Article
Multidisciplinary Sciences
Humberto Garcia-Ortiz, Francisco Barajas-Olmos, Cecilia Contreras-Cubas, Miguel Angel Cid-Soto, Emilio J. Cordova, Federico Centeno-Cruz, Elvia Mendoza-Caamal, Isabel Ciceron-Arellano, Marlen Flores-Huacuja, Paulina Baca, Deborah A. Bolnick, Meradeth Snow, Silvia Esperanza Flores-Martinez, Rocio Ortiz-Lopez, Austin W. Reynolds, Antonio Blanchet, Mirna Morales-Marin, Rafael Velazquez-Cruz, Aleksandar David Kostic, Carlos Galaviz-Hernandez, Alejandra Guadalupe Garcia-Zapien, Jose Concepcion Jimenez-Lopez, Guadalupe Leon-Reyes, Eva Gabriela Salas-Bautista, Blanca Patricia Lazalde-Ramos, Juan Luis Jimenez-Ruiz, Guadalupe Salas-Martinez, Jazmin Ramos-Madrigal, Elaheh Mirzaeicheshmeh, Yolanda Saldana-Alvarez, Maria del Carmen Abrahantes-Perez, Francisco Loeza-Becerra, Raul Mojica-Espinosa, Federico Sanchez-Quinto, Hector Rangel-Villalobos, Martha Sosa-Macias, Jose Sanchez-Corona, Augusto Rojas-Martinez, Angelica Martinez-Hernandez, Lorena Orozco
Summary: The genetic makeup of Indigenous populations in Mexico has been greatly influenced by geography and demographic history. A genome-wide analysis of 716 individuals from 60 recognized ethnic groups showed strong genetic structure influenced by geography and a decline in population size over the last 15-30 generations. Aridoamerican and Mesoamerican populations diverged around 4-9.9 ka, with a complex history of divergence among Indigenous populations in Mexico.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Morgan M. Sparks, Claire E. Schraidt, Xiaoshen Yin, Lisa W. Seeb, Mark R. Christie
Summary: In this study, the effects of genetic drift and rapid genetic adaptation in pink salmon introduced to the Great Lakes were investigated. It was found that despite a decrease in genetic diversity during the introduction process, the introduced salmon populations showed evidence of selection at multiple loci, suggesting a rapid response to the new environment.
Article
Biochemistry & Molecular Biology
Menno J. de Jong, Fiona Lovatt, A. Rus Hoelzel
Summary: This study examines genetic signals of selection in founder populations of reindeer on South Georgia Island. Shared genomic regions under selection are identified in the two parallel founder populations, supporting the hypothesis that these outlier regions represent true loci under selection. Wright-Fisher model simulations show that GWDS is most likely to detect loci under selection in small founder populations.
Article
Multidisciplinary Sciences
Gabriel Jorgewich-Cohen, Luis Felipe Toledo, Taran Grant
Summary: Non-native species are a significant problem in various biomes worldwide. Understanding their population genetics is essential to comprehend their invasion history and dynamics. This study assessed the population structure of the non-native American bullfrog in Brazil, using genetic analysis of samples collected from feral and captive groups. The results indicated that there are two distinct populations of bullfrogs in Brazil, with limited genetic exchange between them. Additionally, there was no genetic differentiation between feral and captive populations, suggesting continuous releases. The findings also highlighted the importance of preventing escapes from farms to control the feral bullfrog population.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Vanessa Camara Fernandes, Marco Antonio M. Pretti, Luiza Tamie Tsuneto, Maria Luiza Petzl-Erler, Guilherme Suarez-Kurtz
Summary: The highly polymorphic CYP2C19 gene is associated with the CYP2C19 drug metabolism enzyme. A high frequency of the CYP2C:TG haplotype in Native American populations may contribute to the discordance between predicted and verified CYP2C19 metabolic phenotypes.
