Article
Critical Care Medicine
Joseph Khoa Ho, Abdollah Safari, Amin Adibi, Don D. Sin, Kate Johnson, Mohsen Sadatsafavi
Summary: The management of COPD relies on exacerbation history to stratify patients for future exacerbations. Prediction models can improve risk stratification, but their clinical utility can vary between populations.
Article
Biochemistry & Molecular Biology
Chunman Germain Ho, Stephen Milne, Xuan Li, Chen Xi Yang, Fernando Sergio Leitao Filho, Chung Yan Cheung, Julia Shun Wei Yang, Ana I. Hernandez Cordero, Cheng Wei Tony Yang, Tawimas Shaipanich, Stephan F. van Eeden, Janice M. Leung, Stephen Lam, Don D. Sin
Summary: This study found an association between eosinophilia in bronchoalveolar lavage (BAL) fluid and acute exacerbations of chronic obstructive pulmonary disease (AECOPD), suggesting BAL may be a sensitive marker for eosinophilic inflammation in the distal lung.
Article
Respiratory System
Kenneth Verstraete, Iwein Gyselinck, Helene Huts, Nilakash Das, Marko Topalovic, Maarten De Vos, Wim Janssens
Summary: This study developed machine learning models to estimate and predict individual treatment effects of interventions in patients with chronic obstructive pulmonary disease (COPD). The results showed that poor lung function and blood eosinophils were the strongest predictors of individual treatment effects. The findings suggest that machine learning models can be used to guide personalized treatment decisions in COPD.
Article
Multidisciplinary Sciences
Jiachen Li, Lirong Liang, Siyu Cao, Hengmo Rong, Lin Feng, Di Zhang, Shuilian Chu, Hang Jing, Zhaohui Tong
Summary: This study described the secular trend and identified risk factors of COPD-related 30-day readmission in Beijing from 2012 to 2017. The overall readmission rate increased from 11.5% in 2012 to 17.2% in 2017, with a higher rate for men. Comorbidities such as osteoporosis, coronary heart disease, congestive heart failure, and cancer were associated with an increased risk of readmission.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Nebal S. Abu Hussein, Stephanie Giezendanner, Pascal Urwyler, Pierre-Olivier Bridevaux, Prashant N. Chhajed, Thomas Geiser, Ladina Joos Zellweger, Malcolm Kohler, David Miedinger, Zahra Pasha, Robert Thurnheer, Christophe von Garnier, Joerg D. Leuppi
Summary: This study describes recurrent exacerbations in a GP-based Swiss COPD cohort and develops a statistical model for predicting exacerbation rates. A nomogram is created to assist clinicians in the decision-making process of COPD care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Jing Yuan Tan, Edwin Philip Conceicao, Liang En Wee, Xiang Ying Jean Sim, Indumathi Venkatachalam
Summary: During the COVID-19 pandemic, public health measures were effective in reducing hospital admissions for all AECOPD as well as RVI-associated AECOPD, highlighting the importance of such measures in controlling respiratory infections.
Article
Critical Care Medicine
Charles R. Esther, Wanda K. O'Neal, Wayne H. Anderson, Mehmet Kesimer, Agathe Ceppe, Claire M. Doerschuk, Neil E. Alexis, Annette T. Hastie, R. Graham Barr, Russell P. Bowler, J. Michael Wells, Elizabeth C. Oelsner, Alejandro P. Comellas, Yohannes Tesfaigzi, Victor Kim, Laura M. Paulin, Christopher B. Cooper, MeiLan K. Han, Yvonne J. Huang, Wassim W. Labaki, Jeffrey L. Curtis, Richard C. Boucher
Summary: This study identified altered physiologic pathways associated with COPD airway pathophysiologic features through the analysis of sputum samples. Several biomarkers were found to be correlated with disease severity and predicted exacerbations in COPD patients.
Article
Critical Care Medicine
Brian W. Carlin
Summary: COPD exacerbations are serious and costly, but can be better managed through improved detection, personalized care, and preventive strategies. The GOLD recommendations have refined the definition of exacerbations and highlighted the importance of pharmacologic treatment. New technologies, such as artificial intelligence and wearable monitoring devices, are being utilized for early detection. These advancements have the potential to significantly improve outcomes for COPD patients.
Article
Multidisciplinary Sciences
Peter Alter, Tanja Lucke, Henrik Watz, Stefan Andreas, Kathrin Kahnert, Franziska C. Trudzinski, Tim Speicher, Sandra Soehler, Robert Bals, Benjamin Waschki, Tobias Welte, Klaus F. Rabe, Jorgen Vestbo, Emiel F. M. Wouters, Claus F. Vogelmeier, Rudolf A. Joerres
Summary: Cardiovascular comorbidities are predictors of mortality but not exacerbation risk in patients with chronic obstructive pulmonary disease.
