Article
Oncology
Olga Lyudovyk, Justin Y. Kim, David Qualls, Madeline A. Hwee, Ya-Hui Lin, Sawsan R. Boutemine, Yuval Elhanati, Alexander Solovyov, Melanie Douglas, Eunise Chen, N. Esther Babady, Lakshmi Ramanathan, Pallavi Vedantam, Chaitanya Bandlamudi, Sigrid Gouma, Philip Wong, Scott E. Hensley, Benjamin Greenbaurn, Alexander C. Huang, Santosha A. Vardhana
Summary: This study analyzes the immune responses of 103 patients with prior COVID-19 infection and finds that delayed viral clearance is associated with antibody loss and increased T cell responses. CD8(+) T cell differentiation and diverse COVID-specific T cell receptor (TCR) repertoire indicate prolonged disease. Conversely, a CD4(+) T cell dominant immunophenotype promotes effective viral clearance and T cell memory development.
Article
Immunology
Julia Niessl, Takuya Sekine, Joshua Lange, Viktoria Konya, Marianne Forkel, Jovana Maric, Anna Rao, Luca Mazzurana, Efthymia Kokkinou, Whitney Weigel, Sian Llewellyn-Lacey, Emma B. Hodcroft, Annika C. Karlsson, Johan Fehrm, Joar Sundman, David A. Price, Jenny Mjosberg, Danielle Friberg, Marcus Buggert
Summary: The study found that in individuals who had not been exposed to SARS-CoV-2, the frequencies of SARS-CoV-2-specific memory CD4(+) T cells were similar in tonsils and peripheral blood, but functional SARS-CoV-2-specific memory CD8(+) T cells were mostly found in tonsils. This suggests that preexisting tissue-resident memory CD8(+) T cells in unexposed individuals could potentially mount rapid immune responses against SARS-CoV-2.
SCIENCE IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Wei-Shan Chin, Shih-Cheng Liao, Shin-Chun Pan, Yue-Liang Leon Guo
Summary: This study investigated and compared the effects of occupational injury, non-occupational injury, and no injury on the development of psychiatric diseases. The results showed that both occupational injury and non-occupational injury were associated with increased incidence of psychiatric disorders, highlighting the importance of long-term psychological care among injured workers in workers' compensation mechanisms.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biology
Scott M. Anthony, Natalija Van Braeckel-Budimir, Steven J. Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M. Hartwig, Isaac J. Jensen, Steven M. Varga, Noah S. Butler, Hai-Hui Xue, Vladimir P. Badovinac, John T. Harty
Summary: IAV infection generates Trm CD8(+)T cells in mice, while repeated antigen exposure produces 4M CD8(+)T cells with enhanced protective capacity. Enhanced protection by 4M cells is associated with increased expression of granzyme A/B and stable maintenance of CD69(+)CD103(+) 4M CD8(+)T cells, improving control of viral infections in mLN.
Article
Immunology
Rui Dai, Xiaopei Huang, Yiping Yang
Summary: This study demonstrates the critical role of gamma delta T cells in promoting the CD8(+) T cell response to VV infection. Gamma delta T cells are able to present viral antigens and activate CD8(+) T cells, with MyD88 signaling playing a key role in this process. Understanding the regulation of adaptive T cell response by gamma delta T cells may provide insight for the development of more effective vaccine strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Paul E. Monahan, Claude Negrier, Michael Tarantino, Leonard A. Valentino, Federico Mingozzi
Summary: Gene therapy using AAV vectors has shown promise as a potential cure for hemophilia, but immune responses remain a challenge. Various strategies have been explored to overcome immunogenicity and immune response issues, but more efficient methods are needed to deliver lasting, predictable outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jie Zhangl, Dan Lu, Min Li, Maoshun Liu, Sijia Yao, Jianbo Zhan, William J. Liu, George F. Gao
Summary: This study identified a newly derived T-cell epitope from SARS-CoV-2, which could be helpful in detecting cellular immunity against different sarbecoviruses. It also provided an evaluation method and peptide candidate for the research and development of T-cell based vaccine for the virus.