FRONTIERS IN GENETICS
(2023)
Article
Multidisciplinary Sciences
Suncica Stipoljev, Toni Safner, Pavao Gancevic, Ana Galov, Tina Stuhne, Ida Svetlicic, Stefano Grignolio, Jorge Cassinello, Nikica Sprem
Summary: The genetic diversity of European aoudad populations is relatively low, with individuals likely originating from multiple genetic sources. The Sierra Espuna population in Spain is the only one where multiple haplotypes have been detected.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Rocio Gomez, Yessica S. Tapia-Guerrero, Bulmaro Cisneros, Lorena Orozco, Cesar Cerecedo-Zapata, Elvia Mendoza-Caamal, Gerardo Leyva-Gomez, Norberto Leyva-Garcia, Luis Velazquez-Perez, Jonathan J. Magana
Summary: This study examined the allele frequencies of five SCA microsatellite loci in eleven Mexican Native American populations. The results showed that MNA populations had certain genetic homogeneity, except for Mayans who had distinctive genetic profiles. No pathological or large normal alleles were found in MNA populations, except for a pre-mutated allele in the Zapotec population. The findings suggest that MNA ancestry has shaped the genetic structure of contemporary Mexican Mestizo populations, but Native American ancestry does not impact the origin of SCAs in the Mexican population.
Article
Pharmacology & Pharmacy
Vanessa Camara Fernandes, Marco Antonio M. Pretti, Luiza Tamie Tsuneto, Maria Luiza Petzl-Erler, Guilherme Suarez-Kurtz
Summary: This study investigated the predictive performance of rs1061235 and rs17179220 as HLA-A*31:01 tags in populations of Native American ancestry, and found that they are not optimal proxies for HLA-A*31:01 across these populations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Zachary Giano, Ricky L. Camplain, Carolyn Camplain, George Pro, Shane Haberstroh, Julie A. Baldwin, Denna L. Wheeler, Randolph D. Hubach
Summary: This study represents the largest empirical investigation of adverse childhood experiences among American Indian and Alaska Native populations to date. American Indians and Alaska Natives had higher average adverse childhood experience scores compared to individuals identifying as White, Black, and Hispanic. Female participants, younger individuals, those with lower incomes, and sexual minorities reported higher average adverse childhood experience scores.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Genetics & Heredity
Amanda de Nazare Cohen-Paes, Darlen Cardoso de Carvalho, Lucas Favacho Pastana, Elizabeth Ayres Fragoso Dobbin, Fabiano Cordeiro Moreira, Tatiane Piedade de Souza, Marianne Rodrigues Fernandes, Diana Feio da Veiga Borges Leal, Roberta Borges Andrade de Sa, Angelica Leite de Alcantara, Joao Farias Guerreiro, Andrea Ribeiro-dos-Santos, Sidney Emanuel Batista dos Santos, Paulo Pimentel de Assumpcao, Ney Pereira Carneiro dos Santos
Summary: This study investigated the genetic variations in the PCLO gene in Amazonian indigenous populations and compared them with global populations. The results revealed higher frequencies of several PCLO variants in Amerindian populations, highlighting the unique genetic profile of Native American populations in the Brazilian Amazon region.
Article
Genetics & Heredity
Svend V. Nielsen, Andrew H. R. Vaughn, Kalle Leppaelae, Michael J. R. Landis, Thomas Mailund, Rasmus R. Nielsen
Summary: One way to summarize historical relationships between genetic samples is by constructing an admixture graph. The authors improve on existing approaches by developing a novel MCMC sampling method, AdmixtureBayes, that can sample from the posterior distribution of admixture graphs. They apply AdmixtureBayes to Native American and Arctic genomes, reconstructing the demographic history of these populations and reporting posterior probabilities of specific admixture events. The authors find that the Siberian Koryak population, rather than the Saqqaq culture, serves as the best proxy for gene flow into Athabascans.
Article
Environmental Sciences
Joseph Zydlewski, Daniel S. Stich, Samuel Roy, Michael Bailey, Timothy Sheehan, Kenneth Sprankle
Summary: The construction of dams has significantly reduced the spawning habitat for American shad, impacting the ecosystem and decreasing both total production and fishery potential.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Biology
Khai C. Ang, Victor A. Canfield, Tiffany C. Foster, Thaddeus D. Harbaugh, Kathryn A. Early, Rachel L. Harter, Katherine P. Reid, Shou Ling Leong, Yuka Kawasawa, Dajiang Liu, John W. Hawley, Keith C. Cheng
Summary: This study focused on a Native American population with high Native American genetic ancestry, aiming to investigate the impact of this ancestry on skin color variation. The results showed that Native American genetic ancestry had the greatest effect on reducing skin pigmentation, while genetic mutations from European and African ancestries had smaller effects. However, the specific genetic variants responsible for light skin in Native American/East Asian populations remain to be identified.
