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Biochemistry & Molecular Biology
Toyoshi Yanagihara, Kazuya Tsubouchi, Mahsa Gholiof, Sy Giin Chong, Kenneth E. Lipson, Quan Zhou, Ciaran Scallan, Chandak Upagupta, Jussi Tikkanen, Shaf Keshavjee, Kjetil Ask, Martin R. J. Kolb
Summary: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by the accumulation of myofibroblasts. The study found that connective-tissue growth factor (CTGF) plays a key role in pulmonary fibrosis. Increased levels of CTGF exacerbate lung fibrosis and CTGF expression is upregulated in patients with idiopathic pulmonary fibrosis. Different cells contribute to the maintenance of the fibrotic phenotype during fibrogenesis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
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Obstetrics & Gynecology
Yanqin Zhang, Xiangyu Chang, Di Wu, Mengqi Deng, Jinwei Miao, Zhaoyu Jin
Summary: Exosomal miR-214-3p can inhibit fibrosis in endometriosis by targeting CCN2, providing a potential therapeutic approach for EMs.
REPRODUCTIVE SCIENCES
(2021)
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Immunology
Yu-Wen Cheng, Ze-Bei Zhang, Bei-Di Lan, Jing-Rong Lin, Xiao-Hui Chen, Ling-Ran Kong, Lian Xu, Cheng -Chao Ruan, Ping-Jin Gao
Summary: Obesity-induced adipose tissue-derived factors play a key role in cardiac damage, with the newly identified adipokine PDGF-D potentially regulating cardiac remodeling in obese mice. The study demonstrates that uPA activates PDGF-D and accelerates AngII-induced cardiac remodeling in obese mice by a new interaction pattern between macrophage and adipocyte.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
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Pharmacology & Pharmacy
Xiaoqi Nie, Qianqian Yu, Long Li, Minxiao Yi, Bili Wu, Yongbiao Huang, Yonghui Zhang, Hu Han, Xianglin Yuan
Summary: Kinsenoside alleviates radiation-induced liver fibrosis by regulating the TGF-beta 1/Smad/CTGF pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
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Medicine, General & Internal
Xiaozheng Song, Yuqiang Cui, Teng Zhu
Summary: The study aimed to verify the effects of miR-19 on cardiac fibrosis and its target. The expression of miR-19 was reduced in the heart tissue and cardiac fibroblasts. Upregulating miR-19 can improve cardiac function and attenuate cardiac fibrosis by inhibiting the CTGF and MAPK pathways.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
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Nanoscience & Nanotechnology
Rong Liu, Min Zhu, Jiaojiao Chen, Junwei Gai, Jing Huang, Yingqun Zhou, Yakun Wan, Chuantao Tu
Summary: In this study, a novel nanobody (Nb) against human connective tissue growth factor (CTGF) was identified, which showed antifibrotic effects in vitro by regulating the biological functions of human stellate cells. This study is of great importance for the development of antifibrotic therapies for liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
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Cell Biology
Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Summary: This study found that bile acids, particularly glycocholic acid (GCA), can induce the expression of connective tissue growth factor in hepatocytes by promoting the nuclear translocation of yes-associated protein, thereby activating hepatic stellate cells and promoting the progression of liver fibrosis in cholestatic disease.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Wei Xiang, Longhui Li, Fuyan Hong, Yongcheng Zeng, Jin Zhang, Jinye Xie, Gang Shen, Jinhong Wang, Zhenzhen Fang, Weiwei Qi, Xia Yang, Guoquan Gao, Ti Zhou
Summary: N-cadherin plays a significant role in diabetic retinopathy by inducing retinal fibrosis; a new drug called PEDF has been discovered to inhibit N-cadherin cleavage and alleviate retinal fibrosis.
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Pharmacology & Pharmacy
Panxia Wang, Minghui Wang, Yuehuai Hu, Jianxing Chen, Yanjun Cao, Cui Liu, Zhongkai Wu, Juan Shen, Jing Lu, Peiqing Liu
Summary: YAP1 plays a significant role in Dox-induced cardiomyopathy, while Isorhapontigenin (Isor) could be a potential new compound for combating Dox-induced cardiotoxicity by increasing YAP1 expression.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell Biology
You -Tien Tsai, Hsiang -Yuan Yeh, Chia -Ter Chao, Jenq-Wen Huang, Chih-Kang Chiang
Summary: This study found that the transforming growth factor-beta (TGF-beta) plays a crucial role in vascular calcification (VC). The mechanism of TGF-beta's involvement in VC was investigated using experimental models and clinical specimens. The results revealed that TGF-beta 1 can regulate the occurrence and progression of VC by modulating the miR-378a-3p/CTGF signaling pathway at specific time points.
Article
Biochemistry & Molecular Biology
Yoshiko Hada, Haruhito A. Uchida, Ryoko Umebayashi, Masashi Yoshida, Jun Wada
Summary: Cilostazol can attenuate Angiotensin II-induced cardiac fibrosis by activating the cAMP-PKA pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Si-Min Zhang, Chuan-Yuan Wei, Qiang Wang, Lu Wang, Lu Lu, Fa-Zhi Qi
Summary: Our research showed for the first time that M2 promotes wound healing by secreting CTGF, which further mediates the proliferation and migration of fibroblasts via the AKT, ERK1/2, and STAT3 pathways.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Multidisciplinary Sciences
Wei Liang, Yingnan Zhang, Liang Zhou, Xiaoqin Lu, Margaret E. Finn, Wei Wang, Hui Shao, Douglas C. Dean, Lijun Zhang, Yongqing Liu
Summary: The study found that Zeb1 forms a positive regulatory loop with Tgfb to regulate early corneal inflammation by controlling immune cell viability and mobility, and later promotes corneal wound healing through activation of various signaling pathways.
Article
Medicine, General & Internal
Iris I. Mueller, Martina Schneider, Karin A. L. Mueller, Oleg Lunov, Oliver Borst, Thomas Simmet, Meinrad Gawaz
Summary: Gremlin-1 is expressed in myocardial tissue and infiltrating cells after transient myocardial ischaemia and colocalizes with the pro-fibrotic cytokine transforming growth factor-beta. Gremlin-1 reduces TGF-beta-induced collagen production in myocardial fibroblasts and administration of mGremlin-1-Fc significantly reduces infarct size.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)