Article
Chemistry, Medicinal
Carly Deusenbery, Olivia Carneiro, Carleigh Oberkfell, Anita Shukla
Summary: This study evaluated the synergistic eradication mechanism of six compounds in nine combinations against MRSA biofilms. Two promising combinations of antibiotics and antibiofilm agents were identified, providing insight for the development of effective treatments against MRSA biofilms.
ACS INFECTIOUS DISEASES
(2023)
Article
Microbiology
Jordy Evan Sulaiman, Lexin Long, Pei-Yuan Qian, Henry Lam
Summary: Elasnin, a newly reported antibiofilm agent, has been found to have superior activity in eradicating daptomycin-resistant MRSA strain biofilms compared to the wild type. This study highlights the lower expression of key proteins involved in pathogenesis and cell adhesion in the daptomycin-resistant strain, leading to weaker biofilm development. Elasnin shows great potential for clinical use in settings with daptomycin-resistant strains and biofilm formation.
MICROBIOLOGY SPECTRUM
(2022)
Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Pooi Yin Chung, Ranon Earn Yueh Khoo, Hui Shan Liew, May Lee Low
Summary: The study demonstrated that the two SBD compounds showed significant antimicrobial and antibiofilm activities against Staphylococcus aureus, with mild toxicity against normal cells. Combinations of the compounds with oxacillin and vancomycin mainly had additive effects. These compounds exhibited greater cytotoxicity towards Staphylococcus aureus compared to normal cells, indicating potential as antimicrobial agents.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Microbiology
Razieh Kebriaei, Katherine L. Lev, Rahi M. Shah, Kyle C. Stamper, Dana J. Holger, Taylor Morrisette, Ashlan J. Kunz Coyne, Susan M. Lehman, Michael J. Rybak
Summary: Bacterial biofilms are difficult to eradicate and can complicate infections. Phage+antibiotic combinations (PAC) may be more effective on biofilms than single agents. Our study demonstrated the effectiveness of phage Sb-1 on MRSA biofilms and suggested PAC regimens as adjuncts to antibiotics.
MICROBIOLOGY SPECTRUM
(2022)
Review
Materials Science, Multidisciplinary
Shreya Kanth, Akshatha Nagaraja, Yashoda Malgar Puttaiahgowda
Summary: The current global death rate is threatened by deadly unknown infections and the emergence of multidrug-resistant bacteria. Combatting drug-resistant bacteria, such as MRSA, has become a daunting challenge globally, with polymer synthesis being explored as a significant approach in preventing the spread of infections.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Food Science & Technology
Martina Florianova, Kristyna Korena, Helena Juricova
Summary: This study evaluated the prevalence of Staphylococcus aureus in dry-fermented salami and found multidrug-resistant and virulent strains. The source of contamination was identified as raw pork and human carriers. Therefore, maintaining high standards of hygiene and manufacturing practices in food processing is crucial.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Feiteng Zhu, Hemu Zhuang, Shujuan Ji, Er Xu, Lingfang Di, Zhengan Wang, Shengnan Jiang, Haiping Wang, Lu Sun, Ping Shen, Yunsong Yu, Yan Chen
Summary: The study found that in households of CA-MRSA infected patients in China, most MRSA isolates belonged to epidemic CA-MRSA clones, while no MRSA was detected in the control group households. The research revealed that the home environment is an important reservoir for MRSA.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Isabel Guthridge, Simon Smith, Matthew Law, Enzo Binotto, Josh Hanson
Summary: Lincosamides, particularly when used as a predominant therapy, show potential efficacy in the treatment of MRSA bacteremia, especially in young, clinically stable patients with few comorbidities. Patients receiving lincosamide-predominant therapy had lower in-hospital mortality and a lower incidence of renal complications compared to those receiving an alternative regimen. Prospective studies are needed to further define the optimal role of lincosamides in the treatment of MRSA bacteremia.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Jin Liang, Yuanfang Hu, Mingxia Fu, Na Li, Fengxia Wang, Xiaojun Yu, Bing Ji
Summary: The study investigated the molecular epidemiology of Staphylococcus aureus (S. aureus) in patients from the Yellow River Delta region and examined antibiotic resistance profiles in different genetic backgrounds. Antibiotic susceptibility testing, spa typing, and agr typing were conducted on all 204 strains. The results identified 39 MRSA strains and 22 hVISA isolates. The majority of MRSA isolates belonged to agrI and were associated with type IV SCCmec. The most common genotypes among MRSA population were ST59-t437-agrI-IVa and ST72-t2431-agrI-IVF. The study highlights the genetic diversity and drug resistance patterns among MSSA strains exhibiting phenotypic hVISA.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Public, Environmental & Occupational Health
Sara Quero, Marina Serras-Pujol, Noemi Parraga-Nino, Carmen Torres, Marian Navarro, Anna Vilamala, Emma Puigoriol, Javier Diez de los Rios, Elisenda Arque, Judit Serra-Pladevall, Alba Romero, Daniel Molina, Roger Paredes, Maria Luisa Pedro-Botet, Esteban Reynaga
Summary: This study investigated the prevalence of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) among workers in the pork production chain. The results showed that the prevalence of MRSA was high among workers in contact with live animals, especially in pig farms, livestock transporters, and slaughterhouses.
