Article
Multidisciplinary Sciences
Jose Ignacio Fernandez-Vigo, Francisco Javier Moreno-Morillo, Emilio Lopez-Varela, Jorge Novo-Bujan, Marcos Ortega-Hortas, Barbara Burgos-Blasco, Lorenzo Lopez-Guajardo, Juan Donate-Lopez
Summary: This study assessed the repeatability of flow signal voids (FSV) measurements of the choriocapillaris (CC) and choroid (CH) in central serous chorioretinopathy (CSCR) using Swept-Source optical coherence tomography angiography (SS-OCTA). The results showed that SS-OCTA offers good repeatability for quantifying macular FSV in both CSCR eyes and fellow eyes.
Article
Medicine, General & Internal
Kyu Jin Han, Hyeong Ju Kim, Je Moon Woo, Jung Kee Min
Summary: Retinal layer thickness and capillary vessel density were investigated in patients with spontaneously resolved CSC, showing a decrease in outer retinal layer thickness and choriocapillaris VD. Outer retinal layer thickness may be an important visual predictor of CSC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Enrico Borrelli, Marco Battista, Costanza Barresi, Domenico Grosso, Maria Cristina Gabela, Alberto Quarta, Andrea Saladino, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
Summary: The purpose of this study was to quantitatively evaluate the inner and outer choroidal changes in the fellow eyes of patients with unilateral central serous chorioretinopathy (CSC). The results showed that both the choriocapillaris and stromal areas were increased in the unaffected eyes of unilateral CSC patients, along with a higher choroidal vascularity index. Additionally, the percentage and number of choriocapillaris flow deficits were also increased in these patients.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Bo-Een Hwang, Jae-Hyuck Kwak, Joo-Young Kim, Rae-Young Kim, Mirinae Kim, Young-Geun Park, Young-Hoon Park
Summary: The study investigates the choriocapillaris flow in central serous chorioretinopathy and its relationship with choroidal thickness and choroidal vascularity index. The results suggest that there is a decrease in choriocapillaris flow in acute CSC eyes, especially in the foveal lesion. This finding may be attributed to unmodulated choroidal blood flow.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Geun Woo Lee, Yun Young Kim, Kyung Jun Choi, Se Woong Kang
Summary: This retrospective cross-sectional study aimed to investigate biomarkers associated with visual symptoms and best corrected visual acuity (BCVA) improvement after photodynamic therapy (PDT) for central serous chorioretinopathy. Forty-two consecutive eyes from 42 patients who underwent successful PDT were divided into complete (20 eyes) and incomplete recovery groups (22 eyes) based on improvement in subjective visual complaints. Clinical characteristics, such as central foveal thickness (CFT), foveal avascular zone (FAZ) area, and changes in signal voiding of the choriocapillaris, were compared between the two groups. The study found that CFT and FAZ areas at baseline were significantly different between the groups. Logistic regression analysis showed that greater CFT predicted complete recovery from visual complaints. Reduction or disappearance of signal voiding in the choriocapillaris was more frequent in the complete recovery group. The study also revealed correlations between FAZ area before PDT and BCVA before and after treatment, as well as BCVA improvement during the study period.
Review
Chemistry, Medicinal
Stefano Da Pozzo, Pierluigi Iacono, Alessandro Arrigo, Maurizio Battaglia Parodi
Summary: Central serous chorioretinopathy (CSC) is a contentious disease involving various eye structures, with multiple therapeutic options available. Imaging plays a crucial role in evaluating and guiding treatment, while biomarkers serve as diagnostic and prognostic reference points.
