Article
Obstetrics & Gynecology
Gabriella Mayne, Ayisha Buckley, Luwam Ghidei
Summary: Preterm birth is a major cause of neonatal mortality in the US, with significant racial disparities. Maternal stress is a key risk factor for preterm birth, particularly for Black women who experience unique stressors related to racism and discrimination. Stress is not an all-or-none variable, and interventions aimed at reducing stress during pregnancy may help decrease preterm birth rates and improve birth outcomes for all women, especially Black women.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Masafumi Amano, Noriko Amiya, Keisuke Fukushima, Hanako Hagio, Naoyuki Yamamoto, Yoshitaka Sakakura
Summary: The study showed that crowding stress affects the HPI axis in self-fertilizing fish, Kryptolebias marmoratus. Specifically, paired fish had significantly higher numbers of CRH-ir cell bodies in the hypothalamus and cortisol levels compared to solitary-reared fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Neurosciences
Danique La Torre, Lukas Van Oudenhove, Tim Vanuytsel, Kristin Verbeke
Summary: Stress can increase intestinal permeability through mast-cell dependent mechanisms, but there are difficulties in drawing conclusions about the relationship between stress and intestinal permeability in human research compared to animal studies.
NEUROBIOLOGY OF STRESS
(2023)
Article
Multidisciplinary Sciences
Manuela Filippa, Maria Grazia Monaci, Carmen Spagnuolo, Paolo Serravalle, Roberta Daniele, Didier Grandjean
Summary: This study found that the mother's voice can effectively alleviate pain in preterm infants and is associated with the release of endogenous oxytocin. Vocal contact may serve as a promising protective mechanism during early painful interventions.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Gioia M. Guerrieri, Rivka Ben Dor, Xiaobai Li, Shau-Ming Wei, Pedro E. Martinez, Lynnette K. Neiman, David R. Rubinow, Peter J. Schmidt
Summary: Research examined HPA axis function in perimenopausal women with and without depression, finding no abnormalities associated with PMD compared to women without depression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Ozlem Guzeloglu-Kayisli, Nihan Semerci, Xiaofang Guo, Kellie Larsen, Asli Ozmen, Sefa Arlier, Duygu Mutluay, Chinedu Nwabuobi, Bradley Sipe, Irina Buhimschi, Catalin Buhimschi, Frederick Schatz, Umit A. Kayisli, Charles J. Lockwood
Summary: Depression and posttraumatic stress disorder increase the risk of idiopathic preterm birth, with the involvement of FKBP51 and FKBP5 gene polymorphisms. The binding of FKBP51 to progesterone receptors inhibits their function, leading to labor induction. In mouse models, maternal stress-induced FKBP51 expression and FKBP51-PR binding mediate a mechanism for P4 withdrawal and consequent preterm birth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Dennis Yuezen, Isabel Graf, Ann-Christin Tallarek, Bettina Hollwitz, Christian Wiessner, Ekkehard Schleussner, Detlef Stammer, Amy Padula, Kurt Hecher, Petra Clara Arck, Anke Diemert
Summary: Climate change, especially exposure to heat, has a negative impact on human health and can lead to diseases. This study conducted in Hamburg, Germany, reveals that extreme heat and prolonged heat exposure increase the risk of preterm birth in a temperate climate region. The critical period of heat exposure was found to be between gestational ages 34-37 weeks, and pregnancies with female fetuses were more susceptible to heat stress-induced preterm birth. These findings emphasize the importance of monitoring and providing appropriate care for pregnant women at risk in temperate climate regions.
Article
Medicine, General & Internal
Marin Gergics, Greta Pham-Dobor, Csilla Kurdi, Gergely Montsko, Krisztina Mihalyi, Gabor Banfai, Peter Kanizsai, Tamas Koszegi, Emese Mezosi, Laszlo Bajnok
Summary: In this prospective observational study, the researchers investigated the prognostic role of apelin-13 in critically ill patients and explored its correlations with free cortisol, aldosterone, CRH, and copeptin. The results showed a strong positive correlation between apelin-13 and CRH concentrations, and apelin-13 was significantly higher in non-septic patients. Multivariate Cox regression analysis revealed that apelin-13 and free cortisol were independent determinants of survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Dongni Huang, Zheng Liu, Xiyao Liu, Yuxiang Bai, Mengshi Wu, Xin Luo, Hongbo Qi
Summary: This study established a predictive model for sPTB with five variables, including psychological factors, biomarkers, and metabolites, to accurately and sensitively predict sPTB in the second trimester. The model had an optimum corrected AUC value of 89.5%, with a sensitivity of 100.0% and specificity of 78.9%.
FRONTIERS IN PEDIATRICS
(2021)
Article
Clinical Neurology
Xi Chen, Xiaoli Zhang, Wenhua Li, Wendong Li, Yong Wang, Shan Zhang, Changlian Zhu
Summary: Preterm births with different etiologies are associated with varying neonatal complications, but no differences in neurodevelopmental outcomes were observed at 12 months of corrected age.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Dvora Kluwgant, Tamar Wainstock, Eyal Sheiner, Gali Pariente
Summary: Placenta previa, multiple gestations, and placental abruption were identified as the strongest risk factors for extreme preterm birth. Risk factors including placental abruption and previa, lack of prenatal care, and recurrent pregnancy loss were observed in sub-populations with multiple gestations, previous PTB, and indicated PTBs. Placental abruption emerged as the most significant risk factor across all groups, with no significant differences observed between sub-populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Lahari Vuppaladhadiam, Jeannette Lager, Oliver Fiehn, Sandra Weiss, Margaret Chesney, Burcu Hasdemir, Aditi Bhargava
Summary: The study findings indicate that maternal perceived stress did not affect fetal cortisol levels, cortisone levels, or birth weight, but were positively correlated with maternal BMI. Furthermore, hair progesterone levels were positively associated with stress, while cord estradiol levels were negatively associated with stress.
Article
Pediatrics
Ingrid Marie Husby Hollund, Kristina Anna Djupvik Aakvik, Silje Dahl Benum, Sigrid Hegna Ingvaldsen, Stian Lydersen, Marjaana Tikanmaki, Petteri Hovi, Katri Raikkonen, Eero Kajantie, Samantha Johnson, Neil Marlow, Nicole Baumann, Dieter Wolke, Marit S. Indredavik, Kari Anne I. Evensen
Summary: The associations between mental health, pain, and tiredness in adults are independent of gestation or birthweight. Further research should explore other potential mechanisms to explain the increased risk of mental health problems in the preterm population.
Letter
Medicine, General & Internal
Lovemore Nkhalamba, Thomas Hampton, Wakisa Mulwafu
Summary: The review highlights the neurological consequences of preterm birth, emphasizing the prevalence of cognitive and social-emotional difficulties among preterm survivors. It points out the omission of the impact of hearing loss on learning impairment and the predictive factors for hearing impairment. Studies in this area are crucial for understanding language, cognitive development, and educational outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Endocrinology & Metabolism
Ifigeneia Kassotaki, Georgios Valsamakis, George Mastorakos, Dimitris K. Grammatopoulos
Summary: Early life is a critical period with significant vulnerability to external influences that can impact development and health, especially fetal exposure to prenatal stress which can affect brain development and neurodevelopment of offspring. Increased stress hormones have been associated with alterations in fetal brain structure, while epigenetic changes may lead to long-term modifications of the stress regulatory system in offspring and increased susceptibility to psychosomatic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)