Review
Ophthalmology
Andrzej Grzybowski, Hiroyuki Shimada, Hiroyuki Nakashizuka, Jagger Koerner
Summary: Endophthalmitis following intraocular surgery is rare with current antiseptic techniques, but challenges such as increased multidrug-resistant bacterial endophthalmitis and low rate of endophthalmitis caused by typical bacteria still exist. Recent findings show that povidone-iodine is widely available and repetitively applying diluted povidone-iodine can effectively sterilize the ocular surface.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Seung Min Lee, Jong Ho Park, Su Youn Suh, Sang Min Lee, Iksoo Byon
Summary: Intravitreal administration of povidone-iodine demonstrated efficacy in treating Candida albicans endophthalmitis by reducing inflammation and fungal growth. However, the combination with voriconazole did not show a synergistic effect. The findings suggest that povidone-iodine may be a useful treatment option for this condition.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Seung Min Lee, Jong Ho Park, Chul Hun Jang, Iksoo Byon
Summary: Intravitreal injection of povidone-iodine was effective in treating VRE endophthalmitis, even at low concentrations. High-concentration intravitreal vancomycin injection can also be used to treat resistant strains within the safety threshold.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Medicine, General & Internal
Rosario Musumeci, Pasquale Troiano, Marianna Martinelli, Matteo Piovella, Claudio Carbonara, Scipione Rossi, Giovanni Alessio, Luisa Molteni, Claudio Giuseppe Molteni, Laura Saderi, Giovanni Sotgiu, Clementina Elvezia Cocuzza
Summary: The study showed that using 0.66% povidone-iodine eye drops before cataract surgery effectively reduced the conjunctival bacterial load and facilitated the smooth progress of the operation. Analysis of 120 patients revealed that all subjects showed a reduction or no regrowth of bacterial load. The study indicates that povidone-iodine eye drops can be an effective perioperative prophylactic treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yanling You, Ya-Xuan Zhu, Junjie Jiang, Zhixin Chen, Chenyao Wu, Zhimin Zhang, Han Lin, Jianlin Shi
Summary: In this study, a new two-dimensional iodine nanomaterial called iodinene was proposed for the treatment of infectious diseases in vivo. Iodinene demonstrated enhanced antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by in situ production of active HIO and I2 molecules via allotropic transformation. The in vivo results further confirmed the desirable antibacterial efficacy of iodinene in treating bacterial wound infection and pneumonia.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Biomaterials
Yingmin Ye, Yanmin Wang, Kai Zhang, Wei Guo, Tianyu Kong, Xiaokang Ding, Nana Zhao, Fujian Xu
Summary: In this study, a simple method is reported to prepare two-dimensional iodine nanosheets (2D iodine NSs) with good stability and high biocompatibility using an aqueous solvent-assisted ultrasonic route. Due to the large specific surface area of the 2D morphology, iodine NSs effectively interact with bacterial membranes, leading to the destruction of bacterial integrity and further damage to intracellular DNA. Consequently, the iodine NSs exhibit significant antibacterial activity against S. aureus both in vitro and in vivo.
BIOMATERIALS SCIENCE
(2023)
Article
Surgery
Rod J. Rohrich, Jasson T. Abraham, Brendan Alleyne, Justin Bellamy
Summary: This article describes simple preventative strategies during rhinoplasty procedures to minimize the risk of disease transmission, particularly discussing the use of povidone-iodine in prophylaxis during the perioperative period.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Allergy
Susann Forkel, Caroline Beutner, Katharina Amschler, Silke Sabina Schroeder, Michael P. Schoen, Johannes Geier, Timo Buhl
Summary: Patch testing with PVP-I 2% aq. showed the lowest number of doubtful skin reactions while detecting the single allergic patient, suggesting it as the optimal preparation for iodine patch tests. Overestimation of iodine allergy was indicated, and positive patch test responses to iodine should be confirmed with ROATs before diagnosis.
CONTACT DERMATITIS
(2021)
Article
Medicine, General & Internal
Ender Siyez
Summary: This study aimed to compare the incidence of febrile infectious complications after transrectal ultrasound-guided prostate biopsy in men receiving ciprofloxacin prophylaxis alone versus ciprofloxacin with povidone-iodine transrectal injection. The results showed a lower rate of febrile infectious complications in patients who received both ciprofloxacin and povidone-iodine prophylaxis compared to those who only received ciprofloxacin.