Article
Medicine, General & Internal
Zuofen Wang, Zhaoting Xin, Jun Yang, Huawen Lu, Haiying Wang, Lin Zhu
Summary: The study found that the choriocapillaris vessel density at the leakage point of patients with acute central serous chorioretinopathy (CSC) was significantly reduced, but gradually increased with the recovery process, suggesting that ischemia might be one of the initiating factors in the pathogenesis of acute CSC.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Supriya Arora, Dmitrii S. Maltsev, Niroj Kumar Sahoo, Deepika C. Parameshwarappa, Claudio Iovino, Tarun Arora, Alexei N. Kulikov, Filippo Tatti, Ramesh Vankatesh, Nikitha Gurram Reddy, Ram Snehith Pulipaka, Sumit Randhir Singh, Enrico Peiretti, Jay Chhablani
Summary: The study evaluated the visual acuity and factors influencing it in central serous chorioretinopathy using a new multimodal imaging-based classification. Factors such as foveal involvement and outer retinal atrophy showed strong correlation with visual acuity, while age and duration of the disease also played a significant role. The study suggests that objective parameters of this new classification can help in establishing treatment guidelines for CSCR.
Article
Ophthalmology
Enrico Borrelli, Chiara Vigano, Marco Battista, Riccardo Sacconi, Carlotta Senni, Lea Querques, Domenico Grosso, Francesco Bandello, Giuseppe Querques
Summary: This study assessed the diagnostic accuracy of individual and combined imaging modalities for the detection of CNV in CSC. The results showed that OCTA had a higher diagnostic accuracy in identifying CNV than other imaging modalities. The combination of ICGA and structural OCT also achieved comparable diagnostic efficiency.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Oncology
Jose Ignacio Fernandez-Vigo, Francisco Javier Moreno-Morillo, Marcos Ortega-Hortas, Emilio Lopez-Varela, Jorge Novo-Bujan, Barbara Burgos-Blasco, Lorenzo Lopez-Guajardo, Julian Garcia-Feijoo, Juan Donate-Lopez
Summary: This study used swept-source optical coherence tomography angiography to assess the early changes in the choriocapillaris and choroidal vasculature in patients with persistent central serous chorioretinopathy. The study found that early vessel occlusion after photodynamic therapy was associated with a good treatment response, suggesting that an increase in flow signal voids immediately after therapy could be used as a biomarker to predict the resorption of subretinal fluid.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Ophthalmology
Pasquale Viggiano, Giacomo Boscia, Enrico Borrelli, Lisa Toto, Maria Oliva Grassi, Federica Evangelista, Ermete Giancipoli, Giovanni Alessio, Francesco Boscia
Summary: This study utilized SS-OCTA to evaluate the long-term changes in the choroidal and choriocapillaris layers in the unaffected eyes of patients with unilateral resolved chronic central serous chorioretinopathy. The results demonstrated significant improvements in choriocapillaris flow deficits during continuous oral eplerenone therapy, with no significant changes in best-corrected visual acuity.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Aya Kamimura, Akiko Miki, Maya Kishi, Mina Okuda, Mayuka Hayashida-Hirano, Mari Sakamoto, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
Summary: The purpose of this study was to compare the two-year outcome of half-time photodynamic therapy in chronic central serous chorioretinopathy patients with and without choroidal neovascularization. The study found that htPDT was less effective in eyes with CNV regarding the recurrence and persistence of subretinal fluid.
