Article
Neurosciences
Suzanne M. Underhill, Susan G. Amara
Summary: Stimulation of M-1/M-5 muscarinic receptors in midbrain cultures has been found to decrease the ability of dopamine neurons to transport dopamine through DAT. Cholinomimetic drugs lead to a decrease in DAT activity, while M-1/M-5-specific antagonists can block these effects, implicating M-1/M-5 receptors in the modulation of DAT function on dopamine neurons.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Diana J. M. van den Wollenberg, Vera Kemp, Martijn J. W. E. Rabelink, Rob C. Hoeben
Summary: This study demonstrates that reoviruses efficiently induce necroptosis in mouse cells but not in human cells, likely due to the RIPK3 expression defect in human cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yudian Zhang, Zihua Li, Xinyi Liu, Xinyu Chen, Shujie Zhang, Yuemeng Chen, Jiangnan Chen, Jin Chen, Fuqing Wu, Guo-Qiang Chen
Summary: 3-Hydroxybutyrate (3HB), a small ketone body produced in the liver, has been found to reduce blood glucose levels in type 2 diabetic patients. However, the mechanism behind this effect is not well-understood. This study demonstrates that 3HB decreases fasting blood glucose levels and improved insulin resistance in type 2 diabetic mice through the activation of HCAR2. The mechanism involves the activation of intracellular calcium ion levels, followed by the stimulation of AC, the increase in cAMP concentration, activation of PKA, inhibition of Raf1 activity, suppression of ERK1/2 activity, and the reduction of PPARγ Ser273 phosphorylation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Microbiology
Axel Dietschmann, Sebastian Schruefer, Stefanie Westermann, Fiona Henkel, Kirstin Castiglione, Ralf Willebrand, Jasmin Adam, Jurgen Ruland, Roland Lang, Donald C. Sheppard, Julia Esser-von-Bieren, Daniel Radtke, Sven Krappmann, David Voehringer
Summary: Eosinophilia is associated with various inflammatory diseases, such as allergic bronchopulmonary aspergillosis (ABPA). It has been shown that direct interaction between eosinophils and Aspergillus fumigatus is essential for the activation of eosinophils, which then secrete multiple proinflammatory mediators. The PI3K-AKT-mTOR pathway plays a crucial role in A. fumigatus-induced eosinophil activation.
Article
Biochemistry & Molecular Biology
Juying Jiao, Linjie Ruan, Chien-shan Cheng, Fengjiao Wang, Peiwen Yang, Zhen Chen
Summary: In this study, aberrantly expressed kinases in pancreatic cancer (PC) were identified, and the role of RIPK2 kinase was validated in promoting cancer cell proliferation, migration, and invasion. RIPK2 knockout inhibited tumor growth and metastasis in PC, and also affected autophagosome formation, ROS production, and cell apoptosis. Additionally, the interaction between oncogenic kinase PRKCI and RIPK2 was found to enhance the downstream phosphorylation of NF-κB, JNK, and ERK.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ling Yu, Mohammad-Zaman Nouri, Lauren P. Liu, Niharika Bala, Nancy D. Denslow, John F. Jr Jr LaDisa, Abdel A. Alli
Summary: This study aimed to investigate the mechanisms of EnNaC regulation associated with NPRC activation. The results showed that EnNaC protein expression and activity were reduced after treatment with an NPRC agonist, and this down-regulation was mediated by the DAG-PKC pathway. These findings have important implications for understanding the regulation of endothelial function and aortic stiffness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Rubi Hernandez-Rojas, Carolina Jimenez-Arellano, Marisol de la Fuente-Granada, David Ordaz-Rosado, Rocio Garcia-Becerra, Pedro Valencia-Mayoral, Lourdes Alvarez-Arellano, Pilar Eguia-Aguilar, Marco A. Velasco-Velazquez, Aliesha Gonzalez-Arenas
Summary: Medulloblastoma is the most common and aggressive pediatric intracranial tumor. The expression and phosphorylation of estrogen receptor beta (ER beta) are associated with Medulloblastoma development. Protein kinases C (PKCs) alpha and delta have been identified as potential regulators of ER beta through phosphorylation. The activation of ER beta by PKC alpha and PKC delta promotes proliferation and invasion of Medulloblastoma cells.
