Article
Chemistry, Multidisciplinary
Vanessa N. Frey, Nora Renz, Aljoscha Thomschewski, Patrick B. Langthaler, Frank J. van Schalkwijk, Eugen Trinka, Yvonne Hoeller
Summary: Exercise can modulate the connectivity patterns in brain regions responsible for movement execution and imagination after spinal cord injury. However, the correlation between activity effects on neuroplasticity and connectivity patterns in the brain has not been analyzed.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Grazia Maugeri, Alessandra Amato, Martina Sortino, Velia D'Agata, Giuseppe Musumeci
Summary: Spinal cord injury (SCI) leads to sensory and motor function loss. The pathophysiology of SCI involves primary and secondary phases, with oxidative stress playing a significant role in the secondary phase. Exercise is crucial for promoting well-being and quality of life, impacting various systems and potentially regulating the balance between pro-oxidants and antioxidants. This review aims to investigate the effects of exercise on oxidative stress in individuals with SCI, following an overview of spinal cord anatomy and different types of injury.
Article
Nanoscience & Nanotechnology
Bo Zhao, Hao Huang
Summary: The potential healing function of regular exercise on spinal cord injury healing response was investigated in a rat model. The study demonstrated that animals receiving both regular exercise and hydrogel treatment showed improved histopathological signs and functional recovery. This hybrid treatment reduced edema, vacuolation, and fibrosis, while upregulating the expression levels of VEGF, b-FGF, and TGF-β genes.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Adria Marco-Ahullo, Lluisa Montesinos-Magraner, Luis-Millan Gonzalez, Teresa Crespo-Rivero, Patricia Launois-Obregon, Xavier Garcia-Masso
Summary: This study aimed to analyze the effect of the ParaSportAPP on physical and psychological variables in individuals with paraplegia. Results showed no significant differences in any of the variables between the measurement times. However, the ParaSportAPP mobile application was able to lessen the impact of the pandemic on these variables.
Article
Clinical Neurology
James A. G. Crispo, Lisa J. W. Liu, Vanessa K. Noonan, Nancy P. Thorogood, Brian K. Kwon, Marcel F. Dvorak, Dylan Thibault, Allison W. Willis, Jacquelyn J. Cragg
Summary: This study aimed to describe national trends in emergency department (ED) visits for traumatic spinal cord injury (tSCI) among children in the United States. It found that the annual ED visit rate for tSCI remained stable between 2016 and 2020, with approximately 2,200 new pediatric ED visits for tSCI annually. The study also revealed that most ED visits for tSCI were by older children (15-20 years) and males, who were more likely to be admitted to the hospital. Additionally, it identified American tackle football as the leading cause of sports-related tSCI among children and suggested a possible increase in sports-related tSCI over time.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ciara M. Walsh, Khadija Gull, Dearbhaile Dooley
Summary: Traumatic spinal cord injury (SCI) has a significant impact on motor, sensory and autonomic function in patients. Despite the lack of a curative therapy, modulation of the inflammatory response through motor rehabilitation can improve recovery in SCI models. This review discusses the effect of motor rehabilitation on inflammatory mediators in both preclinical and human SCI studies and highlights the potential of using motor rehabilitation as an immunomodulatory therapy to improve patient outcome after SCI.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Shiwei Sun, Tianlong Zhang, Wuling Zhou, Haitian Huang, Minghai Wang, Feizhou Lyu
Summary: Spinal cord injury was repaired using a moderate treadmill exercise and carica papaya extract-loaded nanocomposite hydrogel. In vitro studies demonstrated that the nanocomposite hydrogel enhanced cell metabolism and exhibited gradual degradation. In vivo study indicated that the developed treatment strategy promoted spinal cord injury repair, as evidenced by histopathological studies and BBB assay.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Sport Sciences
Erin D. Ozturk, Matthew S. Lapointe, Dong-Il Kim, J. W. Hamner, Can Ozan Tan
Summary: This study aimed to assess the cerebral blood flow response to cognitive demand in individuals with SCI and found that aerobic exercise training could improve neurovascular coupling in these individuals.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Review
Health Care Sciences & Services
Gary J. Farkas, Adam M. Burton, David W. McMillan, Alicia Sneij, David R. Jr Jr Gater
Summary: Individuals with spinal cord injuries (SCI) often have risk factors for cardiometabolic risk and cardiometabolic syndrome (CMS), increasing the risk of cardiovascular disease. This narrative review focuses on recent research on the cardiometabolic sequelae of SCI, providing diagnosis and surveillance criteria, as well as lifestyle management strategies to improve cardiometabolic health.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Isley Jesus, Pauline Michel-Flutot, Therese B. Deramaudt, Alexia Paucard, Valentin Vanhee, Stephane Vinit, Marcel Bonay
Summary: This study demonstrated the feasibility of using a mouse model of partial cervical spinal hemisection to investigate the impact of exercise training on locomotor/respiratory plasticity muscles. The results showed that exercise training increased running capacity, improved muscle vascularization, and enhanced fatigue resistance in trained SCI mice, suggesting a promising non-invasive strategy to sustain locomotor and respiratory muscle plasticity following SCI.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Blake M. Hauser, Saksham Gupta, Samantha E. Hoffman, Mark M. Zaki, Anne A. Roffler, David J. Cote, Yi Lu, John H. Chi, Michael W. Groff, Ayaz M. Khawaja, Timothy R. Smith, Hasan A. Zaidi
Summary: The study analyzed a cohort of adult patients with sports-related spinal injuries, finding cycling injuries to be the most common mechanism. Spinal cord injuries were present in 15% of TSI cases and significantly impacted patients' length of stay and discharge to rehabilitative services.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Xiaoping Ren, Weihua Zhang, Jie Qin, Jian Mo, Yi Chen, Jie Han, Xinjian Feng, Sitan Feng, Haibo Liang, Liangjue Cen, Xiaofei Wu, Linxuan Han, Rongyu Lan, Haixuan Deng, Huihui Yao, Zhongquan Qi, Hongjun Gao, Lishan Wei, Shuai Ren
Summary: This study tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal models and developed a new clinical procedure called vascular pedicle hemisected spinal cord transplantation (vSCT) for the treatment of paraplegic patients. The results demonstrated the feasibility and efficacy of vSCT in re-establishing the continuity of spinal nerve fibers, potentially restoring motor, sensory, and autonomic nervous functions in paraplegic patients. Further clinical trials are needed to validate these findings.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Article
Cell Biology
Ganchimeg Davaa, Jin Young Hong, Tae Uk Kim, Seong Jae Lee, Seo Young Kim, Kwonho Hong, Jung Keun Hyun
Summary: The study showed that treadmill exercise can reduce the size of the lesion cavity and the number of macrophages in rats with SCI. It also found increased levels of 5mC and 5hmC in the brain motor cortex, as well as elevated expression of Tet family members (Tet1, Tet2, and Tet3). Moreover, exercise can promote locomotor function recovery in rats with SCI through epigenetic changes in the brain motor cortex.