Article
Ophthalmology
Hoang Mai Le, Sarah Mrejen, Lise Sibilia, Salomon Y. Cohen
Summary: Quantitative analysis using SD-OCTA found no significant change in choriocapillaris flow deficits before and after half-fluence PDT in patients with chronic CSC.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Dominika Podkowinski, Bernhard Foessl, Luis de Sisternes, Sophie Beka, Anna-Sophie Mursch-Edlmayr, Rupert W. Strauss, Matthias Bolz
Summary: The study evaluated retinal blood flow in patients with acute central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (SS-OCTA) over a one-month period. Changes in the area of subretinal fluid (A-SRF) were observed, with differences in vessel density (VD) and perfusion density (PD) of the retinal capillary plexus noted. These alterations may lead to chronic changes in microvasculature and potential morphological changes.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Fabao Xu, Cheng Wan, Lanqin Zhao, Qijing You, Yifan Xiang, Lijun Zhou, Zhongwen Li, Songjian Gong, Yi Zhu, Chuan Chen, Cong Li, Li Zhang, Chong Guo, Longhui Li, Yajun Gong, Xiayin Zhang, Kunbei Lai, Chuangxin Huang, Hongkun Zhao, Daniel Ting, Chenjin Jin, Haotian Lin
Summary: The study aimed to predict the recurrence of central serous chorioretinopathy (CSC) patients using machine learning. The ensemble model performed the best among six different algorithms, demonstrating high accuracy in predicting recurrence at both 3 and 6 months. The simplified model showed comparable predictive power to the ensemble model.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Ophthalmology
Thibaud Mathis, Romain Mouchel, Jean Malecaze, Thibaud Garcin, Thibaud Mautuit, Laurent Kodjikian, Carole Burillon, Loic Druette, Philippe Denis
Summary: This study evaluated the time required to complete a cataract training program for first-year ophthalmology residents using the EyeSi simulator. The results showed that the scores obtained in the cataract challenge increased during the training program, which could lead to better surgery skills in young ophthalmologists.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Salomon-Yves Cohen, Marcel Dominguez, Florence Coscas, Celine Faure, Stephanie Baillif, Hassiba Oubraham, Laurent Kodjikian, Michel Weber
Summary: The purpose of this study was to evaluate the real-world treatment outcomes of neovascular age-related macular degeneration (nAMD) patients treated with intravitreal aflibercept (IVT-AFL) in routine clinical practice in France. The results showed a lack of long-term effectiveness of IVT-AFL treatment due to progressive undertreatment, highlighting the importance of initial monthly injections to achieve optimal functional outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jean-Francois Korobelnik, David Gaucher, Stephanie Baillif, Catherine Creuzot-Garcher, Laurent Kodjikian, Michel Weber
Summary: Optical coherence tomography angiography (OCTA) was used to study changes in macular vessels in eyes with diabetic macular edema (DME) treated with aflibercept. The study found no change in macular perfusion and vessel density during a 48-week follow-up, but improvement in central retinal thickness, macular volume, and visual acuity.
Article
Ophthalmology
Kenny Kodaday, Laurent Kodjikian, Etienne Gadiollet, Nicolas Chirpaz, Olivier Loria, Audrey Feldman, Flore De Bats, Carole Burillon, Philippe Denis, Pierre Pradat, Thibaud Mathis
Summary: The study evaluates the effect of individualizing initial treatment protocol according to macular neovascularization (MNV) subtype on the functional and anatomical response in neovascular age-related macular degeneration (nAMD). The secondary objective is to compare the treatment burden between each MNV subtypes. Results show that individualizing treatment regimen based on MNV subtype can improve the functional outcome and decrease the treatment burden.
Article
Medicine, General & Internal
Thibaud Mathis, Batoul El Ameen, Mayeul Chaperon, Yasmine Serrar, Francois Devin, Mikhail Dziadzko, Amina Rezkallah, Laurent Kodjikian
Summary: The aim of this study was to evaluate whether anatomical criteria based on optical coherence tomography (OCT)-guided strategy could determine the decision to retreat in patients with neovascular age-related macular degeneration (nAMD). A cross-sectional study of 142 eyes treated for nAMD was conducted, and the OCT-guided strategy showed a high level of agreement with the gold standard for treatment decisions. The findings suggest that selected nAMD patients under anti-VEGF treatment can be monitored without regular visual acuity testing.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Lucas Sejournet, Laurent Kodjikian, Sandra Elbany, Benoit Allignet, Emilie Agard, Mayeul Chaperon, Jeremy Billant, Philippe Denis, Thibaud Mathis, Carole Burillon, Corinne Dot
Summary: This study assessed the efficacy of focal photocoagulation in reducing the burden of intravitreal injections in patients with macular edema. The results showed significant reductions in macular thickness and injection frequency at 6 and 12 months after laser treatment, with stable best-corrected visual acuity. Therefore, focal photocoagulation appears to be an effective and safe treatment option for reducing the treatment burden in patients with macular edema.
