The “Skinny” on brown fat, obesity, and bone

Brown adipose tissue thermogenesis contributes to emotional hyperthermia in a resident rat suddenly confronted with an intruder rat

(2014) Mazher Mohammed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

(2014) Shaun F. Morrison et al.   Cell Metabolism

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Searching for signatures of cold adaptations in modern and archaic humans: hints from the brown adipose tissue genes

(2014) M Sazzini et al.   HEREDITY

Presence of Brown Adipose Tissue in an Adolescent With Severe Primary Hypothyroidism

(2014) Mimi S. Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The genomic landscape of Neanderthal ancestry in present-day humans

(2014) Sriram Sankararaman et al.   NATURE

Brown fat fuel utilization and thermogenesis

(2014) Kristy L. Townsend et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A standardized infrared imaging technique that specifically detects UCP1-mediated thermogenesis in vivo

(2014) Justin D. Crane et al.   Molecular Metabolism

Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women

(2013) Ana B. Crujeiras et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Seasonal and socioeconomic influences on thyroid function among the Yakut (Sakha) of Eastern Siberia

(2013) Stephanie B. Levy et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

On the relevance of brown adipose tissue in children

(2013) Skorn Ponrartana et al.   Annals of the New York Academy of Sciences

Positive effects of brown adipose tissue on femoral bone structure

(2013) Miriam A. Bredella et al.   BONE

Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis

(2013) Mei Dong et al.   Cell Metabolism

Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN

(2013) Yan-Chuan Shi et al.   Cell Metabolism

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes

(2013) H. Sacks et al.   DIABETES

Brown Adipose Tissue in Adult Humans: A Metabolic Renaissance

(2013) Paul Lee et al.   ENDOCRINE REVIEWS

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton

(2013) Sima Rahman et al.   ENDOCRINOLOGY

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Functional thermogenic beige adipogenesis is inducible in human neck fat

(2013) P Lee et al.   INTERNATIONAL JOURNAL OF OBESITY

Altered thermogenesis and impaired bone remodeling inMistymice

(2013) Katherine J Motyl et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Evidence of Brown Fat Activity in Constitutional Leanness

(2013) Fabrizio Pasanisi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Changes in Energy Metabolism in Pheochromocytoma

(2013) O. Petrák et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown Fat Activation Mediates Cold-Induced Thermogenesis in Adult Humans in Response to a Mild Decrease in Ambient Temperature

(2013) Kong Y. Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hyperthyroidism Increases Brown Fat Metabolism in Humans

(2013) Minna Lahesmaa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat

(2013) O. Muzik et al.   JOURNAL OF NUCLEAR MEDICINE

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Quantitative proton MR techniques for measuring fat

(2013) H. H. Hu et al.   NMR IN BIOMEDICINE

BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality

(2013) Mariëtte R. Boon et al.   PLoS One

Brown Adipose Tissue Quantification in Human Neonates Using Water-Fat Separated MRI

(2013) Jerod M. Rasmussen et al.   PLoS One

Brown fat in a protoendothermic mammal fuels eutherian evolution

(2013) Rebecca Oelkrug et al.   Nature Communications

Characterization of Human Brown Adipose Tissue by Chemical-Shift Water-Fat MRI

(2012) Houchun H. Hu et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

Loss of Perivascular Adipose Tissue on Peroxisome Proliferator–Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis

(2012) Lin Chang et al.   CIRCULATION

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Young Women with Cold-Activated Brown Adipose Tissue Have Higher Bone Mineral Density and Lower Pref-1 than Women without Brown Adipose Tissue: A Study in Women with Anorexia Nervosa, Women Recovered from Anorexia Nervosa, and Normal-Weight Women

(2012) Miriam A. Bredella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown Adipose Tissue and Its Relationship to Bone Structure in Pediatric Patients

(2012) Skorn Ponrartana et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

Modeling Neanderthal clothing using ethnographic analogues

(2012) Nathan Wales   JOURNAL OF HUMAN EVOLUTION

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

(2012) A. Vitali et al.   JOURNAL OF LIPID RESEARCH

Thermal Imaging to Assess Age-Related Changes of Skin Temperature within the Supraclavicular Region Co-Locating with Brown Adipose Tissue in Healthy Children

(2012) Michael E. Symonds et al.   JOURNAL OF PEDIATRICS

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women

(2012) P. Lee et al.   OSTEOPOROSIS INTERNATIONAL

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity

(2012) Shuangtao Ma et al.   Journal of Molecular Cell Biology

Implications of nonshivering thermogenesis for energy balance regulation in humans