SCIENTIFIC REPORTS
(2022)
Article
Respiratory System
Susan Muiser, Kai Imkamp, Dianne Seigers, Nynke J. Halbersma, Judith M. Vonk, Bart H. D. Luijk, Gert-Jan Braunstahl, Jan-Willem van den Berg, Bart-Jan Kroesen, Janwillem W. H. Kocks, Irene H. Heijink, Helen K. Reddel, Huib A. M. Kerstjens, Maarten van den Berge
Summary: Maintenance and reliever therapy (MART) with inhaled corticosteroid (ICS)/formoterol is as effective as fixed-dose fluticasone/salmeterol therapy in reducing exacerbations in moderate to severe patients with chronic obstructive pulmonary disease (COPD). Furthermore, MART requires a lower daily ICS dosage.
Article
Respiratory System
Bryan A. Ross, Dany Doiron, Andrea Benedetti, Shawn D. Aaron, Kenneth Chapman, Paul Hernandez, Francois Maltais, Darcy Marciniuk, Denis E. O'Donnell, Don D. Sin, Brandie L. Walker, Wan Tan, Jean Bourbeau
Summary: This study investigated the association between short-term air pollution exposure and exacerbations in Canadian adults with mild to moderate COPD, and found that increased ambient concentrations of NO2 and PM2.5 were associated with higher odds of exacerbations.
Review
Biochemistry & Molecular Biology
Suneeta Godbole, Russell P. Bowler
Summary: COPD is a complex lung disease with systemic manifestations that disrupt the metabolome in extrapulmonary compartments. A scoping review of COPD metabolomics literature revealed dysregulation in various metabolic pathways, influenced by age and sex. There is a lack of research on the association between the metabolome and COPD progression, warranting further investigation.
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Article
Pharmacology & Pharmacy
Rui Ye, Cuihong Wang, Pengbo Sun, Shuang Bai, Li Zhao
Summary: The expression of AGR3 in lung tissue may be associated with increased susceptibility to COPD exacerbation. Loss of AGR3 in airway epithelial cells could promote viral and bacterial infections, induce immune inflammation, and increase the risk of COPD exacerbation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Respiratory System
Hannah Whittaker, Clementine Nordon, Annalisa Rubino, Tamsin Morris, Yang Xu, Enrico De Nigris, Hana Mullerova, Jennifer K. Quint
Summary: This study investigated the association between lower respiratory tract infections (LRTIs) before chronic obstructive pulmonary disease (COPD) and future exacerbations and mortality. The results showed that increasing frequency and severity of LRTIs were associated with higher rates of subsequent exacerbations, as well as increased risk of all-cause and COPD-related mortality.
Article
Critical Care Medicine
Zhang Wang, Nicholas Locantore, Koirobi Haldar, Mohammadali Yavari Ramsheh, Augusta S. Beech, Wei Ma, James R. Brown, Ruth Tal-Singer, Michael R. Barer, Mona Bafadhel, Gavin C. Donaldson, Jadwiga A. Wedzicha, Dave Singh, Tom M. A. Wilkinson, Bruce E. Miller, Christopher E. Brightling
Summary: Analyzing the airway microbiome can help stratify neutrophilic COPD into subgroups that require different treatment approaches. Patients with neutrophilic COPD are susceptible to significant microbiome shifts during exacerbations, especially those in a stable state at baseline. Monitoring the temporal variability of the airway microbiome may provide insight into patient inflammatory status over time.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Fernando J. Martinez, Alvar Agusti, Bartolome R. Celli, MeiLan K. Han, James P. Allinson, Surya P. Bhatt, Peter Calverley, Sanjay H. Chotirmall, Badrul Chowdhury, Patrick Darken, Carla A. Da Silva, Gavin Donaldson, Paul Dorinsky, Mark Dransfield, Rosa Faner, David M. Halpin, Paul Jones, Jerry A. Krishnan, Nicholas Locantore, Fernando D. Martinez, Hana Mullerova, David Price, Klaus F. Rabe, Colin Reisner, Dave Singh, Jorgen Vestbo, Claus F. Vogelmeier, Robert A. Wise, Ruth Tal-Singer, Jadwiga A. Wedzicha
Summary: Chronic obstructive pulmonary disease (COPD) is the result of gene-environment interactions. Therapeutic trials targeting young COPD patients and pre-COPD patients are proposed to slow down disease progression. This article provides a detailed approach for RCT design and outcome assessment, and emphasizes the need for treatment trials in young and pre-COPD patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Fernando J. Martinez, Laurent Brochard, Andrew Bush, Gavin Donaldson, MeiLan K. Han
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Koralia Paschalaki, Christos Rossios, Charis Pericleous, Mairi MacLeod, Stephen Rothery, Gavin C. Donaldson, Jadwiga A. Wedzicha, Vassilis Gorgoulis, Anna M. Randi, Peter J. Barnes
Summary: Cellular senescence is accelerated in smokers and COPD patients. In COPD patients on inhaled corticosteroids, cellular senescence and DNA damage response are reduced. In vitro studies suggest that corticosteroids protect endothelial cells by reducing oxidative stress-induced senescence and apoptosis.