Article
Immunology
Marco Kunzli, Stephen D. O'Flanagan, Madeleine LaRue, Poulami Talukder, Thamotharampillai Dileepan, J. Michael Stolley, Andrew G. Soerens, Clare F. Quarnstrom, Sathi Wijeyesinghe, Yanqi Ye, Justine S. McPartlan, Jason S. Mitchell, Christian W. Mandl, Richard Vile, Marc K. Jenkins, Rafi Ahmed, Vaiva Vezys, Jasdave S. Chahal, David Masopust
Summary: The routes of mRNA vaccination can influence humoral and cell-mediated immunity, with intramuscular vaccination establishing lung TRM and intranasal vaccination augmenting respiratory mucosal immunity. Combining intramuscular vaccination with intranasal boost can achieve high levels of both circulating T cell memory and lung TRM.
SCIENCE IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tobias Boettler, Benedikt Csernalabics, Henrike Salie, Hendrik Luxenburger, Lara Wischer, Elahe Salimi Alizei, Katharina Zoldan, Laurenz Krimmel, Peter Bronsert, Marius Schwabenland, Marco Prinz, Carolin Mogler, Christoph Neumann-Haefelin, Robert Thimme, Maike Hofmann, Bertram Bengsch
Summary: This case report highlights the occurrence of autoimmune hepatitis episodes following COVID-19 vaccination in a patient with distinctive T cell-dominant immune-mediated hepatitis. Liver tissue analysis revealed an immune infiltrate with activated cytotoxic CD8 T cells predominantly distributed, indicating a unique pathomechanism associated with vaccination-induced antigens.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yasunaga Shiraishi, Takeshi Adachi, Jose M. Cacicedo, Yasuo Ido
Summary: The study aimed to develop a simple and high-quality method for obtaining enough lung-targeted rAAV. The authors achieved this by introducing mutations, optimizing culture conditions, and improving the purification method, resulting in stable and lung-targeted rAAVs.
Article
Biotechnology & Applied Microbiology
Makoto Horiuchi, Christian J. J. Hinderer, Hailey N. N. Shankle, Peter M. M. Hayashi, Jessica A. A. Chichester, Casey Kissel, Peter Bell, Cecilia Dyer, James M. M. Wilson
Summary: Advancements in AAV-based gene therapy hold significant potential for treating rare genetic disorders and addressing unmet medical needs. However, the presence of anti-AAV neutralizing antibodies (NAbs) in human populations limits the efficacy of these therapies. By using FcRn-inhibiting monoclonal antibodies, such as M281, pre-existing NAbs can be reduced, allowing for enhanced gene delivery in NAb-positive patients. This study highlights the importance of mitigating humoral immunity to make AAV-based gene therapies effective.
HUMAN GENE THERAPY
(2023)
Article
Immunology
Brendan W. MacNabb, Sravya Tumuluru, Xiufen Chen, James Godfrey, Darshan N. Kasal, Jovian Yu, Marlieke L. M. Jongsma, Robbert M. Spaapen, Douglas E. Kline, Justin Kline
Summary: This study demonstrates the importance of MHC-I cross-dressing in regulating anti-tumor immunity. In addition to quantitatively enhancing tumor antigen presentation, it also enables dendritic cells to more accurately mirror the cancer cell peptidome.
Article
Biochemistry & Molecular Biology
Kristina Macakova, Elzbieta Kaczmarek, Kiyoshi Itagaki
Summary: Our work suggests that mtDAMPs, specifically mtFPs released by tissue injury, play a significant role in the development of nosocomial pneumonia after a serious injury. PMN migrate to the injury site by detecting mtFPs through FPR1 to fight bacterial infection, but the activation of FPR1 by mtFPs leads to desensitization/internalization of chemokine receptors, rendering PMN unresponsive to secondary infections. This allows bacterial growth in the lungs and the development of nosocomial pneumonia. Intratracheal application of exogenously isolated PMN may prevent pneumonia coupled with a serious injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Suyash Prasad, David P. Dimmock, Benjamin Greenberg, Jagdeep S. Walia, Chanchal Sadhu, Fatemeh Tavakkoli, Gerald S. Lipshutz
Summary: Adeno-associated viruses (AAVs) used in gene therapy can trigger immune responses that hinder the effectiveness of the therapy. Various immunomodulatory strategies have been used to minimize these responses and enhance the duration of gene therapy.
