Article
Medicine, General & Internal
Keigo Murakami, Shuko Hata, Naoya Ishibashi, Motoki Kubota, Yoshinobu Eishi, Keisuke Uchida, Toshiharu Tabata, Yasuhiro Nakamura, Kazuhiro Murakami
Summary: This case report identified a pulmonary necrotizing sarcoid granulomatosis (NSG)-like lesion possibly associated with coinfection of Mycobacterium avium and Propionibacterium acnes. Both bacteria were detected in the lesion, with more P. acnes genomes found in the granulomas compared to the non-lesion lung tissue. These findings suggest a need to recognize NSG as a continuum spectrum of sarcoidosis/mycobacteriosis.
Article
Biotechnology & Applied Microbiology
Michal Witt, Miron Tokarski, Ewa Zietkiewicz, Arleta Lebioda, Maria Szczypek, Wojciech Falkowski, Przemyslaw Mrozowski, Teresa Kulak, Malgorzata Sobieszczanska, Magdalena Mrugalska-Banaszak, Tomasz Jurek, Tadeusz Dobosz
Summary: This study investigates the heart tissue remains of Thaddeus Kosciuszko as a possible cause of his disease and death. Using nanosequencing, DNA samples from wax surfaces, wooden plates, and linen cloth in contact with the object were analyzed. The results suggest that the presence of Propionibacterium acnes in the original heart tissue may have caused endocarditis and eventually led to rapid deterioration of health and death.
MICROBIAL CELL FACTORIES
(2022)
Article
Infectious Diseases
Hyoung-An Choi, Sang-Oh Ahn, Ho-Dong Lim, Geun-Joong Kim
Summary: Cutibacterium acnes, formerly known as Propionibacterium acnes, is a Gram-positive bacterium that causes acne and other inflammatory diseases, which has developed resistance to antibiotics due to their overuse. Medicinal plant extracts have shown promising antimicrobial activity against C. acnes, with extracts from Chrysosplenium flagelliferum F. and Thuja orientalis L. exhibiting the most significant antimicrobial effects.
Article
Microbiology
Nastassia Knodlseder, Guillermo Nevot, Maria-Jose Fabrega, Julia Mir-Pedrol, Marta Sanvicente-Garcia, Nil Campama-Sanz, Bernhard R. Paetzold, Rolf R. Lood, Marc R. Guell
Summary: A study has identified an R-M system in C. acnes that can perform DNA methylation, demonstrating how this mechanism can be used to selectively kill acne-prone strains while protecting probiotic ones.
Article
Biotechnology & Applied Microbiology
Ming-Shan Kao, Jen-Ho Yang, Arun Balasubramaniam, Supitchaya Traisaeng, Albert Jackson Yang, John Jackson Yang, Benjamin Prethiviraj Salamon, Deron R. Herr, Chun-Ming Huang
Summary: In this study, researchers found that nasal inoculation of nucleocapsid phosphoprotein (NPP) of SARS-CoV-2 increased the level of interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF). However, nasal administration of liquid coco-caprylate/caprate (LCC) onto Staphylococcus epidermidis (S. epidermidis)-colonized mice significantly reduced NPP-induced IL-6. Further investigation showed that S. epidermidis mediated LCC fermentation to produce electricity and butyric acid, which promoted bacterial colonization and activated free fatty acid receptor 2 (Ffar2). Inhibition of Ffar2 impeded the effect of S. epidermidis plus LCC on reducing NPP-induced IL-6. These findings suggest that nasal S. epidermidis plays a role in mitigating the cytokine storm induced by airway infection of SARS-CoV-2.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Cell Biology
Hongshuang Yu, Wanlin Yang, Jiefang Huang, Xiang Miao, Bei Wang, Xiaohui Ren, Yuting Gu, Qiwei Wang, Xinyuan Ding, Xin Guo, Fengtao Qian, Yanyun Zhang, Huanbai Xu, Leizhen Zheng, Min Jin
Summary: Activation of GPR120 can alleviate fulminant hepatic failure by reducing liver injury and mortality. GPR120 activation decreases Th1 cell response and expands Tregs. GPR120 activation also induces a specific population of regulatory DCs in the liver. GPR120 restricts glycolysis through HIF-1α and can be attenuated by inhibiting ERK or activating AMPK.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Vinicius Magno da Rocha, Carla Ormundo Goncalves Ximenes Lima, Eliane de Oliveira Ferreira, Gabriel Correa de Farias, Fabio Cesar Sousa Nogueira, Luis Caetano Martha Antunes, Keila Mara Cassiano, Rossano Kepler Alvim Fiorelli
Summary: This study aims to prospectively examine patients with lumbar disc degeneration (LDD) and low back pain (LBP) to investigate the colonization of Cutibacterium acnes in the lumbar intervertebral discs (LLIVD) and its correlation with LBP. Clinical, radiological, and demographic profiles of participants undergoing surgical microdiscectomy will be tracked, and samples from LLIVD will be characterized phenotypically and genotypically for pathogen identification and analysis.