Review
Infectious Diseases
Martyna Kasela, Mateusz Ossowski, Ewelina Dzikon, Katarzyna Ignatiuk, Lukasz Wlazlo, Anna Malm
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of infectious diseases in humans and animals, resulting in economic losses in human healthcare and the farming sector. The changing epidemiology of MRSA globally affects animal welfare and public health concerns. Livestock have high rates of MRSA colonization, raising questions about reservoirs and transmission, while companion animals vary in MRSA colonization and infection rates, impacting human health. This article highlights the circulation of animal-associated MRSA (AA-MRSA) in the environment and factors influencing its transmission, as well as successful strategies to limit its spread among animals and humans.
Article
Biochemistry & Molecular Biology
Mark Hutchins, Richard A. Bovill, Peter J. Stephens, John A. Brazier, Helen M. I. Osborn
Summary: The increasing number of antibiotic-resistant bacteria poses a serious threat to global human health. This study examines the glycosylation of nadifloxacin to improve its solubility and finds that one glycoside derivative has the potential to be an effective antibacterial agent.
Article
Orthopedics
Hanna H. Sorensen, Robert A. Magnussen, Alex C. DiBartola, Noah T. Mallory, Alan S. Litsky, Paul Stoodley, Steven D. Swinehart, Robert A. Duerr, Christopher C. Kaeding, David C. Flanigan
Summary: This study aimed to determine the impact of bacterial inoculation and length of exposure on the mechanical integrity of soft tissue tendon grafts. The presence of Staphylococcus epidermidis increased the elasticity and decreased the ultimate tensile strength of human cadaveric tendons, with a more significant effect observed with increasing bioburden.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Microbiology
Amelia Staats, Peter W. Burback, Andrew Schwieters, Daniel Li, Anne Sullivan, Alexander R. Horswill, Paul Stoodley
Summary: Infection is a major complication of knee and hip joint replacement surgery. This study aims to evaluate the influence of various factors on bacterial aggregation in synovial fluid and explore the primary mechanism of aggregate formation. The findings contribute to understanding the early bacterial survival in the joint and provide insights for preventing and treating joint infections.
