Article
Radiology, Nuclear Medicine & Medical Imaging
Georgios Benetos, Dominik C. Benz, Georgios P. Rampidis, Andreas A. Giannopoulos, Elia von Felten, Adam Bakula, Aleksandra Sustar, Tobias A. Fuchs, Aju P. Pazhenkottil, Catherine Gebhard, Philipp A. Kaufmann, Christoph Grani, Ronny R. Buechel
Summary: CAVi, derived from CCTA, is proposed as an indicator of diffuse atherosclerosis. This study found that CAVi is moderately correlated with stress MBF and MFR, and has incremental value in predicting abnormal stress MBF and ischemia compared to CCTA alone.
EUROPEAN RADIOLOGY
(2021)
Review
Clinical Neurology
Yanzhao Dong, Ahmad Alhaskawi, Haiying Zhou, Xiaodi Zou, Zhenfeng Liu, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Alenikova Olga, Sahar Ahmed Abdalbary, Yongsheng Chi, Hui Lu
Summary: Peripheral nerve injuries (PNIs) can result from various causes and have different severity levels and clinical manifestations. Imaging techniques play a crucial role in the accurate diagnosis, treatment planning, and monitoring of PNIs. This article provides an overview of the causes, severity, and clinical manifestations of PNIs, emphasizing the importance of imaging in their management.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Mitchel R. Stacy
Summary: Peripheral arterial disease (PAD) is a non-coronary artery atherosclerotic disorder that affects the lower extremities and is associated with various health consequences. The diagnosis is typically made using non-invasive tests, but nuclear medicine techniques have recently emerged as a potential tool for assessing the functional consequences of PAD-related limb ischemia.
FRONTIERS IN MEDICINE
(2022)
Article
Peripheral Vascular Disease
Jeremy B. Provance, John A. Spertus, Philip G. Jones, Mark A. Hoffman, Matthew C. Bunte, Todd R. Vogel, Carlos Mena-Hurtado, Kim G. Smolderen
Summary: This study used an EHR database to investigate the 30-day major amputation rates following PVI in patients with CLI. The results showed that amputation rates varied across institutions, and patient-level factors and site characteristics accounted for most of the variation in these rates.
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yongxing Jiang, Jingxue Fan, Yong Li, Guodong Wu, Yuanqi Wang, Jiemei Yang, Mengjiao Wang, Zhengyu Cao, Qiannan Li, Hui Wang, Zhengyan Zhang, Yu Wang, Bicheng Li, Fengyu Sun, Haiyu Zhang, Zhiguo Zhang, Kang Li, Ye Tian
Summary: Sonodynamic therapy significantly decreased plaque inflammation and improved walking performance among symptomatic PAD patients, showing potential and efficacy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Surgery
Isaac N. Naazie, Isibor Arhuidese, Ahsan Zil-E-Ali, Jeffrey J. Siracuse, Mahmoud B. Malas
Summary: Despite prior literature recommending against limb salvage in patients with poor functional status such as nonambulatory patients with chronic limb-threatening ischemia (CLTI), peripheral endovascular interventions continue to be carried out in this group of patients. Clinical outcomes following these interventions are, however, not well-characterized. Ambulatory impairment in patients with CLTI is associated with a significant increase in 30-day mortality and significant decrease in amputation-free survival after peripheral endovascular intervention. Bedridden patients had a 6-fold increase in the 30-day death rate, whereas their amputation-free survival dropped to less than 50% at 1 year. These risks should be considered during shared decision-making regarding management options for nonambulatory patients with CLTI.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Hematology
Joshua Zhaojun Xian, Mimi Lu, Felicia Fong, Rong Qiao, Nikhil Rajesh Patel, Dishan Abeydeera, Sidney Iriana, Linda L. Demer, Yin Tintut
Summary: The study suggests that pravastatin treatment alters the microarchitecture of aortic calcium deposits, potentially impacting plaque stability.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Chemistry, Organic
Aaron Schuell, Lisa Grothe, Eduardo Rodrigo, Thomas Erhard, Siegfried R. Waldvogel
Summary: A novel electrosynthetic approach for the synthesis of aryl dibenzothiophenium salts, including the metal-free, electrochemical formation of a C-S bond under ambient conditions, has been reported. The broad applicability of this method has been demonstrated with 14 examples, achieving isolated yields of up to 72%, including nitrogen-containing heterocycles. The resulting sulfonium salts can serve as precursors for the synthesis of [F-18]fluoroarenes found in PET tracer ligands.
Article
Clinical Neurology
James Morgan, Oscar Moreno, Mariana Alves, Zurine Baz, Aida Menendez Mendez, Hanna Leister, Ciara Melia, Jonathon Smith, Alexander Visekruna, Annette Nicke, Anindya Bhattacharya, Marc Ceusters, David C. Henshall, Vanessa Gomez-Vallejo, Jordi Llop, Tobias Engel
Summary: This study tested the P2X7R antagonist as a potential noninvasive biomarker of seizure-damage and epileptogenesis using PET imaging. The results showed that P2X7R levels correlated strongly with seizure severity in brain structures and peripheral organs, suggesting that P2X7R-based PET imaging could help identify seizure-induced neuropathology and patients who may benefit from P2X7R-based treatments.
