4.2 Article

An Outcomes-based Approach to Curriculum Development in Pharmacy

Journal

Publisher

AMER ASSOC COLL PHARMACY
DOI: 10.5688/aj730114

Keywords

learning outcomes; curriculum; assessment

Ask authors/readers for more resources

Objective. To implement an outcomes-based approach to pharmacy curriculum development. Design. Desired learning outcomes were identified; course content, learning activities, and assessment instruments were designed; and evaluation was conducted and feedback obtained to refine the curriculum. Assessment. All professional skills, 4 generic capabilities, and the coherence of the curriculum scales showed significant improvement compared to graduates' performance under both the old and transitional curriculum. Conclusion. An outcomes-based approach to pharmacy curriculum development provided convincing evidence of enhancement to the curriculum. Such an approach should be considered when implementing or revising pharmacy curriculum.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Pharmacology & Pharmacy

A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer

Huihai Yang, Grace Gar Lee Yue, Ping Chung Leung, Chun Kwok Wong, Clara Bik San Lau

Summary: This review summarizes the potential mechanisms connecting obesity and colorectal cancer and discusses potential therapeutic targets and the use of herbs in the management of obesity-associated colorectal cancer.

PHARMACOLOGICAL RESEARCH (2022)

Article Environmental Sciences

Impacts of Educational Interventions with Support of Mobile App versus Booklet for Patients with Hypertension and Metabolic Syndrome: A Secondary Data Analysis

Eliza Mi Ling Wong, Hon Lon Tam, Angela Yee Man Leung, Alice Siu Ping Cheung, Ka Ching Cheung, Doris Yin Ping Leung

Summary: Educational intervention supported by a mobile app had better effects compared to booklet support in patients with hypertension and metabolic syndrome, leading to a reduction in body weight and waist circumference, increase in total exercise, and improvement in self-efficacy for exercise.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Chemistry, Applied

Oligosaccharide analysis of the backbone structure of the characteristic polysaccharide of Dendrobium officinale

Tin-Long Wong, Li-Feng Li, Ji-Xia Zhang, Quan-Wei Zhang, Xue-Ting Zhang, Li-Shuang Zhou, Hau-Yee Fung, Lei Feng, Hui -Yuan Cheng, Chu-Ying Huo, Man Liu, Wan-Rong Bao, Wen-Jie Wu, Cheuk-Hei Lai, Su -Ping Bai, Shao-Ping Nie, Pema-Tenzin Puno, Clara Bik-San Lau, Ping -Chung Leung, Quan-Bin Han, Han-Dong Sun

Summary: In this study, an oligosaccharide sequencing analysis was used to successfully correct the backbone of Dendrobium officinale polysaccharide (DOP) to mannan. This analysis involved producing oligosaccharide fragments through mild acid hydrolysis of DOP followed by p-aminobenzoic ethyl ester (ABEE) derivatization. The isolated and identified oligosaccharides with varied polymerization degrees (DP = 2-10) confirmed that the backbone of DOP is a beta-D-1,4-mannan. This oligosaccharide analysis is more straightforward and reliable compared to conventional methods.

FOOD HYDROCOLLOIDS (2023)

Article Biochemistry & Molecular Biology

The Application of Adipose Tissue-Derived Mesenchymal Stem Cells (ADMSCs) and a Twin-Herb Formula to the Rodent Wound Healing Model: Use Alone or Together?

Hui Ma, Wing-Sum Siu, Chi-Man Koon, Xiao-Xiao Wu, Xiang Li, Wen Cheng, Wai-Ting Shum, Clara Bik-San Lau, Chun-Kwok Wong, Ping-Chung Leung

Summary: NF3 enhances the therapeutic effect of MSCs in the wound healing model and is related to the TGF beta/Smad and Wnt pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Oncology

Mediating role of self-efficacy between unmet needs and quality of life in palliative cancer caregivers

Hui-Lin Cheng, Doris Yin Ping Leung, Po Shan Ko, Wai Man Lam, Po Tin Lam, Andrew Leung Luk, Ming Wai Chung, Simon Ching Lam

Summary: This study aimed to examine whether caregiving self-efficacy (SE) mediated the relationship between unmet support needs and health-related quality of life (HRQOL) in family caregivers of palliative cancer patients. The findings indicated that caregiving SE mediated the relationship between unmet support needs and mental HRQOL.