HUMAN GENE THERAPY
(2022)
Review
Biochemistry & Molecular Biology
J. Abraham Dominguez-Avila, Norma J. Salazar-Lopez, Marcelino Montiel-Herrera, Alejandro Martinez-Martinez, Monica A. Villegas-Ochoa, Gustavo A. Gonzalez-Aguilar
Summary: Phenolic compounds have the potential to regulate immune response, counter inflammation, and maintain health, particularly that of the central nervous system.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Oncology
Amita Patnaik, S. Peter Kang, Drew Rasco, Kyriakos P. Papadopoulos, Jeroen Elassaiss-Schaap, Muralidhar Beeram, Ronald Drengler, Cong Chen, Lon Smith, Guillermo Espino, Kevin Gergich, Liliana Delgado, Adil Daud, Jill A. Lindia, Xiaoyun Nicole Li, Robert H. Pierce, Jennifer H. Yearley, Dianna Wu, Omar Laterza, Manfred Lehnert, Robert Iannone, Anthony W. Tolcher
CLINICAL CANCER RESEARCH
(2015)
Article
Biotechnology & Applied Microbiology
Robert H. Pierce, Jean S. Campbell, Sara I. Pai, Joshua D. Brody, Holbrook E. K. Kohrt
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2015)
Article
Biochemistry & Molecular Biology
C. Burkart, A. Mukhopadhyay, S. A. Shirley, R. J. Connolly, J. H. Wright, A. Bahrami, J. S. Campbell, R. H. Pierce, D. A. Canton
Article
Immunology
I. H. Chan, R. Jain, M. S. Tessmer, D. Gorman, R. Mangadu, M. Sathe, F. Vives, C. Moon, E. Penaflor, S. Turner, G. Ayanoglu, C. Chang, B. Basham, J. B. Mumm, R. H. Pierce, J. H. Yearley, T. K. McClanahan, J. H. Phillips, D. J. Cua, E. P. Bowman, R. A. Kastelein, D. LaFace
MUCOSAL IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Paul C. Tumeh, Christina L. Harview, Jennifer H. Yearley, I. Peter Shintaku, Emma J. M. Taylor, Lidia Robert, Bartosz Chmielowski, Marko Spasic, Gina Henry, Voicu Ciobanu, Alisha N. West, Manuel Carmona, Christine Kivork, Elizabeth Seja, Grace Cherry, Antonio J. Gutierrez, Tristan R. Grogan, Christine Mateus, Gorana Tomasic, John A. Glaspy, Ryan O. Emerson, Harlan Robins, Robert H. Pierce, David A. Elashoff, Caroline Robert, Antoni Ribas
Editorial Material
Immunology
Ian N. Crispe, Robert H. Pierce
Article
Biochemistry & Molecular Biology
Jonathan P. Sherlock, Barbara Joyce-Shaikh, Scott P. Turner, Cheng-Chi Chao, Manjiri Sathe, Jeff Grein, Daniel M. Gorman, Edward P. Bowman, Terrill K. McClanahan, Jennifer H. Yearley, Gerard Eberl, Christopher D. Buckley, Robert A. Kastelein, Robert H. Pierce, Drake M. LaFace, Daniel J. Cua
Article
Biochemistry & Molecular Biology
Anandaroop Mukhopadhyay, Jocelyn Wright, Shawna Shirley, David A. Canton, Christoph Burkart, Richard J. Connolly, Jean S. Campbell, Robert H. Pierce
Article
Oncology
Ingunn M. Stromnes, Adam L. Burrack, Ayaka Hulbert, Patrick Bonson, Cheryl Black, J. Scott Brockenbrough, Jackson F. Raynor, Ellen J. Spartz, Robert H. Pierce, Philip D. Greenberg, Sunil R. Hingorani
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Oncology
Samantha K. Greaney, Alain P. Algazi, Katy K. Tsai, Kathryn T. Takamura, Lawrence Chen, Christopher G. Twitty, Li Zhang, Alan Paciorek, Robert H. Pierce, Mai H. Le, Adil Daud, Lawrence Fong
CANCER IMMUNOLOGY RESEARCH