Article
Plant Sciences
Donatas Naugzemys, Jolanta Patamsyte, Silva Zilinskaite, Yoichiro Hoshino, Audrius Skridaila, Donatas Zvingila
Summary: The genetic diversity of native L. caerulea populations from the western and eastern edges of the Eurasian range was evaluated. The analyses showed clustering of individuals and populations according to geographic origin. However, no phylogeographic structure was found among the populations based on sequence analysis of two chloroplast DNA regions. Eastern populations of blue honeysuckle exhibited significantly greater genetic diversity compared to the populations from the Baltic region.
Article
Genetics & Heredity
Andres Jimenez-Kaufmann, Amanda Y. Chong, Adrian Cortes, Consuelo D. Quinto-Cortes, Selene L. Fernandez-Valverde, Leticia Ferreyra-Reyes, Luis Pablo Cruz-Hervert, Santiago G. Medina-Munoz, Mashaal Sohail, Maria J. Palma-Martinez, Gudalupe Delgado-Sanchez, Norma Mongua-Rodriguez, Alexander J. Mentzer, Adrian V. S. Hill, Hortensia Moreno-Macias, Alicia Huerta-Chagoya, Carlos A. Aguilar-Salinas, Michael Torres, Hie Lim Kim, Namrata Kalsi, Stephan C. Schuster, Teresa Tusie-Luna, Diego Ortega Del-Vecchyo, Lourdes Garcia-Garcia, Andres Moreno-Estrada
Summary: This study aims to improve imputation performance and statistical power in Latin American individuals of mixed ancestry by adding Native American genomes to the existing reference panel. Through experimentation, it was demonstrated that this approach can increase the number of SNPs and improve imputation accuracy for low-frequency variants in Native American ancestry tracts. Our research highlights the issue of imbalance in diversity within current reference genomes and contributes to reducing this imbalance.
FRONTIERS IN GENETICS
(2022)
Article
Pathology
Leticia Orozco-Arguelles, Sergio De los Santos, Alberto Tenorio-Torres, Juan Pablo Mendez, Marcela Leal-Garcia, Ramon Coral-Vazquez, Claudia Vega-Garcia, Veronica Bautista-Pina, Maria Elena Tejeda, Eduardo Cardenas-Cardenas, Patricia Canto
Summary: The study analyzed the expression of adiponectin (ADIPOQ) and its receptors ADIPOR1 and ADIPOR2 in breast cancer tissue of postmenopausal women with different body mass indexes (BMIs). Women with overweight or obesity had lower ADIPOQ expression and higher ADIPOR1 expression in breast cancer tissue compared to those with a normal BMI. The expression of ADIPOR2 in the cytoplasm was similar across all groups studied.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Pathology
Eduardo Cardenas Cardenas, Alberto Tenorio-Torres, Juan Pablo Mendez, Leticia Orozco-Arguelles, Marcela Leal-Garcia, Ramon Mauricio Coral-Vazquez, Claudia Cecilia Vega-Garcia, Veronica Bautista-Pina, Patricia Canto
Summary: This study investigated the expression of leptin and its receptor in breast cancer tissue of postmenopausal women with different body mass indexes, and found higher expression in patients with obesity. Additionally, positive expression of LEPR was associated with poorer recurrence-free survival.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Article
Pathology
Maria Elena Tejeda, Patricia Canto, Alberto Tenorio-Torres, Letica Orozco-Arguelles, Ramon Mauricio Coral-Vazquez, Alejandro Zentella-Dehesa, Marcela Leal-Garcia, Claudia Cecilia Vega-Garcia, Veronica Bautista-Pina, Juan Pablo Mendez
Summary: The study found that postmenopausal women with breast cancer and obesity had significantly increased FNDC5/irisin expression in their tumorous tissue compared to women with a normal BMI. Additionally, different breast cancer cell lines were capable of synthesizing and expressing FNDC5/irisin, with the BT-474 cell line exhibiting the highest intensity of expression.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sergio De los Santos, Ramon Mauricio Coral-Vazquez, Marta Menjivar, Maria de los Angeles Granados-Silvestre, Sebastian De la Rosa, Luis Antonio Reyes-Castro, Juan Pablo Mendez, Elena Zambrano, Patricia Canto