Article
Critical Care Medicine
James P. Allinson, Shoaib Afzal, Yunus Colak, Debbie Jarvis, Helena Backman, Maarten van den Berge, H. Marike Boezen, Marie-Kathrin Breyer, Robab Breyer-Kohansal, Guy Brusselle, Otto C. Burghuber, Rosa Faner, Sylvia Hartl, Lies Lahousse, Arnulf Langhammer, Bo Lundback, Bright Nwaru, Eva Ronmark, Sigrid A. Aalberg Vikjord, Judith M. Vonk, Sara R. A. Wijnant, Peter Lange, Borge G. Nordestgaard, Nuria Olvera, Alvar Agusti, Gavin C. Donaldson, Jadwiga A. Wedzicha, Jorgen Vestbo, Lowie E. G. W. Vanfleteren
Summary: Socioeconomic and scientific advances have led to improvements in lung function among European populations, which may impact the interpretation of lung function measurements and the diagnosis of lung diseases. Analysis of cross-sectional data from ten European population-based studies revealed an increase in FEV1 and FVC values over the past century, while the FEV1/FVC ratio decreased.
LANCET RESPIRATORY MEDICINE
(2022)
Editorial Material
Critical Care Medicine
James P. Allinson, Pujan H. Patel, Gavin C. Donaldson
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Tessa M. Kole, Elise Vanden Berghe, Monica Kraft, Judith M. Vonk, Martijn C. Nawijn, Salman Siddiqui, Kai Sun, Leonardo M. Fabbri, Klaus F. Rabe, Kian Fan Chung, Gabriele Nicolini, Alberto Papi, Chris Brightling, Dave Singh, Thys van der Molen, Sven-Erik Dahlen, Alvar Agusti, Rosa Faner, Jadwiga A. Wedzicha, Gavin C. Donaldson, Ian M. Adcock, Lies Lahousse, Huib A. M. Kerstjens, Maarten van den Berge
Summary: This post-hoc analysis investigates the determinants, clinical implications, and outcome of persistent airflow limitation (PAL) in patients with asthma. The study reveals that PAL is not only present in severe asthma, but also in a considerable proportion of patients with milder disease. In patients with mild asthma, PAL is associated with eosinophilic inflammation and a higher risk of exacerbations, suggesting the need for increased treatment intensity.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nidhish Jeyin, Sujal R. Desai, Simon P. G. Padley, Kshama Wechalekar, Sima Gregg, Tiago Sousa, Pallav L. Shah, James P. Allinson, Nicholas S. Hopkinson, Sofina Begum, Simon Jordan, Samuel V. Kemp, Carole A. Ridge
Summary: The purpose of this study was to evaluate whether dual-energy computed tomographic pulmonary angiography (DECTPA) derived lobar iodine quantification can accurately estimate lobar perfusion in patients with severe emphysema, and provide an adjunct to single-photon emission CT perfusion scintigraphy (SPECT-PS) in assessing suitability for lung volume reduction (LVR). The results showed that DECTPA provides an accurate estimation of lobar perfusion, showing good agreement with SPECT-PS, and could potentially streamline preoperative assessment for LVR.
JOURNAL OF THORACIC IMAGING
(2023)
Article
Critical Care Medicine
Pallav L. Shah, Christopher M. Orton, Beatriz Grinsztejn, Gavin C. Donaldson, Brenda Crabtree Ramirez, James Tonkin, Breno R. Santos, Sandra W. Cardoso, Andrew Ritchie, Francesca Conway, Maria P. D. Riberio, Dexter J. Wiseman, Anand Tana, Bavithra Vijayakumar, Cielito Caneja, Craig Leaper, Bobby Mann, Anda Samson, Pankaj K. Bhavsar, Marta Boffito, Mark R. Johnson, Anton Pozniak, Michael Pelly
Summary: This study evaluated the safety and efficacy of oral favipiravir in hospitalized patients with COVID-19. The results showed that although favipiravir did not improve clinical outcomes for all hospitalized patients, it might have a beneficial clinical response for patients younger than 60 years old. The indiscriminate use of favipiravir globally should be cautioned, and further high-quality studies of antiviral agents and treatment combinations are warranted in COVID-19.
LANCET RESPIRATORY MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Kenki Matsumoto, Nicola Read, Keir E. J. Philip, James P. Allinson
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medicine, General & Internal
James Peter Allinson, Nishi Chaturvedi, Andrew Wong, Imran Shah, Gavin Christopher Donaldson, Jadwiga Anna Wedzicha, Rebecca Hardy
Article
Critical Care Medicine
James P. Allinson, Ben H. Vlies, Simon E. Brill, Martin Law, Girvan Burnside, Lydia J. Finney, Luana Alves-Moreira, Gavin C. Donaldson, Peter M. A. Calverley, Paul P. Walker, Jadwiga A. Wedzicha
Summary: The study suggests that 12-month use of doxycycline did not significantly reduce the exacerbation rate in COPD patients, but it may be beneficial for those with severe COPD or high eosinophil counts.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)