PSYCHO-ONCOLOGY (2023)

Article Infectious Diseases

Enhancing Antibiotics Efficacy by Combination of Kuraridin and Epicatechin Gallate with Antimicrobials against Methicillin-Resistant Staphylococcus aureus

Ben Chung-Lap Chan, Nilakshi Barua, Clara Bik-San Lau, Ping-Chung Leung, Kwok-Pui Fung, Margaret Ip

Summary: This study found that the combination of kuraridin from Sophora flavescens and epicatechin gallate (ECG) from green tea inhibits the growth of MRSA strains and enhances the antibacterial activities of multiple antibiotics. Kuraridin and ECG also have anti-inflammatory effects and reduce MRSA colonization in a mouse pneumonia model.

ANTIBIOTICS-BASEL (2023)

Article Pharmacology & Pharmacy

Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo

Leilei Gou, Grace Gar-Lee Yue, Julia Kin -Ming Lee, Pema Tenzin Puno, Clara Bik-San Lau

Summary: Eriocalyxin B (Eri B), an ent-kaurane diterpenoid, inhibits migration and adhesion in triple negative breast cancer (TNBC) cells, reduces ALDH1A1 expression and colony formation in cancer stem cell (CSC) enriched MDA-MB-231 cells. Eri B demonstrates potent anti-metastatic efficacy in breast tumor-bearing mouse models. Gut microbiome analysis reveals changes in diversity and composition of microbiome after Eri B treatment, potentially contributing to its anti-cancer effects.

BIOCHEMICAL PHARMACOLOGY (2023)

Article Endocrinology & Metabolism

Effects of a culturally tailored, family-supported, community-based self management education and support programme on clinical outcomes among adults with type 2 diabetes in Western Ethiopia: A pilot randomised controlled trial

Dereje Chala Diriba, Lorna K. P. Suen, Doris Y. P. Leung

Summary: This study aimed to examine the effects of a culturally tailored, family-supported, community-based diabetes self-management education and support (DSMES) program on HbA(1c), blood pressure, body mass index, and lipid profiles for Ethiopian people with type 2 diabetes. The results showed significant improvements in HbA(1c) and triglycerides, while the effects on blood pressure, body mass index, and lipid profiles were not significant but with some degree of effectiveness. More research is needed to further test the effectiveness of the DSMES program.

DIABETIC MEDICINE (2023)

Article Nursing

The effect of a lifestyle intervention program using a mobile application versus the effect of a program using a booklet for adults with metabolic syndrome: A three-arm randomized controlled trial

Eliza Mi Ling Wong, Doris Yin Ping Leung, Qun Wang, Angela Yee Man Leung, Alice Siu Ping Cheung

Summary: The research aimed to compare the effectiveness of a lifestyle intervention program using a mobile application versus a booklet for adults with metabolic syndrome in Hong Kong. Both the app and booklet groups showed significant improvement in outcomes when compared to the control group, but the app group had statistically significant and superior results in various measures, including body weight, exercise amount, waist circumference, body mass index, and systolic blood pressure. The lifestyle intervention program supported with a mobile application could be widely used for adults with metabolic syndrome in the community.

JOURNAL OF NURSING SCHOLARSHIP (2023)

Article Chemistry, Medicinal

The effect of Andrographis paniculata water extract on palliative management of metastatic esophageal squamous cell carcinoma-A phase II clinical trial

Philip Wai-Yan Chiu, Grace Gar-Lee Yue, Man Kit Cheung, Hon-Chi Yip, Siu-Kai Chu, Man-Yee Yung, Justin Che-Yuen Wu, Shannon Melissa Chan, Anthony Yuen-Bun Teoh, Enders Kwok-Wai Ng, Hisayoshi Norimoto, Clara Bik-San Lau

Summary: This study investigated the effect of Andrographis paniculata (AP) on palliative care of patients with metastatic esophageal squamous cell carcinoma (ESCC). The results showed that patients who completed AP treatment had significantly longer overall survival periods and maintained a good quality of life. Additionally, the treatment also changed the composition of gut microbiota. This study establishes AP as a safe and effective palliative treatment for squamous cell carcinoma of the esophagus.

PHYTOTHERAPY RESEARCH (2023)

Article Multidisciplinary Sciences

Factors predicted quality of life of people with type 2 diabetes in western Ethiopia

Dereje Chala Diriba, Doris Y. P. Leung, Lorna K. P. Suen

Summary: This study aimed to assess factors related to the quality of life of adults with type 2 diabetes in western Ethiopia. The results showed that age, gender, occupation, marital status, duration of diabetes, self-management practice, and support needed were associated with quality of life. Encouraging self-management practice and providing continuous support from family and friends are essential to enhance the quality of life of individuals with type 2 diabetes.

