Article
Pharmacology & Pharmacy
Tomohisa Takagi, Tetsuya Okayama, Jun Asai, Katsura Mizushima, Yasuko Hirai, Kazuhiko Uchiyama, Takeshi Ishikawa, Yuji Naito, Yoshito Itoh
Summary: The incidence of pressure ulcers in the elderly and intractable skin ulcers in diabetic patients is increasing. Carbon monoxide (CO) has shown potential in accelerating wound healing, and this study aimed to evaluate the therapeutic effects of topically applied CO-containing solution and understand the underlying mechanism. The results suggest that CO could be a novel therapeutic agent for the treatment of cutaneous wounds.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Rogerio Marchete, Sarah Oliveira, Leonardo Bagne, Jennyffer Ione de Souza Silva, Ana Paula Valverde, Andrea Aparecida de Aro, Mariana Moreira Figueira, Marcio Fronza, Thaina Mikaela Bressam, Vivian Fernandes Furletti de Goes, Fernanda Oliveira de Gaspari de Gaspi, Glaucia Maria Tech dos Santos, Thiago Antonio Moretti Andrade
Summary: The extract of Alternanthera brasiliana exhibits important anti-inflammatory and antioxidant activities, promoting angiogenesis and tissue formation, accelerating wound healing process.
INFLAMMOPHARMACOLOGY
(2021)
Article
Immunology
Xiaoying Cai, Ying Li, Xiaoyang Zheng, Rong Hu, Yingyuan Li, Liangcan Xiao, Zhongxing Wang
Summary: The research shows that the phagocytic ability of microglia is significantly reduced after propofol treatment, but MFG-E8 can reverse the inhibition of phagocytosis by propofol. MFG-E8 may reverse the suppression of phagocytosis induced by propofol through the regulation of the AMPK and Src signaling pathways.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Biochemistry & Molecular Biology
Yun Xiao, Ying Tang, Xiao Shu, Jinshuo Zhu, Xinan Wu, Yuan Zhang
Summary: Wound healing is crucial for maintaining skin function, and MFG-E8 plays a key role in this process by regulating various functions. However, MFG-E8 function may be dysregulated in pathological conditions. Application of exogenous MFG-E8 can restore function and promote wound healing.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Hou-Yu Chiang, Pao-Hsien Chu, Shao-Chi Chen, Ting-Hein Lee
Summary: MFG-E8 plays a critical role in VSMC migration by regulating Arp2-mediated actin polymerization in a dose-dependent manner.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kangkang Zha, Yuan Xiong, Wenqian Zhang, Meijun Tan, Weixian Hu, Ze Lin, Peng Cheng, Li Lu, Kaiyong Cai, Bobin Mi, Qian Feng, Yanli Zhao, Guohui Liu
Summary: This study explores the ability of humic acids (HAs) to modulate the inflammatory response, particularly macrophage polarization, and the potential underlying mechanism. A near-infrared (NIR)/pH dual-responsive Cu-HAs nanoparticle (NP)-based poly(vinyl alcohol) (PVA) hydrogel film loaded with SEW2871 (SEW), a macrophage recruitment agent, was developed to treat bacteria-infected cutaneous wounds. The results show that HAs could promote M2 macrophage polarization in a dose-dependent manner. The Cu-HAs NPs successfully eradicated bacterial infection through NIR-induced local hyperthermia. This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing.
Article
Engineering, Biomedical
Hyosuk Kim, Da Eun Kim, Geonhee Han, Nu Ri Lim, Eun Hye Kim, Yeongji Jang, Haeun Cho, Hochung Jang, Ki Hun Kim, Sun Hwa Kim, Yoosoo Yang
Summary: Wound healing is a complex process involving various biological events, requiring a multifaceted approach for successful transitions between different phases. Bovine milk extracellular vesicles have shown promising results in promoting wound healing, especially in enhancing fibroblast proliferation, angiogenesis, and tissue remodeling. Colostrum-derived milk EVs are particularly effective in promoting re-epithelialization, angiogenesis, and maintaining stability and efficacy even after freeze-drying procedures, showing great potential as anti-inflammatory therapeutics for cutaneous wounds.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang, Yur-Ren Kuo
Summary: The study revealed that FIR therapy could significantly accelerate diabetic wound healing, associated with suppressed inflammatory response, increased neovascularization, and tissue regeneration.
