Review
Biochemistry & Molecular Biology
Juhi K. Gupta, Ana Alfirevic
Summary: This systematic literature review aimed to identify and summarize maternal omic and multi-omic biomarker studies of preterm birth (PTB). A total of 149 omic studies were identified, with proteomics being the most investigated discipline. Pathway analysis revealed several cellular processes associated with the omic biomarkers reported in the literature. However, heterogeneity was observed across the research articles, including differences in the definition of PTB.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Review
Obstetrics & Gynecology
Elyse C. Mead, Carol A. Wang, Jason Phung, Joanna Y. X. Fu, Scott M. Williams, Mario Merialdi, Bo Jacobsson, Stephen Lye, Ramkumar Menon, Craig E. Pennell
Summary: Preterm birth (PTB), defined as the birth of a child before 37 completed weeks gestation, is a major health issue affecting about 11% of live births and is the leading cause of death in children under 5 years old. Genetic studies have identified genes within various pathways that may be involved in PTB, but many of the published data are inconclusive and have limited power to detect associations. On the other hand, some large hypothesis-free approaches have identified multiple novel genetic variants associated with PTB. Attempts to predict PTB using single -omics datasets have mostly been unsuccessful, while integrating data from multiple -omics datasets has shown promising results.
REPRODUCTIVE SCIENCES
(2023)
Article
Developmental Biology
Rik H. J. Beernink, Joost H. N. Schuitemaker, Eva F. Zwertbroek, Sicco A. Scherjon, Thomas I. F. H. Cremers
Summary: Four candidate biomarkers related to inflammatory pathways and/or the complement system were confirmed through liquid chromatography mass spectrometry and enzyme-linked immunosorbent assay. These biomarkers provide the possibility to discover spontaneous preterm birth in early pregnancy and help intervene or monitor high-risk pregnancies.
Article
Medicine, General & Internal
Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Tomi A. Maatta, Johanna M. Huusko, Steffen Ohlmeier, Ulrich Bergmann, Marja Ojaniemi, Louis J. Muglia, Mikko Hallman, Mika Ramet
Summary: This study aimed to identify placental proteins associated with spontaneous preterm birth. We found rare damaging variants in the SERPINA1 gene in families with recurrent spontaneous preterm deliveries. The protein and mRNA levels of alpha-1 antitrypsin/SERPINA1 were downregulated in spontaneous preterm births, and it played a role in regulating actin cytoskeleton pathway, Slit-Robo signaling, and extracellular matrix organization. Loss of the protease inhibition effects of alpha-1 antitrypsin may render structures critical to maintaining pregnancy susceptible to proteases and inflammatory activation, leading to spontaneous premature birth.
Article
Gastroenterology & Hepatology
Soo Young Cho, Heeyoun Hwang, Yun-Hee Kim, Byong Chul Yoo, Nayoung Han, Sun-Young Kong, Min-Jeong Baek, Kyung-Hee Kim, Mi Rim Lee, Jae Gwang Park, Sung-Sik Han, Woo Jin Lee, Charny Park, Jong Bae Park, Jin Young Kim, Sang-Jae Park, Sang Myung Woo
Summary: Through comprehensive analysis of genomic, transcriptomic, proteomic, and phosphoproteomic data from 102 iCC patients, three clinically supported subtypes were identified (stem-like, poorly immunogenic, and metabolism), and an organoid model was constructed for therapeutic testing. The ALDH1A1 inhibitor NCT-501 showed synergy with nanoparticle albumin-bound-paclitaxel in the organoid model for the stem-like subtype. Dysregulations in oncometabolites were associated with different clinical outcomes in the stem-like and metabolism subtypes. The poorly immunogenic subtype exhibited non-T-cell tumor infiltration. Integrated multiomics analysis reproduced the 3 subtypes and revealed heterogeneity in iCC.