PLOS ONE (2023)

Article Chemistry, Multidisciplinary

Discovery of a heat-generated compound DHD derived from Patrinia villosa water extract with inhibitory effects on colon cancer cells viability and migration

Huihai Yang, Tao Zheng, Chuen-Fai Ku, Cheuk Kit Ngai, Grace Gar-Lee Yue, Hung Kay Lee, Clara Bik-San Lau

Summary: In this study, it was found that active components in the water extract of Patrinia villosa Juss. (PVW) could inhibit the proliferation and migration of colon cancer cells. An active compound, 8,9-didehydro-7-hydroxydolichodial (DHD), was identified in PVW and was derived from a natural compound called valerosidate present in PV. Both DHD and valerosidate showed inhibitory effects on cell viability and migration by increasing the expressions of tumor suppressors (p53 and PTEN) in colon cancer cells.

FRONTIERS IN CHEMISTRY (2023)

Article Biochemistry & Molecular Biology

Creating a Vaccine-like Supplement against Respiratory Infection Using Recombinant Bacillus subtilis Spores Expressing SARS-CoV-2 Spike Protein with Natural Products

Ben Chung-Lap Chan, Peiting Li, Miranda Sin-Man Tsang, Johnny Chun-Chau Sung, Keith Wai-Yeung Kwong, Tao Zheng, Sharon Sze-Man Hon, Ching-Po Lau, Wen Cheng, Fang Chen, Clara Bik-San Lau, Ping-Chung Leung, Chun-Kwok Wong

Summary: Vaccination is effective against COVID-19, but fear of needles and side effects hinders its acceptance. Alternative delivery methods, such as using Bacillus subtilis as a vaccine production host and delivery vector, show promise due to their low cost, safety, and oral administration. By engineering B. subtilis to express spike (S) proteins, researchers have successfully generated S spores. Oral administration of these S spores, along with adjuvants Astragalus membranaceus and Coriolus versicolor, induces immune responses against COVID-19 without toxicity. Co-feeding with these adjuvants enhances mucosal IgA responses, and prior administration of S spores boosts IgG responses to the commercial COVID-19 vaccine CoronaVac. In vitro studies demonstrate that AM, CV, and B. subtilis spores activate macrophages and dendritic cells by secreting immune-related factors. This study suggests that a combination of S spores with AM and CV can be developed as a vaccine-like supplement for respiratory infections.

MOLECULES (2023)

Article Biochemistry & Molecular Biology

Structurally diverse spirocyclic polycyclic polyprenylated acylphloroglucinols from Hypericum ascyron Linn. and their anti-tumor activity

Ya-Li Hu, Grace Gar-Lee Yue, Xing-Ren Li, Gang Xu, Clara Bik-San Lau

Summary: Ten spirocyclic polycyclic polyprenylated acylphloroglucinols (PPAP), named hunascynols A-J (1-10), were isolated from Hypericum ascyron Linn. Compound 1 and 2 share a common spirocyclic PPAP skeleton and were derived from it through Retro-Claisen, keto-enol tautomeric, and esterification reactions. Compound 3, aldolization of normal spirocyclic PPAP, has a caged framework containing a unique 6/5/6/5/6 ring system. The structures of the compounds were determined using spectroscopy and X-ray diffraction. The inhibitory activities of these compounds were tested against human cancer cells and zebrafish, and their mechanisms and target genes were evaluated.

PHYTOCHEMISTRY (2023)

Article Plant Sciences

Mechanistic insights into the anti-tumor and anti-metastatic effects of Patrinia villosa aqueous extract in colon cancer via modulation of TGF-β R1-smad2/3-E-cadherin and FAK-RhoA-cofilin pathways

Huihai Yang, Grace Gar-Lee Yue, Ka-Ki Yuen, Si Gao, Ping Chung Leung, Chun Kwok Wong, Clara Bik-San Lau

Summary: This study investigated the anti-tumor and anti-metastatic effects of Patrinia villosa on colon cancer. The study revealed that Patrinia villosa regulates TGF-beta-smad2/3-E-cadherin and FAK-cofilin pathways, providing scientific evidence for its clinical use in colon cancer patients.

PHYTOMEDICINE (2023)

No Data Available