Correction
Multidisciplinary Sciences
Erin S. Gloag, Guy K. German, Paul Stoodley, Daniel J. Wozniak
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Carsten Ulrich Schwermer, Dirk de Beer, Paul Stoodley
Summary: This study found that denitrification occurs in Pseudomonas aeruginosa biofilms and is present throughout the depth, even in oxic regions. Additionally, there is high heterogeneity in metabolic activity within the colony. The short-term influence of tobramycin on aerobic respiration demonstrated that the oxygen gradient can quickly reestablish and metabolic activity can immediately recover upon tobramycin removal.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Mengfei Li, Yanina Nahum, Karel Matous, Paul Stoodley, Robert Nerenberg
Summary: This study investigates the effects of biofilm mechanical heterogeneity on the results obtained by rheometry. Both experiments and simulations show that the biofilm properties determined by rheometry are strongly influenced by the weakest portion of the biofilm. The findings suggest caution should be exercised when interpreting rheometry data, particularly when the mechanical properties are stratified.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Microbiology
Hans-Curt Flemming, Eric D. van Hullebusch, Thomas R. Neu, Per H. Nielsen, Thomas Seviour, Paul Stoodley, Jost Wingender, Stefan Wuertz
Summary: In this review, the authors revisit the understanding of the biofilm matrix and discuss the diversity of its components and the novel aspects of their functional interactions. The biofilm matrix plays a crucial role in stabilizing microbial cells and fulfilling various functions. It is dynamic and influenced by physico-chemical and biological interactions as well as environmental conditions.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Immunology
Jacob R. Brooks, Douglas J. Chonko, Matthew Pigott, Anne C. Sullivan, Kelly Moore, Paul Stoodley
Summary: This study aimed to investigate whether certain components and their surface features are more prone to biofilm formation in primary total joint arthroplasty. It was found that biofilm predominantly formed on the non-articulating surfaces between components and on ridges and edges. This has important implications for intraoperative debridement, retention choices, and implant design.
Article
Biotechnology & Applied Microbiology
Erum Razvi, Gregory B. Whitfield, Courtney Reichhardt, Julia E. Dreifus, Alexandra R. Willis, Oxana B. Gluscencova, Erin S. Gloag, Tarek S. Awad, Jacquelyn D. Rich, Daniel Passos da Silva, Whitney Bond, Francois Le Mauff, Donald C. Sheppard, Benjamin D. Hatton, Paul Stoodley, Aaron W. Reinke, Gabrielle L. Boulianne, Daniel J. Wozniak, Joe J. Harrison, Matthew R. Parsek, P. Lynne Howell
Summary: Pel exopolysaccharide biosynthetic loci are widespread biofilm matrix determinants in bacteria. In Pseudomonas aeruginosa, the glycoside hydrolase activity of PelA decreases adherent biofilm biomass and generates the low molecular weight secreted form of the Pel exopolysaccharide. Secreted Pel contributes to the biomechanical properties of the biofilm and decreases the virulence of P. aeruginosa in Caenorhabditis elegans and Drosophila melanogaster.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Microbiology
Erin S. Gloag, Yalda Khosravi, James G. Masters, Daniel J. Wozniak, Carlo Amorin Daep, Paul Stoodley
Summary: Mechanical removal of dental plaque is augmented with therapeutic compounds to promote oral health. A dentifrice containing the ingredients zinc and arginine has shown efficacy at reducing dental plaque both in vitro and in vivo. However, how these active compounds interact together to facilitate dental plaque removal is unclear. Here, we used a combination of biophysical analyses and microscopy to demonstrate that combined treatment with zinc and arginine targets the matrix of dental plaque biofilms, which destabilized the mechanical integrity of these microbial communities, making them more susceptible to removal by shear forces.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Amelia Staats, Peter W. W. Burback, Nadia N. N. Casillas-Ituarte, Daniel Li, Michaela R. R. Hostetler, Anne Sullivan, Alexander R. R. Horswill, Steven K. K. Lower, Paul Stoodley
Summary: The formation of a bacterial biofilm in the postsurgical joint environment significantly complicates the resolution of an infection. This study investigated the mechanisms of Staphylococcus aureus aggregation in synovial fluid and identified clumping factor A as the primary genetic determinant of aggregation. The study also found that the size and antibiotic tolerance of the aggregates formed under different conditions varied.
JOURNAL OF BACTERIOLOGY
(2023)
Article
Chemistry, Physical
Rui Han, Xi-Qiao Feng, Waldemar Vollmer, Paul Stoodley, Jinju Chen
Summary: Bacteria adapt the mechanical properties of their cell envelope, including cell wall stiffness, turgor, and cell wall tension and deformation, to grow and survive in harsh environments. This study quantified the mechanical properties and turgor of Staphylococcus epidermidis using theoretical modelling and experimental approaches. The results showed that high osmolarity leads to a decrease in both cell wall stiffness and turgor, and that the turgor change is associated with a change in bacterial cell viscosity. The study also found that cell wall tension is higher in deionized water and decreases with an increase in osmolality.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Microbiology
Victor Choi, Jennifer L. Rohn, Paul Stoodley, Dario Carugo, Eleanor Stride
Summary: In this Review, emerging drug delivery strategies are discussed as a means to improve the clinical efficacy of antibiofilm agents in preventing and eliminating pathogenic biofilms. The potential benefits of these techniques include improved penetration of antimicrobials through biofilms, enhanced drug dispersal, and synergistic bactericidal effects. However, current limitations and future prospects for these therapies in the clinic are also highlighted.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Microbiology
Kelly Moore, Anthony Li, Niraj Gupta, Tripti Thapa Gupta, Craig Delury, Sean S. Aiken, Phillip A. Laycock, Paul Stoodley
Summary: This in-vitro study found that high purity antibiotic-loaded calcium sulfate beads containing vancomycin and tobramycin in combination may be more effective in treating multispecies biofilm orthopedic infections than monotherapy alone.