Article
Multidisciplinary Sciences
Hsin-Jou Kao, Yan-Han Wang, Sunita Keshari, John Jackson Yang, Shinta Simbolon, Chun-Chuan Chen, Chun-Ming Huang
Summary: The study identified a natural acidic formulation containing propionic acid which effectively reduces skin pigmentation by inhibiting tyrosinase activity without affecting melanocyte proliferation. The fermentation metabolites from Cutibacterium acnes mediated the inhibition of melanogenesis, showing potential as a safe and harmless alternative to chemical whitening products. The use of propionic acid did not disrupt the balance of the skin microbiome and did not affect the growth of its parent bacteria, making it a potent fermentation metabolite for reducing hyperpigmentation.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Xuqin Du, Lihong Song, Ruie Feng, Qiao Ye
Summary: This case report presents a 48-year-old woman with 27 months of exposure to aluminum dust and silica, resulting from polishing processing. The patient was diagnosed with aluminum-associated sarcoid-like granulomatous lung disease, instead of sarcoidosis, based on occupational exposure evaluation by a multidisciplinary panel.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Junjie Cao, Meifeng Xu, Longfei Zhu, Shengxiang Xiao
Summary: This study found that viaminate, a vitamin A acid drug, can improve acne by inhibiting the activation of the MAPK pathway and keratinocyte proliferation and keratinization levels.
CURRENT DRUG TARGETS
(2023)
Article
Multidisciplinary Sciences
Karl-Jan Spittaels, Katleen van Uytfanghe, Christos C. Zouboulis, Christophe Stove, Aurelie Crabbe, Tom Coenye
Summary: Acne-associated Cutibacterium acnes strains and their porphyrins can activate NRLP3 inflammasome assembly, leading to K+ leakage, inflammasome activation, and IL-1 beta release. Acneic strains produce more porphyrins, which interact with keratinocyte cell membrane, explaining why some C. acnes strains dominate on healthy skin while others dominate on acneic skin.
Article
Biotechnology & Applied Microbiology
Mengyuan Shan, Fanqiang Meng, Chao Tang, Libang Zhou, Zhaoxin Lu, Yingjian Lu
Summary: Accumulating evidence suggests that suppressing Propionibacterium acnes-induced inflammation is a promising strategy to alleviate acne vulgaris. This study evaluated the alleviating effect of surfactin-oleogel on P. acnes-induced inflammatory acne vulgaris in mice. The results demonstrated that surfactin-oleogel has antibacterial and anti-inflammation activities, making it a potential treatment for P. acnes-induced inflammatory acne vulgaris.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jennifer L. Larson-Casey, Shanrun Liu, Jennifer M. Pyles, Suzanne E. Lapi, Komal Saleem, Veena B. Antony, Manuel Lora Gonzalez, David K. Crossman, A. Brent Carter
Summary: It has been found that environmental heavy metal exposure is associated with lung diseases, including lower respiratory tract infections. Through single-cell RNA sequencing, an increase in Pparg gene expression in lung macrophages from mice exposed to cadmium and/or infected with Streptococcus pneumoniae was observed. However, it was discovered that the heavy metal cadmium or infection led to an inhibitory posttranslational modification of the peroxisome proliferator-activated receptor gamma (PPAR gamma), exacerbating lower respiratory tract infections.
Article
Cell Biology
Guoqing Tang, Xiaoguang Han, Zhijie Lin, Hongbin Qian, Bing Chen, Chengliang Zhou, Yong Chen, Weimin Jiang
Summary: Our study showed that P. acnes induces nucleus pulposus cell pyroptosis through the ROS-NLRP3 signaling pathway, leading to intervertebral disc degeneration. Targeting P. acnes-induced pyroptosis may be a potential treatment strategy for IVD degeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biotechnology & Applied Microbiology
M. Y. Shan, F. Q. Meng, L. B. Zhou, F. X. Lu, X. M. Bie, H. Z. Zhao, Z. X. Lu
Summary: The study found that surfactin effectively inhibits the growth of Propionibacterium acnes by destroying the cell wall and altering membrane integrity. Additionally, in a mouse model of acne, surfactin was shown to significantly reduce epidermal swelling and erythema induced by P. acnes, highlighting its potential as a candidate for acne treatment.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Dermatology
Shintaro Takeoka, Teruo Shimizu, Masahiro Kamata, Carren Sy Hau, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Shuko Takeuchi, Masahiro Kamata, Hideaki Uchida, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Hideaki Uchida, Masahiro Kamata, Aika Kato, Itsumi Mizukawa, Ayu Watanabe, Ai Agematsu, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Letter
Pathology
Yuki Sano, Yoshinao Kikuchi, Shigeki Morita, Teruaki Oka, Koji Saito, Nanami Takeda, Kento Terashima, Hikaru Toyota, Hideaki Uchida, Shiori Watabe, Satoe Numakura, Shoki Miyoshi, Hiroyuki Nagase, Masahiro Kamata, Yayoi Tada, Hiroshi Uozaki
PATHOLOGY INTERNATIONAL
(2021)
Article
Dermatology
Kei Mukai, Masahiro Kamata, Mirei Miyazaki, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada, Takamitsu Tanaka