CELLULAR SIGNALLING
(2022)
Review
Endocrinology & Metabolism
Devanshi Mishra, Chinmoy Sankar Dey
Summary: Protein kinase C alpha (PKCα) is involved in various signaling pathways and may play a crucial role in regulating both Alzheimer's disease and diabetes simultaneously, though the interconnection between these pathways has not been fully explored. Understanding the complexities of PKCα interactions with common molecules could provide insights into its therapeutic potential in relevant pathophysiologies.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Baptiste Colcombet-Cazenave, Florence Cordier, Yanlei Zhu, Guillaume Bouvier, Eleni Litsardaki, Louise Laserre, Marie S. Prevost, Bertrand Raynal, Celia Caillet-Saguy, Nicolas Wolff
Summary: Hearing relies on the transduction of sound-evoked vibrations into electrical signals, and the proteins ADGRV1 and PDZD7 are involved in the formation and function of stereocilia. PDZD7 inhibits the GPCR activity of ADGRV1 during hair cell development through an unknown mechanism. The N-terminal PDZ domains of PDZD7 interact with the cytoplasmic domain of ADGRV1, and their stability and binding properties are affected by deafness-causing mutations in PDZD7.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Joy Kar, Sumanta Kar, Arnab Gupta, Siddhartha S. Jana
Summary: Endocytic vesicular trafficking requires the merging of two lipid bilayers, and the involvement of nonmuscle myosin IIs (NM IIs) in fusion and fission processes has been explored. Knocking down NM IIs or inhibiting their activities leads to the formation of ring-like assemblies of early endosomes (raEE). The assembly and disassembly dynamics of NM II play a role in regulating fission and maintaining the size of early endosomes.
Article
Biochemistry & Molecular Biology
Md Omar Faruk, Daisuke Tsuboi, Yukie Yamahashi, Yasuhiro Funahashi, You-Hsin Lin, Rijwan Uddin Ahammad, Emran Hossen, Mutsuki Amano, Tomoki Nishioka, Anastasios Tzingounis, Kiyofumi Yamada, Taku Nagai, Kozo Kaibuchi
Summary: The nucleus accumbens (NAc) plays crucial roles in emotional behaviors, and muscarinic signaling induces the phosphorylation of KCNQ2 at T217 via PKC activation for aversive learning. Electric foot shock and donepezil can induce this phosphorylation, while an M1R antagonist can suppress this process.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Keon-Hee Lee, Jae Won Song, Chong -Su Kim, Hobin Seong, Dong-Mi Shin, Woo- Jeong Shon
Summary: This study investigates the role of TAS1R3 in regulating cognitive impairment induced by long-term consumption of a western diet (WD) in mice. The results show that only wild-type mice fed WD exhibit cognitive impairment, while mice lacking TAS1R3 are not affected even under long-term WD feeding.
Article
Cell Biology
Hanlin Ma, Fang Han, Xiaohui Yan, Gonghua Qi, Yingwei Li, Rongrong Li, Shi Yan, Cunzhong Yuan, Kun Song, Beihua Kong
Summary: Cervical cancer is the fourth most common cancer in women globally, and the overexpression of PBK in cervical cancer tissues promotes proliferation, metastasis, and cisplatin resistance of cancer cells through the ERK/c-Myc signaling pathway. Inhibition of PBK with OTS514 shows promising results in suppressing tumor growth and enhancing chemosensitivity. Further studies on PBK as a molecular target for cervical cancer treatment are warranted.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dermatology
Zhiping Wang, Yeon Jung Yoo, Rachel De La Torre, Christina Topham, Jon Hanifin, Eric Simpson, Robert O. Messing, Molly Kulesz-Martin, Yuangang Liu
Summary: TRIM32 deficiency enhances Th2 cell differentiation and is associated with atopic dermatitis. PKC is specifically ubiquitinated by TRIM32, influencing Th2 signaling regulation. High PKC and low TRIM32 levels are associated with the pathogenesis of AD.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shotaro Michinaga, Ayaka Nagata, Ryosuke Ogami, Yasuhiro Ogawa, Shigeru Hishinuma
Summary: This study aimed to explore how H1 receptor-mediated ERK phosphorylation is regulated by Gq proteins and arrestins. The results showed that the Gq protein pathway mainly regulates early phosphorylation reaction, while the arrestin pathway mainly regulates late phosphorylation reaction.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Neurosciences
