilona Ignatikova, Stephen J. Butler, Radoslaw Stachowiak, Michal J. Chmielewski, Hennie Valkenier
Summary: This study investigated the transport of bicarbonate and chloride ions by carbazoles with two amido/thioamido groups using a bicarbonate-sensitive probe. The researchers found a significant concentration dependence of the transporters. Based on insights into anion transport mechanisms, the compounds were tested for antimicrobial activity and showed a strong correlation with their ion transport properties.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Umatai A. Hale, Nandita Madhavan
Summary: A cyclic dipeptide ion-carrier with ester motifs for cation binding and amide-NH for anion binding is reported. The inclusion of lipophilic norbornene units facilitates membrane insertion and enables MCl co-transport with this simple design.
CHEMICAL COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Stephen J. Keely, Kim E. Barrett
Summary: One of the primary functions of the intestinal epithelium is to regulate the transport of fluid and electrolytes. Under normal circumstances, absorption is predominant, enabling conservation of water. However, in secretory diarrhea, excessive fluid secretion overwhelms absorption, leading to water loss in stool. This review discusses the regulation of Cl- and fluid secretion in the intestine, dysregulation in secretory diarrhea, therapeutic approaches, and innovative strategies for treating constipation by exploiting intestinal secretory mechanisms.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuan-Wei Zhang, Stacy Uchendu, Vanessa Leone, Richard T. Bradshaw, Ntumba Sangwa, Lucy R. Forrest, Gary Rudnick
Summary: The study found that chloride ions, along with sodium ions and glycine, stabilize an inward-open conformation of the human GlyT1 transporter, providing an unexpected insight into the role of chloride in this transporter family.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Ida Heden, Kristina Sundell, Elisabeth Jonsson, Henrik Sundh
Summary: Based on the study on salmonids, it was found that the absorption of L-lysine is lower in seawater compared to freshwater. This is due to the allocation of the Na+ gradient towards ion-driven fluid uptake in seawater, rather than the impairment of amino acid transport.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
Lanmei Yin, Qing Yang, Yiming Zhang, Dan Wan, Yuebang Yin, Qiye Wang, Jing Huang, Jianzhong Li, Huansheng Yang, Yulong Yin
Summary: The study revealed that dietary copper supplementation during the weaning period improves the intestinal morphology of finishing pigs by modulating the activity of intestinal stem cells.
Article
Chemistry, Organic
Giacomo Picci, Israel Carreira-Barral, Daniel Alonso-Carrillo, Chiara Busonera, Jessica Milia, Roberto Quesada, Claudia Caltagirone
Summary: A new family of squaramide-based anionophores has been synthesized and characterized to investigate the influence of indolyl substituents on their anion binding and transmembrane transport properties. Compounds with 7-indolyl/indol-7-yl moiety as the substituent exhibited the highest stability constants for chloride binding and showed the most potent anion transport capabilities. Specifically, L6 with a 3,5-bis(trifluoromethyl)phenyl group was found to be the most efficient transporter, outperforming symmetrically-substituted squaramide analogues previously reported in the literature.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Debashis Mondal, Manzoor Ahmad, Bijoy Dey, Abhishek Mondal, Pinaki Talukdar
Summary: The authors report a synthetic supramolecular double-stranded helical system that can undergo reversible unwinding and regeneration, providing a new approach for the synthesis of smart materials with better biomedical applications.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Krystyna Maslowska-Jarzyna, Maria L. Korczak, Michal J. Chmielewski
Summary: This study investigates the influence of various electron-withdrawing substituents on the chloride transport activity of 1,8-diamidocarbazoles, finding that 3,6-dicyano- and 3,6-dinitro- substituted receptors are highly active chloride carriers. Mechanistic studies reveal that diamidocarbazoles form complexes with chloride in lipid bilayers and facilitate chloride/nitrate exchange by carrier mechanism. Additionally, the 3,6-dinitro- substituted receptor acts as a pH-switchable transporter with a physiologically relevant apparent pK(a) of 6.4.