Article
Biochemistry & Molecular Biology
Celine Abueva, Hyun Seok Ryu, Jun Won Min, Phil Sang Chung, Hyeon Sook You, Myung Suk Yang, Seung Hoon Woo
Summary: The study synthesized a quaternary ammonium chitosan derivative, which when complexed with povidone-iodine showed increased effectiveness against multidrug-resistant bacteria and fungi, with no cytotoxic effects and promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Reproductive Biology
Juan E. Romano, Renato G. Zanoni, Beatrice Mislei, Diego Bucci, Domenico Mion, Gaetano Mari
Summary: The study estimated the number of colonies forming units (CFU) in penile mucosa and semen and compared the effect of two antiseptic solutions used to reduce bacterial counts in those areas. The results showed that flushing the preputial cavity with 0.05% chlorhexidine digluconate or 1% povidone-iodine solution reduced the CFU counts in penile mucosa and semen.
Article
Ophthalmology
Juan Marin-Nieto, Carmen Reino-Perez, Genoveva Santillana-Cernuda, Jose Manuel Diaz-Bernal, Rafael Luque-Aranda, Ignacio Garcia-Basterra
Summary: The study revealed that patients wearing surgical face masks for more than 4 hours had higher bacterial contamination in the periocular area, but the contamination was significantly reduced by using povidone-iodine. These findings suggest that the contamination of masks should be taken into consideration in the asepsis protocol for intravitreal injections.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Juan Marin-Nieto, Carmen Reino-Perez, Genoveva Santillana-Cernuda, Jose Manuel Diaz-Bernal, Rafael Luque-Aranda, Ignacio Garcia-Basterra
Summary: The study showed that surgical face masks worn for more than 4 hours had higher bacterial contamination in the periocular area, which could be significantly reduced by applying povidone-iodine. Therefore, the contamination of masks should be considered in the asepsis protocol for intravitreal injections.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Biochemical Research Methods
Mohamed Ibrahim Halawa, GuoXing Wu, Bing Shi Li
Summary: By synthesizing PVP-I-2@AuNPs and forming a chemiluminescent system with luminol, ultra-sensitive detection of Hg2+ ions with a detection limit of 0.1 nM was achieved. The system showed excellent selectivity and linear response, making it a promising sensor for real-time detection of Hg2+.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
C. Freeman, E. Duan, J. Kessler
Summary: The study found that compared with other iodine disinfectants, the iodine molecule I2 does not cause irritation or staining on the skin, and at high concentrations, I2 does not exhibit cytotoxicity on the skin compared to PVP-I. Additionally, I2 can penetrate into the dermis and out-gas from the skin.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Ophthalmology
Karlos Italo S. Viana, Camila T. Gordilho, Felipe P. P. Almeida, Marcelo M. Esperandio, David R. Lucena, Denny M. Garcia, Ingrid U. Scott, Andre M. Messias, Rodrigo Jorge
Summary: The study compared functional and anatomic outcomes of combined pars plana vitrectomy (PPV) and phacoemulsification (phaco) versus PPV and deferred phaco in patients with full-thickness macular hole (FTMH) and no significant cataract. Results showed similar outcomes in terms of visual acuity, macular sensitivity, and FTMH closure rate at 1-year follow-up between the two treatment approaches.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Andrew Hendrick, Paul C. VanVeldhuisen, Ingrid U. Scott, Jacquie King, Barbara A. Blodi, Michael S. Ip, Rahul N. Khurana, Neal L. Oden
Summary: Reduced intraretinal macular hemorrhage was associated with visual acuity improvement, with aflibercept-treated eyes showing the best outcomes. The presence of hemorrhage and change in central subfield thickness were significantly associated with the change in visual acuity at month 6, with central subfield thickness being a more important predictor.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Neal Kansara, David Cui, Kalins Banerjee, Zachary Landis, Ingrid U. Scott, Seth M. Pantanelli
Summary: The study aimed to investigate the relationship between ACA, PCA, and RA, showing that total keratometric astigmatism did not fully explain ocular astigmatism, with significant contributions from noncorneal astigmatism, especially in eyes with specific types of ACA.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2021)
Article
Ophthalmology
John C. Lin, Anagha Lokhande, Ingrid U. Scott, Paul B. Greenberg
Summary: Among ophthalmology residents in the US, having a graduate degree and the number of publications are key predictors of future research productivity.