Clint J. Perry, Lars Chittka
CURRENT OPINION IN NEUROBIOLOGY
(2019)
Article
Entomology
Cui Guan, Michaela Egertova, Clint J. Perry, Lars Chittka, Alexandra Chittka
JOURNAL OF INSECT PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Simon Klein, Cristian Pasquaretta, Xu Jiang He, Clint Perry, Eirik Sovik, Jean-Marc Devaud, Andrew B. Barron, Mathieu Lihoreau
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Cwyn Solvi, Selene Gutierrez Al-Khudhairy, Lars Chittka
Article
Behavioral Sciences
HaDi MaBouDi, Cwyn Solvi, Lars Chittka
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Article
Behavioral Sciences
Jose E. Romero-Gonzalez, Cwyn Solvi, Lars Chittka
Article
Biology
HaDi MaBouDi, Andrew B. Barron, Sun Li, Maria Honkanen, Olli J. Loukola, Fei Peng, Wenfeng Li, James A. R. Marshall, Alex Cope, Eleni Vasilaki, Cwyn Solvi
Summary: The study explores how bees solve a visual discrimination task with stimuli, finding that bees rely on continuous rather than numerical cues, and proposing a new network model. The results support the idea that a sense of magnitude may be more primitive and basic than a sense of number, while highlighting the challenges of inadvertent continuous cues in studies of numerical cognition.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Biology
Luigi Baciadonna, Cwyn Solvi, Sara La Cava, Cristina Pilenga, Marco Gamba, Livio Favaro
Summary: The research showed that penguins can cross-modally recognize familiar conspecifics through sound, but this ability was not observed when they were paired with their partners. This suggests that social communication strategies among penguins may involve visual cues as well, contrary to previous beliefs.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Li Li, Cwyn Solvi, Feng Zhang, Zhaoyang Qi, Lars Chittka, Wei Zhao
Summary: The study demonstrates a causal link between certain gut bacteria in bumblebees and their long-term memory, suggesting the potential for gut microbiome to influence cognitive differences in animals is still not fully explored.
NATURE COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Hiruni Samadi Galpayage Dona, Cwyn Solvi, Amelia Kowalewska, Kaarle Makela, HaDi MaBouDi, Lars Chittka
Summary: In this study, we found that bumble bees engage in play behavior by rolling wooden balls, fulfilling the criteria for animal play and resembling play behavior in other animals. The results contribute to our understanding of insect sentience and provide further evidence for the presence of positive affective states in these animals.
Article
Urology & Nephrology
Seong-Ki Lee, Rossana Occhipinti, Fraser J. Moss, Mark D. Parker, Irina I. Grichtchenko, Walter F. Boron
Summary: This study aims to differentiate the movements of HCO3 2, CO35, and H1 across membranes. Through electrophysiology and heterologous expression in Xenopus oocytes, the researchers investigated the transport of bicarbonate (HCO32) by SLC4 family members. The results showed that the Cl-HCO3 exchanger AE1 (SLC4A1) can transport HCO32, while the electrogenic Na/HCO3 cotransporter NBCe1 (SLC4A4) and the electroneutral Na1-driven Cl-HCO3 exchanger NDCBE (SLC4A8) cannot. Mathematical simulations further supported CO35 transport as the mechanism for NBCe1.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biology
Cwyn Solvi, Yonghe Zhou, Yunxiao Feng, Yuyi Lu, Mark Roper, Li Sun, Rebecca J. Reid, Lars Chittka, Andrew B. Barron, Fei Peng
Summary: This study found that bumblebees' preferences are based only on memories of ordinal comparisons. They use absolute information to rank different flowers, but memories for absolute information are lost or cannot be retrieved after 1 hour.
Article
Entomology
Jose E. Romero-Gonzalez, Amanda L. Royka, HaDi MaBouDi, Cwyn Solvi, Janne-Tuomas Seppanen, Olli J. Loukola
Article
Behavioral Sciences
Yonghe Zhou, Li Sun, Xiaodan Peng, Cwyn Solvi, Fei Peng
Article
Multidisciplinary Sciences
James C. Makinson, Joseph L. Woodgate, Andy Reynolds, Elizabeth A. Capaldi, Clint J. Perry, Lars Chittka
SCIENTIFIC REPORTS
(2019)