Article
Oncology
Leah A. Marsh, Emeline M. Aviki, Jason D. Wright, Ling Chen, Nadeem Abu-Rustum, Ritu Salani
Summary: This study estimates the annual cost of wasted indocyanine green (ICG) used for sentinel lymph node mapping in patients with endometrial cancer. The findings show that the current manufactured vial size of ICG leads to wasted costs exceeding $2 million for hospitals and $13.3-$17.7 million for patients annually. The study suggests packaging ICG in smaller vials to avoid drug waste and financial impact.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Xiao Wu, Qian-Ying Mao, Yi-Fan Kang, Shang Xie, Xiao-Feng Shan, Zhi-Gang Cai
Summary: This study demonstrated the feasibility of using methylene blue for NIR fluorescence imaging in detecting oral sentinel lymph nodes in rats. Methylene blue caused less fluorescent contamination compared to indocyanine green, showing promise for clinical research and application.
Article
Oncology
M. Maramai, M. T. Achilarre, A. Aloisi, I. Betella, S. Bogliolo, A. Garbi, M. Maruccio, C. Quatrale, G. D. Aletti, A. Mariani, N. Colombo, A. Maggioni, F. Multinu, V. Zanagnolo
Summary: A study on 251 endometrial cancer patients undergoing robotic-assisted surgical staging and SLN biopsy found that cervical re-injection of ICG significantly increased SLN detection rates, reducing the need for side-specific lymphadenectomies.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Nicolo Bizzarri, Andrea Rosati, Giovanni Scambia, Francesco Fanfani
Summary: Occult endometrial cancer after supracervical hysterectomy is rare, and restaging should be considered for optimal management. A case report described a patient with metastatic parametrium after laparoscopic surgery, highlighting the feasibility of SLN mapping with cervical injection even without the uterine corpus.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Ori Tal, Ehud Grinstein, Elinor Goshen, Yakov Oksman, Mordechai Lorberboym, Osnat Elyashiv, Erez Ben Shem, Ofri Peled, Tally Levy
Summary: The combination of ICG and Tc99m-FSC can improve the bilateral sentinel lymph node detection rate in endometrial cancer patients. However, in cases of unilateral mapping failure, relying solely on the anatomic location of the ipsilateral SLN for predicting the location of the complementary node is not reliable due to poor symmetric concordance.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Review
Oncology
Lirong Zhai, Xiwen Zhang, Manhua Cui, Jianliu Wang
Summary: Endometrial cancer is a common gynecological malignancy with increasing incidence rates annually. Lymph node status is crucial for prognosis evaluation and treatment selection. Sentinel lymph node mapping (SLNM) in early-stage lower risk EC patients has shown high detection rate and sensitivity without compromising patient survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yu Xue, Wei-wei Shan, Qian Wang, Chao Wang, Xue-zhen Luo, Xiao-jun Chen
Summary: SLN mapping with ICG showed high detection rates and acceptable diagnostic efficacy in Chinese women with endometrial cancer, but may lead to higher missed diagnoses in patients with high-intermediate risk.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Philippe Van Trappen
Summary: The concept of pelvic sentinel lymph node mapping has been well investigated in endometrial and cervical cancer, showing safety, efficacy, and diagnostic accuracy. The concept of pelvic sentinel lymph node biopsy has been incorporated in international guidelines for early-stage endometrial and cervical cancer. The application of para-aortic sentinel lymph node mapping is still in development but shows promising results in initial studies.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Review
Medicine, General & Internal
Hans Nagar, Nina Wietek, Richard J. Goodall, Will Hughes, Mia Schmidt-Hansen, Jo Morrison
Summary: Pelvic lymphadenectomy provides prognostic information for endometrial cancer patients, but has not shown therapeutic benefits and causes significant morbidity. Sentinel lymph node biopsy (SLNB) has high diagnostic accuracy in detecting pelvic lymph node involvement in early stage endometrial cancer, with different tracers affecting detection rates. Further research is needed to evaluate the value of SLNB in treatment pathways and to conduct high-quality intervention studies.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Obstetrics & Gynecology
Aharon Dick, Tamar Perri, Liron Kogan, Benny Brandt, Raanan Meyer, Gabriel Levin
Summary: The guidelines for sentinel lymph node mapping in endometrial cancer are comparable in terms of surgical technique, ultrastaging, and management in case of failed mapping. However, there are some variations in the management of high-grade histology and positive pelvic lymph nodes.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Chenguang Zhang, Yongtao Li, Xiaowen Wang, Mingshuai Zhang, Weihua Jiang, Jianghua Ou
Summary: The study showed that the combined application of ICG and MB for SLNB is more effective in detecting SLNs compared to using MB alone, with a higher detection rate and more SLNs harvested per patient. However, there was no significant difference in false negative rate between the two methods.