Summary: Both maternal obesity and high-fat diet have negative effects on the offspring, but treatment with epicatechin can reverse these effects. In male rats descended from obese mothers and fed a high-fat diet, epicatechin reduced fat mass and increased lean mass, but did not fully restore body mineral density.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Anthropology
Guadalupe Melo, Keren Uscanga, Mauro Lopez-Armenta, David Aviles-Villada, Pablo Hernandez-Romano, Hector Rangel-Villalobos, P. Aquino, A. Meza, Carlos Jimenez, Patricia Denis, Nayali Lopez-Balderas
Summary: This study analyzed the frequency of 21 autosomal short tandem repeat (STR) loci and forensic parameters in individuals from Veracruz state, Mexico using the Investigator 24plex GO! Kit. The study found that the STRs analyzed were in Hardy-Weinberg Equilibrium (HWE) and identified new population clusters related to geographic regions that are consistent with previously reported ancestral differences.
ANNALS OF HUMAN BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Magally Ramirez-Ramirez, Francisca Fernandez-Valverde, Andrea Resendiz-Garcia, Mirna G. Martinez-Damas, Luis Javier Cano-Martinez, Alejandro Zentella-Dehesa, Ramon M. Coral-Vazquez
Summary: Several studies have shown the beneficial effects of Epicatechin (Epi) on skeletal muscle in murine models, muscular dystrophy patients, diabetic patients, and murine sarcopenia models. Epi enhances antioxidant pathways, improves muscle architecture, and accelerates skeletal muscle repair after chemically induced damage. The study found that Epi significantly reduced damage area and hypertrophy in the Tibialis anterior muscle of mice with BaCl2-induced damage. In addition, Epi increased the expression of beta-catenin (active) and myogenic proteins such as MyoD and Myogenin.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Obstetrics & Gynecology
T. Canto-Cetina, D. Silva-Nicanor, R. M. Coral-Vazquez, L. J. Cano-Martinez, L. Gonzalez Herrera, S. Garcia, E. Lara Padilla, P. Canto
Summary: The study identified a significant association between rs3480 and osteopenia at the total hip and femoral neck, while rs16835198 was found to be positively associated with osteopenia at these sites.
Article
Pediatrics
Diana Alejandra Cruz-Chavez, Brian Javier Lopez-Perez, Elsa Solorzano-Gomez, Jose Antonio Venta-Sobero, Luz Victoria Flores-Villegas, Christian Gabriel Toledo-Lozano, Gabriela Vianney Castro-Loza, Roberto Sandoval-Pacheco, Andrea Torres-Vallejo, Karen Sharlot Faisury Marmol-Realpe, Yazmin Evelyn Flores-Jurado, Cristal Lucero Hernandez-Soriano, Sofia Lizeth Alcaraz-Estrada, Paul Mondragon-Teran, Juan Antonio Suarez-Cuenca, Ramon Mauricio Coral-Vazquez, Silvia Garcia
Summary: Acute leukemia is a significant disease in children, with frequent neurological manifestations such as CNS infiltration, seizures, headache, and neuropathy. This study found that neurological manifestations are associated with a higher mortality rate.
Article
Anthropology
Ingrid Yali Ibarra-Tapia, Ariadna Juarez-Sandoval, Itzel Torres Perez, Luis Javier Cano-Martinez, Sergio Sanchez-Garcia, Juana Marlen Ruiz-Batalla, Irma Angelica Aroche-Reyes, Silvia Garcia, Patricia Canto, David-Rojano Mejia, Ramon Mauricio Coral-Vazquez
Summary: This study found a significant association between the rs1131620 polymorphism of the LTBP4 gene and sarcopenia in patients with type 2 diabetes. This suggests that LTBP4 polymorphisms may play a role in the development of sarcopenia in these patients.