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Review
Medicine, General & Internal
Ashish Tiwari, Betsalel Elgrably, Galit Saar, Katrien Vandoorne
Summary: Cardiovascular diseases cause systemic changes in the blood vessels, particularly in the endothelial cells that line them. Inflammation triggers adjustments in endothelial cells, leading to changes in blood flow and permeability, expression of adhesion molecules, vessel wall inflammation, thrombosis, angiogenic processes, and extracellular matrix production. Advancements in imaging techniques have allowed for preclinical multi-scale imaging of these endothelial changes, providing insights into vascular biology and potential diagnostic applications in managing cardiovascular diseases.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Hematology
Andrew Wirth, N. George Mikhaeel
Summary: This study demonstrates that in patients with DLBCL, those who are EOT PET-negative may be spared from radiotherapy, while selected patients with EOT PET-positive sites can achieve outcomes comparable to PET-negative patients when receiving selective treatment.
Article
Clinical Neurology
Emily A. Largent, Joshua D. Grill, Kyra O'Brien, David Wolk, Kristin Harkins, Jason Karlawish
Summary: Alzheimer's Disease (AD) is characterized by three pathologic processes: beta-amyloid, hyperphosphorylated tau, and neurodegeneration. Advances in measuring biomarkers of these processes have led to a growing interest in using AD biomarker tests in care and research. Therefore, a 5-step approach is proposed, including determining the appropriateness of testing, providing pretest education and consent, administering the test, disclosing the results, and follow-up for well-being.
Article
Engineering, Biomedical
Alberto Bert, Ivan Dmitriev, Silvano Agliozzo, Natalia Pietrosemoli, Mark Mandelkern, Teresa Gallo, Daniele Regge
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2009)
Article
Radiology, Nuclear Medicine & Medical Imaging
Delia Campanella, Lia Morra, Silvia Delsanto, Vincenzo Tartaglia, Roberto Asnaghi, Alberto Bert, Emanuele Neri, Daniele Regge
EUROPEAN RADIOLOGY
(2010)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Vignati, Valentina Giannini, Alberto Bert, Pasquale Borrelli, Massimo De Luca, Laura Martincich, Francesco Sardanelli, Daniele Regge
INVESTIGATIVE RADIOLOGY
(2012)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriella Iussich, Loredana Correale, Carlo Senore, Cesare Hassan, Nereo Segnan, Delia Campanella, Alberto Bert, Giovanni Galatola, Cristiana Laudi, Daniele Regge
INVESTIGATIVE RADIOLOGY
(2014)
Article
Geriatrics & Gerontology
Huali Wang, Edward Golob, Alberto Bert, Ke Nie, Yong Chu, Malcolm B. Dick, Mark Mandelkern, Min-Ying Su
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2009)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Vignati, Valentina Giannini, Massimo De Luca, Lia Morra, Diego Persano, Luca A. Carbonaro, Ilaria Bertotto, Laura Martincich, Daniele Regge, Alberto Bert, Francesco Sardanelli
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2011)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. Agliozzo, M. De Luca, C. Bracco, A. Vignati, V. Giannini, L. Martincich, L. A. Carbonaro, A. Bert, F. Sardanelli, D. Regge
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicholas Petrick, Berkman Sahiner, Samuel G. Armato, Alberto Bert, Loredana Correale, Silvia Delsanto, Matthew T. Freedman, David Fryd, David Gur, Lubomir Hadjiiski, Zhimin Huo, Yulei Jiang, Lia Morra, Sophie Paquerault, Vikas Raykar, Frank Samuelson, Ronald M. Summers, Georgia Tourassi, Hiroyuki Yoshida, Bin Zheng, Chuan Zhou, Heang-Ping Chan
Article
Anesthesiology
Johanna M. Jarcho, Natasha A. Feier, Alberto Bert, Jennifer A. Labus, Maunoo Lee, Jean Stains, Bahar Ebrat, Stephanie M. Groman, Kirsten Tillisch, Arthur L. Brody, Edythe D. London, Mark A. Mandelkern, Emeran A. Mayer
Article
Medicine, Research & Experimental
Daniele Regge, Gabriella Iussich, Carlo Senore, Loredana Correale, Cesare Hassan, Alberto Bert, Stefania Montemezzi, Nereo Segnan
Proceedings Paper
Engineering, Biomedical
C. Bracco, L. Martincich, D. Regge, M. Becchio, D. Persano, A. Bert, G. Rizzo
2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16
(2007)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kimberly M. Ray, Huali Wang, Yong Chu, Ya-Fang Chen, Alo Bert bert, Anton N. Hasso, Min-Ying Su