Summary: This case report highlights a patient with BRAF-mutated melanoma who developed adverse events including elevated D-dimer levels and pyrexia after receiving CombiDT and CombiEB treatments, which were prevented by concomitant edoxaban. This allowed the patient to continue receiving CombiEB therapy.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Atsuko Fukuyasu, Masahiro Kamata, Carren Sy Hau, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada, Naoko Kanda
Summary: The severity of herpes zoster is significantly correlated with the duration of postherpetic neuralgia, with serum IL-10 levels potentially serving as a practical predictor of neuralgia duration.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Iori Okura, Masahiro Kamata, Yoshihide Asano, Aya Mitsui, Teruo Shimizu, Shinichi Sato, Yayoi Tada
Summary: This study demonstrated that fingolimod effectively alleviated IMQ-induced psoriasiform dermatitis, suggesting its potential as a therapeutic agent for psoriasis.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Review
Dermatology
Sayaka Shibata
Summary: The skin maintains its integrity by rapidly responding to external signals, with most genes in a poised state for stress responding. Local chromatin dynamics, supported by an interplay between epigenetic regulators and transcription factors, underlie transcriptional responses upon stress exposure. Epigenetic regulators play a leading role in chromatin remodeling during stress adaptation, and the timely release and restoration of these factors are indispensable for appropriate skin repair.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Letter
Dermatology
Hideaki Uchida, Masahiro Kamata, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Yuka Mizuno, Sayaka Shibata, Tomomitsu Miyagaki, Yukiko Ito, Haruka Taira, Issei Omori, Teruyoshi Hisamoto, Kenta Oka, Kazuki M. Matsuda, Hikari Boki, Naomi Takahashi-Shishido, Makoto Sugaya, Shinichi Sato
Summary: In recent years, circulating cell-free DNA (cfDNA) has gained attention as a biomarker for cancer. This study found that serum cfDNA levels in patients with cutaneous T-cell lymphoma (CTCL) were significantly higher than healthy controls and increased with disease progression. There were positive correlations between cfDNA levels and certain blood markers and clinical findings, and higher cfDNA levels were associated with a worse prognosis in CTCL patients.
JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Yuka Mizuno, Sayaka Shibata, Yukiko Ito, Haruka Taira, Eiki Sugimoto, Kentaro Awaji, Shinichi Sato
Summary: Bullous pemphigoid (BP) is an autoimmune disease characterized by the activation of immune cells and blister formation through excess extracellular DNA production. This study demonstrates that interleukin (IL)-26 binds to extracellular DNA, contributing to DNA sensing in BP. Patients with BP showed elevated levels of circulating IL-26, forming IL-26-DNA complexes that play a dual role in regulating local immunity and blister formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sayaka Shibata
Summary: Epigenetics plays a crucial role in immune cell activation in the skin. Disruption of normal epigenetic regulation can lead to dysregulation of immune factors and impact skin immunity. This review focuses on the epigenetic regulation of histone modification and chromatin remodeling and their potential involvement in chronic cutaneous immune disorders.
IMMUNOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Eiki Sugimoto, Hiroki Matsuda, Sayaka Shibata, Yuka Mizuno, Asumi Koyama, Lixin Li, Haruka Taira, Yukiko Ito, Kentaro Awaji, Takashi Yamashita, Shinichi Sato
Summary: This study examined accessible systemic inflammatory markers in patients with psoriasis vulgaris and psoriatic arthritis, and evaluated their association with psoriasis severity, the presence of arthritis, and treatment continuation rates. The findings showed positive correlations between various inflammatory markers and Psoriasis Area and Severity Index scores. Higher platelet/lymphocyte ratio (PLR) or CRP values were associated with psoriatic arthritis diagnosis. Higher pretreatment neutrophil or platelet count, PLR, and SII were associated with lower treatment continuation rates of conventional systemic agents. These findings suggest that accessible inflammatory markers can effectively assess systemic inflammation and guide therapeutic approaches for psoriasis vulgaris and psoriatic arthritis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Hideaki Uchida, Masahiro Kamata, Shota Egawa, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
Summary: In this study, tacrolimus ointment was investigated for its effectiveness on facial lesions refractory to topical corticosteroid in AD patients receiving dupilumab, showing improvement in some patients after switching treatment methods.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2022)
Letter
Allergy
Hideaki Uchida, Masahiro Kamata, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Kenjiro Mitsuhashi, Yayoi Tada
Summary: This case report presents a 44-year-old male patient with atopic dermatitis who developed malignant lymphoma (diffuse large B-cell lymphoma) during treatment with dupilumab.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2021)