mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy

Targeting the Vicious Inflammation–Oxidative Stress Cycle for the Management of Heart Failure

(2010) Neelam Khaper et al.   ANTIOXIDANTS & REDOX SIGNALING

Thyroid Replacement Therapy and Heart Failure

(2010) Anthony Martin Gerdes et al.   CIRCULATION

Proinflammatory cytokines in heart failure: double-edged swords

(2010) Mona Hedayat et al.   HEART FAILURE REVIEWS

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated Cytokine and Metabolic Analysis of Pathological Responses to Parasite Exposure in Rodents

(2010) Jasmina Saric et al.   JOURNAL OF PROTEOME RESEARCH

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

Critical Role for IL-6 in Hypertrophy and Fibrosis in Chronic Cardiac Allograft Rejection

(2009) J. A. Diaz et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant Immunity

(2009) M. D. Säemann et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Interleukin-6 is a stronger prognostic predictor than high-sensitive C-reactive protein in patients with chronic stable heart failure

(2009) Borut Jug et al.   HEART AND VESSELS

Mammalian Target of Rapamycin Is a Critical Regulator of Cardiac Hypertrophy in Spontaneously Hypertensive Rats

(2009) Will Soesanto et al.   HYPERTENSION

Noninvasive Detection of Fibrosis Applying Contrast-Enhanced Cardiac Magnetic Resonance in Different Forms of Left Ventricular Hypertrophy

(2009) Andre Rudolph et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages

(2008) Jian-Qiu Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload

(2008) Ying Xia et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Protein Kinase C-δ and Phosphatidylinositol 3-Kinase/Akt Activate Mammalian Target of Rapamycin to Modulate NF-κB Activation and Intercellular Adhesion Molecule-1 (ICAM-1) Expression in Endothelial Cells

(2008) Mohd Minhajuddin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function

(2008) Wei-Hua Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokines and Myocardial Dysfunction: State of the Art

(2008) Ayman A. El-Menyar   JOURNAL OF CARDIAC FAILURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

(2008) Jian-Hua Mao et al.   SCIENCE

Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction

(2007) Leo Timmers et al.   CIRCULATION RESEARCH