Article
Medicine, Research & Experimental
Chang-Zhu Pei, Lan Jin, Kwang-Hyun Baek
Summary: PCOS is a common gynecological endocrine disease involving multiple genes and pathways, and cannot be explained by a single factor. Omics analysis plays a key role in studying the pathogenesis of PCOS, offering new perspectives for explaining new mechanisms and potential biomarkers discovery.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Xi Chen, Xiaoli Zhang, Wenhua Li, Wendong Li, Yong Wang, Shan Zhang, Changlian Zhu
Summary: Preterm births with different etiologies are associated with varying neonatal complications, but no differences in neurodevelopmental outcomes were observed at 12 months of corrected age.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Dvora Kluwgant, Tamar Wainstock, Eyal Sheiner, Gali Pariente
Summary: Placenta previa, multiple gestations, and placental abruption were identified as the strongest risk factors for extreme preterm birth. Risk factors including placental abruption and previa, lack of prenatal care, and recurrent pregnancy loss were observed in sub-populations with multiple gestations, previous PTB, and indicated PTBs. Placental abruption emerged as the most significant risk factor across all groups, with no significant differences observed between sub-populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Medicine, General & Internal
Lovemore Nkhalamba, Thomas Hampton, Wakisa Mulwafu
Summary: The review highlights the neurological consequences of preterm birth, emphasizing the prevalence of cognitive and social-emotional difficulties among preterm survivors. It points out the omission of the impact of hearing loss on learning impairment and the predictive factors for hearing impairment. Studies in this area are crucial for understanding language, cognitive development, and educational outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Teresa Janevic, Kimberly B. Glazer, Luciana Vieira, Ellerie Weber, Joanne Stone, Toni Stern, Angela Bianco, Brian Wagner, Siobhan M. Dolan, Elizabeth A. Howell
Summary: This study found no evidence for increased racial/ethnic disparities in preterm birth in New York City during the early stages of the COVID-19 pandemic, regardless of whether women tested positive or negative for SARS-CoV-2.
Article
Biochemistry & Molecular Biology
Catarina Marques-Pereira, Manuel N. Pires, Raquel P. Gouveia, Nadia N. Pereira, Ana B. Caniceiro, Nicia Rosario-Ferreira, Irina S. Moreira
Summary: This study examined the structural characteristics of the Membrane (M) protein of the Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) and predicted its dimeric structure and membrane orientation using computational methods. The study also identified a number of mutation sites in the M protein that appeared in variants of the virus, which could have implications for the development of new therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
T. Tingleff, A. Vikanes, S. Raisanen, L. Sandvik, G. Murzakanova, K. Laine
Summary: The study revealed that more than one in six women who had a preterm first birth also experienced a preterm second birth. Placental disorders played a more significant role in recurrent extremely and very preterm births compared to recurrent late preterm births.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Biochemical Research Methods
Nathaniel Kwok, Zita Aretz, Sumiko Takao, Zheng Ser, Paolo Cifani, Alex Kentsis
Summary: Recent advances in nucleic acid sequencing and mass spectrometry proteomics have enabled genome-scale analysis of genetic variation and transcription as well as whole proteome-scale studies of protein expression. However, most proteomic studies are limited to canonical protein sequences. Here, we develop ProteomeGenerator2 (PG2), which integrates genome and transcriptome sequencing to incorporate protein variants and other non-canonical features caused by genomic and transcriptomic variation. PG2 has been benchmarked using synthetic data and analysis of human leukemia cells and can be used with current and emerging sequencing technologies, assemblers, variant callers, and mass spectral analysis algorithms. It is open-source and available at https://github.com/kentsisresearchgroup/ProteomeGenerator2.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Cristina Arias-Sarda, Sarah Quigley, Marta Farre
Summary: This study reconstructed ancestral karyotypes and identified chromosome rearrangements in ruminants using 26 genome assemblies. The results show that ruminant karyotype evolution is characterized by inversions, while interchromosomal rearrangements occurred preferentially in the oldest ancestor. Additionally, evolutionary breakpoints regions (EBRs) were found to be depleted of protein coding genes and not enriched in high GC regions.
Article
Obstetrics & Gynecology
Mert Ozan Bahtiyar, Emre Ekmekci, Emine Demirel, Roxanna A. Irani, Joshua A. Copel
FETAL DIAGNOSIS AND THERAPY
(2019)
Article
Obstetrics & Gynecology
Mehboob Ali, Lynette K. Rogers, Kathryn M. Heyob, Catalin S. Buhimschi, Irina A. Buhimschi
REPRODUCTIVE SCIENCES
(2019)
Meeting Abstract
Obstetrics & Gynecology
Catalin S. Buhimschi, Mert-Ozan Bahtiyar, Osama Abdelghany, Lydia Schneider, Sonya Abdel-Raqez, Antonette T. Dulay, Heather Lipkind, Elizabeth Lopez, Guomao Zhao, Lynette Rogers, Vineet Bhandari, Irina A. Buhimschi
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Article
Obstetrics & Gynecology
Terrence K. Allen, Matthew N. Nazzal, Liping Feng, Irina A. Buhimschi, Amy P. Murtha
REPRODUCTIVE SCIENCES
(2019)
Letter
Pediatrics
Bethany T. Stetson, Catalin S. Buhimschi, Brian A. Kellert, Krystal Hay, Irina A. Buhimschi, Nathalie L. Maitre
Article
Obstetrics & Gynecology
Courtney A. Ware, Catalin S. Buhimschi, Guomao Zhao, Yara El Helou, Irina A. Buhimschi
Summary: IAI is associated with increased concentrations of total proteasome and immunoproteasome in amniotic fluid, with CHE-L activity of the immunoproteasome being the primary lytic activity upregulated in pregnancies complicated by IAI. Additionally, proteasome activity is highest in amniotic fluid compared to matched maternal blood and cord blood, suggesting a potential role of immunoproteasome activity in triggering preterm birth.