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Review
Physiology
Olga Krizanova, Adela Penesova, Jozef Sokol, Alica Hokynkova, Amir Samadian, Petr Babula
Summary: This review outlines new possibilities for cutaneous wound healing through modulation of signaling molecules, with a specific focus on gasotransmitters and calcium. It also highlights the importance of addressing chronic wounds caused by diabetes and inflammation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wenfeng Li, Rui Qing, Haojie Zhang, Ziwei Wang, Yuhan Yuan, Lili Wang, Jia Deng, Bochu Wang, Shilei Hao
Summary: The study demonstrates the significant promise of trichocyte keratins in promoting wound healing, with distinct behaviors and advantages observed among different types. Transcriptomic analysis reveals the regulatory mechanisms of keratins in cell proliferation, migration, and blood vessel generation. These findings can contribute to the development and precision application of keratins.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Jianghui Qin, Fang Chen, Pingli Wu, Guoming Sun
Summary: Wound healing is a complex biological process with bioengineered scaffolds playing a key role in regenerative therapy. Although advancements have been made, challenges remain in achieving ideal treatment for deep cutaneous injuries. Designing innovative scaffolds, precursor development, and therapeutic interventions hold promise for future wound healing strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meng-Yun Ke, Yi Fang, Hui Cai, Jian-Wen Lu, Lin Yang, Yue Wang, Rong-Qian Wu, Xu-Feng Zhang, Yi Lv, Jian Dong
Summary: This study demonstrates that the m6A reader YTHDF1 plays a protective role in fulminant hepatitis by regulating the translation of MFG-E8 protein in an m6A-dependent manner. YTHDF1 deficiency exacerbates liver damage, whereas YTHDF1 overexpression mitigates cell death and improves mitochondrial function. These findings provide insights into the molecular mechanisms underlying fulminant hepatitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Letter
Dermatology
Akiko Sekiguchi, Sei-ichiro Motegi, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2016)
Article
Dermatology
Sei-ichiro Motegi, Kazuya Yamada, Sayaka Toki, Akihiko Uchiyama, Yuka Kubota, Tetsuya Nakamura, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2016)
Article
Oncology
Akira Shimizu, Kyoichi Kaira, Keita Mori, Madoka Kato, Kimihiro Shimizu, Masahito Yasuda, Ayumi Takahashi, Tetsunari Oyama, Takayuki Asao, Osamu Ishikawa
Editorial Material
Dermatology
Mai Hattori, Sei-ichiro Motegi, Hiroo Amano, Norihisa Ishii, Osamu Ishikawa
ACTA DERMATO-VENEREOLOGICA
(2016)
Editorial Material
Dermatology
Mai Hattori, Akira Shimizu, Takeshi Hisada, Takaya Fukumoto, Osamu Ishikawa
ACTA DERMATO-VENEREOLOGICA
(2016)
Review
Dermatology
Sei-ichiro Motegi, Masahito Yasuda, Masayoshi Yamanaka, Hiroo Amano, Osamu Ishikawa
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2017)
Article
Oncology
Kazuya Yamada, Akihiko Uchiyama, Akihito Uehara, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi, Mark C. Udey, Osamu Ishikawa, Sei-ichiro Motegi
Article
Dermatology
Masahito Yasuda, Sayaka Yamaguchi, Yoshiki Miyachi, Osamu Ishikawa, Kenzo Takahashi
EXPERIMENTAL DERMATOLOGY
(2016)
Article
Dermatology
Sei-ichiro Motegi, Akihiko Uchiyama, Kazuya Yamada, Sachiko Ogino, Yoko Yokoyama, Buddhini Perera, Yuko Takeuchi, Osamu Ishikawa
EXPERIMENTAL DERMATOLOGY
(2016)
Letter
Dermatology
Sei-Ichiro Motegi, Akiko Sekiguchi, Sayaka Toki, Hiroo Amano, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
Mai Hattori, Akira Shimizu, Kyoichi Kaira, Osamu Ishikawa
JOURNAL OF DERMATOLOGY
(2017)
Article
Oncology
Akira Shimizu, Kyoichi Kaira, Masahito Yasuda, Takayuki Asao, Osamu Ishikawa
Article
Oncology
Akira Shimizu, Kyoichi Kaira, Masahito Yasuda, Takayuki Asao, Osamu Ishikawa
PATHOLOGY & ONCOLOGY RESEARCH
(2017)
Article
Multidisciplinary Sciences
Yoshiki Yamakoshi, Sei-ichiro Motegi, Osamu Ishikawa
Article
Oncology
A. Shimizu, K. Kaira, M. Yasuda, T. Asao, O. Ishikawa