Article
Oncology
Xinyue Zhang, Bingting Bao, Sixue Wang, Mingyu Yi, Li Jiang, Xiaoling Fang
Summary: This study revealed that sentinel lymph node biopsy can accurately predict lymph node metastasis in early stage cervical cancer patients, with a high detection rate and specific sensitivity. Despite heterogeneity in studies, the use of indocyanine green tracer for sentinel lymph node mapping appears to be superior to other methods currently available.
Article
Oncology
Stefano Cianci, Andrea Rosati, Virginia Vargiu, Vito Andrea Capozzi, Giulio Sozzi, Alessandro Gioe, Salvatore Gueli Alletti, Alfredo Ercoli, Francesco Cosentino, Roberto Berretta, Vito Chiantera, Giovanni Scambia, Francesco Fanfani
Summary: Aging is a risk factor for SLN mapping failure, increasing the risk of mapping failure with each year. Older patients have a higher incidence of independent risk factors such as LVSI, non-endometrioid histotype, and BMI, leading to increased likelihood of unsuccessful mapping.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lina Salman, Maria C. Cusimano, Zibi Marchocki, Sarah E. Ferguson
Summary: Sentinel lymph node mapping is a viable alternative to full lymphadenectomy for evaluating lymphatic spread in clinical stage I endometrial cancer. While lymphadenectomy provides valuable information, most patients do not benefit from this procedure. SLN mapping offers prognostic information and avoids postoperative complications.
Review
Oncology
Julio Jimenez-Lillo, Eduardo Villegas-Tovar, Dulce Momblan-Garcia, Victor Turrado-Rodriguez, Ainitze Ibarzabal-Olano, Borja De Lacy, Alejandro Diaz-Giron-Gidi, Regina Faes-Petersen, Raigam J. Martinez-Portilla, Antonio Lacy
Summary: The study evaluated the detection rate of ICG imaging for sentinel lymph node mapping and lymph node metastases in esophageal cancer, with a detection rate of 89% for SLNM and a sensitivity of 84% for LNMs in the pooled analysis.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Ignacio Zapardiel, Myriam Gracia, Javier Diez, Alessandro Buda, Maria C. Noya, Pierandrea De Iaco, Pedro Vieira-Baptista, Sara Iacoponi
Summary: The study concluded that postoperative radiotherapy appears to be the only independent factor associated with recurrence and overall survival in rare types of vulvar cancer.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Oncology
David Cibula, Roman Kocian, Andrea Plaikner, Jiri Jarkovsky, Jaroslav Klat, Ignacio Zapardiel, Radovan Pilka, Aureli Torne, Borek Sehnal, Marcela Ostojich, Almerinda Petiz, Octavio A. Sanchez, Jiri Presl, Alessandro Buda, Francesco Raspagliesi, Peter Kascak, Luc van Lonkhuijzen, Marc Barahona, Lubos Minar, Pawel Blecharz, Maja Pakiz, Dariusz Wydra, Leon C. Snyman, Kamil Zalewski, Cristina Zorrero, Pavel Havelka, Mikulas Redecha, Alla Vinnytska, Ignace Vergote, Solveig Tingulstad, Martin Michal, Barbara Kipp, Jiri Slama, Simone Marnitz, Sylva Bajsova, Alicia Hernandez, Daniela Fischerova, Kristyna Nemejcova, Christhardt Kohler
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Oncology
Lorenzo Ceppi, Tommaso Grassi, Francesca Galli, Alessandro Buda, Giovanni Aletti, Andrea Alberto Lissoni, Marco Adorni, Annalisa Garbi, Nicoletta Colombo, Cristina Bonazzi, Fabio Landoni, Robert Fruscio
Summary: The study found that early-stage clear cell ovarian cancer has a longer relapse-free interval and similar cancer-specific survival compared to serous ovarian cancer, but a shorter post-relapse cancer-specific survival. Histological subtype of ovarian tumors affects patients' prognosis, and early use of adjuvant chemotherapy can improve the relapse-free interval.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Giorgio Bogani, Andrea Papadia, Alessandro Buda, Jvan Casarin, Violante Di Donato, Maria Luisa Gasparri, Francesco Plotti, Ciro Pinelli, Maria Chiara Paderno, Salvatore Lopez, Anna Myriam Perrone, Fabio Barra, Rocco Guerrisi, Claudia Brusadelli, Antonella Cromi, Debora Ferrari, Valentina Chiapp, Mauro Signorelli, Umberto Leone Roberti Maggiore, Antonino Ditto, Innocenza Palaia, Simone Ferrero, Pierandrea De Iaco, Roberto Angioli, Pierluigi Benedetti Panici, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Francesco Raspagliesi
Summary: This study evaluated the outcomes of high-risk EC patients undergoing SNM, with or without back-up lymphadenectomy, and found that the type of nodal assessment did not impact survival outcomes. Back-up lymphadenectomy may help remove positive nodes, but its therapeutic value remains controversial.