SEMINARS IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ingrid U. Scott, Neal L. Oden, Paul C. VanVeldhuisen, Michael S. Ip, Barbara A. Blodi
Summary: Greater fluctuations in central subfield thickness as assessed by standard deviation and Zigzag measures were negatively associated with Month 12 visual acuity letter score. However, early post-treatment visual acuity letter score is a stronger predictor of visual acuity outcomes than the central subfield thickness fluctuation measures.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Saagar N. Patel, Charles Lee, David Cui, Andreas M. Wingert, Shouhao Zhou, Ingrid U. Scott
Summary: This study aimed to compare the incidence rate of delayed retinal break or detachment after diagnosis of acute, symptomatic PVD when the clinic is staffed by different professionals. The results showed no statistically significant difference in the incidence rates of delayed retinal tears or detachments among the staffing groups.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Editorial Material
Ophthalmology
John C. Lin, Sophia Y. Ghauri, Ingrid U. Scott, Paul B. Greenberg
OPHTHALMIC EPIDEMIOLOGY
(2023)
Article
Ophthalmology
Ingrid U. Scott, Neal L. Oden, Paul C. VanVeldhuisen, Michael S. Ip, Barbara A. Blodi
Summary: This study compared the baseline characteristics, treatment burden, and outcomes of macular edema in HRVO and CRVO patients. The study found a higher proportion of Black participants in HRVO group compared to CRVO group, and no significant differences in the frequency of macular edema treatments between the two groups. Although CRVO eyes had worse visual acuity and more macular edema compared to HRVO eyes at baseline, the magnitude of VALS improvement, central retinal thickness response to anti-VEGF therapy, and treatment burden were similar between the groups.
JAMA OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ingrid U. Scott, Paul C. Vanveldhuisen, Neal L. Oden, Michael S. Ip, Barbara A. Blodi
Summary: This study investigates the long-term outcomes of using aflibercept or bevacizumab to treat macular edema. The results show that while there is significant improvement in visual acuity and central subfield thickness during the initial treatment period, the improvement lessens when treatment is at the discretion of the investigator. However, most patients continue to receive treatment in the 5-year period.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Health Policy & Services
John C. Lin, Sophia Y. Ghauri, Dustin French, Ingrid U. Scott, Paul B. Greenberg
Summary: Most state-sponsored price transparency programs include pricing information for ophthalmic services, but specific out-of-pocket costs, insurance costs, or prices by insurers for ophthalmic services are not provided. There is substantial price variation for ophthalmic services both within and between states.
HEALTH POLICY AND TECHNOLOGY
(2022)
Article
Ophthalmology
Ingrid U. Scott, Neal L. Oden, Paul C. Vanveldhuisen, Michael S. Ip, Barbara A. Blodi
Summary: This study aimed to investigate the relationship between early discontinuation of anti-vascular endothelial growth factor (anti-VEGF) treatment and baseline factors and outcomes. The study found that compared to the continuous treatment group, patients who discontinued treatment early were younger and had a higher proportion of black individuals. They also had a higher proportion of complete resolution of macular edema and a lower central thickness over follow-up, but their visual acuity was not better than the continuously treated and intermittently treated groups. The results support the need for continued monitoring and individualized treatment for patients with macular edema from central or hemiretinal vein occlusion.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Brian L. L. VanderBeek, Yinxi Yu, Neal Oden, Paul VanVeldhuisen, Barbara Blodi, Michael Ip, Ingrid U. U. Scott
Summary: This study aims to quantify the association between visit adherence and visual acuity in patients with retinal vein occlusions. Visit adherence was measured by the number of missed visits, average and longest visit interval, and average and longest missed days. The study found that the number of missed visits was associated with a decrease in visual acuity, but the length of visit interval was not associated with changes in visual acuity.
OPHTHALMIC EPIDEMIOLOGY
(2023)
Article
Ophthalmology
Ingrid U. Scott, Neal L. Oden, Paul C. Vanveldhuisen, S. Michael, B. A. Blodi
Summary: There is a nonlinear association between central subfield thickness (CST) on spectral-domain OCT and concurrent visual acuity letter score (VALS) in eyes treated initially with afli-bercept or bevacizumab for macular edema associated with central retinal vein occlusion (CRVO) or hemiretinal vein occlusion (HRVO). The best expected VALS is observed when post-treatment CST is close to the estimated inflection points.
Article
Ophthalmology
Francyne Veiga Reis, Pedro Dalgalarrondo, Jose Edisio da Silva Tavares Neto, Murilo Wendeborn Rodrigues, Ingrid U. Scott, Rodrigo Jorge
Summary: This study aimed to investigate the safety and effects of combined intravitreal injection of dexamethasone and bevacizumab in patients with refractory diabetic macular edema (DME). The results indicated that the combined therapy led to increased intraocular pressure and the need for anti-glaucomatous eye drops, as well as reduced central sub-foveal thickness. However, there was no significant improvement in best-corrected visual acuity.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Article
Ophthalmology
A. U. Adrian, I. P. Michael, Barbara A. Blodi, Ingrid U. Scott, Neal L. Oden, Paul C. van Veldhuisen, David Sarraf
Summary: This study found a strong correlation between the severity of macular infarction measured by hyper-reflectivity of the middle and inner retinal layers and long-term visual outcomes in participants with central retinal vein occlusion. Despite significant improvement in macular edema after treatment, participants with more severe macular infarction showed worse visual outcomes, suggesting that macular infarction may play a role in visual acuity even after anti-VEGF treatment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