FRONTIERS IN CHEMISTRY
(2021)
Article
Engineering, Chemical
Ivy Wu, Ryan J. Park, Ria Ghosh, Mei-Chen Kuo, Soenke Seifert, E. Bryan M. Coughlin, Andrew M. Herring
Summary: The development of improved durable, conductive, and selective anion exchange membranes (AEMs) is crucial for electrodialysis. In this study, a series of ABA triblock copolymers with different block sizes were synthesized and quaternized with methylpiperidine. The small block AEM showed excellent performance with high selectivity and improved salt removal efficiency compared to a commercial AEM. The enhanced properties of the small block AEM are attributed to its unique structure and water-rich region.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Food Science & Technology
Anne-Sofie Ravn Ballegaard, Katrine Lindholm Bogh
Summary: Food allergies affect 5-8% of young children and 2-4% of adults, and the prevalence is increasing. The cause of the increase is largely unknown but it may be influenced by environmental and lifestyle factors. Changes in intestinal barrier functions and increased uptake of dietary proteins have been suggested as important factors in food allergies. This review provides an overview of gastrointestinal digestion, intestinal barrier function, and protein uptake, as well as discussing the various routes of protein transport and how they may be affected by intrinsic and extrinsic factors. The knowledge gained from this research could be useful in assessing allergenicity and developing preventive and treatment strategies.
FOOD RESEARCH INTERNATIONAL
(2023)
Editorial Material
Chemistry, Physical
John E. T. Corrie, Jack H. Kaplan, Biff Forbush, David C. Ogden, David R. Trentham
Review
Neurosciences
Michael J. Shattock, Michela Ottolia, Donald M. Bers, Mordecai P. Blaustein, Andrii Boguslavskyi, Julie Bossuyt, John H. B. Bridge, Ye Chen-Izu, Colleen E. Clancy, Andrew Edwards, Joshua Goldhaber, Jack Kaplan, Jerry B. Lingrel, Davor Pavlovic, Kenneth Philipson, Karin R. Sipido, Zi-Jian Xie
JOURNAL OF PHYSIOLOGY-LONDON
(2015)
Article
Cell Biology
Rebecca J. Clifford, Edward B. Maryon, Jack H. Kaplan
JOURNAL OF CELL SCIENCE
(2016)
Article
Cell Biology
Edward B. Maryon, Shannon A. Molloy, Jack H. Kaplan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Takashi Ashino, Varadarajan Sudhahar, Norifumi Urao, Jin Oshikawa, Gin-Fu Chen, Huan Wang, Yuqing Huo, Lydia Finney, Stefan Vogt, Ronald D. McKinney, Edward B. Maryon, Jack H. Kaplan, Masuko Ushio-Fukai, Tohru Fukai
CIRCULATION RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Edward B. Maryon, Jing Zhang, John W. Jellison, Jack H. Kaplan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Shannon A. Molloy, Jack H. Kaplan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Rebecca J. Clifford, Jack H. Kaplan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Elmira Tokhtaeva, Rebecca J. Clifford, Jack H. Kaplan, George Sachs, Olga Vagin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Elena Arystarkhova, Yi B. Liu, Cynthia Salazar, Violeta Stanojevic, Rebecca J. Clifford, Jack H. Kaplan, Gerald M. Kidder, Kathleen J. Sweadner
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Edward B. Maryon, Shannon A. Molloy, Kristin Ivy Huijun Yu, Jack H. Kaplan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Multidisciplinary Sciences
Lawrence W. Gray, Fangyu Peng, Shannon A. Molloy, Venkata S. Pendyala, Abigael Muchenditsi, Otto Muzik, Jaekwon Lee, Jack H. Kaplan, Svetlana Lutsenko
Article
Multidisciplinary Sciences
Adriana M. Zimnicka, Haiyang Tang, Qiang Guo, Frank K. Kuhr, Myung-Jin Oh, Jun Wan, Jiwang Chen, Kimberly A. Smith, Dustin R. Fraidenburg, Moumita S. R. Choudhury, Irena Levitan, Roberto F. Machado, Jack H. Kaplan, Jason X. -J. Yuan
Article
Pharmacology & Pharmacy
Kristin D. Ivy, Jack H. Kaplan
MOLECULAR PHARMACOLOGY
(2013)