GYNECOLOGIC ONCOLOGY
(2021)
Biographical-Item
Oncology
Alessandro Buda, Pedro T. Ramirez, Giovanni Scambia
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Correction
Oncology
Alessandro Buda, Jvan Casarin, Michael Mueller, Francesco Fanfani, Ignacio Zapardiel, Liliana Mereu, Andrea Puppo, Elena De Ponti, Marco Adorni, Debora Ferrari, Maria Luisa Gasparri, Fabio Ghezzi, Giovanni Scambia, Andrea Papadia
Summary: The name of the second author in the original article is incorrect.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Francesco Fanfani, Luigi Pedone Anchora, Giampaolo Di Martino, Nicolo Bizzarri, Maria Letizia Di Meo, Vittoria Carbone, Mariachiara Paderno, Camilla Fedele, Cristiana Paniga, Anna Fagotti, Fabio Landoni, Giovanni Scambia, Alessandro Buda
Summary: Objective conization/simple trachelectomy is feasible for early-stage cervical cancer patients desiring fertility preservation. This study in two Italian centers provided oncologic and obstetric outcomes of patients with 2018 FIGO stage IB1 cervical cancer managed by conization, demonstrating favorable oncologic outcomes and successful pregnancies in this group of patients. Future prospective studies are needed for further insight.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Kristen Moloney, Monika Janda, Michael Frumovitz, Mario Leitao, Nadeem R. Abu-Rustum, Emma Rossi, James L. Nicklin, Marie Plante, Fabrice R. Lecuru, Alessandro Buda, Andrea Mariani, Yee Leung, Sarah Elizabeth Ferguson, Rene Pareja, Rainer Kimmig, Pearl Shuang Ye Tong, Orla McNally, Naven Chetty, Kaijiang Liu, Ken Jaaback, Julio Lau, Soon Yau Joseph Ng, Henrik Falconer, Jan Persson, Russell Land, Fabio Martinelli, Andrea Garrett, Alon Altman, Adam Pendlebury, David Cibula, Roberto Altamirano, Donal Brennan, Thomas Edward Ind, Cornelis De Kroon, Ka Yu Tse, George Hanna, Andreas Obermair
Summary: Specific mandatory and prohibited steps of sentinel lymph node dissection in endometrial cancer have been identified and validated based on consensus among a large number of international experts. A competency assessment tool is now available and can be used for surgeon selection in clinical trials and for ongoing, prospective quality assurance in routine clinical care. The tool demonstrated high internal consistency and was effective in differentiating between skill levels in surgical videos.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Chiara Comerio, Marta Jaconi, Benedetta Zambetti, Mariachiara Paderno, Maria Gabriella Valente, Alessandro Buda
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Khaled Ghoniem, Alyssa M. Larish, Giorgia Dinoi, Xun Clare Zhou, Mariam Alhilli, Sumer Wallace, Christoph Wohlmuth, Glauco Baiocchi, Nedim Tokgozoglu, Francesco Raspagliesi, Alessandro Buda, Vanna Zanagnolo, Ignacio Zapardiel, Nisha Jagasia, Robert Giuntoli, Ariel Glickman, Michele Peiretti, Maximillian Lanner, Enrique Chacon, Julian Di Guilmi, Augusto Pereira, Enora Laas, Ami Fishman, Caroline C. Nitschmann, Susan Parker, Amy Joehlin-Price, Brittany Lees, Allan Covens, Louise De Brot, Cagatay Taskiran, Giorgio Bogani, Cristiana Paniga, Francesco Multinu, Alicia Hernandez-Gutierrez, Amy L. Weaver, Michaela E. McGree, Andrea Mariani