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Joseph B. Lillegard, Stephanie A. Eyerly-Webb, David A. Watson, Mert Ozan Bahtiyar, Kelly A. Bennett, Stephen P. Emery, Allan J. Fisher, Ruth B. Goldstein, William H. Goodnight, Foong-Yen Lim, Laurence B. McCullough, Ueli Moehrlen, Julie S. Moldenhauer, Anita J. Moon-Grady, Rodrigo Ruano, Daniel W. Skupski, Marjorie C. Treadwell, KuoJen Tsao, Amy J. Wagner, Michael V. Zaretsky
Summary: This study investigated whether an anterior placenta was associated with increased rates of complications in mothers and babies who underwent open maternal-fetal surgery for fetal myelomeningocele closure. The results showed that an anterior placenta was associated with a higher risk of intraoperative fetal resuscitation and thinning at the hysterotomy closure site, but did not significantly impact gestational age at delivery or maternal or fetal clinical outcomes.
FETAL DIAGNOSIS AND THERAPY
(2022)
Article
Obstetrics & Gynecology
Gian Diaz-Rodriguez, Alexis Braverman, Gloria G. Elam, Doreen Norris-Stojak, Kathleen Harmon, Julie Hartwig, Tiana Dunlap, Heather Nixon, Phornphat Rasamimari, Irina A. Buhimschi, Catalin S. Buhimschi
Summary: Objective timely response to obstetrical emergencies is crucial, with a recommended decision-to-incision (DTI) time of not more than 30 minutes. A study was conducted to analyze the efficiency of an institutional-specific CD acuity classification system in reflecting actual DTI time, Apgar scores, and newborn acid-base status. The findings suggest that the need for neonatal resuscitation is associated with the acuity of the procedure rather than the actual DTI time.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Abigail Wilpers, Erica Goldblatt Hyatt, Mert Ozan Bahtiyar, Yunzhe Hu, Daisy Leon-Martinez, Frank Chervenak, Judith L. M. Mccoyd
Summary: The study aims to develop a deeper understanding of the methods clinicians currently use to train for and provide counseling about maternal-fetal surgery. Findings indicate a lack of evidence-based communication practices and guidance, as well as systemic limitations affecting pregnant people's decision-making options related to maternal-fetal surgery.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Peripheral Vascular Disease
William E. Ackerman, Catalin S. Buhimschi, Thomas L. Brown, Guomao Zhao, Taryn L. Summerfield, Irina A. Buhimschi
Summary: By applying transcriptomics with weighted gene correlation network analysis, this study provides evidence for a molecular subphenotype consistent with a glycolytic metabolic shift in placental specimens of early-onset preeclampsia (EOPE) with or without fetal growth restriction (FGR). The identified gene group is enriched for hypoxia-response and metabolic pathways, and the expression ratios of specific genes could be used as surrogate indices for identifying this subgroup.
Editorial Material
Cardiac & Cardiovascular Systems
William E. Ackerman, Irina A. Buhimschi, Catalin S. Buhimschi
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Abigail Wilpers, Anna Y. Lynn, Barbara Eichhorn, Amy B. Powne, Megan Lagueux, Janene Batten, Mert Ozan Bahtiyar, Cary P. Gross
Summary: The quality of sociodemographic reporting in maternal-fetal surgery studies is poor and fails to adequately represent the racial and ethnic diversity of different disease populations.
FETAL DIAGNOSIS AND THERAPY
(2022)
Letter
Medical Laboratory Technology
Irina A. Buhimschi, Laura J. Frye, Beverly Winikoff, Elizabeth G. Raymond
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Allison L. Fisher, Veena Sangkhae, Pietro Presicce, Claire A. Chougnet, Alan H. Jobe, Suhas G. Kallapur, Sammy Tabbah, Catalin S. Buhimschi, Irina A. Buhimschi, Tomas Ganz, Elizabeta Nemeth
Meeting Abstract
Obstetrics & Gynecology
Martina S. Burn, Masaru Negi, Joshua A. Copel, Anna K. Sfakianaki, Christina M. Ackerman, Elizabeth Ackley, Marissa Platner, Mert O. Bahtiyar
REPRODUCTIVE SCIENCES
(2019)