(2020)
Review
Oncology
James C. Lee, Michael D. Green, Laura A. Huppert, Christine Chow, Robert H. Pierce, Adil Daud
Summary: Liver metastases have a significant impact on the effectiveness of immune checkpoint inhibitors in patients with solid-tumor malignancies. Multiple clinical and translational studies have shown that liver metastasis leads to systemic immune suppression through the generation of suppressive macrophages and activation of regulatory T-cells. Various interventions, such as radiation therapy and combination checkpoint blockade, have been reported to address liver immune suppression.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Peter H. Goff, Laura Riolobos, Bonnie J. LaFleur, Matthew B. Spraker, Y. David Seo, Kimberly S. Smythe, Jean S. Campbell, Robert H. Pierce, Yuzheng Zhang, Qianchuan He, Edward Y. Kim, Stephanie K. Schaub, Gabrielle M. Kane, Jose G. Mantilla, Eleanor Y. Chen, Robert Ricciotti, Matthew J. Thompson, Lee D. Cranmer, Michael J. Wagner, Elizabeth T. Loggers, Robin L. Jones, Erin Murphy, Wendy M. Blumenschein, Terrill K. McClanahan, Jon Earls, Kevin C. Flanagan, Natalie A. LaFranzo, Teresa S. Kim, Seth M. Pollack
Summary: This study aims to characterize the changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy and provides insights for neoadjuvant immunotherapy trial design. The results show that neoadjuvant therapy significantly increases immune cell infiltration in the tumor and affects the expression of immune-related genes and cytokines. These findings inform the incorporation of immune checkpoint inhibitors and novel immunotherapies into the neoadjuvant setting for STSs.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Robert H. I. Andtbacka, Yan Wang, Robert H. Pierce, Jean S. Campbell, Melinda Yushak, Mohammed Milhem, Merrick Ross, Katie Niland, Robert D. Arbeit, Sudha Parasuraman, Kris Bickley, Cecilia C. S. Yeung, Lauri D. Aicher, Kimberly S. Smythe, Lu Gan
Summary: The study found that treatment with single-agent mavorixafor can increase CD8+ T-cell infiltration, granzyme B signal, antigen presentation machinery, and both tumor inflammatory signature (TIS) and IFNγ gene expression signature scores. When mavorixafor was combined with pembrolizumab, the increases in the key serum cytokines CXCL9 and CXCL10 were further enhanced. Reported adverse events included diarrhea, fatigue, maculopapular rash, and dry eye, all of which were ≤ grade 3.
CANCER RESEARCH COMMUNICATIONS
(2022)
Meeting Abstract
Oncology
Adil Daud, Alain Patrick Algazi, Michelle T. Ashworth, Lawrence Fong, Jera Lewis, Stephen E. Chan, Michael Buljan, Manuel Alberto Molina, Kathryn Toshimi Takamura, Tuan Tu Diep, Richard Heller, Robert H. Pierce, Shailender Bhatia
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Meeting Abstract
Medicine, General & Internal
Jonathan P. Sherlock, Barbara Joyce-Shaikh, Scott Turner, Manjiri Sathe, Jeff Grein, Daniel M. Gorman, Edward P. Bowman, Terrill K. McClanahan, Jennifer Yearley, Christopher D. Buckley, Robert A. Kastelein, Robert H. Pierce, Drake LaFace, Daniel J. Cua