Summary: The study evaluated oncologic outcomes in endometrial cancer patients with low-volume metastasis in the sentinel lymph nodes, finding that Non-endometrioid histology, lymphovascular space invasion, and uterine serosal invasion were independent risk factors for recurrence. Patients with any of these risk factors had poor prognosis even with adjuvant therapy. On the other hand, patients with isolated tumor cell and grade 1 endometrioid disease had favorable prognosis even without adjuvant therapy, suggesting a potential for withholding adjuvant therapy in this low-risk subgroup.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Giorgio Bogani, Andrea Papadia, Alessandro Buda, Jvan Casarin, Violante Di Donato, Francesco Plotti, Maria Luisa Gasparri, Chiara Cimmino, Ciro Pinelli, Anna Myriam Perrone, Fabio Barra, Antonella Cromi, Giampaolo Di Martino, Innocenza Palaia, Simone Ferrero, Alice Indini, Pierandrea De Iaco, Roberto Angioli, Daniela Luvero, Ludovico Muzii, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Pierluigi Benedetti Panici, Francesco Raspagliesi
Summary: The study identified body mass index and open abdominal surgery as independent factors predicting surgery-related morbidity in patients undergoing surgical staging for high-risk endometrial cancer. Laparoscopic surgery and sentinel node mapping were associated with a lower risk of surgery-related events in these patients.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Oncology
Stefano Restaino, Alessandro Buda, Andrea Puppo, Vito Andrea Capozzi, Giulio Sozzi, Jvan Casarin, Vitalba Gallitelli, Ferdinando Murgia, Giuseppe Vizzielli, Alessandro Baroni, Giacomo Corrado, Tina Pasciuto, Debora Ferrari, Antonia Novelli, Roberto Berretta, Francesco Legge, Enrico Vizza, Vito Chiantera, Fabio Ghezzi, Fabio Landoni, Giovanni Scambia, Francesco Fanfani
Summary: This study aimed to evaluate the anatomical distribution of sentinel lymph nodes (SLNs) and the most frequent locations of nodal metastasis in endometrial cancer patients. The majority of SLNs and positive SLNs were found at the external iliac and obturator level. Older age, higher body mass index, and non-endometrioid histology negatively impacted SLN mapping.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Oncology
Alessandro Buda, Martina Borghese, Andrea Puppo, Stefania Perotto, Antonia Novelli, Chiara Borghi, Elena Olearo, Elisa Tripodi, Alessandra Surace, Enrica Bar, Giovanni Scambia, Francesco Fanfani
Summary: This article aims to provide assistance to women affected by IB2 cervical cancer who wish to preserve fertility. Research indicates that neoadjuvant chemotherapy offers a conservative option for tumors larger than 2cm, and suboptimal response may have a negative impact on survival. An algorithm is proposed to aid in decision-making for this specific subgroup of patients.
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Lavinia Monaco, Gregory Mathoux, Cinzia Crivellaro, Federica Elisei, Alessandro Buda, Robert Fruscio, Claudio Landoni, Luca Guerra, Cristina Messa, Elisabetta De Bernardi
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Alessandro Buda, Jvan Cesarin, Michael Mueller, Francesco Fanfani, Ignacio Zapardiel, Liliana Mereu, Andrea Puppo, Elena De Ponti, Marco Adorni, Debora Ferrari, Maria Luisa Gasparri, Fabio Ghezzi, Giovanni Scambia, Andrea Papadia
Summary: Ultrastaging analysis increased the detection rate of low-volume metastasis in women with early-stage cervical cancer, but the type of nodal staging did not impact patients' 3-year disease-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)