(2011) Wouter D. van Marken Lichtenbelt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inducible Brown Adipogenesis of Supraclavicular Fat in Adult Humans

(2011) Paul Lee et al.   ENDOCRINOLOGY

Thyroid hyperactivity with high thyroglobulin in serum despite sufficient iodine intake in chronic cold adaptation in an Arctic Inuit hunter population

(2011) Stig Andersen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Cardiac Natriuretic Peptides, Obesity, and Insulin Resistance: Evidence from Two Community-Based Studies

(2011) Abigail May Khan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Negative correlation between milk production and brown adipose tissue gene expression in lactating mice

(2011) E. Krol et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

MR properties of brown and white adipose tissues

(2011) Gavin Hamilton et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Pediatric Brown Adipose Tissue: Detection, Epidemiology, and Differences from Adults

(2011) Laura A. Drubach et al.   JOURNAL OF PEDIATRICS

Changes in Brown Adipose Tissue in Boys and Girls during Childhood and Puberty

(2011) Vicente Gilsanz et al.   JOURNAL OF PEDIATRICS

Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men

(2011) Dariush Mozaffarian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Decrease in Cold-Activated Brown Adipose Tissue and Accumulation of Body Fat in Healthy Humans

(2011) Takeshi Yoneshiro et al.   Obesity

Could increased time spent in a thermal comfort zone contribute to population increases in obesity?

(2011) F. Johnson et al.   Obesity Reviews

Brown Adipose Tissue in Morbidly Obese Subjects

(2011) Guy H. E. J. Vijgen et al.   PLoS One

Brown Adipose Tissue in Humans Is Activated by Elevated Plasma Catecholamines Levels and Is Inversely Related to Central Obesity

(2011) Qidi Wang et al.   PLoS One

A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans

(2010) Paul Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Uncoupling protein-1 is not leaky

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Brown Fat and the Myth of Diet-Induced Thermogenesis

(2010) Leslie P. Kozak   Cell Metabolism

The role and importance of brown adipose tissue in energy homeostasis

(2010) Aaron M Cypess et al.   CURRENT OPINION IN PEDIATRICS

Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans

(2010) C. Pfannenberg et al.   DIABETES

Hot fat in a cool man: infrared thermography and brown adipose tissue

(2010) P. Lee et al.   DIABETES OBESITY & METABOLISM

Visceral fat is negatively associated with B-type natriuretic peptide levels in patients with advanced type 2 diabetes

(2010) Takako Sugisawa et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Sympathetic and sensory innervation of brown adipose tissue

(2010) T J Bartness et al.   INTERNATIONAL JOURNAL OF OBESITY

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice

(2010) R. Oelkrug et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Oxidative stress in cold-induced hyperthyroid state

(2010) P. Venditti et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Functional Brown Adipose Tissue is Related to Muscle Volume in Children and Adolescents

(2010) Vicente Gilsanz et al.   JOURNAL OF PEDIATRICS

Determinants of Physiologic 18F-FDG Uptake in Brown Adipose Tissue in Sequential PET/CT Examinations

(2010) Leonardo Pace et al.   MOLECULAR IMAGING AND BIOLOGY

In season, atmospheric conditions can drive disease

(2010) Roxanne Palmer   NATURE MEDICINE

Cold-Induced Adaptive Thermogenesis in Lean and Obese

(2010) Sander L.J. Wijers et al.   Obesity

Adiposity and human regional body temperature

(2009) David M Savastano et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nonshivering thermogenesis without interscapular brown adipose tissue involvement during conditioned fear in the rat

(2009) Andrew Marks et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Brown Adipose Tissue and Seasonal Variation in Humans

(2009) I. T.H. Au-Yong et al.   DIABETES

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats

(2009) Asuka Mano-Otagiri et al.   JOURNAL OF ENDOCRINOLOGY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolutionary history of the UCP gene family: gene duplication and selection

(2008) Joseph Hughes et al.   BMC EVOLUTIONARY BIOLOGY

Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans

(2008) A. L. Birkenfeld et al.   DIABETES

Inactivation of UCP1 and the Glycerol Phosphate Cycle Synergistically Increases Energy Expenditure to Resist Diet-induced Obesity

(2008) Rea Anunciado-Koza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dixon techniques for water and fat imaging

(2008) Jingfei Ma   JOURNAL OF MAGNETIC RESONANCE IMAGING

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Human Skeletal Muscle Mitochondrial Uncoupling Is Associated with Cold Induced Adaptive Thermogenesis

(2008) Sander L. J. Wijers et al.   PLoS One