Article
Chemistry, Physical
Alexandra A. Snowdon, Simon P. Dennington, Jennifer E. Longyear, Julian A. Wharton, Paul Stoodley
Summary: Marine biofilms on ship hulls increase frictional drag, which has economic and environmental consequences. The study aimed to characterise the rheological properties of ship-relevant marine biofilms. The results confirmed that surface treatment influences the structural and mechanical properties of marine biofilms, which could have implications for drag.
Article
Radiology, Nuclear Medicine & Medical Imaging
Monique Doran, Gemma Reemst, Kenny Ng, Courtney Shaw, Paul Stoodley
Article
Otorhinolaryngology
Jason Lee, Alia Tayara, James D. Warren, Boris Kuyeb, Elizabeth McKee, Alexander Velazquez, Oishika Paul, Andrea F. Lewis
Summary: The purpose of the study was to understand the impact of COVID-19 on facial trauma incidence and etiology in Mississippi. The research found a significant increase in facial trauma caused by family members during the pandemic, which may be related to the reported increase in domestic violence. Additionally, there were notable changes in the etiology and insurance payor of facial trauma cases during the COVID-19 pandemic.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Sheila Moran, Cassidy Anderson, Risha Sheni, Monica Azmy, Daniel T. Li, Anthony M. Loizides, Christina J. Yang
Summary: This retrospective study found that a family history of eczema and a dairy-free diet may be associated with an increased risk of future diagnosis of EoE in children with aerodigestive dysfunction.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Robert Brinton Fujiki, Amanda Edith Fujiki, Susan L. Thibeault
Summary: This study examined the number of therapy sessions required for patients with EILO/ILO to sufficiently improve their symptoms. The results showed that patients with comorbid behavioral health diagnosis, higher vocal handicap index score, and reduced physical activity due to EILO/ILO symptoms required more therapy sessions. Patients with secondary environmental triggers also required more sessions. Only a small percentage of patients returned for additional therapy sessions after discharge, and they were mostly from affluent neighborhoods.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Brian W. Herrmann, Salina H. Goff, Juri Boguniewicz, Sarah A. Gitomer
Summary: This retrospective case series analyzed nHiB H. influenzae meningitis cases diagnosed at Children's Hospital Colorado from 2000 to 2020. The results showed that nHiB H. influenzae can cause both transient and permanent postmeningitic hearing loss. The use of steroids may offer otoprotection in nHiB H. influenzae meningitis. Further research is needed to better understand hearing outcomes after nHiB H. influenzae meningitis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
M. Kovacs, J. Uzsaly, G. Bodzai, I. Pap, B. Lippai, T. Dergez, A. Nemeth, I. Gerlinger, I. Szanyi, P. Bako
Summary: The pathophysiology and treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) are still debated. A randomized controlled trial showed no significant differences in hearing improvement between different treatments, but identified clinical factors such as vertigo, cardiovascular comorbidity, and initial hearing loss severity as significant predictors of hearing outcomes.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Roee Noy, Yotam Shkedy, Nadeem Habashi, Salem Billan, Jacob Cohen
Summary: Salvage cordectomy offers favorable larynx preservation rates and oncological outcomes for recurrent glottic cancer amenable to conservative surgery. Smoking, advanced age, and advanced tumor stages are associated with salvage cordectomy failure.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Pietro De Luca, Ignazio La Mantia, Federico Maria Gioacchini, Massimo Re, Marco Radici, Angelo Camaioni, Arianna Di Stadio
Summary: In this study, the effect of nasal packaging using Fitostimoline (R) gauze on nasal outcomes after septoplasty and FESS surgery was evaluated. The results showed that the use of Fitostimoline (R) gauze improved healing of nasal mucosa and reduced discomfort during tampon removal.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Anna Frants, Antonios N. Varelas, Alexa M. Franco, W. Matthew White, Minas S. Constantinides, Philip J. Miller, Judy W. Lee