ANNALS OF HUMAN BIOLOGY
(2022)
Article
Genetics & Heredity
Carlos Palma-Flores, Paola B. Zarate-Segura, J. Manuel Hernandez-Hernandez, Sergio de los Santos, Andrea S. Tejeda-Gomez, Luis Javier Cano-Martinez, Patricia Canto, Jorge Omar Garcia-Rebollar, Ramon M. Coral-Vazquez
Summary: This study demonstrates that (-)-epicatechin upregulates miRNAs involved in muscle adaptation, induces muscle hypertrophy, and increases the level of myogenic proteins.
Article
Genetics & Heredity
Jose Alonso Aguilar-Velazquez, Blanca Jeannete Llamas-de-Dios, Miranda Fabiola Cordova-Mercado, Carolina Elena Coronado-Avila, Orlando Salas-Salas, Andres Lopez-Quintero, Benito Ramos-Gonzalez, Hector Rangel-Villalobos
Summary: Forensic genomic systems can simultaneously analyze identity informative, ancestry informative, and phenotype informative genetic markers. The ForenSeq DNA Signature prep kit analyzes identity STRs and SNPs as well as 24 phenotype informative SNPs to predict hair and eye color. In this study, the 24 phenotype informative SNPs were analyzed in 88 samples from Monterrey City, Mexico using the ForenSeq DNA Signature prep. Brown eyes (96.5%) and black hair (75%) were the predominant phenotypes observed, while blue eyes and blond/red hair were not observed. Both Universal Analysis Software and the web tool of the Erasmus Medical Center showed high performance in eye color prediction (p = 96.6%), but lower accuracy in hair color prediction.
Article
Medicine, Legal
Mayra Elizabeth Garcia-Aceves, Diana Gabriela Jasso-Razo, Xochitl Xitlally Diaz-Navarro, Hector Rangel-Villalobos
Summary: This study analyzed paternity test data from a Mexican laboratory over a five-year period and found a significant increase in motherless duo paternity tests. The PowerPlex & REG; Fusion system showed high accuracy in excluding paternity and provided reliable results in confirming paternity compared to other systems.
Article
Medicine, Research & Experimental
Thelma Canto-Cetina, Diana Silva-Nicanor, Ramon Mauricio Coral-Vazquez, Luis Javier Cano-Martinez, Patricia Canto
Summary: The rs3480 and rs16835198 of FNDC5/Irisin and their haplotypes were found to be associated with the presence of type 2 diabetes mellitus in Maya-Mestizo women.
METABOLIC SYNDROME AND RELATED DISORDERS
(2023)
Article
Anthropology
Alma Faviola Favela-Mendoza, Andrea Dinorah Godinez-Lopez, Mariana Chavez-Arreguin, Jose Alonso Aguilar-Velazquez, Gabriela Martinez-Cortes, Hector Rangel-Villalobos
Summary: In the TYMS gene promoter, the TSER repeat polymorphism and SNP G>C variant affect the expression level of the TS enzyme. The Mexican population has a high frequency of genotypes associated with low TS enzyme expression, which has biomedical implications for pharmaceutical treatments.
ANNALS OF HUMAN BIOLOGY
(2023)
Article
Health Care Sciences & Services
Mauricio Ivan Garcia-Rubio, Maria Elisa Otero-Cerdeira, Christian Gabriel Toledo-Lozano, Sofia Lizeth Alcaraz-Estrada, Juan Antonio Suarez-Cuenca, Ramon Mauricio Coral-Vazquez, Paul Mondragon-Teran, Juan Antonio Pineda-Juarez, Luis Fernando Diaz-Lopez, Silvia Garcia
Summary: This study identified dopamine agonists as being associated with the development of ICDs in PD patients, while the tremorgenic form may have a protective effect. Positive associations were found between the rigid-akinetic form and compulsive shopping, and between males and hypersexuality. Binge eating, compulsive shopping, and hypersexuality were the most common ICDs observed.