Review
Medicine, General & Internal
Stephane Giorgiutti, Robin Jacquot, Thomas El Jammal, Arthur Bert, Yvan Jamilloux, Laurent Kodjikian, Pascal Seve
Summary: Sarcoidosis is an inflammatory disease that can affect the eyes, with uveitis being the most common ocular manifestation. This can lead to vision loss. Granulomatous uveitis is usually bilateral with synechiae. Diagnosis is based on histology or clinico-radiological features. Corticosteroids are the first-line treatment, but immunosuppressive treatments may be required for some patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Thibaud Mathis, Batoul El Ameen, Cristina Vartin, Yasmine Serrar, Frederic Matonti, Aditya Sudhalkar, Alper Bilgic, Amina Rezkallah, Laurent Kodjikian
Summary: This study examined the validity of using anatomical criteria alone to make retreatment decisions in patients with DME, compared to the gold standard that incorporates visual acuity. The OCT-guided strategy yielded equivalent results to the gold standard in 82.7% of cases, with variations in sensitivity and specificity based on the patient's treatment regimen.
Article
Ophthalmology
Laurent Kodjikian, Cecile Delcourt, Catherine Creuzot-Garcher, Pascale Massin, John Conrath, Marie-eve Velard, Thibaut Lassalle, Sybil Pinchinat, Laure Dupont-Benjamin
Summary: This study aimed to evaluate the real-world efficacy, safety, and treatment patterns of the dexamethasone intravitreal implant (DEX) in patients with diabetic macular edema (DME) in France. The results showed that DEX improved visual acuity and central retinal thickness in patients with DME, and resolution of DME was observed during follow-up, supporting the treatment benefits of DEX in DME.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Dino Ferracci, Thibaud Mathis, Antoine Gavoille, Mathieu Gerfaud-Valentin, Arthur Bert, Meriem Hafidi, Philippe Denis, Olivier Loria, Laurent Kodjikian, Pascal Seve
Summary: The purpose of this study was to report the progression of patients initially treated with corticosteroids for birdshot chorioretinopathy (BSCR). A total of 39 BSCR patients were included in the study and followed up for =1 year. The study found that prolonged corticosteroid therapy resulted in inflammation control in 50% of BSCR patients, with low doses of cortisone (<5 mg/day) being sufficient to maintain this control.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Joelle Al-Choboq, Thibaud Mathis, Juliette Restier-Verlet, Laurene Sonzogni, Laura El Nachef, Adeline Granzotto, Michel Bourguignon, Nicolas Foray
Summary: The study of radiation-induced cataractogenesis is limited by the shortage of available epithelial lens cell lines and reliable biomarkers of aging caused by radiation. A mechanistic model, RIANS, has been developed based on the nucleoshuttling of the ATM protein, which suggests the formation of perinuclear ATM crowns as a potential biomarker of aging. The radiobiological characterization of human and porcine lens cell lines showed delayed RIANS and the overexpression of the BFSP2 protein, which interacts with ATM and may facilitate the formation of perinuclear ATM crowns.
Article
Ophthalmology
Agnes Glacet-Bernard, Jean-Francois Girmens, Laurent Kodjikian, Cecile Delcourt, Franck Fajnkuchen, Catherine Creuzot-Garcher, Pascale Massin, Nathalie San Nicolas
Summary: The BOREAL-RVO study evaluated the use, effectiveness, and safety of ranibizumab treatment in patients with macular edema secondary to retinal vein occlusion in a real-world setting. The results showed significant improvements in visual acuity and central retinal thickness for both branch and central RVO patients, but under-treatment may lead to decreased efficacy.
OPHTHALMIC RESEARCH
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)