Article
Biochemistry & Molecular Biology
Fang Guo, Hui He, Zhi-Chao Fu, Shengping Huang, Tingtao Chen, Christopher J. Papasian, Leslie R. Morse, Yan Xu, Ricardo A. Battaglino, Xiao-Feng Yang, Zhisheng Jiang, Hong-Bo Xin, Mingui Fu
BIOCHEMICAL JOURNAL
(2015)
Article
Medicine, General & Internal
Nitin B. Jain, Gregory D. Ayers, Emily N. Peterson, Mitchel B. Harris, Leslie Morse, Kevin C. O'Connor, Eric Garshick
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2015)
Article
Clinical Neurology
Alan M. Jette, Mary D. Slavin, Pengsheng Ni, Pamela A. Kisala, David S. Tulsky, Allen W. Heinemann, Susie Charlifue, Denise G. Tate, Denise Fyffe, Leslie Morse, Ralph Marino, Ian Smith, Steve Williams
JOURNAL OF SPINAL CORD MEDICINE
(2015)
Article
Clinical Neurology
Jaime E. Hart, Leslie Morse, Carlos G. Tun, Robert Brown, Eric Garshick
JOURNAL OF SPINAL CORD MEDICINE
(2016)
Article
Genetics & Heredity
Liang Ye, Leslie R. Morse, Li Zhang, Hajime Sasaki, Jason C. Mills, Paul R. Odgren, Greg Sibbel, James R. L. Stanley, Gee Wong, Ariane Zamarioli, Ricardo A. Battaglino
Article
Biochemistry & Molecular Biology
Yan Xu, Leslie R. Morse, Raquel Assed Bezerra da Silva, Dianhua Wang, Ricardo A. Battaglino
Article
Rehabilitation
Ralph J. Marino, Mary Schmidt-Read, Steven C. Kirshblum, Trevor A. Dyson-Hudson, Keith Tansey, Leslie R. Morse, Daniel. E. Graves
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2016)
Article
Rehabilitation
Mary D. Slavin, Pengsheng Ni, David S. Tulsky, Pamela A. Kisala, Allen W. Heinemann, Susan Charlifue, Denise C. Fyffe, Daniel E. Graves, Ralph J. Marino, Leslie R. Morse, David Rosenblum, Denise Tate, Lynn A. Worobey, Mary Beth Dawson, Alan M. Jette
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2016)
Article
Rehabilitation
Eric Garshick, Sara Mulroy, Daniel E. Graves, Karen Greenwald, John A. Horton, Leslie R. Morse
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2016)
Article
Endocrinology & Metabolism
L. R. Morse, N. Nguyen, R. A. Battaglino, A. J. Guarino, D. R. Gagnon, R. Zafonte, E. Garshick
OSTEOPOROSIS INTERNATIONAL
(2016)
Article
Anesthesiology
Yumi Maeda, Norman Kettner, Jieun Kim, Hyungjun Kim, Stephen Cina, Cristina Malatesta, Jessica Gerber, Claire McManus, Alexandra Libby, Pia Mezzacappa, Ishtiaq Mawla, Leslie R. Morse, Joseph Audette, Vitaly Napadow
Article
Biophysics
Y. Fang, L. R. Morse, N. Nguyen, N. G. Tsantes, K. L. Troy
JOURNAL OF BIOMECHANICS
(2017)
Article
Endocrinology & Metabolism
Ashley L. Doherty, Ricardo A. Battaglino, Jayne Donovan, David Gagnon, Antonio A. Lazzari, Eric Garshick, Ross Zafonte, Leslie R. Morse
JOURNAL OF BONE AND MINERAL RESEARCH
(2014)
Article
Clinical Neurology
Yumi Maeda, Hyungjun Kim, Norman Kettner, Jieun Kim, Stephen Cina, Cristina Malatesta, Jessica Gerber, Claire McManus, Rebecca Ong-Sutherland, Pia Mezzacappa, Alexandra Libby, Ishtiaq Mawla, Leslie R. Morse, Ted J. Kaptchuk, Joseph Audette, Vitaly Napadow
Article
Rehabilitation
Bianca F. Marcondes, Shruti Sreepathi, Justin Markowski, Dung Nguyen, Shannon R. Stock, Sandra Carvalho, Denise Tate, Ross Zafonte, Leslie R. Morse, Felipe Fregni
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2016)