Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 181, Issue 5, Pages 1484-1492Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2012.08.010
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Funding
- NIH (Training Grant in Molecular Neuropathology T32) [N5007098-31, NS069577, A1076248]
- Burroughs-Wellcome Fund (Career Awards for Medical Scientists)
- Einstein-Montefiore Institute for Clinical and Translational Research (Career Development Award)
- NIH (Training Grant in Molecular Neuropathology T32) [N5007098-31, NS069577, A1076248]
- Burroughs-Wellcome Fund (Career Awards for Medical Scientists)
- Einstein-Montefiore Institute for Clinical and Translational Research (Career Development Award)
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Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria. (Am J Pathol 2012, 181:1484-1492; http://dx.doi.org/10.10164/j.ajpath.201208.010)
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