Summary: This article introduces DESS as a new educational format to increase the comfort of residents with the surgical evaluation and intraoperative planning of rhinoplasty. Through DESS, residents display significant improvement in their comfort with facial nasal analysis and overall surgical preparation.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Zhengcai Lou, Zihan Lou, Tian Lv, Zhengnong Chen
Summary: This study compared the operation time, graft success, audiometric outcomes, and complications of the over-under technique using temporalis fascia and cartilage grafts for repairing large perforations. The results showed that both techniques had similar graft success rates and hearing outcomes, but the temporalis fascia graft technique prolonged the operation time and increased the risk of re-perforation and graft atelectasis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Ciaran Lane, Maxwell Wright, Janice Linton, Neerav Goyal
Summary: This study systematically reviewed the data on surgical closure of enlarged tracheoesophageal fistula after laryngectomy and compared different reconstruction techniques. The results showed that using vascularized tissue for reconstruction had a higher success rate compared to primary closure.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
John Q. Odom, Andrew R. Mangan, Anna Celeste Gibson, Michael Larson, John L. Dornhoffer, Robert A. Saadi
Summary: Granulomatosis with polyangiitis is often associated with otolaryngologic complaints, and in rare cases, patients may experience facial nerve palsy. It is important for healthcare professionals to recognize facial nerve palsy as a potential presentation of granulomatosis with polyangiitis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
R. Bar, A. Mattei, R. Haddad, A. Giovanni
Summary: Office-based flexible interventional laryngoscopy under local anesthesia is a safe and well-tolerated procedure, suitable for various ambulatory and office-based settings.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Do Hyun Kim, Soo Whan Kim, Sung Won Kim, Gulnaz Stybayeva, Se Hwan Hwang
Summary: This systematic review and meta-analysis compared the effects of cryotherapy and radiofrequency neurolysis in treating rhinitis-related symptoms caused by ablation of the posterior nasal nerves. The results showed that both cryotherapy and radiofrequency neurolysis significantly improved rhinitis-related symptoms and quality of life. Radiofrequency neurolysis was found to be more effective than cryotherapy in reducing total nasal symptom scores.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Mengdie Gao, Liyu Cheng, Qingcui Wang, Qingwen Yang, Xiaoyi Wang, Yanru Li, Rong Hu, Wen Xu
Summary: This study investigates the clinical characteristics, diagnosis, and prognosis of patients with laryngeal tuberculosis (LTB) combined with respiratory tuberculosis. The study found that LTB commonly affects middle-aged men and presents with symptoms such as hoarseness, abnormal sensation of pharyngeal, and pharyngalgia. The lesions mainly involve multiple subregions, primarily the glottis, and can also involve the pharynx. Half of the patients were complicated with pulmonary tuberculosis (PTB), and chest CT was superior to X-ray in detecting pulmonary lesions. Most patients showed significant improvement in symptoms and morphology of the pharyngeal and laryngeal mucosa after regular anti-tuberculosis treatment.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Alfonso Scarpa, Emilio Avallone, Mario Carucci, Giovanni Salzano, Giuseppe Chiarella, Claudia Cassandro, Pasquale Viola, Filippo Ricciardiello, Massimo Ralli, Pietro De Luca, Francesco Antonio Salzano
Summary: This study assessed the efficacy and safety of low-dose intratympanic gentamicin for vertigo attacks in Meniere's disease. The treatment significantly reduced vertigo attacks without causing hearing deterioration. The method primarily affected vestibular function while preserving cochlear integrity. These findings suggest that a low-dose, clinical symptomatology-based gentamicin treatment regimen could be an effective and safe strategy for managing unilateral Meniere's disease.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
